I became a social entrepreneur because I am a father of children with disabilities.

When my first child was born with a disability, I felt the vulnerability of families like ours and realized how few truly safe and gentle care options existed. That pain became my driving force.

In 2012, together with researcher Kohei Nagatoshi, I launched the ORALPEACE Project with just ¥500,000 and a small team of parents who shared the same fears about their children’s future. We developed “Neonisin” — a revolutionary oral care technology derived from natural lactic acid bacteria that kills harmful oral bacteria yet is completely safe if swallowed. It was created for babies, the elderly, people with disabilities, and now even astronauts.

What started in a tiny rented room in Yokohama has grown into something far beyond what I imagined:

• Selected by JAXA and loaded onto the International Space Station (the world’s first oral care product in space)
• Winner of Japan Venture Awards Grand Prize & Minister of Economy, Trade and Industry Award
• Good Design Award recipient (including the first personal care product for space use)
• Now available in 15+ countries

After moving to California in 2022, we accelerated our global mission. In 2025, in response to the FDA’s announcement to phase out swallowable fluoride products for young children, we launched a new fluoride-free toothpaste gel for babies and kids using cutting-edge natural green technology. We are expanding from Japanese supermarkets in California to premium retailers like Whole Foods and preparing for local U.S. production.

My journey hasn’t been easy — I lost everything after the Lehman Shock, continued volunteer work by bicycle, and faced deep personal losses. Yet these hardships taught me that loneliness and setbacks are simply the price of individuality. With humility, belief, and the right companions, they can become our greatest strength.

ORALPEACE is more than a product. It is a movement to create jobs for people with disabilities, solve the “post-parental death problem,” protect children’s health and the planet, and contribute to humanity’s future — even in space.

If you share the vision of using business to build a kinder, healthier, and more inclusive world — whether you’re a parent, retailer, distributor, researcher, investor, or simply someone who cares — I would love to connect.

Let’s protect the smiles of the next generation, together.

ORALPEACE Founder Daisuke Teshima interview on Japanese National broadcast
https://www.youtube.com/watch?v=ByuIqlJHxl4&t=26s

Springer Entrepreneurship in the Asia-Pacific: Case Studies
Daisuke Teshima & TRIFE Inc.ORALPEACE—Creating a New Business to Support the Elderly & Handicapped
https://oralpeace.com/wp-content/uploads/2021/01/Springer-Entrepreneurship-in-the-Asia-Pasific-ORALPEACE.pdf

Daisuke Teshima News Video Collection
https://www.youtube.com/playlist?list=PLBegZ2BmeuTIaOS55wJXZSj7G_-VmPOAF

Daisuke Teshima Reference Materials
https://oralpeace.com/en/library

Media Coverage
http://oralpeace.com/category/news

ORALPEACE Blog
http://oralpeace.com/category/blog

Born in Fukuoka Prefecture in 1971. He was born to a family who runs a dairy company that his grandfather founded in Kyushu about 100 years ago. Interested in the study of living things and animals since childhood. He admired Dr. William Smith Clark, who is famous for “Boys be ambitious”, and worked hard to study. After graduating, engaged in research and development of sanitary products (antibacterial agents) for the food environment at a major chemical manufacturer and health care cosmetics at a cosmetic manufacturer in 2000. From the days of research and development using rubber gloves and protective glasses, I strongly felt the need for an antibacterial agent that is kind to the body and the environment, and in 2002 I encountered a natural peptide “Nisin A” made by lactic acid bacteria at my father’s dairy company. He has promoted many industry-academia-government collaborative projects in Fukuoka Prefecture for research on safe antibacterial agents using “Nisin A”, and in 2007 he and Vice-President Emeritus Kenji Sonomoto of Kyushu University established a venture centered on the lactic acid bacteria antibacterial peptide “Nisin A”. Established the company (Quark Bio LLP). In 2011, while searching for research and commercialization of “highly purified Nisin A”, in 2011, he met Mr Teshima, who was looking for a strong business and technology for social contribution activities. 2012 Established Gentle Research Institute Co., Ltd. In order to develop a drug product that meets market needs in collaboration with Mr Teshima, after a further research period of one year, stable, transparent, tasteless and odorless “highly purified Nisin A” has overcome the weaknesses of “Nisin A” so far. , We succeeded in inventing a new lactic acid bacterium antibacterial peptide formulation, “Neonisin®”, which has a broad antibacterial spectrum that can be used not only for Gram-positive bacteria but also for Gram-negative bacteria. We will challenge the research and development and practical application of the world’s most friendly antibacterial agent that utilizes unique lactic acid bacterium research and biotechnology that have never been seen before. In 2016, we also succeeded in inventing the lactic acid bacterium antibacterial peptide formulation “Neonisin-e(evolution)®”, which is compatible with Candida (yeast/fungus), where natural antibacterial substances that are safe for the human body were desired. Won the 2017 Next Generation Healthcare Industry Award. Won the Agricultural Chemistry Technology Award from the Japan Society for Agricultural Chemistry in 2019 with Professor Kenji Sonomoto.
Until the Edo period, the Nagatoshi area in the southern part of Kyushu was the Satsuma(Kagoshima) domain, and the remains and place names of the Nagatoshi castle by Mr. Nagatoshi who occupied this area from the end of the Kamakura period are still present. The grandfather’s dairy company was sold to a major urban capital by M&A to protect local employment, and the Nagatoshi clan left management. His younger brother moved to Hokkaido and runs a ranch with his family. He is father of two college students and one high school student. He has a high level of trust as an active basketball player and as a leader for local children.
“I can connect what I have studied and learned to socially meaningful projects. I will do my best.”

