Japanese innovative bacteriocin
(lactic acid bacteria antibacterial peptide)
safety chemical-free oral-care gel/liquid for dog and cat
made from 100% plant-based food ingredients

“ORALPEACE for Pet” utilizes space and medical technology to provide dog and cat lovers who seek genuine products and their precious dogs and cats. This is an innovative toothpaste and oral care product for pets with safe Ingredients.

This antibacterial lactic acid bacterium was invented based on more than 20 years of research into lactic acid bacterium biotechnology to control bacteria, conducted by Kenji Sonomoto, a professor emeritus at Kyushu University and a doctor of engineering who has served as president of the Japan Lactic Acid Bacteria Society and president of the Japan Society of Bioengineering. Contains peptide (bacteriocin) patented formulation “Neonisin-e

“Neonisin-e®”, a patented formulation created from nisin, the only lactic acid bacteria antibacterial peptide (bacteriocin) approved as food in the world, instantly attacks bad breath, periodontal troubles, and tartar-causing bacteria at an ultra-low concentration. , plant-based, chemical-free toothpaste and oral care products for dogs and cats that are safe to swallow.

Japan’s 21st century green technology has solved the conflicting issues that could not be overcome with traditional chemical technology: “effectiveness against causative bacteria at ultra-low concentrations, high biodegradability, and safety when swallowed.” It is an animal oral hygiene brand originating from Japan that has created a new concept and category in the global pet market due to its unique characteristics.

The background to the development is the development of ORALPEACE, a toothpaste and oral care product for humans that is clinically effective against bacteria that cause oral problems such as periodontal disease and bad breath, and is safe to swallow, in response to the needs of the medical field. Since our launch in 2013, we have received many comments every day from people who want to use human-grade products and products that can experience the effects of innovative research results to care for their beloved pets, just like their own children. This project started because, like the research members who love pets, we were moved by the love that dog and cat owners have for their pets.

In response to the feelings of people all over the world that pets such as dogs and cats are irreplaceable members of the family just like humans, the Oral Peace Project has been established in Japan in four difficult years since its launch from scratch. We started a development plan for “ORALPEACE for Pet” as a commemorative project in 2015, when we won the Grand Prize at the Venture Awards and stood at the pinnacle of Japan’s bio x social ventures, and after a one-year research and development period, we launched it on the market in 2016. We have started offering.

Since then, the research and efforts of the innovative and patentable “ORALPEACE” have won numerous awards such as the Social Products Award, the Nippon Foundation Social Innovator, the Good Design Award, and the Japan Agricultural Chemistry Technology Award, as well as NHK World Broadcasting. In December 2020, it was selected by the Japan Aerospace Exploration Agency (JAXA) to be installed on the International Space Station (ISS), and was introduced in many public media. It is used for oral care and supports humankind’s expansion into space.

Currently, “ORALPEACE for Pet” is provided to advanced dog and cat lovers who understand the essence of products in more than 15 countries around the world, mainly in Japan, and is used not only on earth but also in space. This marks a major departure among global pet products.

Throughout the world, many pets have brought comfort and energy to humans during the coronavirus pandemic. In Japan, the number of pets exceeds the number of children under the age of 15, and pets are becoming an integral part of the family.

“ORALPEACE for Pet” maintains the concept of “ORALPEACE for your beloved family” as an item for humans, and aims to help you enjoy happy days with your irreplaceable and important family members, your dog or cat.
Through the passion and patented technology of researchers from national universities and other institutions who sincerely engage in new research and development every day, and through loving social projects with various project partners,
We will continue to deliver high-quality Japanese-made pet oral care products to people all over the world at honest, affordable, and reasonable prices.


  • People who want their pet to stay healthy
  • People who are worry about their pet’s body odour due to bad breath
  • Pet that is in hospital
  • Pregnant or nursing pet
  • Pet periodontal care before tartar is formed
  • People who care about food and what their pet can eat
  • People who hope that pet oral care can be done easily
  • People who value the brand background, concept and focus on product’s quality
  • People who like simple design even for pet products
  • People who want their pet to live safe, healthy and long-lived
  • People who worry about their pet’s oral problem
  • Senior pet
  • Pet daily oral cleaning
  • Tartar prevention and reduce unnecessary anesthesia
  • People who like products that has solid research background
  • People who do not want their pet to ingest synthetic ingredients such as chemical
  • People who like product from trusted stores
  • People who value the protection of the global environment
  • People who value social brands
  • People who value social brands
  • Pet that is taking medication and dry mouth
  • Puppy / Kitten
  • Pet daily oral care
  • People who pay attention to their family health
  • People who focus on product safety
  • synthetic raw materials, synthetic germicides, synthetic surfactant, synthetic preservatives, etc.
  • People who like eco-friendly products


By popular demand, we launched the “ORALPEACE for PET” series.

  • There are a few pet products that contain effective ingredients for solving oral problems, and very few of the products that are jointly developed by hospitals and universities using scientific methods.
  • The pets’ body are small, and hoped that the pet’s oral care products have undergone careful research and verification of effectiveness and safety.
  • Hope that effective oral care patent for human can also be applied to pet product.
  • It would be greatly appreciated if there are any pet care products that utilized research or technology that had an effect on the causative bacteria.
  • Hope that pet oral care products not only have good reputation, but also have the verification of effectiveness and safety.
  • Daily brushing is more difficult. An effective oral care product for pets would be more appreciated.
  • Hope there are high value-added oral care products that can help reduce total spending on the pet’s health, not just cheap low value-added products.
  • Products developed for humans being use for pets.
  • Hope that pet oral care products use food ingredients as safe raw materials, which will have a significant effect.
  • Hoped to use safe oral care products for pets to prevent disease entering from the mouth.
  • Hope oral care products are good for pets.
  • Hope to give pets family-like care and oral care.
  • Hope oral care products use 100% natural raw materials for puppies/ kittens to senior pets.
  • Hope that pet oral care products meet international organic certification standards and have high safety standard.
  • The trans-dermal absorption rate of chemical components through oral mucosa is 10 times more than the trans-cutaneous through skin. Pet’s parent doesn’t want to let the pets swallow the chemical components.
  • Hope pet oral care products will not put a burden on the global environment.
  • Under normal circumstances, general anesthesia is required for a pet to remove calculus, but there are always risks and concerns.
  • It is time consuming and the cost is high to remove calculus. Pet’s parent want to prevent it easily and effectively through daily brushing.
  • Bad breath will occur if pets’ oral is not taken care. They will easily have body odour after licking the fur. Eliminating bad breath will reduce the smell of pets, and it will be better to live with humans.
  • Hoped that pet oral care products will take into account the effectiveness and safety, and the price is reasonable.
  • Hope to get the pet oral care products with simple design.

Features of “ORALPEACE for PET”

  • Joint research and co-developed with Faculty of Agriculture – Kyushu University, Faculty of Dentistry – Kagoshima University, National Center for Geriatrics and Gerontology and Eco Friendly Institute. The research members including pet lovers medical doctor, dentistry doctor, engineering doctor, agriculture doctor, veterinarian, dentist and etc.
  • This product adopts biotechnology from Japan. It Contains lactobacillus bacteriocin patented formulation “Neonisin-e *”. The product’s research and innovation, technology patents, and convenience, sociality, and public welfare are recognized by public institutions only in Japan but worldwide. The ingredients used in this product have been verified by international institutions and various research institutions and are completely free of chemically synthesized ingredients. With 100% natural plant-derived ingredients and water as raw materials, there is no hidden safety hazard and it is safe to swallow for people and pets.
  • Both pet series and human series use the same ingredients, manufacturing methods, and factories that meet the standards of the international organic certification organization.
  • Rest assured that there are no chemically synthesized components and other components will absorb by the body through the oral mucosa.
  • Easy oral care is possible. Simply apply or dilute with water, no gargle needed.
  • Hypoallergenic and alcohol (ethanol) free. It can be used from puppies/ kittens to senior pets.
  • A refined design that enriches everyday life with the Good Design Award 2017. Reasonable price for long-term use.
  • ORALPEACE does not imitate or follow, and is determined to be an original brand.
  • ORALPEACE for PET supports facility dogs that providing comfort for children in hospital.
  • ORALPEACE business strives to provide employment opportunities for people with disabilities throughout Japan.
  • ORALPEACE oral care products bring warmth and happiness to you and your pets.

Key points of upgrading the “ORALPEACE for PET (gel)” released on 13 February 2020

  • Bulgarian Damascus Rose Oil was added to the original patented ingredient “Neonisin” and upgraded to “Neonisin-e”.
  • Thereby enhancing the sterilizing ability of oral candida, becoming a pet oral care product that more effectively responds to various pathogenic bacteria in the oral cavity.
  • Come with aluminum laminated tube and flip top cap, more convenient to use.
  • Improve the viscosity of the gel, better texture and taste milder and more natural Volume increased to 80g, price fixed same price.

* Cleaning aid

Product Line up

ORALPEACE for Pet. A drinkable toothpaste/oral care health gel for dogs and cats that contains the patented lactic acid bacteriocin formulation “Neonisin-e*” (Patent No. 5750552) derived from plant foods, and is made from water and plant-derived food ingredients.

Pet toothpaste and oral care gel for dog and cat lovers who want genuine pet products and for their beloved dogs and cats.

Tooth brushing and oral care that can be used forever for the health of your irreplaceable family. Gentle and refreshing taste. A soft, colorless and transparent gel.

Just apply it inside your mouth with a special toothbrush, finger cot, or clean gauze. Of course, you don’t need to rinse your mouth. If your dog does not want to open his mouth, it is also effective to give it to him by dissolving it in drinking water or mixing it with food.

ORALPEACE for Pet is

Pursuing unprecedented safety and clinical effectiveness,

Through industry-academia-government joint research with Kyushu University Graduate School of Agriculture, Kagoshima University Graduate School of Medical and Dental Sciences, National Center for Geriatrics and Gerontology, and other organizations,

Invented from Japanese research on lactic acid bacteria antibacterial peptides that control bacteria.

Contains a patented lactic acid bacterium peptide formulation “Neonisin-e®” (Patent No. 5750552) derived from plant foods,

Kind to your body and the earth.

Toothbrushing and oral care products with drinkable ingredients.

This one product provides total daily oral care for your pet, meeting the needs of pet owners who care about the health of their beloved pets.

Streptococcus mutans in the oral cavity, Pg bacteria, bacteria that cause periodontal problems, Escherichia coli, bacteria that cause aspiration lung problems, bacteria that cause bad breath, Candida bacteria, etc.

More than conventional antibiotics, synthetic bactericides, and phytotoxic antibacterial agents,

While instantly approaching with ultra-low concentration,

When swallowed, it is quickly broken down and digested as amino acids in the intestinal tract.

A safe product with no side effects that protects the intestinal flora, which is the source of your pet’s immunity, without sterilizing it.

Contains “Neonisin-e®”, a patented lactic acid bacterium peptide preparation produced by lactic acid bacteria derived from clean plant food, discovered in “okara” produced in Fukuoka Prefecture.

It also contains a humectant to keep the oral cavity moisturized.

By increasing the cleaning action of saliva, it prevents stains (pigments) from adhering and maintains white teeth.

Prevents bad breath by moisturizing the oral cavity, which tends to dry out from breathing through the mouth.

Made with only water that is safe to swallow, natural plant foods, and organic ingredients, it tastes delicious and your pet will love it.

It polishes well without using foaming agents, abrasives, or irritating ingredients, leaving little residue.

Contains no strong acidic water that dissolves teeth or strong alkaline water that damages mucous membranes.

Made possible by technological innovation and green technology from Japanese industry, academia and government, it is free of chemically synthesized ingredients and chemicals, and does not contain alcohol (ethanol), so it can be used even by pets that cannot gargle or spit.

Contains no synthetic disinfectants, synthetic preservatives, or persistent chemicals that kill intestinal bacteria, which are the source of immunity.

Even if it is discharged into the natural environment, it is quickly biodegraded by microorganisms and does not affect the beautiful natural soil and waterside microbial ecosystem.

It is also an environmentally friendly SDGs-compliant product that does not pollute the ocean where it is washed away and keeps the earth beautiful.

In addition, the research results to date have been recognized, and this product is expected to be used in space as a space toothpaste and oral care product.

For your beloved pet. People who are concerned about the health of their pets who swallow toothpaste and want safety in what they eat and put in their mouths on a daily basis. People who are concerned about daily health and preventive care.

Also for those who want to protect the beautiful environment of the earth.

This is a toothpaste and oral care gel with drinkable ingredients that are kind to the body and the earth, and can be used by the whole family every day, for beloved pets and pet owners who care about their health.


  • Content:80 g(about 2 months usage)


Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), xanthan gum* (thickener), plum fruit extract* (patented formulation “Neonisin-e®” aid, cleaning aid, product) (preservation performance aid), Caesarpinia spinosa gum* (thickener), peppermint oil*** (product preservation performance aid), spearmint oil*** (product preservation performance aid), damask rose flower oil*** (patented) Formulation “Neonisin-e®︎” auxiliary agent, product preservation performance aid) *Plant-derived ** Plant-derived lactic acid bacteria-derived ***Organic ingredients

ORALPEACE for Pet spray. A drinkable toothpaste/oral care health spray for dogs and cats made with water and plant-derived food ingredients, containing the patented lactic acid bacteriocin formulation “Neonisin-e*” (patent no. 5750552) derived from plant foods.

Pet toothpastes, oral care sprays, and liquids for dog and cat lovers who want genuine pet products and for their beloved dogs and cats.

