オーラルピース

 

It is safe to swallow made from natural edible ingredients, Naturally derived oral care formulation "Neonashin® *"

"Neionisin® *" is a novel naturally occurring oral care made from plant lactic acid bacteria-derived antimicrobial peptides (proteins) and plant extracts born from the University of Kyushu University Faculty of Agriculture, Kagoshima University School of Dentistry, National Longevity Medical Center, and a gentle research institute It is a formulation. (Japanese Patent No. 5750552)

Neonaishin ® A

"Neionicin® *" is a naturally occurring preparation for oral care developed by industry-academia collaboration with Kyushu University Graduate School of Agricultural Research, Kagoshima University Graduate School of Medical and Dental Sciences, National Institute of Longevity Research Center Center Oral Disease Research Department, etc.

It is safe to digest and decompose promptly even when ingested gastrointestinally by accidental ingestion while approaches to bacteria in oral cavity · periodontitis bacteria · aspiration pneumonia causative bacteria, caused by naturally derived edible ingredients It is a big feature.

"Neionicin® *" is made by combining a protein made by a plant lactic acid bacterium living in Okara produced in Fukuoka Prefecture, "Nisin A" which is a bacteriocin, highly refined by its own technology and "plum extract" .

One ingredient, "Nisin A", was found in cheese by British dairymen in 1928. It is naturally contained in traditional fermented foods such as yoghurt, cheese and rice bran, and the food that human beings have eaten since ancient times. A certain lactic acid bacteria makes proteins that interfere with the bacterial population by getting rid of enemies for themselves to live. This is called bacteriocin.

Bacteriocin has been used worldwide for preserving food so far. Since "Nisin A" was approved by WHO and FAO in 1969, in the United States it has been generally approved as safe (GRAS) in 1988, and it is safe to use human naturally safe natural antibacterial agent in either method of ingestion or mucosal absorption It is approved for use in over 50 countries around the world. In the UK, France etc etc, the permission to use for cheese etc is unlimited, and in Japan we cleared all genotoxicity tests, carcinogenicity tests and other tests at the Ministry of Health, Labor and Welfare in 2009 and was recognized as a safe food It was.

However, general "Nisin A" has low stability, saltiness is high, it is cloudy, it has a smell, it can not be used as a preparation for oral care, and its use was limited exclusively to some foods. If you use an amount that can be expected as a preparation for oral care, it affects the taste and only a small amount There is a problem with stability with "nisin" alone.

Today, our company focuses on developing original separation and purification technology aiming at "Nisin A" of quality (taste, smell and stability) that does not matter even if put in its mouth, after 10 years of research and development It was able to invent the highly purified highly purified "Nisin A" which is superior in purity, salt free, liquid solubility and stability.

Furthermore, by combining "plum extract" with unique blending ratio, we overcome the weak point of "Nisin A" so far, and gained patent and invention of "Neionisin® *" ideal as a preparation for oral care. And in 2013 it was the first time in the world to open up a path to the use of bacteriocins for medical and cosmetic applications.

From the above, "Neionicin® *" can be said to be a new oral care formulation that meets the safety needs of various people.

* Cleaning aids

" Neonaishin ® " Media Information

The research results of Neonaishin® was announced at the Kyushu University Press Club on December 19, 2012 and was taken up in many media. Other images and articles can be viewed on the web.

Media Information

Research paper on Neonaishin ®

 
ネオナイシン・オーラルピース 論文-特集 飲み込んでも安全な乳酸菌抗菌ペプチドの効果と臨床応用「FRAGRANCE JOURNAL 2016-3」

2016.03.15

ネオナイシン・オーラルピース 論文-特集
飲み込んでも安全な乳酸菌抗菌ペプチドの効果と臨床応用
「FRAGRANCE JOURNAL 2016-3」

PDF : 1.1MB
 
 
オーラルピース 論文-総説 乳酸菌バクテリオシンの探索と利用 九州大学「Japanese Journal of Lactic Acid Bacteria」 日本乳酸菌学会

2014.05.25

オーラルピース 論文-総説
乳酸菌バクテリオシンの探索と利用 九州大学
「Japanese Journal of Lactic Acid Bacteria」
日本乳酸菌学会

PDF : 1.9MB
 
 
オーラルピース 論文 特集 乳酸菌の高度利用 乳酸菌バクテリオシンの探索と展望 九州大学 「食品と開発」UBMメディア株式会社

2014.05.25

ORALPICEC Thesis-Feature
Kyushu University outlook and advanced use lactic acid bacteria bacteriocins search of lactic acid bacteria "food and Development" UBM Media Co., Ltd.

PDF : 1.9MB
 
 

Neonaishin® was developed over 10 years of Years ;

Approach to bacteria

Neonaishin to drill a hole in the bacterial cell membrane

Form holes in the cell membranes such as dental caries

 

Neonaishin ® survival rate of bacteria after contact with the

Survival rate of bacteria
 

Neonaishin ® effect on the biofilm of bacteria

Effect on bacterial biofilms

Neonaishin® was born from such a voice

And "In swallowed the oral care agent broke stomach wrong ."
" Mouth is not rough , oral care agent is smarting "
" I want care agent that can be used with confidence because they use every day ."