After graduated from Faculty of Dentistry at Hiroshima University in 1992, Hitoshi Komatsuzawa served as a teaching assistant at the Faculty of Dentistry at Hiroshima University. He is the Associate Professor at Faculty of Dentistry, Hiroshima University in 2000. He is the Professor at Faculty of Medical Dentistry, Kagoshima University in 2008. He affiliates with the following society: Japan Bacteriological Society, Japanese Dental Association of Medical Sciences. He is specialized in Bacteriology, Oral Bacteriology, Basic Chemotherapy. He researched on the role of antimicrobial peptide in innate immune mechanism, studies on oral care, Staphylococcus aureus. He also studied on drug resistance and pathogenic factors, research on pathogenic factors of periodontal disease, nosocomial infections Molecular epidemiological analysis of bacteria.
“I have great expectation for the oral application of new antibacterial agent! We are looking forward to the contribution from Japan to the world and contribute to society. As an expert of antibacterial agent, I will continue to contribute down-to-earth.”

In 2004, Takeshi Zendo graduated from Faculty of Biological Resources and Environmental Science (Agriculture) of Kyushu University. He was the Assistant Professor at Institute of Agronomy, Kyushu University in 2006 and Associate Professor in 2007. He affiliates with the following society: Japan Agricultural Chemistry Society, Japan Bio Engineering Society, Japan Lactobacillus Academic Society. His area of expertise is Applied Microbiology. Takeshi Zendo’s research topic: Antibacterial peptides produced by lactic acid bacteria, bacteriocin studies (Search for new lactic acid bacteria, from search to application).
“It is with great emotion that the lactic acid bacteria we found is able to help the society, and I will continue to contribute in the future.”

Born in Matsuyama City, Ehime Prefecture, where her father was transferred to in 1971. She entered Ehime Prefectural Matsuyama Higashi High School, which was established in 1805 as a domain school by the lord of the Matsuyama domain, Sadanori Matsudaira, who was a well-known secondary school in Shiki Masaoka and Soseki Natsume. In 1990, she entered the School of Dentistry at Tokyo Medical and Dental University, which is a national university and the head of the Japanese School of Dentistry. 1996 Completed doctoral course at Tokyo Medical and Dental University Graduate School of Dentistry. After working as a researcher at Tokyo Medical and Dental University Graduate School and working at the Department of Oral Surgery at the National General Hospital, worked at the Dental Clinic in 2002. Involved in visiting dentistry.
Her father is Dr. Atsushi Sumida, a well-known researcher of carbon fiber at Toray Industries, Inc. He is a graduate of Kyoto University’s Faculty of Engineering and is an undergraduate student of the Nobel Prize-winning Professor Kenichi Fukui. She also has a doctor’s brother.
She met the ORALPEACE Project at the “Home Health Sciences Association” she attended in 2014. She is an angel mama who lost her daughter with a disability at the age of 0. Although she was in a mentally difficult time, in 2018, she overcame the rehabilitation of her right knee, which had been severely injured during a high school basketball game and lost her meniscus organization.
“Thoughts every day; I want to convey the importance of the mouth to many people. I want to contribute to the creation of mouths that can be eaten deliciously. I want to support the health of many people’s mouths. I want to reduce people’s suffering and illness, and want to go surfing this weekend.
When I first met ORALPEACE, the thoughts I had been thinking about every day seemed to be tightly packed in the green package, and I fell in love at first sight. As a doctor, I would like to objectively evaluate ORALPEACE and study various possibilities of ORALPEACE. “