Easy to spray. Of course, you don’t need to rinse your mouth.

Easy to use for pets that have fallen asleep.

If you are reluctant to open your mouth, it is also effective to dissolve it in drinking water.

Oral care that can be used forever for the health of your irreplaceable family.

Gentle and refreshing taste. Colorless and transparent liquid.

Through technological innovation and green technology from industry, academia, and government, we pursue effectiveness against trouble-causing bacteria and safety when swallowed.

Because of its unprecedented feature of targeting trouble-causing bacteria and making it safe to swallow, we pioneered the world’s first product category that can be dissolved in drinking water.

This one product provides total daily oral care for your pet, meeting the needs of pet owners who care about the health of their beloved pets.

Streptococcus mutans in the oral cavity, Pg bacteria, bacteria that cause periodontal problems, Escherichia coli, bacteria that cause aspiration lung problems, bacteria that cause bad breath, Candida bacteria, etc.

More than conventional antibiotics, synthetic bactericides, and phytotoxic antibacterial agents,

While instantly approaching with ultra-low concentration,

When swallowed, it is quickly broken down and digested as amino acids in the intestinal tract.

Protects the intestinal flora, which is the source of your pet’s immunity, without sterilizing it.

Safe with no side effects,

Contains “Neonisin-e®”, a patented lactic acid bacterium peptide preparation produced by lactic acid bacteria derived from clean plant food, discovered in “okara” produced in Fukuoka Prefecture.

Made with only water that is safe to swallow, natural plant foods, and organic ingredients, it tastes delicious and your pet will love it.

Made possible by technological innovation and green technology from Japanese industry, academia and government, it is free of chemically synthesized ingredients and chemicals, and does not contain alcohol (ethanol), so it can be used even by pets that cannot gargle or spit.

Even if it is discharged into the natural environment, it is quickly biodegraded by microorganisms, does not affect the microbial ecosystem, does not pollute the ocean where it is washed away, and is an environmentally friendly product that keeps the earth beautiful.

In addition, the research results to date have been recognized, and this product is expected to be used in space as a space toothpaste and oral care product.

For your beloved pet. People who are concerned about the health of their pets who swallow toothpaste and want safety in what they eat and put in their mouths on a daily basis. People who are concerned about daily health and preventive care.

Also for those who want to protect the beautiful environment of the earth.

Mouth sprays, mouth rinses, and oral care products with drinkable ingredients that are gentle on the body and nature, and can be used by the whole family every day, for beloved pets and pet owners who care about their health.

ORALPEACE for PET Refresh and Cleansing Liquid

  • Content:30 ml(about 2 months usage)


Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), plum fruit extract* (patented formulation “Neonisin-e®︎” aid, cleaning aid, product preservation performance aid), peppermint oil *** (product preservation performance aid), spearmint oil*** (product preservation performance aid), damask rose flower oil*** (patented formulation “Neonisin-e®︎” aid, cleaning aid, product preservation performance aid) *Plant-derived ** Plant-derived lactic acid bacteria-derived ***Organic ingredients

Designed by Noriteru Minezaki ((Studio))

The following ingredients are not used

ORALPEACE for Pet do not contain the following ingredients:

×Ingredients that are not approved for food that can be taken into the mouth
×Alcohol (ethanol, cause of dry mouth/avoidable for pets)
×Petroleum-derived ingredients
×Chemical substances
×Forever Chemical (PFAS)
×Cyanide(potassium cyanide, etc., poisonous substance, substance not permitted for food, substance prohibited from being released into the environment in ppm units)
×Potassium thiocyanate(Thyroid side effects, hazardous substance, substance prohibited from being mixed into food or released into the environment in ppm units, regulated by the U.S. Environmental Protection Agency in 2011, regulated by the European Union in 2014, and regulated by the Japan Ministry of Health, Labor and Welfare for hypothyroidism in 2021, the Japan Ministry of the Environment will classify it as an endocrine organ disruptor and prepare for regulations.)
×Hydrogen peroxide(deleterious substance, residual unlicensed substance in food, prohibited in Japanese toothpaste products in ppm units)
×Enzymes such as lactoperoxidase and glucose oxidase that cause a chemical reaction with hydrogen peroxide and thiocyanate in the oral cavity to generate cyanide and sterilize E. coli(Thyroid side effects, Japan Ministry of Health, Labor and Welfare and Ministry of the Environment impact risk
×Potassium iodide (Iodine, disinfectant, risk of side effects such as iodine poisoning and thyroid dysfunction)
×Formaldehyde (poisonous substance, bactericidal agent, there are cases where it is added to imported products in ppm units for antibacterial purposes due to carryover of preservatives from raw materials)
×Synthetic fungicides that disrupt the intestinal flora, which is the source of immunity, and are toxic in nature when released into the environment
×Synthetic disinfectants such as cetylpyridinium chloride (also known as cetylpyridinium chloride, CPC), benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, IPMP (isopropylmethylphenol), triclosan, methyl salicylate, lauroylsarcosine salt (LSS), etc.
×Chlorine, chlorine dioxide (CIO2), sodium chlorite, sodium hypochlorite, chlorine gas, etc. (deleterious substances, dangerous substances, bleach, pool disinfectants)
×Na hydroxide/K hydroxide (deleterious substance, caustic soda/potassium, strong alkali, biohazardous, corneal damage observed with 2% solution, prohibited substance remaining in food)
× Strong alkaline electrolyzed water (although it is water, it is strongly alkaline and there is a risk of damaging the oral cavity and visceral mucosa and diluting stomach acid if swallowed accidentally, so it is not used for oral care in medical care settings)
×Water-soluble synthetic polymers such as carbomer, sodium polyacrylate, and hydroxyethyl cellulose (liquid microplastics, may impede skin breathing, and are difficult to decompose in the environment as nanoplastics, posing risks to seafood and the body)
×Fluoride (Repellent for dogs)
×Titanium dioxide, TI dioxide, titanium oxide, TI oxide (coloring agent, bleach, suspected of carcinogenicity, French government has banned its inclusion in food from 2020)
×Phosphorus (phosphates such as polyphosphoric acid, metaphosphoric acid, pyrophosphoric acid, bleach)
×Aspartame (artificial sweetener, WHO suggested it may be carcinogenic in 2023)
×Artificial sweeteners such as sorbitol, sucralose, maltitol, erythritol, and saccharin sodium (effects on intestinal bacteria, etc.)
×Xylitol (effect on intestinal bacteria)
×Paraben (paraoxybenzoic acid ester, methylparaben, butylparaben)
×Phenoxyethanol (synthetic preservative, substance not permitted for food)
×Sodium benzoate (synthetic preservative)
×Sorbic acid potassium (synthetic preservative)
×Pentylene glycol (synthetic preservative)
×Glycine (preservative/food additive chemically synthesized from formaldehyde and hydrogen cyanide)
×Poly-ε-lysine (polylysine, an antibiotic analog produced by fungi-like actinomycetes, preservative and food additive)
×Synthetic surfactants and foaming agents such as sodium lauryl sulfate, lauryl glucoside, cocamidopropyl betaine, and sodium cocoyl glutamate that pose risks of swallowing and environmental pollution.
×Soap base, soap such as coconut oil fatty acid K, olive fatty acid K, etc., foaming agent
×Abrasives (stones, microplastic beads, mud, salt, etc.) that can be swallowed, accumulate in the gums, or abrade too much enamel and risk hypersensitivity.
×Calcium carbonate (Ca carbonate, large-particle abrasive, limestone powder, powder for drawing white lines on playgrounds, raw material for chalk), zeolite (zeolite), sodium bicarbonate (baking soda), coral powder, shells, Abrasives (compound, stone powder, etc.) such as mud (clay, montmorinite), charcoal, microbeads (plastic), etc.
×Large amounts of hydroxyapatite (risk of absorbing and sterilizing microorganisms in septic tanks and sewage treatment plants when discharged into the environment; risk of environmental pollution when discharged into the natural world)
×Strong synthetic fragrances and chemical fragrances that can disguise signs of illness such as bad breath (treatment of the affected area is necessary for health)
×Chemical substances whose names are hidden and only written as “fragrances” and “preservatives” (medicinal and quasi-drugs are not required to list all ingredients, and display names and INCI names can be hidden)
×Synthetic fragrances and flavors such as grape and cola made from chemicals
×Solubilizers such as PEG (polyethylene glycol) and propanediol
×BG (butylene glycol) ×PG (propylene glycol)
×EDTA-2Na × etidronic acid × phytic acid × nanoparticles
×Synthetic colorants made from petroleum tar raw materials such as Blue No. 1 and Yellow No. 2
×Metals such as copper and silver, heavy metals, heavy metals
×Poisonous components of animals and plants (natural poisons) × Aconite (alkaloids)
×Essential oils and resins with distilled and concentrated plant toxicity ×Tea tree essential oil
×Hinokitiol (teratogenic risk, avoid for pregnant women and girls)
×Pine tar × Japanese cedar resin × Mastic resin × Eucalyptus essential oil × Wintergreen essential oil × St. John’s wort essential oil
×Yucca Schidigera extract (complex mixture of compounds, 2021 EU/European Food Safety Authority has determined that the effects of triterpenoid saponin and steroid saponin mixture (thyrotoxicity and male reproductive toxicity), serious skin and eye (suggests irritation and effects on aquatic organisms)
×Indigestible dextrin × Catechin × Tea leaves × Caffeine × Salt/Sea salt
×Insects, larvae, caterpillars, insect eggs, insect-derived raw materials × Honey, propolis × Saliva × Body fluids × Feces
×Animal-derived materials that sacrifice the tiny lives of other animals, such as bird eggs and animal placentas
×Animal-derived lactic acid bacteria (lactic acid bacteria derived from human/animal feces, intestinal tract, oral bacteria, dental plaque, etc. are not used)
×Lactic acid bacteria itself (no combination of live bacteria or dead bacteria, no evidence data on the immediate effect of lactic acid bacteria itself on oral bacteria)
×Limited natural biological raw materials such as corals in the marine environment
×Chemical substances that are toxic to the natural environment and biological ecosystems in the rivers and soil where they are discharged, and that indirectly affect human health from edible seafood and agricultural products.
×Chemical substances that the World Health Organization is considering regulating in the future due to their negative effects on the human body and the environment

Whenever you purchase a product that you can put in your mouth, we recommend that you check the “all ingredients” (all the ingredients that are included) of each product before making your selection.

Also, some Internet search services are capable of various information manipulations such as SEO to prevent consumers from knowing the truth, so the same content can be used on new AI question answering services, etc.We encourage you to investigate the truth for yourself.

Teeth brushing and oral care products for pets are legally miscellaneous goods, and unlike cosmetics, they are not required to display all ingredients, but the name of the ingredients (display name/INCI name) added as “preservatives” and “fragrances” must be clearly stated. Since this can be omitted, there are cases in which products are sold with only “preservatives” or “fragrances” listed, concealing the name of the chemical substance (display name/INCI name) actually contained in the product from the consumer.

Due to the recent increase in health damage and environmental destruction caused by certain chemical substances, what is really being mixed into and sold in the things that families put into their mouths every day and the things that they urinate into nearby fields, rivers, and nature? If you are concerned, please request disclosure to consumers of the exact ingredient names (displayed names/INCI names) of chemical substances that are not clearly labeled as “preservatives” or “fragrances” from the perspective of consumer protection. We recommend that you check before giving it to your dog or cat.

In places where the birthrate is declining and the population is aging, the number of dogs and cats exceeds the number of people under the age of 15, resulting in health risks from pet products consumed and excreted as members of the family (legal regulations are not yet as advanced as for humans) and environmental pollution from urination. The impact of factors such as the declining birthrate has grown rapidly in recent years, and we are now in an era where consumers are required to make responsible choices for their future families and the surrounding environment.

* Cleaning aid

How to use

for PET (gel)

Use toothbrush or finger cot

Apply a proper amount of the gel to toothbrush/ finger cot or apply the gel evenly to the mouth with clean fingers or gauze. After brushing or smearing, do not need to rinse with water. Can also be used with molar toys.

Dissolved in drinking water

You can dissolve the gel in drinking water, stir it with clean fingers, and use it.

for PET (spray)

Spray directly in the mouth

Simple care when going out, sleeping, and spraying in drinking water.
Spray it directly into the mouth several times, or open the pet’s lips and spray it on the upper and lower teeth, brush or smear the teeth with clean fingers or gauze. Do not need to rinse after use.

Dissolved in drinking water

It can also be sprayed 1-2 times in drinking water for simple care.

Supported by Certified NPO corporation Shine On Kids アイビー(Labrador Retriever female)


Other videos and articles can be viewed on the Web.

Q  &  A

First is the confirmation of “all components”.

When you buy a product to put in your “mouth”, which is the entrance to all of your important physical and health needs to create the body and mind of your beloved family, be sure to buy “all ingredients” of each product ( It is recommended that you check and check (ingredients of) by yourself before selecting.

“All ingredients” can be found on the product packaging.

Often, it’s easy to get distracted by “other than the essence of the product.”

However, in the world of science, research, and manufacturing, all new research and technological innovation and safety-related efforts and efforts that underlie the products result in the achievement of “all ingredients.”

It is important to check “all ingredients” and determine the essence of the product.

Second is the confirmation of “research background” and “results”.

What kind of project members, universities/graduate schools and research institutes (whether national or private, internationally competitive public institutions),

What kind of career and profile the researcher has (researcher who can have international competitiveness in his/her institution or field of expertise) has researched and developed the technology/product, and what they are doing. Or

And whether there is innovation or objective superiority (“patent”, “thesis”, “award history”, “newspaper publication”, etc.) in the research/technology,

It is an era where you can easily search “research background”, “data”, “papers”, “patents”, “awards” and “media publications” for each product on the Internet.