Positioning of oral care agent

Positioning of oral care agent
 

Characteristic

  • Because it is natural ingredients that are produced from the lactic acid bacteria and plum from Okara , quickly decompose in the body of digestive enzymes if swallowed .
  • Environmental load is small with excellent biodegradability .
  • The unique blend of high purity of nisin A and plum extract , is less impact on the taste .

And to neonisin-e® corresponding 
also to oral cavity candida

Neonacin®, a safe oral care agent that can be swallowed evolves -Based on vegetable lactobacillus-derived peptide (protein) and rose essential oil Antimicrobial effect on oral candida on natural antibacterial agent "neonincin-e®"~ Covers compliance with infectious disease causative bacteria in the oral cavity

Candida is an indigenous fungus living in human skin and mucous membranes who are undergoing medical treatment for some basic diseases (cancer, blood disorders, immunodeficiencies such as AIDS, diabetes etc.) and immunosuppressants and antibacterial agents Infants and weak infants and elderly people cause infections. Especially in the elderly, oral candidiasis (*) covered with white molds on the surface of the tongue occurs many problems and becomes a problem.

Treatment of oral candidiasis is usually done with oral care and use of natural formulations that are concerned about safety when swallowed, such as antifungal agents (potent synthetic bactericidal agents to kill molds) or tree-based essential oils came. However, oral care alone can not sterilize or cure oral candidiasis once developed, and the use of antifungal drugs or conventional natural preparations is problematic of resistant bacteria and side effects (stomach break, teratogenic effect Other), there is a need for new therapeutic drugs that are safe and effective even when swallowed are worldwide.

 

Development of neonacin-e®

Neonicin has an excellent antimicrobial effect against bacteria, but had a weak point that it is less effective for fungi (yeast). Therefore, in order to complement the weak point of neionicin, selection test of various natural substances was conducted, and as a result, we found a synergistic effect with Nisin in a small amount of "damask rose essential oil" for yeast. Although it is said that "Damask rose essential oil" has antimicrobial activity than before, a certain concentration is necessary, and little effect was seen in trace amount. However, the antibacterial effect of the lactic acid bacterial peptide preparation "neonisin-e®", which combines "high-purity nisin" and a trace amount of "damask rose essential oil" at its unique blending ratio, was observed. "Neionicin-e®" is an evolutionary version of the conventional "neonicin". With this safe lactic acid bacteria peptide formulation to swallow it will cover most infectious disease causative organisms in the oral cavity

Damask rose from Bulgaria

Damask rose from Bulgaria

 

The characteristic of neonisin-e®

  • Further evolve utilizing the features of neonacin®
  • Excellent antimicrobial activity against causative bacteria against a wide range of oral infectious diseases such as Candida, tooth and bacteria, periodontitis bacteria, bad breath fungus, aspiration pneumonitis causative bacteria
  • High safety as natural origin
  • It has excellent biodegradability and is safe after decomposition (environment friendly · human friendly)
 
抗菌ペプチド(ナイシンA)とローズ油(ダマスクローズ精油)の酵母に対する抗菌活性 酵母に対する乳酸菌ペプチド製剤「ネオナイシン-e」の抗菌活性 細菌・真菌に対する乳酸菌ペプチド製剤「ネオナイシン-e」(ローズ油)の抗菌活性 各口腔用殺菌剤の比較
 

※ "Oral candidiasis"

Oral candidiasis is an infection caused by opportunistic infection of Candida, an indigenous bacterium in the oral cavity. It is caused by systemic factors such as some basic diseases (cancer, blood diseases, immunodeficiency diseases such as AIDS, diabetes, etc.), weak infants and elderly, immunosuppressants and antibiotics, Mossy spots appear in the mucous membranes. Treatment of oral candidiasis is usually done with oral care and use of natural formulations that are concerned about safety when swallowed, such as antifungal agents (potent synthetic bactericidal agents to kill molds) or tree-based essential oils came. However, oral care alone can not sterilize or cure oral candidiasis once developed, and the use of antifungal drugs or conventional natural preparations is problematic of resistant bacteria and side effects (stomach break, teratogenic effect Other), there is a demand for new therapeutic drugs that are safe and effective even when swallowed are worldwide.

※ "Candida albicans"

Candida albicans is a kind of causative bacteria of oral candidiasis in yeast. Originally living in human body surface, gastrointestinal tract, vaginal mucosa, it becomes the cause of opportunistic infection causing lesions when physical condition gets worse.

 

Press release material

 
Evolution of oral care agents safe to swallow ~ Antimicrobial effect on oral candida to heaven antibacterial agent by vegetable lactobacillus-derived peptide (protein) and rose essential oil ~ Covers compliance with infectious disease causative bacteria in the oral cavity

2017.07.28

Evolution of oral care agents safe to swallow
~ Antimicrobial effect on oral candida to heaven antibacterial agent by vegetable lactobacillus-derived peptide (protein) and rose essential oil ~
Covers compliance with infectious disease causative bacteria in the oral cavity

PDF : 1.0MB
 
 

"Neionisin-e®" Media Listing Information

神奈川新聞 2017年7月29日 日刊工業新聞 2017年7月31日 日本歯科新聞 2017年8月8日 日刊工業新聞 2017年7月31日