He is member of the Japan Oral Hygiene Association. He is specialized in Vascular biology, dentistry conservation, periodontal disease, oral immunology, oral cavity Bacteriology, gerontology. His current research topic is development of an infection control method for oral infections, especially periodontal disease, development of an oral health and method for healthy aging.

Ryoji Kako was working with Nichimen Business Co. Ltd. (Currently known as Sojitz Corporation). During this period, he was responsible for the operation, management of export business, new business development, local sales, factories and etc. Later, Ryoji Kako joined Daiko Pharmaceutical Co., Ltd. He was responsible to oversee overseas business of pharmaceutical products and infection control materials. After the company listed, he was responsible for the business management of the international department and overseas, development of new markets, signing of contracts with overseas sales agencies, strengthening of risk management, and training of talents in overseas businesses. He joined Nichimen Business Co. Ltd. in 1972. In 1977, he was the Director of Textile Division for Nichimen Representative Office at Jeddah, Saudi Arabia. In 1980, he was the Director of Textile Division for Nichimen Representative Office at Republic of Panama. In 1985, he was the Director of Textile Division at Nichimen Representative Office at Dubai, United Arab Emirates. He was the General Manager of the Europe Textile Division at London, Europe, London in 1989. In 1995, he was the Director of Textile Materials of the Headquarters Textile Trading Division. In 1996, he was the Vice President of Nichimen America New York Branch in USA. In 1999, he was Hong Kong Nichimen Orient Wear Hong Kong Textile Division Manager. In 2004, he was the China General Manager of Sojitz Textile (Shanghai). In 2007, he was Sojitz Corporation, Head Office Apparel Division, Nichimen Infinity Consultant. In 2008, he was the Director of International Affairs of Daiko Pharmaceutical Co., Ltd. Ryoji Kako left Daiko Pharmaceutical Co. In 1972, Ryoji Kako graduated from Kansai University Business School. He graduated from Osaka City University in 2012. He graduated from the Arab Islamic College in 2016. He was Kobe City Economic and Tourism Bureau Overseas Business Center Advisor and former part-time lecturer at Faculty of Business Administration, Meiji University.

Lecturer at Faculty of Medicine and Dentistry, Kagoshima University, Doctor of Dentistry
Miki Matsuo graduated from the Faculty of Dentistry of Kyushu University (Professional Dental Science)

She is affiliate with the following society: Japan Bacteriological Society, Dental Fundamental Medical Society. Her area of expertise is Oral Bacteriology and Bacteriology. she researched on the relationship between the two-component control system of bacteria and bacteriocin. She also researched bacterial sugar metabolism mechanism.
“OralPeace not only prevents tooth decay and periodontal disease, but also gives you the peace of mind and safety that you never have. As a researcher, as a mother of a child, as a daughter with a senior parent, I am very happy to be involved as OralPeace project team.

Born in Hakone Japan in 1976. Started kendo in his childhood. After graduating from Kuwasawa Design School, he was involved in the design of famous magazine “Taiyo,” “BRUTUS,” and “Fashion News” at the design office “CAP.” 2003 Moved to Los Angeles, USA. After returning to Japan, started a design office ((STUDIO)) in Tokyo. Worked on art direction for magazines such as “Spectator”, “STUDIO VOICE” and “FRaU”, title design for NHK TV drama series “Kokoro”, fashion catalog such as “THE NORTH FACE 50th Anniversary Book”, art direction design for many artists’ CDs, books and photo books. Creating cutting-edge designs from Tokyo to the world. Since 2010, he has been in charge of “She with Shaplaneer” as a member of the NPO “Sell the Challenge”, a volunteer organization, and since 2013, he has been in charge of the art direction and design of “ORALPEACE”. 2017 Good Design Award winner, his package design is loved by many people around the world such as Asia, Europe, North America, Latin America and Australia. From the sharpened sensitivity, he always bring out advanced designs to the world and attract attention from all over the world.