It is important to identify what kind of research institute, researchers, involved members, etc. are engaged in the “research background” and what “results” are obtained as a result.

Thirdly, what kind of newspapers, televisions, and other news media, and public media, such as magazines, handle these research results and products?

Is it a research result or product that has value as news that is treated as an article rather than an advertisement by a reliable news agency or public media?

Received press releases from many research institutes and companies every day, and made into articles and reported through filters of exhausted reporters are research results with new social usefulness for many consumers without expertise. It will be a big factor to judge whether or not it is a product with unprecedented value.

Fourthly, what kind of medical institution/store is selected and in what countries are they sold and used?

For highly reliable medical institutions and stores such as department stores, it is the responsibility of medical personnel who select various products in the world at their own risk and provide patients and customers with products that their hospitals and stores can proceed with confidence. There are buyers (purchasing staff).

With so many things and information overflowing around the world, there are shops with high-class stores that consumers can buy without doubt.

It is said that being selected by those medical institutions and department stores is a product that is selected by a filter of discerning buyers who are overlooking products all over the world, trusted, and recommended to important patients and customers. It will be a thing.

Also, in order to be officially sold locally not only in Japan but also in overseas countries, it can be sold only after strict approval by the health organizations in each country.

The products that are officially sold locally are those that have been carefully examined in their respective countries and judged to be used as those that contribute to the health of the people.

What kind of medical institution, government agency, public institution, and what kind of store and department store should you choose?

Is it a product that is sold not only in Japan but also in the US, Europe, China, Asian countries, Latin America and other countries around the world? And is it a product that is needed by many people around the world?

It is also important for many consumers who do not have specialized knowledge to know the handling and sales results of the product calmly because of the difference from other products in the world, the essence of the product, the superiority of research and technology, and the product to be selected. It is a factor to judge the goodness.

Finally, it is confirmation of “sociality”.

Whether the product/business depends on the selection and is good not only for yourself but also for society and other people, whether it is a product that gives priority to human health and environmental consideration, is a product for mere commercial purposes, or is social It is important to check if the product you are working on.

We are now in an era where the actual conditions and management attitudes of the above companies can be easily checked on Wikipedia.

It is important for medical professionals and consumers to judge smartly not only the product specifications themselves, but also the “sociality” of products and companies.

With a wealth of information, companies and products, it is important to be able to identify and judge the essence in order to protect the health of ourselves, families and patients, and to protect our health and lives. The time has come for us.

In the era after the coronary virus crisis, which has changed drastically from the past, each medical person and consumer knows how corporate products will lead to better things for society and themselves, We need to change to a wise choice.

① “Sweet gel and liquid”
Made with artificial sweeteners and preservatives, synthetic polymers, and flavorings to make tooth brushing easier
(Substrate, base, ingredients: Artificial sweeteners such as aspartame, sorbitol, sucralose, maltitol, erythritol, sodium saccharin, water-soluble synthetic polymers such as carbomer, sodium polyacrylate, hydroxyethyl cellulose, liquid plastics, synthetic fragrances, parabens) ・Synthetic preservatives such as phenoxyethanol, sodium benzoate, potassium sorbate, BG, PG)
Growth: Proportional to increase/decrease in total number of pets
Risk factors: Emergence of new technology to deal with oral bacteria, development of clinical efficacy data and safety data, etc.

② “Chemical gel and liquid”
Contains synthetic disinfectants, chlorine, bleach, surfactants, other chemicals and compounds, and antibiotics for the purpose of killing oral bacteria.
(Key ingredients: CPC, IPMP, chlorhexidine gluconate, benzethonium chloride, benzalkonium chloride, LSS, triclosan, salicylic acid, yucca extract, phenol, cresol, hydrogen peroxide, chlorine, chlorine dioxide, phosphate, iodine, formaldehyde , ammonia, cyanide/cyanic acid, pesticide/insecticide ingredients, etc.)
Growth potential: Trend of replacement by alternative green technologies
Risk factors: Side effects, drug-related litigation risk, environmental pollution risk

③ “Thiocyanate gel and liquid”
For the purpose of sterilizing oral bacteria, this product contains saliva components such as glucose oxidase and chemically reacts with saliva components in ppm units (thiocyanate) to generate cyanide in the oral cavity.
(Key ingredients: glucose oxidase, lactoperoxidase, potassium thiocyanate, sodium thiocyanate, hydrogen peroxide)
Growth potential: Trend of replacement by alternative green technologies
Risk factors: Laws and regulations (Thyroid side effects, ex 2014 European Union regulations), drug-related litigation risk, environmental pollution risk

④“Strong alkaline gel and liquid”
Contains strong alkali (K hydroxide, caustic potash, Na hydroxide, caustic soda) and electrolyzed alkaline water with a pH of 10 or higher for the purpose of sterilizing oral bacteria.
(Key ingredients: K hydroxide/caustic potash, sodium hydroxide/caustic soda, alkaline electrolyzed water/pH adjustment strong alkaline agent, salt)
Growth potential: Trend of replacement by alternative green technologies
Risk factors: laws and regulations, drug-related litigation risk, environmental pollution risk

⑤ “Gels and liquids containing naturally derived ingredients”
Contains alcohol (ethanol), natural toxin antibacterial ingredients (plants/organisms), lactic acid bacteria themselves, heavy metals, etc. based on the effect on oral bacteria.
(Key ingredients: grain ethanol, hinokitiol, catechin, mastic resin, St. John’s wort essential oil, wintergreen essential oil, tea tree essential oil, plant extract, koji extract, Chinese herbal medicine, alkaloids, propolis, yogurt, lactic acid bacteria themselves, lactic acid bacteria culture extract, mold) products, silver, zinc, etc.)
Growth potential: Trend of replacement by alternative biotechnology
Risk factors: Preparation of clinical efficacy data and safety data, etc.

⑥ “Lactic acid bacteria antibacterial peptide gel and liquid”
Contains lactic acid bacteria antibacterial peptide for the purpose of cleaning oral bacteria.
(Key ingredients: lactic acid bacteria antibacterial peptide/plant extract)
Growth potential: Popularization in the niche field as an invention that is useful to humanity and is utilized in space.
Risk factors: increased costs in research and production and maintaining competitive prices

Until the 2010s, before the coronavirus pandemic, category 3, which also included products for human use, accounted for a large share, but the formulation changed in 2015 in response to the European Union (EU) regulations on chemical substances in 2014. As a result, it has become a ① category, and the share of ① is increasing, and since 2020, the miscellaneous goods industry and mail order businesses have entered the ④ category one after another, but declined due to non-compliance and dangerous for skins. Regarding ② and ⑤, the main products are human products, and although there are sub-line players, they are on the decline.

The exact market size of each category, future growth potential, health/environmental/business risks, position map of each brand, market share, and market trends 30 years from now are currently under investigation, but health and environmental protection are important. In the 21st century, there will be a generational shift to alternative green technologies, and category 6 will become mainstream.

DTC World Pets product review 2024 Health and Environment

It has a gentler formula with fewer flavor ingredients than Oral Peace Clean & Moisture Orange for babies and children, so that it can be used even by baby pets whose organs are smaller than humans.

Contains “Neonisin-e®︎”, a patented lactic acid bacterium peptide formulation that is digested and broken down into amino acids in the intestinal tract when swallowed while cleaning the oral cavity by brushing. 100% food ingredients, no alcohol or chemical ingredients, 100% biodegradable innovation. Oral care products for pets.

Humans and pets, who are animals, have the same functions and structure of the oral cavity such as teeth, gums, and saliva.

In the case of dogs, the PH in the oral cavity is different than in humans, and the types of bacteria that are resident in the oral cavity are slightly different, but there is not much difference in oral function.

There is also no significant difference between toothpaste and oral care products for humans and pets.

If you want to check the efficacy and safety of your beloved pet’s oral care product, it may be one way for the owner to try it for himself.

Whether you want to use it for yourself, including safety, how you feel by brushing your teeth yourself, whether you think it is okay to swallow it like a pet who can not gargle or spit, actually use it Can you feel the effect for yourself?

ORALPEACE is developed for humans who cannot gargle or spit, such as infants, pregnant women, the elderly and fighters, and has the same ingredients as human products (prescription that eliminates unnecessary taste in pets) and is safe under the Pharmaceutical Affairs Law. Made in a domestic certified organic factory under a high production system.

A product that responds to the needs of pet dogs and cats who want to use products that have the same level of safety and efficacy as the ones for humans that are loved and loved by humans and that have been researched and developed by Kyushu University. We are working on manufacturing.

ORALPEACE Forpet is a human-grade product that is made of the same materials as those for humans and infants, and manufactured under a strict hygiene and production control system at an organic certified factory, and can be used by humans and infants.

Before you use it on your favorite pet, please try the product that you put in the mouth of an important pet by yourself, it seems that you may swallow it by yourself, the quality of the product such as taste, ingredients, hygiene and production control We recommend that you use it as an important pet’s mouth after experiencing, trying out and comparing the effects and research background.

“Oral care products, oral hygiene agents, oral moisturizers and oral moisturizers for pets and dogs that are expected to have the function of preventing tartar and bad breath while simultaneously brushing, periodontal and oral care for pets and dogs”・The following are the selection points for oral care products.

First and foremost, try the tasting yourself. With this, you can understand most of the differences, such as “feeling whether it is a safe ingredient even if swallowed as it is” “feeling whether it feels good or bad when put in the mouth” “real feeling of effect of using” I will.

Secondly, it may be important to confirm whether or not “ingredients that are expected to have safe antibacterial properties even if swallowed” are included.

In order to prevent the increase of bacteria causing troubles in the oral cavity, simple gel cannot meet the needs of clinical sites, and “a product containing an antibacterial agent that is safe to swallow” should be kept clean, moisturized, and clean in the oral cavity. Is considered to be highly useful.

The third major point is the usability of pets and dogs.

Materials that contain a large amount of chemical components such as synthetic thickeners and synthetic polymers, which are not food products, have low raw material costs, but have problems in terms of usability and water solubility. In other words, it feels like a foreign body in your mouth and you feel uncomfortable. For example, it feels like vaseline, lard and paint cling to your mouth all the time.

You can also check the water solubility of each product at home.

Put a small amount of the product you want to compare with a petri dish (a small plate is also acceptable).

Then add water and leave for about 1 hour.

Finally, drain the water and watch the condition of the remaining product.

If it remains unmelted, it will feel like sticking to the upper jaw. There is a type that remains almost as it is even if it has water (saliva), to a type that spreads naturally and thinly, like “Oral Peace Fourpets”.

Substances that are difficult to dissolve that contain a large amount of chemical raw materials are difficult to digest in the body and decompose by microorganisms in the intestinal tract, and are difficult to decompose even if they are discharged to the natural world, making them difficult to biodegrade by microorganisms.

Does it not dissolve in saliva and feel good as it stays in the mouth, or is it comfortable to spread in the mouth and feels comfortable to work with? We recommend that you choose the best product.

It is important to thoroughly understand the research and development background of each product and the characteristics such as feeling of use, and select the product that suits the needs of the pet or dog to be used.

It is a coined word that combines oral and peace.

It is said that about 700 kinds of bacteria are always present in the oral cavity, and they maintain a balanced and healthy condition.

If this calm balance is disturbed and the total number of bacteria increases too much, you will end up in an unhealthy state and get sick.

Therefore, we named it “ORALPEACE” in the sense that “it maintains a peaceful state in the oral cavity with safe ingredients.”

It also expresses peace of mind, family health and peace.

It is made in Japan.

Like medical products for humans, ORALPEACE for Pet is produced cleanly in a factory dedicated to cutting-edge oral care that is strictly controlled under Japan’s Pharmaceutical Affairs Law, and during the distribution process, it is kept clean and safe as something to be put in the mouth. We strive to deliver the products so that they can be used at hospitals and at home.

As mentioned above, we are working hard every day to meet the “clean Japanese quality” you mentioned.

For any other questions, please see our Frequently Asked Questions.

Thank you for your continued support of the ORALPEACE project.

Animals, just like humans, they will have tartar due to oral bacteria, which form calculus after hardening.

Oral bacteria can also cause bad breath and periodontal disease. By reducing oral pathogens through daily oral care, they can prevent tartar, calculus and bad breath.

On the other hand, animals are not able to gargle need ingredients that are safe and effective when swallowed. Using synthetic fungicides to animals always a topic for clinical challenges.

Hence, research and development of a new formulation that effective against causative bacteria and being safe even if swallowed has been desired by pet dogs and cat lovers around the world.

Animals, just like humans, they will have tartar due to oral bacteria, which form calculus after hardening.

Oral bacteria can also cause bad breath and periodontal disease. By reducing oral pathogens through daily oral care, they can prevent tartar, calculus and bad breath.

On the other hand, animals are not able to gargle need ingredients that are safe and effective when swallowed. Using synthetic fungicides to animals always a topic for clinical challenges.

Hence, research and development of a new formulation that effective against causative bacteria and being safe even if swallowed has been desired by pet dogs and cat lovers around the world.

Synthetic fungicides made from petroleum and chemical ingredients have excellent bactericidal activity, but there is a risk of their effects on the body.

“Neonisin-e” derived from plant ingredients is gentle on animals and has no side effects.

Although lactic acid bacteria can produce antibacterial substances themselves to exert antibacterial properties, it is difficult for live lactic acid bacteria to stay in the oral cavity.

The time required for the production of antimicrobial substances and the amount of output are also unstable. It is difficult to achieve the desired effect.

In addition, there are approximately 100 species of antimicrobial peptides derived from lactic acid bacteria have been discovered in the world, including human and animal sources. Only “Nisin A” is approved in Japan, others are unapproved substances.

Neonisin-e® *” is a natural antibacterial agent with high antibacterial activity, which is highly refined with a unique method and then combined with plant components.

Its action structure is that it adheres to the cognitive site (lipid II) of the cell membrane of the target bacteria, and perforates the bacteria instantly.

The most important features are stable effect, quick action and safety. (Patent No. 5750552)

For more information, please refer to Neonisin’s website.

In Japan, it is a legal obligation to conduct experiments on animals such as rabbits, mice and other living organisms for ingredients such as synthetic fungicides.

ORALPEACE products do not require animal experiments because we do not contain the above ingredients.

We develop and manufacture products with the aim of not sacrificing small animals.

The pet series and human series of ORALPEACE products are completely the same from ingredients to production process. Pet series products can also be used by human.

However, we recommend that humans and pets use oral care products separately to avoid cross-infection of oral bacteria between humans and pets.

Although ORALPEACE for humans can also be used for pets from the ingredients, we do not suggest you to do so because human series has a stronger taste. Therefore, it is recommended to use a mild-tasting pet series for your pets.

ORALPEACE products are safe to swallow, so eating one tube of gel has no effect on the body.

However, it is recommended to keep the product out of the reach of pets.

You can use it as many times as you like.

Are there any clinical efficacy experiment data or evidence from research institutes regarding the usefulness of “Neonisin-e®︎” in the oral microbiology of dogs?

Although this is an external research, we would appreciate it if you could confirm the following.
“About the usefulness of “Neonisin-e®︎” and “ORALPEACE for Pet” in oral microbiology of dogs”
Consideration and conclusion on oral care for pets such as dogs and cats, mammals, and animals. Clinical effects on oral bacteria such as periodontal disease bacteria.

Experimental data results, safety evaluation, and evidence.
(External research: Summary of verification experiment presented at the 2018 Japan University Stomatology Society Academic Conference by a group of veterinarians, dentists, and dentists specializing in dentistry and oral care)

ORALPEACE products have sold hundreds of thousands since it’s released, and no cases of allergies and side effects have been received.

If your pet is allergic to a certain substance, please confirm the ingredients of the product and check with the doctor to determine whether to continue use it or not to.

ORALPEACE has the same ingredient as food, so you don’t have to worry about it.
There is no problem if it is kept in good hygiene.
No strict ratio is required. Take a small amount of gel with your clean fingers and dissolve it in water,: for spray, spray 1-2 pushes. In order to keep your pet’s drinking water clean and fresh, please change the water once a day.

If your dog has calculus, just applying gel and drinking water cannot completely prevent calculus. Brushing is needed.

Please refer to the purchase method page.

If you can’t find a store near you, we would appreciate it if you ask a nearby retailer, pet shop, pet salon, veterinary hospital, etc. to order ORALPEACE.

Regarding the safety of essential oils for cats, in 1990s in US, cats became sick after applying a product containing high-concentration distilled tea tree essential oil directly on the skin of cats. Since then, it has been verified that the ratio of tea tree essential oil for cat products must be less than 1%.

However, there is no credible scientific research show that essential oils are harmful to cats.

Some people think that cats have no metabolic capacity for essential oils and avoid using products containing essential oils. Some people think that high-concentration tea tree essential oils are safe for cats, and some essential oils are dangerous for cats. None of the above opinions have been confirmed by relevant experiments and research, and the actual situation is unknown.

In addition, pet products (categorized as daily necessities) do not require all ingredients to be listed like cosmetics and pharmaceutical products. Many products simply described as “preservatives”, but actually contain chemically synthesized ingredients or preservatives. (ORALPEACE products list the full ingredients).

The amount of ingredients usually varies depending on body size. Smaller cats might have greater impact as compare to larger animals.

ORALPEACE is made of pure natural plant-derived ingredients. There is only very small amount of mint essential oil (below 0.1%) for the purpose of preservation. According to the method of use, if the product is diluted with pet saliva or water, the intake of essential oils is very small, and it will not adversely affect the pet.

Safety always the first concern in ORALPEACE development process. However, every cat are different. If you have any safety or allergy concerns after use, please suspend and consult a doctor.

Is fragrant oil harmful to dogs and cats? (Source: Homepage of the Japanese Veterinary Society)

The major differences are:

“It contains the patented formulation “Neonisin-e®”.”

“We are conducting research to respond to bacteria that cause oral problems with safe ingredients.”

Safe to swallow, 100% naturally derived, only food ingredients, organically certified toothpaste, oral care products can be made without the need for basic research or patented technology at national universities or research institutes.

Regarding ORALPEACE, we think that it is almost the same as other safety-promoting oral care products unless “Neonisin-e®︎” is added.

Gels with similar shapes can be easily and inexpensively made at home if you purchase the materials at online shops.

[How to make a toothpaste gel]

In the case of “Toothpaste Gel”, refer to the ingredients of your favorite product and refer to the ingredients of glycerin (moisturizer) and mint essential oil or orange essential oil (preferably organic certified) and thickener xanthan gum at online shops etc. If you purchase it and mix it at home, you can make a toothpaste gel with 100% food ingredients that are safe ingredients made only from food ingredients.

If you want sweetness for children, xylitol, which is an alternative sweetener for sugar, is also sold at online shops, so you can mix it.

Also, if you want to see if lactic acid bacteria (itself) actually has an effect or effect on the oral cavity and teeth, mix the yogurt supernatant (lactic acid bacteria fermentation extract/whey) or yogurt itself (live lactic acid bacteria) I think that is also good.

If the lactic acid bacteria contained in the product are alive, it is possible to make it by culturing and fermenting the bacteria from milk at the home in a yogurt maker.
(Products such as yogurt that are sold in refrigerated storage without preservatives and bactericides. Products that are distributed at room temperature will ferment and decay when lactic acid bacteria are alive. It is inactive because it is sterilized by mixing with a strong alkali, and the lactic acid bacteria have been killed and left behind.)

[How to make natural toothpaste (abrasive)]

In the case of “natural toothpaste”, similarly, calcium carbonate, Ca carbonate (abrasive, limestone powder, white line powder on the playground, raw material for chalk), glycerin (moisturizer), and mint essential oil (with organic certification) Is preferred), and you can easily make natural toothpaste powder by purchasing it at an online shop or drug store and mixing it with water at home.

In addition, you can get your favorite plant extract, essential oil, xylitol, propolis, sodium hydrogen carbonate (baking soda, polishing action, strong alkali), salt (polishing action, preservative), other polishing agents, etc. at the online shop. It is an ingredient that is easy to obtain, so I think you can try mixing it.

You can purchase undiluted solutions of almost all of the above materials and various ingredients and extracts that have been appealed as key ingredients of cosmetics at online shops.

I think that it is a good opportunity to actually try on your own oral cavity and teeth and judge for yourself what kind of effect these ingredients can be expected and realized clinically in the oral cavity and teeth. ..

The above is not a patentable ingredient, so anyone can mix it to make a toothpaste gel or paste.

However, in order to respond to the needs of the new 21st century and to cope with bacteria causing troubles in the oral cavity in clinical settings of medical care and nursing care, a patent for lactic acid bacteria antibacterial peptide invented in joint research with Kyushu University etc. over 10 years The formulation “Neonisin-e®” (cleaning aid) is a research result/invention that plays a major clinical role that could not be realized with conventional ingredients of natural origin.

To experience the difference, use an interdental brush or floss to clean the spaces between your teeth with the oral piece in your mouth before bedtime, and use a tongue brush (a toothbrush may be used) to clean your tongue. After cleaning and rinsing again, we recommend that you spread a small amount over the entire mouth, teeth, interdental space, periodontium, and tongue.

The next day after carefully taking care of your mouth and resting, you will be able to experience the changes in bad breath and mouth refreshment when you wake up.

We believe that ORALPEACE has no new significance for humankind as a product unless it contains “Neonisin-e®”.

The major differences are as follows.

Regarding research on response to bacteria causing oral problems,

“Use of lactic acid bacterium antibacterial peptide “Neonisin-e®︎” instead of conventional synthetic bactericides and alcohols”

“The product is made only from food ingredients that are considered safe even if swallowed.”

“Chemical synthetic ingredients such as synthetic bactericides and alcohol are not added to the product”

We are responding to the new world-wide medical and nursing care clinical needs and consumer needs, bacteria that cause oral problems.

“I want to use ingredients that are safe to swallow,”

“I would like to use a safe antibacterial agent that replaces conventional synthetic antibacterial agents, alcohol (ethanol), and highly concentrated plant antibacterial agents with side effects.”

In order to respond to the aging of the world and the paradigm shift towards the consumer’s safety and health consciousness, a century after the birth of toothpaste, the lactic acid bacterium antibacterial peptide “Neonisin- e®” research.

ORALPEACE is a new product invented and developed in Japan in the 21st century for the following people.

Worried about problems in the oral cavity,
I’m careful about what I eat,
We are committed to family health and prevention,
Want to avoid daily oral intake of chemical ingredients,
Pregnant woman/lactating
I don’t like additives or synthetic fungicides,
Elderly people and illnesses requiring nursing care who have difficulty gargle or spit and accidentally swallow the product,
And I do not want to destroy the natural environment with persistent chemical products.

And ORALPEACE is a product for people all over the world who really need ORALPEACE not only to pursue the superiority of the product but also to sympathize with the background of the brand and contribute to society through the business.

ORALPEACE has been developed with the aim of making it a product that can be used by infants, the elderly who need care, elderly people who are difficult to gargle and vomiting, fighting persons and people with disabilities.

Originally, we have spent a lot of time researching and developing foods that human beings have eaten since ancient times, and products that use only plant-derived food ingredients whose safety has been verified by insurance organizations around the world.

Therefore, we do not use chemically synthesized ingredients, petroleum-derived ingredients, or even plants that have no edible history.

Even if it is recognized as a raw material for food, it was developed with the policy of not adding chemical synthetic components or petroleum-derived components.

Regarding the antibacterial peptide (bacteriocin) that may be produced by the compounded lactic acid bacteria component, those that have not been approved as food or food additives after undergoing safety verification by the World Health Organization or the Japanese Ministry of Health, Labor and Welfare Is not used at all.

There are various kinds of “lactic acid bacteria” that you can eat.

Lactic acid bacteria taken from plaque in the mouth of people who cannot brush their teeth but have caries or periodontal disease, and lactic acid bacteria ingested from other people’s mouth or excrement are unapproved substances as food. ..

The only ingredients used in ORALPEACE are those approved by WHO, GRAS certified in the United States, and approved by Japan’s Ministry of Health, Labor and Welfare as foods.

Regarding antibacterial peptides (bacteriocin), we also avoid blending non-approved food products.

Not used

ORALPEACE is made from water and all-edible plant-derived food ingredients.

ORALPEACE is a product newly developed for elderly people requiring nursing care, fighting patients, infants, etc. who have difficulty in gargle and vomiting. It was created with a lot of effort and more than 10 years.

All ingredients, except water, are made from plant-derived food ingredients. It is made entirely of plant materials that are sustainable and environmentally friendly, rather than limited fossil materials such as petroleum.

Synthetic agents derived from petroleum such as cetylpyridinium chloride (also known as cetylpyridinium chloride/CPC), benzethonium chloride, chlorhexidine gluconate, IPMP (isopropylmethylphenol), and triclosan, which are chemically synthesized from light oil, etc., are not added.

The above are extremely powerful bactericides, and the Ministry of Health, Labor and Welfare strictly limits the compounding percentage in products, and there are side effects to the action.

However, in practice, among the petroleum-based synthetic bactericides, it has been recognized in the world’s research that a concentration of 0.1% or more is effective, but in one country, the concentration recognized in product formulations is 0.05% or less. As a product, it is difficult to expect actual clinical effects.

On the other hand, side effects such as taste disorders and black hair tongue may occur due to long-term use even at low concentrations where no effect can be expected, and there have been difficult problems with actual clinical use.

For details on the synthetic fungicides derived from petroleum, their effects, side effects, and their environmental impact, please do your own research on the Internet.

Not compounded.

Alcohol (ethanol) is not added so that it can be used by infants, those who do not want to take alcohol, and those who are dry.

Alcohol has the effect of clearing the inside of the mouth and not spoiling the product, but it may cause damage to the oral mucous membranes, thirst in the mouth, and dry teeth in the oral cavity. There are side effects that can cause trouble.

Therefore, it is unblended in ORALPEACE.

If you like alcohol (ethanol), we would appreciate it if you could get a high-frequency alcohol product from a pharmacy or a liquor store and use it with ORALPEACE.

Do you mix bleaching agents such as chlorine, chlorine dioxide (CIO2), sodium chlorite, sodium hypochlorite, chlorine-based gas, etc.?

ORALPEACE does not contain bleach, chlorine, chlorine dioxide (CIO2), which is a deleterious substance used for disinfecting and disinfecting pools, sodium chlorite, sodium hypochlorite, chlorine-based gas, etc. ..

ORALPEACE has devoted a great deal of time to research and development aiming at products that can be used by elderly people, fighters and people with disabilities who require nursing care, which makes it difficult to gargle and spit.

Please investigate the effects, side effects, and effects on the human body of chlorine and chlorinated gases on the Internet by yourself.