Born in Hino City, Tokyo in 1975. In 2002, after witnessing economic poverty in India, he retired from a semiconductor trading company general career and joined a well-established international cooperation NGO, the nonprofit corporation Shaplanir = an overseas cooperation group by citizens.Mainly engaged in fair trade projects aimed at improving the lives of economically disadvantaged women in Bangladesh and Nepal, and support activities for children engaged in child labor.In 2011 she asked the volunteer group Sell the challenge, led by Mr Teshima, to help launch the brand.She launched Japan’s first Fair Trade Ayurveda soap brand “She with Shaplaneer” with designer Noriteru Minezaki, public relations Hiroshi Igarashi, and interior designer Shingo Abe.As a project leader, she works on alternative jobs for women who have no choice but to do sex work in Bangladesh and Nepal.In 2012, she was appointed as the head of the Dhaka office in Bangladesh.After local activities and top management in Dhaka, she retired from the NGO after she gave birth.Participated in the ORALPEACE project in 2016.
She has been a female lacrosse player and captain since high school. She also has a teacher license as an English teacher.Both her parents are teachers and prominent sports leaders who have completed the physical education course at the University of Tsukuba.
“Realization of a society in which no one is left behind. We sincerely hope that everyone can feel at ease and maximize the potential of everyone’s potential. A peaceful world with ORALPEACE!”

Born in Tsuchiura City, Ibaraki Prefecture in 1969. Ibaraki Prefectural Tsuchiura Daiichi High School graduate. Since he was a teenager, he woke up to mountaineering and travel around the world and became a pioneer of Japanese backpackers. After entering Keio University, he established FMS with his friends near his seat in the Sundai prep school.After graduating from university, engaged in system programming at Fuji Research Institute Co., Ltd. (now Mizuho Research Institute), which is a think tank.1998 Established a limited partnership central office. Established E-Soken Co., Ltd. in 2000 due to business expansion. Currently, President of the company. Director of Synagic Co., Ltd., Director of Gigadesign Co., Ltd., SME diagnostician, IT coordinator, second-class information processing engineer. Since 2006, he has been an advisor to Trif Inc.
Aspiring to be an entrepreneur from the judo club and university days until high school, he acquired a qualification as a small and medium-sized business diagnostician at the age of 26 when working at a think tank, became independent at the age of 28, and became an independent consultant under the “Office Security Mark Certification System”. Launch of various certification systems including the “Japan Color Certification System”, and as a think tank business, “Aizuwakamatsu City Regional Energy Conservation Vision Formulation Business, etc.”, “Small and Medium Business IT Utilization Support Manual”, “University-initiated ventures and commercialization possible” Sex survey” and so on. In addition to “Expert.com” as our own business, we are also developing our own Web service business such as “Lecture.com”, “Lecturer.com”, “Fruitya.com” (actually suspended due to the Fukushima City and Tohoku Earthquake). Deployment is also pioneering.
Previous members: Small Business IT Proposal Study Group (Ministry of Economy, Trade and Industry Information Processing Promotion Division) Member, IT Management Textbook Creation Committee Member (IT Coordinator Association), Koriyama Technopolis Regional Strategic Alliance Formation Committee Member, Ministry of Economy, Trade and Industry Information Policy Promotion Department, Information Processing Promotion Department, IT management support team, IT management textbook creation committee member.Dedicated to judo since childhood. Triathlete.
“I’m cheering for my best friend Teshima’s company when I was a teenager when I met him at Sundai Preparatory School.

He had a father of entrepreneurs who had a wide range of businesses in the prefecture, and he aimed to be an entrepreneur from his teens. Having acquired a national qualification as a management consultant at a young age, he had the foresight to start an IT company in his twenties and sincerely devote himself to the business.His way of life, knowledge, and room-filled books have led many entrepreneurs and business leaders of the same age, and many spills to their current positions.During the difficult times of Mr Teshima after the Lehman shock, he gave lectures and other work to support his life.In the fight against the pain of sinus cancer, which has lost the inside of the face for 5 years, he did not emit a weak sound and died in September 2018.After getting sick, he tried to stay healthy for his wife and daughter as long as possible, and at the end, he was taken care of by his wife and daughter, mother and brother, and Mr Teshima, who accidentally visited him.With a hot heart inside, a calm and quiet personality was loved and loved by many people.Mr Kazuo Nakamura, 48 years old with a strong life.