All components of ORALPEACE are made from plants (food) except water.

It is made entirely of plant materials that are sustainable and environmentally friendly, rather than limited fossil materials such as petroleum.

Also, ORAL PEACE is a product that you can put into your mouth.

Regarding the lactic acid bacteria used during the production of “Neonisin-e®”,

Not “animal-derived fungus” that lives in “excretion” in the intestinal tract of “animal”, which is found from human or animal feces, etc.

We use “Lactococcus lactis”, which is a “plant” found in “Tofu” from Japan and a “plant-derived fungus” that lives in “food”.

Not compounded.

ORALPEACE contains the bacteriocin preparation “Neonisin-e®︎” (cleaning aid), which is a highly purified lactic acid bacterium peptide produced by lactic acid bacteria.

Regarding the clinical effects of adding “lactic acid bacteria” itself to oral care products, we would like to ask you to visit the website of “Neonisin” for the past problems by research institutions around the world.

In addition, there is a big problem that “a product containing lactic acid bacteria” and the following ingredients “cannot be combined together”.

“Antibacterial substances” and “preservatives” “alcohol (ethanol)” “synthetic germicide” “sodium hydrogen carbonate (baking soda/alkali)” etc.

Because, “antibacterial substances” such as lactic acid bacterium bacteriocin, “preservatives” such as paraben, phenoxyethanol, sodium benzoate, K sorbate, alcohol (ethanol), “synthetic germicides” and “sodium hydrogen carbonate (sodium bicarbonate/alkali)” )” is for killing the “lactic acid bacteria” mixed together.

Also, if you want to use oral care products that can be stored and used at room temperature instead of refrigerated storage like yogurt, it is necessary to sterilize because “lactic acid bacteria” will perish if they are alive.

Therefore, a product that contains both “lactic acid bacteria” and “antibacterial substances” is said to have “combined both components that evoke the effect.”
Actually, “lactic acid bacteria” have been killed by “antibacterial substances” etc., and there was a problem that it became meaningless in use and clinical.

ORALPEACE contains “Neonisin-e®︎”, which is a purified peptide produced by lactic acid bacteria, and does not contain “lactic acid bacteria” itself.

ORALPEACE does not contain lactic acid bacteria itself, but “Neonisin-e®︎” is produced from lactic acid bacteria.

The lactic acid bacteria used for the production are explained below.

Even if you say “lactic acid bacteria” that you can eat, their habitat and origin are various.

Even if you say “lactic acid bacteria” with a good image, it will be completely different depending on the bacterial species and strain.

There are also lactic acid bacteria derived from the ground, rivers, insects and animals, and humans. There are also lactic acid bacteria that live in the intestinal tract (feces) and excrement of animals, and in blister and sludge.

There are also lactic acid bacteria found in plaque accumulated in the mouth of people who cannot brush their teeth but have caries or periodontal disease, and lactic acid bacteria found in the feces and dirt of other people.

In fact, the strains of adult feces and dental plaque are often stronger than the bacteria of infants and children’s feces and dental plaque, and the product contains bacteria isolated from adult human feces and dental plaque. The reality is that they are often used.

However, until now, in the practical application of lactic acid bacteria research by research institutes all over the world, yogurt, beverages and oral products produced by fermenting feces and plaque of other people have been consumer-oriented and are themselves, families, children and patients. There was a big problem that I didn’t want to put it in your mouth.

Regarding the antibacterial peptide (bacteriocin) that may be mixed in the “fermented products” of the bacteria derived from feces and dental plaque, there is a possibility that the habitat of the bacteria may be effective against miscellaneous bacteria. Antibacterial peptides (bacteriocin) other than “A” are unapproved substances that have not been verified for safety by WHO, the world health organizations, or the Japanese Ministry of Health, Labor and Welfare.

The lactic acid bacterium “Lactococcus lactis” contained in ORALPEACE is a lactic acid bacterium discovered in “Tofu”, a clean and safe food produced in Japan.

And for decades, a lactic acid bacterium that lives in plant-derived foods that mass-produces lactobacillus antibacterial peptide “Nisin A”, which has been licensed all over the world. It is a research result.

The lactic acid bacteria used in ORALPEACE are clean and safe lactic acid bacteria found in foods derived from edible plants called tofu, so you can safely put them in your mouth.

For the type and origin of lactic acid bacteria that you put in your mouth, we recommend that you check the name of each bacterium on the Internet.

Not used at all.

As mentioned above, this point is a major advantage of ORALPEACE in the world due to the background of long and deep research including the world’s leading researchers in lactic acid bacteriocin research.

ORALPEACE is a product that you can put in your mouth.

Not “animal-derived fungus” that lives in “excretion” in the intestinal tract of “animal”, which is found in the feces of humans and livestock

Regarding the lactic acid bacteria used during the production of “Neonisin-e®”,

We use “Lactococcus lactis” which is a “plant” found in Japanese “tofu” and a “plant-derived fungus” that lives in “food”.

For the type and origin of lactic acid bacteria that you put in your mouth, we recommend that you check the name of each bacterium on the Internet.

ORALPEACE does not contain Forever Chemical (PFAS), which has been strongly suspected of being linked to cancer and fetal growth disorders, and whose regulations have been significantly tightened, including complete banning.

For more information about “Forever Chemicals (PFAS),” which is now a worldwide problem for all of humanity, please check the news reports on the Internet and TV, and be mindful of the health of your children and other important family members. Thank you very much.

Now in the 21st century, where the destruction of the earth’s environment and the health risks to humankind have become more apparent, we are living in a world where the effects of persistent substances developed and utilized in the 1900s (that are not biodegradable by bacteria in the natural world and that can be absorbed into the human body, the internal organs of living things, soil, and water) Since the 2010s, it has become clear that chemicals (forever concentrated and accumulated) pose serious risks to humanity, including health damage, environmental destruction, and contamination of food and drinking water.

The labeling of “Neonisin-e®︎” is “Lactic acid bacteria culture extract”, “Plum fruit extract”, and “Damask rose oil”.

This is because “Neonisin-e®︎” is a mixture of the above ingredients.

Ordinary “lactic acid bacterium culture/fermented extract” is a liquid obtained by fermenting lactic acid bacteria, and in many cases, it is like the supernatant of yogurt. And many things such as water, impurities, and salt are turbid in the fermented liquid.

On the other hand, “Lactobacillus culture extract” used in “Neonisin-e®” is very different from other fermentation broths, and only the antibacterial peptide “Nisin A” produced by lactic acid bacterium from the fermentation broth fermented It will be isolated and highly purified by biotechnology.

It is “highly purified nisin A” as a highly pure lactic acid bacterium antimicrobial peptide liquid that can be extracted from a normal lactic acid bacterium fermentation liquor in an amount of only about 1/10, manufacturing costs and labor are more than 10 times.

Highly purified “Nisin A” has a 100 times or more difference in purity, degree of purification, stability and effect from the fermentation liquid of normal lactic acid bacteria.

The patented ingredient “Neonisin-e®︎”, which has been researched and developed through industry-academia collaboration with Kyushu University, etc., has the same label name as other “lactic acid bacterium culture/fermentation extract” “enzyme” etc. However, the reality is that the dimensions are completely different.

ORALPEACE for Pet does not contain potassium thiocyanate for the following reasons.

The “potassium thiocyanate” you are asking about seems to be a chemical substance that is useful as a “raw material for plating,” “a raw material for the production of synthetic resins,” “agrochemicals,” “insecticides,” etc.

The purpose of its inclusion in oral care products seems to be to combat oral bacteria, but since it is a chemical that also affects the human body, we cannot confirm that it has been approved for inclusion in human food. I think there may be issues with edible consumption and accidental ingestion.

According to literature on the Internet, the enzyme causes a chemical reaction in the presence of thiocyanate, generates ions, and exhibits antibacterial activity. However, the “thiocyanic acid and its salts” used have problems with their effects on humans and aquatic organisms in the environment.

(Source: Advanced Utilization of Milk P375 Reference)

There is a method that uses chemical reactions of enzymes to sterilize and preserve milk. The antibacterial effect is due to the lactoperoxidase activity of the enzyme contained in milk. The enzyme decomposes hydrogen peroxide in milk into water and active oxygen, and the active oxygen generated here is converted into thiocyanate ion (SCN), which is present in small amounts in milk. -) is said to be oxidized into hypothiocyanate ion (OSCN-) through a chemical reaction. This hypothiocyanate ion is said to exhibit antibacterial activity against some Gram-negative bacteria such as Escherichia coli by inactivating the SH enzyme within the bacterial cells. (However, it has a narrow antibacterial range and does not show antibacterial activity against other Gram-negative bacteria and Gram-positive bacteria such as caries bacteria.)

For the antibacterial activity of lactoperoxidase to work efficiently, approximately 12 ppm of thiocyanate ions and approximately 8 ppm of hydrogen peroxide are required for the chemical reaction, but only 1 to 10 ppm of thiocyanate ions are present in milk. First, it is necessary to add thiocyanate ions and hydrogen peroxide.

However, Japan’s Ministry of Health, Labor and Welfare does not by law permit the addition or residual presence of thiocyanic acid or hydrogen peroxide in food or milk, even in trace amounts of ppm (1 part per million, 1 ppm = 0.0001%). Therefore, in Japan, the antibacterial effect of lactoperoxidase, which is the addition of potassium thiocyanate, cannot be used to sterilize and preserve milk, or to prevent E. coli contamination. (Hydrogen peroxide is carcinogenic, but easily decomposed, and if it does not ultimately remain in food, the law has been revised to permit its use in sterilization, bleaching, etc.)


In addition, the International Dairy Federation states that lactoperoxidase/thiocyanate/hydrogen peroxidase (lactoperoxidase system) is a chemical means of preserving raw milk when refrigeration conditions cannot be secured, such as in developing countries in tropical regions. Milk quality can be temporarily controlled during milk storage and transportation to processing plants. In 1991, the Codex Alimentarius Alimentarius Alimentarius, an intergovernmental organization established by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO), decided to In countries where refrigeration is not possible, the use of peroxidase systems is permitted, but any trade in milk treated with lactoperoxidase systems is subject to mutual agreements between the parties without prejudice to third countries. It is recommended that this should be done based on the following. However, decomposition products of chemical activators such as cyanic acid may be a concern. Continuous consumption of high or even low concentrations can have an adverse effect on the health of consumers. The conclusion is that developing countries, especially small-scale village dairy producers in regions with temperate or tropical climates without refrigeration, should consider the use of chemicals that stimulate the effects of lactoperoxidase systems. There may be no other option than using an activator. This method is a low-cost option that provides a source of income for farmers and maintains the quality of nutritious food. However, in order to maintain the positive image of dairy products among consumers and to increase the consumption of milk and dairy products in all parts of the world, this option should be used only when no other options are available. There is. (Source: International Dairy Federation Lactoperoxidase IDF Fact Sheet January 2013)


*While cyanide is generally bactericidal, it is also highly toxic. Cyanide contains cyanide ions (CN^-), which affect the respiratory chain of cells and inhibit oxygen utilization, resulting in cell death. Therefore, when used in proper concentrations, cyanide can kill bacteria and other microorganisms. However, it is also harmful to humans and animals, so care must be taken. (Source: ChatGTP)

Furthermore, we were unable to confirm any clinical efficacy data or academic papers on potassium thiocyanate against oral bacteria that cause plaque, tartar, and periodontal problems in humans and animals.

“Potassium thiocyanate” appears to be a chemical substance that is not approved as a food in Japan.

List of food additives in Japan (Source: Japan Food Additives Association)

Existing additives (revised on February 26, 2020) Designated additives (revised on March 1, 2020)


Japan’s Ministry of Health, Labor and Welfare has classified potassium thiocyanate as a “dangerous substance” that must not be put into the mouth or taken continuously.

“Potassium thiocyanate”

Source: Ministry of Health, Labor and Welfare


[Summary of hazards]

Health hazards Acute toxicity (oral) Category 4

Specific target organ/systemic toxicity (repeated exposure) Category 1 (thyroid)

Hazardous to the environment Acute hazard to the aquatic environment Category 3

[Label element]

Pictogram or Symbol Exclamation Mark Health Hazard

Signal word: danger

Hazard statement: Harmful if swallowed

Thyroid damage due to long-term or repeated exposure

Harmful to aquatic life

【Safety measure】

Wash hands thoroughly after handling.

Do not eat, drink or smoke when using this product.

Do not breathe dust, fumes, vapors or spray.

Avoid release to the environment.

[First aid measures]

If swallowed: Call a doctor if you feel unwell.

Rinse mouth.

If you feel unwell, seek medical advice and treatment.

[Chemical name or common name]

potassium thiocyanate

Other names Potassium rhodanide, Potassium sulfocyanide

[Molecular formula (molecular weight)]

KSCN (97.18)

[CAS number]


[Official Gazette Publication Number (Chemical Substances Control Law/Safety and Safety Law)]


[Expected acute symptoms and delayed symptoms]

Ingestion: confusion, convulsions, nausea, vomiting, weakness

[Specific hazards]

It is non-combustible and will not burn itself but may decompose when heated producing corrosive and/or toxic fumes. In the event of a fire, irritating, corrosive and toxic gases may be generated.

[Environmental precautions]

Should not be released into the environment.

[Possibility of hazardous reactions]

The substance decomposes producing highly toxic fumes (sulfur compounds, nitrogen oxides, cyanides). Reacts violently with strong oxidants. Strong cooling effect when in contact with water.

[Hazardous decomposition products]

Very toxic fumes (sulfur compounds, nitrogen oxides, cyanides)

[Acute toxicity]

Oral rat LD50 value: 854 mg/kg (RTECS (2007): Original document Journal of the American Pharmaceutical Association, Scientific Edition. Volume 29,152 (1940)). “See also other thiocyanates for health hazards” (GHS classification: Category 4)

[Specific target organ/systemic toxicity (repeated exposure)]

Although there is no data on this substance, thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))

[Environmental impact information]


Hazardous to the aquatic environment (acute hazard) 96-hour LC50 for fish (rainbow trout) = 52.5 mg/L (ECETOC TR91, 2003). (GHS classification: Category 3)

– Hazardous to the aquatic environment (long-term hazard) Acute toxicity category 3, non-rapidly degradable (BIOWIN), 124-day NOEC (reproduction) for fish (rainbow trout) = 1.1 mg/L. (GHS classification: Not classified)

[Disposal precautions]

Residual waste Before disposal, carry out treatments such as detoxification, stabilization, and neutralization to the extent possible to reduce the level of hazards.

When disposing of the product, follow relevant laws and regulations and local government standards.

If an industrial waste disposal company licensed by the prefectural governor or a local government is in charge of the disposal, the disposal is outsourced to them.  

[Contaminated containers and packaging]

Clean and recycle containers or dispose of them appropriately in accordance with relevant laws and local government standards. When disposing of an empty container, completely remove the contents.

[Transportation precautions]

Do not transport with food or feed.

A yellow card must be maintained during transportation.

“Potassium thiocyanate” is present in Japan’s natural environment, even if it is invisible or odorless and is present in very small amounts in ppm units (1/1 million, 1ppm = 0.0001%), it is prohibited to be released. (Ministry of Health, Labor and Welfare) and Japanese law stipulates that it must not be detected (quantification limit 0.1 mg/L, Ministry of the Environment).

Ministry of the Environment Basis for setting environmental standard items, etc.

Total cyanide (thiocyanate)


After the war, from the 1930s to the 1930s, in the industrial area of the downtown area where there were many plating factories, there were pollution problems such as cyanide poisoning by craftsmen and dumping into rivers, lakes, and the sea, which wiped out fish, shellfish, and algae, making fishing grounds unusable. In the past, administrative personnel at ward offices and other offices have worked on health education for workers, water purification and coordination of issues with artisanal fisheries, and industrial promotion and health coordination with local residents.

A notable example is that even a small amount of cyanide-containing wastewater from a plating factory can cause fish death.

Source: Industrial Wastewater and Fisheries Chemistry and Biology 1962


In recent years, the Ministry of the Environment has been conducting an environmental survey of “thiocyanate” in Japan’s environment, and concentrations exceeding standard values have been detected in various places, creating a problem.

Ministry of the Environment 2018 detailed environmental survey results “thiocyanic acid and its salts (CAS registration number: 463-56-9, etc.)” https://www.env.go.jp/chemi/kurohon/2019/shosai/2_0.pdf (P120)

[2018 survey medium: water quality]

Reason for request:

Copper thiocyanate is designated as a Priority Assessment Chemical Substance under the Chemical Substances Control Law, and it is necessary to consider designating it as a Class 2 Specified Chemical Substance, but as there is no research record in recent years, priority should be given to investigating the actual status of environmental residue. This was because it was necessary to conduct research and understand the actual situation in the environment. Note that copper thiocyanate was not used in the analysis method applied in this study.

Since thiocyanate ions can only be measured, in this study, we conducted a survey to measure the total amount of thiocyanate and its salts. 

Survey details and results:
<Water quality>
Regarding water quality, 2018 was the first time for this survey, and 24 points were investigated, and the lower limit of detection was 1.1 ng/L, and it was detected at all 24 points, and the detected concentration was 2.5 to 120 ng/L. It was in the range of L.

[Reference: Regarding thiocyanic acid and its salts]・Application:
The main uses of sodium thiocyanate are as a solvent for acrylic fibers, dyes, herbicides, and pharmaceuticals. 

The main uses of potassium thiocyanate are synthetic resins, insecticides and fungicides, dye synthesis, photographic aids, reagents, and plating. 

The main uses of copper thiocyanate are ship bottom paints, antifungal agents, insecticides, copper plating, lubricating oil additives, photosensitizers, color formers for recording paper, and toothpaste. 

The main use of mercuric thiocyanate is as an analytical reagent. 

The main uses of ammonium thiocyanate are synthetic resins, hydrogen peroxide stabilizers, dyeing aids, photography, fertilizers, and herbicides. 

・Production volume/Import volume:
FY2017: Manufacture/import less than 1,000t (value published as a result of general chemical substance notification under the Chemical Substances Control Law)
・Distribution prediction by medium:
Thiocyanic acid: water 39.5%, sediment 0.08%, air 21.2%, soil 39.2%
Copper thiocyanate (I): water 33.7%, sediment 0.0737%, air 2.65%, soil 63.6%
・Acute toxicity, etc.:
Sodium thiocyanate: LD50 (dose that causes 50% mortality) = 232 mg/kg rat (oral) iv) LD50 = 362 mg/kg mouse (oral) LDLo = 600 mg/kg guinea pig (oral) iv LDLo = 750 mg/kg rabbit (oral)
Ammonium thiocyanate: LD50=24.5mg/kg mouse (oral) iv) LD50=46mg/kg rat (oral) iv)
Mercury(II) thiocyanate: LD50=24.5mg/kg mouse (oral) LD50=46mg/kg rat (oral)
・Ecological impact:
Thiocyanate: 96h-LC50 (50% mortality concentration) = 0.09 mg/L: Grass shrimp (Palaemonetes pugio) 96h-LC50 = 0.15 mg/L: Fathead minnow (Pimephales promelas)
Copper thiocyanate: PNEC= 0.0000031mg/L (Reason: 96h-LC50 (Rainbow trout lethal) = 0.031mg/L, assessment coefficient 10,000)
[Chemical Substances Control Law] Law (revised on May 20, 2009) Article 2, Paragraph 5, Priority Assessment Chemical Substances (142 Copper(I) thiocyanate)


The details of “potassium thiocyanate” as a chemical substance are as follows.

What is “thio”:
Thio is a prefix that means sulfur. A chemical compound containing “sulfur”. A linked form used especially for special compounds in which an oxygen atom is replaced with a sulfur atom.
“Thiocyanate” is a similar chemical substance in which “oxygen” of “cyanate ion [OCN]-” is replaced with “sulfur” through a chemical reaction.

What is “cyan (CN)”:
1. A highly poisonous, colorless gas with a distinctive odor. When dissolved in water, it produces hydrogen cyanide (cyanic acid gas) and cyanic acid.
2 Blue. Blue is the primary color in paints, printing inks, etc. It has a greenish blue color. (Source: Weblio)

What is “cyanic acid (CNHO)”:
It is a compound represented by the molecular formula CNHO. Structural isomers include isocyanic acid (H-N=C=O) and thunderic acid (HO-N=C:). However, cyanic acid is tautomeric with isocyanic acid, and they continue to mutually convert and are in an equilibrium state. (Source: Wikipedia) https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8

What is “potassium (K)”:
Alkali metal, one of the typical elements. Potassium is an element with atomic number 19. Also called “potassium” or “potash”. The element symbol is K. It is an essential element for living things. It is a silver-white metal with a specific gravity of 0.86, which is lighter than water, the second lightest after lithium, and is a soft metal that can be easily cut with a knife. (Source: Wikipedia)

What is “cyanide (potassium cyanide, etc., CN)”:
A name referring to a salt having cyanide ion (CN-) as an anion. Also called cyanide, cyanide, cyanide, and cyanide. Cyanide compounds, as “potassium cyanide” is famously known, are generally toxic to the human body, and even small amounts can cause death. In order to protect the developing fruits and seeds from being eaten by herbivores due to the struggle for survival, amygdalin, a poison contained in green plums, etc. (spreading seeds) is also a cyanide compound. As the fruit ripens, amygdalin is broken down into hydrogen cyanide (cyanic acid gas), benzaldehyde (an aromatic component common to almonds, apricot kernels, and loquats), and glucose by the enzyme emulsin contained in plants. disappears. The “cyanic acid” generated at this time also disappears through volatilization and decomposition. Processing also promotes decomposition. Processed products such as ripe fruit pulp and pickled plums are safe to eat if consumed in normal amounts. Amygdalin itself is non-toxic, but when ingested orally, it is broken down in the body by emulsin, a safe enzyme also found in plants, and β-glucosidase, a safe enzyme found in human intestinal bacteria, resulting in a chemical reaction. It is said to generate dangerous hydrogen cyanide (cyanic acid gas). It is safely broken down in very small amounts, but if a certain amount is ingested, it will cause toxic symptoms such as vomiting, facial flushing, diarrhea, and headaches, and if large amounts are ingested, it will cause confusion, coma, and even death, so be careful. is required. (Source: Wikipedia)

What is “thiocyanic acid (HSCN)”:
Thiocyanic acid is a type of inorganic acid with the chemical formula HSCN. Also called “rhodanic acid”. It is an unstable colorless liquid and a relatively strong acid. It exists as a mixture with its tautomer, isothiocyanic acid (HN=C=S). In the synthetic production method of thiocyanate, lead(II) thiocyanate is liberated by reacting hydrogen sulfide. When ammonia and carbon disulfide react, an ammonium salt of thiocyanate is produced. Some N-esters of thiocyanate (isothiocyanates) are used as insecticides. (Source: Wikipedia)

What is “sodium thiocyanate (thiocyanate/NaSCN)”:
It is a sodium salt of thiocyanate with the chemical formula NaSCN. At room temperature, it is a colorless, hygroscopic crystal or white powder that is soluble in water, ethanol, and acetone. It is toxic, with an LD50 of 764 mg/kg when administered orally to rats. When ingested, it affects the central nervous system, causing symptoms such as vomiting, diarrhea, weakness, confusion, and convulsions. Although it is nonflammable, it decomposes when heated, producing toxic gas (cyanic acid gas) containing sulfur oxides, nitrogen oxides, sodium oxide, and cyanide. Reacts violently with acids, strong bases and oxidizing agents. It is used as a reagent, color film developer, herbicide, and solvent in the production of acrylic fibers. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E5 %A1%A9

What is “potassium thiocyanate (KSCN)”:
Potassium thiocyanate is a deliquescent crystalline solid. It dissolves well in water, and the resulting aqueous solution becomes very cold due to heat absorption. Also soluble in ethanol and acetone. It is a chemical substance obtained by melting potassium cyanide and elemental sulfur, or by reacting ammonium thiocyanate and potassium hydroxide. Japan’s Ministry of Health, Labor and Welfare has designated it as a hazardous material. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E3 %82%AB%E3%83%AA%E3%82%A6%E3%83%A0

“Sodium thiosulfate (Na2S2O3)”
It is a sodium thiosulfate salt with the chemical formula Na2S2O3. Like sodium sulfite and sodium hyposulfite, it has bleaching and antioxidant effects, so it is used as a food additive in some countries. However, this is not allowed in Japan. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E7%A1%AB%E9%85%B8%E3%83%8A%E3%83%88%E3 %83%AA%E3%82%A6%E3%83%A0

“Potassium cyanide (KCN)”
Potassium cyanide, also known as potash cyanide or potash cyanide, is synonymous with poison, but is an industrially important inorganic compound. It is designated as a poisonous substance as “cyanide” under the Poisonous and Deleterious Substances Designation Ordinance. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E3%82%AB%E3%83%AA%E3 %82%A6%E3%83%A0

“Hydrogen cyanide (cyanic acid gas/HCN)”
Poisonous gas. Hydrogen cyanide, also known as methanenitrile, formonitrile, and formic acid nitrile, is a highly toxic substance. Its aqueous solution is weakly acidic and is called hydrocyanic acid (cyanic acid gas). Cyanide is hydrolyzed by cyanide glycosides by enzymes such as β-glucosidase found in animal intestinal bacteria, producing sugars, aldehydes, and hydrogen cyanide (cyanic acid gas). (Source: Wikipedia)

Additionally, when released into the environment, there is a risk that hypochlorous acid and thiocyanate will undergo a chemical reaction, resulting in the production of cyanide (poisonous gas) that is not expected or intended by companies.

Due to the death of fish in Tokyo Bay, the chemical (sodium hypochlorite) used to remove nitrogen from factory wastewater remained in the treatment tank and reacted with thiocyanide in the wastewater, resulting in the production of cyanogen. ” was generated (“hypochlorous acid (NaClO) + thiocyanic acid (HSCN) → cyanide (CN)”) 2022 Chiba Prefecture


Symptoms of chronic poisoning due to cyanide (CN):
Feeling of helplessness, headache, dizziness, nervousness

Irritability, hair loss, skin diseases, weight loss, loss of appetite, loss of energy

Safety evaluation of “cyanide (CN)” in oral intake (soft drink)
Ministry of Health, Labor and Welfare Food Safety Commission Special Investigation Committee on Chemical Substances and Contaminants August 2010

Reproductive and developmental toxicity and repeated dose toxicity of “potassium thiocyanate (KSCN)” (external research experiment): http://www.jpec.gr.jp/detail=normal&date=safetydata/ta/dati3.html

Toxicity evaluation of “potassium thiocyanate (KSCN)” in animals (1954-1997)
● Repeated dose toxicity
・As a result of oral administration of potassium thiocyanate to rats for 4 or 11 months, an increase in thyroid weight and a decrease in thyroxine levels were observed. (Philbrick et al, 1979) The same study showed spinal cord lesions including disruption of the myelin sheath.
・As a result of intraperitoneal administration of 50 to 850 mg/kg of potassium thiocyanate, brain damage was observed in 10% of rats. (Rose et al, 1954)
●Reproductive and developmental toxicity
– When potassium thiocyanate was orally administered to pregnant mothers, goiter was observed in the neonates. (Rudert & Oliver, 1976) RTETECS, 1997)
・When potassium thiocyanate was administered intravenously to mother mice and rats, transfer of thiocyanate to the fetus was confirmed. (Moedder, 1980)
– When 0.1-0.5% potassium thiocyanate was orally administered to female rats during pregnancy and 2 weeks after delivery, growth inhibition was observed in the newborns. (Pyska, 1977)
・High doses of 5-10 g/100 g affected the reproductive ability of female rats. (Olusi, 1979)

Thiocyanates that also exist in nature
Be careful not to eat too much of kale, which is said to be a super healthy ingredient. This is because it is said to have a serious effect on the thyroid gland. Kale contains a substance called “thiocyanate,” and if you consume too much of it, it may affect the function of iodine, a mineral that is a component of thyroid hormone, and may cause decreased thyroid function. It is said that there is. (Source: COSMOPOLITAN)
According to a report by the German Federal Institute for Risk Assessment, the cause of reduced iodine absorption in the thyroid is a substance called “thiocyanate” found in “cabbage” and “radishes.” Corn and millet contain cyanogenic glycosides, which are converted to thiocyanates in the body. (Source: Food Safety Information (Chemical Substances) No. 8/ 2020. 04. 15 National Institute of Health Sciences)

Foods containing cyanide
Avoid eating loquat seed powder (Source: Ministry of Agriculture, Forestry and Fisheries, January 15, 2021) https://www.maff.go.jp/j/syouan/seisaku/foodpoisoning/naturaltoxin/loquat_kernels .html?utm_source=dlvr.it&utm_medium=twitter

“Inorganic cyanide compounds” Effects on human health (Summary) P52
Accumulation in the blood or other tissues after oral ingestion of inorganic cyanide compounds has not been confirmed, but the metabolite “thiocyanate ion” is known to have a cumulative effect, causing thyroid toxicity such as thyroid adenoma and cretinism. . The long-term toxic effects on the thyroid gland are presumed to be due to the metabolite “thiocyanate ion.” Cyanide binds to Fe3+ ions in cytochrome oxidase in tissue cells and to proteins such as hemoglobin in red blood cells. Inhibition of cytochrome oxidase prevents the oxidation of reduced cytochrome c, stopping cellular enzyme utilization and leading to cell death. Hydrogen cyanide and cyanide compounds are mainly metabolized by rhodanese present in the liver into “thiocyanate ions” and excreted in the urine. Chronic effects of inorganic cyanide include headaches, dizziness, nervous anxiety, weakness, decreased vision, slurred speech, gastrointestinal disturbances, and enlarged thyroid gland. The effects of long-term exposure on the thyroid gland are probably due to inhibition of iodine uptake into the thyroid gland by the metabolite thiocyanate ion. (Source: Initial Risk Assessment Report for Chemical Substances “Inorganic Cyanide Compounds” National Institute of Technology and Evaluation, October 2008)

Danger of cyanide
Chronic systemic cyanide poisoning can occur but is rarely recognized because of the gradual onset of disability and symptoms consistent with other diagnoses. The reported symptoms are similar to those seen when thiocyanate is used as a drug, thus explaining the chronic disease caused by cyanide due to excess thiocyanate in the extracellular fluid. It has been suggested that this is possible. Symptoms of chronic disease have been reported in electroplaters and silver polishers after several years of exposure. The most notable were weakness in the arms and legs, headaches, and thyroid disease. These findings have also been reported as “complications of thiocyanate therapy.” (Source: International Labor Organization Encyclopedia of Occupational Safety and Health)

Evaluation, classification, and regulation of “potassium thiocyanate” by international health organizations
World Health Organization International Chemical Safety Program International Chemical Concise Assessment Document IPCS UNEP/ILO/WHO
Concise International Chemical Assessment Document No61 Hydrogen Cyanide and Cyanides: Human Health Aspects (2004) World

Hydrogen cyanide and cyanide: effects on human health
Thiocyanic acid classification display

Regulatory trends for “potassium thiocyanate (KSCN)” in Europe

In 2013, the European Food Safety Authority (EFSA) disapproved “potassium thiocyanate.”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
On 19 June 2013, the European Food Safety Authority (EFSA) published conclusions on the risk assessment of potassium thiocyanate (approved 19 October 2012, page 46). Safety to humans and animals, safety from environmental emissions could not be guaranteed, data gaps regarding physical and chemical properties and concerns in the mammalian toxicology section were identified. Due to the lack of toxicity and exposure data regarding the LP-system (Lactoperoxidase System) mixture, a risk assessment for users, workers, and bystanders cannot be conclusively completed. If the definition of this reaction mixture residue is unknown and toxicity reference values are not available, a consumer risk assessment cannot be carried out. Also insufficient to perform an environmental exposure assessment. Although we believe that the active ingredient potassium thiocyanate has an effective bactericidal effect, the qualitative effects of the compound (cyanide) and its decomposition/conversion products formed from the reaction mixture with naturally occurring enzymes and hydrogen peroxide are uncertain. and quantitative environmental exposure assessments are lacking. Additionally, in the ecotoxicology section, data deficiencies were identified to submit screening studies for non-target terrestrial plants for representative field use.

In 2014, the European Union (EU) disapproved “potassium thiocyanate”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
On February 6, 2014, the European Union (EU) published in the Official Gazette Commission Implementing Regulation (EU) No 108/2014 disapproving potassium thiocyanate. The applicant withdrew the application after the Food Safety Authority (EFSA) identified several data gaps on potassium thiocyanate that required additional data, including safety.

Potassium thiocyanate (KSCN) is being regulated in Europe, and Japan’s Ministry of the Environment is also preparing to legalize it as an “endocrine organ disruptor.”

Ministry of the Environment “Report related to endocrine disrupting effects of thiocyanic acid and its salts 2021”
Materials from the 1st Study Group on Endocrine Disrupting Effects of Chemical Substances in FY2021
Thiocyanic acid and its salts have been shown to have effects on the hypothalamus-pituitary-thyroid axis in animal test reports, and androgenic or anti-androgenic effects, effects on thyroid hormone synthesis ability, and in vitro test reports. It shows an effect on thyroid hormone synthesis ability by activating peroxidase, shows an effect on the hypothalamus-pituitary-thyroid axis in human administration studies, and shows an effect on the hypothalamus-pituitary-thyroid axis in an epidemiological survey. As it has been suggested that it exhibits anti-parathyroid hormone-like effects, it can be used as a test substance for endocrine disrupting effects (P25).

* “Endocrine disruptors” are chemical substances that affect the “endocrine system” and have a negative impact on human health and the environment.
*The endocrine organs of the human body include the pituitary gland, thyroid, adrenal glands, ovaries, testes (front), pineal gland, brain, liver, heart, pancreas, “Kidney” etc. These “endocrine organs” secrete appropriate amounts of hormones at appropriate times that correspond to the development and development of the human body.

Ministry of the Environment Reliability evaluation and test implementation status regarding endocrine disrupting effects of chemical substances
“Thiocyanate and its salts”
2021 Reliability evaluation completed (first stage biological testing currently being conducted or scheduled to be conducted)

Reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021, P16~) https://www.env.go.jp/chemi/%E8%B3%87%E6 %96%991-2.pdf

Excerpt: Literature reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021) https://www.env.go.jp/content/000081308.pdf
Chemical reaction between enzyme and thiocyanate (HSCN)

The milk sterilization method used involves a chemical reaction (peroxidase activity) between a harmless enzyme and a small amount of thiocyanic acid (HSCN), which deactivates the SH enzyme within the cells of some Gram-negative bacteria such as Escherichia coli, resulting in an antibacterial effect. An active ion (OSCN-) is generated, which can sterilize some Gram-negative bacteria such as Escherichia coli in invisible amounts of ppm (1/1,000,000, 1 ppm = 0.0001%) (thiocyanate-added milk India P18 ) produce an effect.

However, in the 2020s, the effects on the human body (endocrine organ disruption effects such as inhibiting the intake of iodine from the thyroid and lowering the production capacity of hormones such as thyroxine at very small amounts of ppm) have become clear. In 2015, Japan’s Ministry of the Environment identified thiocyanic acid (HSCN) and its salts as potential test substances for endocrine disrupting effects (P25), and the first biological tests are currently underway or scheduled.

Regarding environmental impacts and regulations, Japan’s Ministry of Health, Labor and Welfare states that thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). ). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))
“Potassium thiocyanate (KSCN)” must not be released into the beautiful natural environment of Japan in ppm units (1 part per million, 1ppm = 0.0001%), and the Ministry of the Environment has announced that it must not be released into Japan’s beautiful natural environment in soil, rivers, lakes, seawater, etc. The law stipulates that total cyanide (CN) must not be detected (detection limit 1.1 (ng/L)).

It contains enzymes that are harmless as a single substance, which are contained in microscopic amounts of ppm (ppm = 0.0001%) in milk and saliva, and a less toxic cyanide substance called thiocyanate, which is also contained in milk and saliva. By administering an increased amount of an enzyme that is harmless to the chemical reaction partner alone, a chemical reaction (The LP-system, lactoperoxidase or glucose oxidase reaction) is caused in the oral cavity, producing cyanide, which causes Escherichia coli among Gram-negative bacteria. Although cyanide has an antibacterial action mechanism that can kill some oral bacteria (it is not effective against Gram-positive bacteria such as Streptococcus mutans, which causes dental caries), and other Gram-negative bacteria, cyanide can also be used in humans and animals. It has the side effect of disrupting endocrine organs, such as inhibiting iodine intake and affecting thyroid hormone production and reproductive function.It also has clinical effects on the concentration of cyanide generated in the body, effects on the thyroid and kidneys in the human body, and environmental emissions. In recent years, health organizations around the world have become concerned about the health risks of the antibacterial mechanism of action (the LP-system, lactoperoxidase and glucose oxidase reactions), as safety data regarding the effects of antimicrobials are not available, and regulations are progressing.

Based on the above, “potassium thiocyanate (KSCN)” is a very useful chemical substance for “manufacturing raw materials for synthetic resins,” “raw materials for plating,” “agrochemicals,” “insecticides,” etc., but it is not suitable for oral ingestion or food formulation. Recently, it has become clear that it has an effect on endocrine organs such as the thyroid gland and reproductive function, including the risk of causing hypothyroidism in dogs and cats, the risk of affecting reproductive function, and the fact that it is excreted into the natural environment through urination. Impact on aquatic organisms and soil microbial ecosystems, marine products and vegetables, impact on nearby residents, farmers, and fishermen, impact on Japanese food, risk of impact on thyroid function, risk of declining birthrate among Japanese people It is inferred that issues related to health and environmental compliance, such as risks to compliance with laws and regulations stipulated by the Ministry of Health, Labor and Welfare and the Ministry of the Environment, have begun to be understood in the 2020s, when medical science and technology have advanced.

From the development of human science to the world’s first products using cutting-edge research technology, times and social needs change, the generations of scientists and researchers and the countries they live in change, and the population and needs change. New technological innovations are born in the country.
We respect the pioneering products and the scientists who developed them through chemical technology in the 20th century, and the research and products that have been helpful in the development of many human beings can be said to have shaped today’s humanity and the earth. You can call it an invention.
Then, in the 21st century, humans are evolving little by little, and with the development of medicine and science, new issues such as effectiveness, side effects, and environmental burden are becoming clearer.
We have also entered the age of the Internet, where consumers around the world can access a variety of new and correct information.

We have entered an era in which consumers choose products with safe and reliable ingredients for their loved ones, and demand that producers disclose all ingredients honestly and with traceability.

In recent years, chemicals with concerns about their safety, such as Forever Chemical, an endocrine disruptor that has become a problem for humanity as a whole, have the potential to take away health and happiness, and the risk of burdening medical costs has led to a change in the latest prescriptions. Responding to consumers’ health needs for improvement (I am sorry that it is difficult to fully promote the safety of products for those who use them as health products.Also, even in trace amounts, they may be released into the environment through urination, causing Ogawa I’m also concerned about the impact on killifish and red dragonflies, aquatic life and seafood from nearby rivers and the sea, vegetables and rice, children playing in rivers and the sea, fishing and clam-gathering, swimming and surfing, and my descendants living in Japan. companies are focusing on product development.

For the sake of the health of their families, consumers are also responsible for carefully examining safety and environmental toxicity, and if possible, developing new formulations, and making sure that all ingredients and purpose of the formulation are not concealed and are easy to understand for consumers. The developer’s face is clearly visible and trustworthy, and the medical basis and safety of the doctor of dentistry, who specializes in oral medicine for animals including humans, is involved in the research and development. Explore oral care products from oral care formulation manufacturers, etc.

We would like to take this opportunity to examine various compounded chemicals, their development background, year of prescription development, experimental data, and clinical trials, to clarify that there may be old products from before the green innovation era that do not meet 21st century medical standards, safety, and environmental protection standards. I think it would be a good idea to look into efficacy data, safety evaluation data, etc.

Endocrine disrupting chemicals, which have been considered dangerous in Europe, have only recently begun to attract attention in Japan, starting in the 2020s when Japan’s birthrate was declining.

As a trusted brand, we provide information on “all compounded ingredients and their purpose,” “action mechanism and risk of side effects,” “efficacy and safety data,” and “risk of environmental emissions,” etc., for the sake of our customers’ precious little families. In today’s world, consumers and patients need honest ingredients that are clearly visible and easy to understand when making a purchase, and that is clearly displayed on each page of online shopping sites. This is considered to be absolutely important for the trust of our customers, the health of our beloved dogs and cats, and the future survival of our business.

In addition, we also provide experimental data, clinical data (effect data in the oral cavity of actual animals), academic papers, explanations of the mechanism of action, explanations of side effects, and safety data regarding the actual effects of the product (whether it works or not). (Are there side effects or not?), etc., and the existence of evidence (scientific evidence). We protect the lives and health risks of our beloved dogs, cats, medical professionals, patients and their families, and people all over the world, the reliability of brands and companies, managers, directors, researchers, regulatory affairs personnel, and business personnel. Also, as an outside collaborator and a person with a family, I believe that this is an important and important thing that has a great social responsibility.

For consumers, it has a serious impact not only on their own health but also on the environment. Products that do not comply with laws and regulations on the market not only increase the burden on the surrounding environment, but also harm the lives of nearby residents. It can also have negative health effects. In that case, ultimately the consumer who uses the product is also responsible. Therefore, European consumer organizations are raising awareness that it is important for consumers to not only think about themselves, but also to adopt environmentally friendly consumption practices that do not endanger the lives and health of nearby residents and the entire nation.

Since the 2000s, when the world’s aging population and environmental destruction have become more serious, the green technology of the 21st century has achieved a balance between oral action and safety when swallowed, something that traditional chemical technology from the 1900s could not overcome. “Several thousand times more effective at an ultra-low concentration” ・“Protection of antibacterial activity and the natural environment of rivers and seas and biological ecosystems when discharged into the environment after fulfilling its role” ・“Medical costs and health care increasing with the declining birthrate and aging population” In the 1900s, in order to overcome the contradictory issue of “reducing the burden on people,” in Japan, where the population is aging, research was carried out for more than 30 years at Kyushu University’s Faculty of Agriculture, Faculty of Agriculture, a national research institution. This is an alternative green technology from the 2000s that realized a generational shift from the 2000s, and the world’s most cutting-edge microbial biotechnology research, as well as research on lactic acid bacteria antibacterial peptides that are made from food raw materials and are safe to swallow.

Discovered as a safe antibacterial substance in cheese by British dairy farmers in the 1920s, it has a wide range of excellent antibacterial properties at ultra-low concentrations in ppb units (1/1 billion, 1/1,000th of ppm, 1ppb = 0.001ppm) Nisin, a lactic acid bacteria antibacterial peptide (protein) that has been considered as safe as salt and spices around the world since the 1980s due to its safe activity and mechanism of action, has been confirmed to be the safest in the world, and is now available in Japan. Approximately 100 years later, in 2009, it was finally approved as a food by the Ministry of Health, Labor and Welfare. While the approval of nisin as a food product was not progressing in Japan, its social usefulness was recognized and research was progressing on applications such as oral care formulations that are safe for elderly people to swallow. “Neonisin-e®︎” is the result of research that has brought about an innovation that expands the spectrum to include Gram-negative bacteria and Candida bacteria, which is impossible with other methods.

The research results of neonisin, which paved the way for the world’s first practical application of lactic acid bacterium antibacterial peptides for medical and healthcare applications and obtained a patent in 2016, are a major social issue for caregivers in Japan, the world’s oldest nation. In addition to helping to reduce the burden on patients and improve patients’ QOL, they have also made small contributions to humanity, such as being used at disaster sites and on the International Space Station, spreading around the world, and winning various awards. It can be said to be a research result by a Japanese national institution that is extremely useful for elderly people in need of care, infants, people who have difficulty gargling or spitting due to illness or disability, pets, etc.

In order to meet the needs of advanced pet owners around the world, who are raising their pets as important family members like their own children as the birthrate declines and the population ages, we develop new products for the 21st century that contribute to the development of humanity. In order to ensure that pets who love research results can also enjoy them, we have Japanese human-grade safety and efficacy, innovative patentability that realizes low environmental impact, and are used by many people around the world at an honest and reasonable price. Aiming to create the best oral care products for pets, we are working with leading experts in lactic acid bacteria biotechnology research, such as Doctors of Engineering, Doctors of Agriculture, and Doctors of Dentistry, as well as doctors, veterinarians, pharmacists, breeders, groomers, and pet companies that are oral peace partners around the world. Oral Peace Four Pets was born after a lot of time and effort was put into the research team.

From the above issues, we believe that we should love our pets as part of our family, like our own children, and that what we put in our mouths should also be eaten by humans.

ORALPEACE for Pet, which has been researched with the aim of making it food-grade safe and protecting Japan’s beautiful natural environment and marine products from dangerous chemical contamination, is formulated with potassium thiocyanate (KSCN). This is a prescription that does not require.




To be honest, until recently, we, the research members, were unaware of the progress in regulating potassium thiocyanate (KSCN) by the Japanese Ministry of the Environment. I only realized this after receiving many inquiries from customers. No one really knew. This is the latest issue that humanity as a whole was unaware of, and even expert scientists and strategists were unaware of. We sincerely apologize for the inconvenience, as our research team’s global research efforts were not successful.

Regarding oral care products for human use, in response to the European Union (EU) regulations in 2014, brand ownership changed and a new global distribution system was adopted, and from 2015 onwards, the formulations were completely changed and the corresponding effects were changed. It has been reborn as a new, simple oral moisturizing product brand that eliminates antibacterial action and antibacterial effects on oral bacteria, and has smoothly penetrated the market. Some antibacterial mechanisms of action based on cyanide (thiocyanate peroxidase activity) remain unchanged as we head into the 2020s.

We have been using this pioneering 20th century chemical technology for many years with our own pets. The side effects that have been pointed out in the 2020s are cutting-edge research results that have finally become clear due to advances in human science, and the benefits outweigh the risks that were previously unknown (poor temperate regions Humankind has enjoyed benefits that outweigh the side effects (just as children in developing countries in the region are able to survive hunger and survive by relying on milk as a source of nutrition). Regarding this, as I mentioned at the beginning, I will never forget my gratitude and respect to the pioneering scientists.  

As a businessman, I have always struggled with the gap between the sales, marketing, and management departments, which are close to consumers, and the research and development department, and have experienced much pain in the friction between them. There have been times when front-line department members have overcome various risks that were not pointed out to them by the R&D department by worrying and trying to resolve them. The research side is often forced to comply with the reckless demands of the front department.

As a researcher myself, I believe that side effects require actual clinical experiments and animal experiments, and the results vary depending on the person, individual, and various conditions, so they are not something that can be obtained easily and in practice. We need to make sure that consumers, sales, marketing departments, and management departments understand that it is difficult to obtain clear answers clinically. In reality, it is difficult to understand the correlation on a case-by-case basis.
However, this time, we need to discuss the side effects and environmental burden of chemical substances, which have recently begun to be pointed out around the world, and work together to create choices that will create a better future. However, rather than blaming ourselves or someone else for the past, I think this action will lead to good things for future consumers, collaborators, and ourselves.

As researchers, we respect and collaborate in each other’s fields of expertise.This time, WHO, FAO, Codex Alimentarius Commission, the European Union (EU), the International Dairy Federation, the Ministry of Health, Labor and Welfare, and the Ministry of the Environment have collaborated to collaborate and respect each other’s fields of expertise. We need to involve many colleagues in conducting deeper research into chemical substances and mechanisms of action that suggest safety, proving their safety one by one, and working together to overcome new challenges one by one. We believe that this is the real thrill of research, and that it is a breakthrough and a valuable challenge that will produce true inventions and innovations, and dispel the concerns of people around the world.

When it comes to research that is beneficial to humanity as a whole, in order to overcome various difficulties, everyone should open their hearts honestly and transcend conflicts of interest between universities and companies, without criticism or self-protection. I think it would be wonderful for these Japanese researchers to work together and work together to develop a mechanism of action that has proven safety for the body and low environmental impact for the benefit of humanity all over the world.
To that end, our research team will work together to prove the safety and low environmental impact of this mechanism of action, and we believe that helping each other will be a breakthrough for us as researchers.
In this time when many people are hurt by disasters and wars, I believe that if we all start moving in a better direction, even little by little, and even from today to tomorrow, we can join hands and change the future for the better. think.
Families will be healthy, nature will be beautiful, the latest research efforts will be appreciated, companies will be trusted, and business will continue to be beautiful. You can change it from today to tomorrow. Every day is a challenge with change, and continuing to improve on it is through research and corporate efforts, and the number of customers and colleagues who do research together will increase.
World health organizations, the Japanese Ministry of Health, Labor and Welfare, and the Ministry of the Environment investigated facts that we did not know on our own and taught us about the risks. At first I was confused, but I took a deep breath, changed my mind, and thought about the best direction. Check with your own eyes the safety of the products you use. We will communicate this risk to the relevant departments and work together to refine new technology to meet the new era. We will work together to prove safety and evolve through friendly competition.

Through the power of science and research, we will use the power of science and research to help people around the world who are struggling to survive despite difficulties due to illness, disability, injury, aging, etc. In front of that ultimate love for humanity, competition between researchers and companies, scrambling for profits, criticism, and self-protection are petty and vain. Excellent minds come together to advance research that will remain in human history, transcending even conflicts of interest.

I believe that the gradual awareness of humanity as a whole and the step-by-step progress we make each day will change the future of this earth and humanity for the better.

Our research team has taken the courage to provide the latest information on chemical substances that health organizations around the world are warning about, and we hope that this information will contribute to the future choices of many people, and that even one person will be aware of it. I would be happy if you could obtain this.

In addition, many oral piece users and professionals contact our research team with their opinions on individual ingredients that are not included in oral pieces, but if possible, please check the details on the Internet etc. Thank you for your understanding.

The ingredients that were not selected simply did not match the concept we were aiming for, and we are not in a position to answer the pros and cons of past diverse research orientations. For the health of your precious family, we believe that it is important to carefully examine the ingredients based on your own value standards.

If you are a researcher and are having trouble with clinical data and proof of the safety of the ingredients and mechanism of action, as well as the low environmental impact, please feel free to contact our research team. If you are in the sales or marketing department and are having trouble reaching out to the research department, we would be happy to hear from you.

Change the future with inventions that contribute to the development of humanity. If we all work together, we can definitely find a way. Love creates a beautiful future.

ORALPEACE for your loved ones

Thank you for your continued support of the ORALPEACE Project.

It is not included for the following reasons.

On November 9, 2011, the U.S. Environmental Protection Agency (EPA) announced the withdrawal of pesticide applications that require the establishment or change of rules regarding pesticide residues in various agricultural products.
In September 2011, an application was made for residual standards for lactoperoxidase in all fresh agricultural products when the active ingredients “potassium iodide” and “potassium thiocyanate” are used as inert ingredients in pesticide formulations before harvest. It was withdrawn on May 9th. (Source: Cabinet Office Food Safety Commission)


If you like iodine, use the brown mouthwash containing povidone-iodine, being careful about swallowing and side effects on your thyroid.

Not compounded.

Sodium hydrogen carbonate (baking soda) is an alkaline substance that has the effect of floating dirt and destroying and decomposing fats and oils and proteins.

In addition, the particles are large and difficult to dissolve in water, which makes them useful as an abrasive for kitchens.

Toothpaste containing sodium hydrogen carbonate (baking soda, polishing agent, alkali) was born about 100 years ago and can be easily made with baking soda in the kitchen.

However, there are various problems that are not recommended for use in tooth brushing and oral care in the modern oral clinics around the world.

First of all, the point that “the teeth are scraped by the polishing action”.

Sodium hydrogencarbonate (baking soda, abrasives, alkalis) is a substance that has a very strong polishing action, as it is also included in cleansers that remove stubborn dirt.

The American Dental Association (ADA) does not recommend sodium bicarbonate (baking soda) for the following reasons:

Particles of sodium hydrogen carbonate (baking soda) are said to be coarser and larger than any of the abrasive components of commercially available dentifrices, which is the same as brushing teeth with a file or cleanser.

After daily polishing, the enamel is scraped off every day, and symptoms of hypersensitivity will eventually occur, prone to tooth decay, pigments will easily remain on the scratches on the tooth surface and cause yellowing, and eventually dentin inside Is visible, and the teeth are gray, over white.

And the tooth that has been scraped will not return to the original, so be careful.

Next, it is “inducing excessive intake of salt”.

Sodium hydrogen carbonate (baking soda, abrasives, alkalis) is composed of sodium compounds as well as salts.

The amount of sodium hydrogen carbonate (baking soda, abrasives, alkalis) that can be taken daily by healthy people is less than 5 grams.

If you accidentally swallow it with toothpaste or gargling with sodium hydrogen carbonate (baking soda, abrasives, alkalis), you will ingest too much salt. Also, salt will be absorbed from the mucous membranes of the oral cavity without swallowing.

In particular, caution is required for those with impaired kidney/cardiopulmonary function, those with salt or sodium restriction, those with high blood pressure, and those with restricted salt intake due to chronic illness.

Also, it is not good for healthy people to increase their salt intake. Excessive salt intake leads to symptoms of metabolic disorders such as swelling and alkalosis.

Secondly, “alkaline tilt in the mouth causes tartar to adhere”.

The human body’s oral cavity has the physiological function of keeping the same weak acidity as the skin, keeping the PH in the mouth constant, suppressing the action of causative bacteria, and promoting the remineralization action of teeth.

Humans’ mouth is kept weakly acidic by saliva, but tartar is more likely to adhere to the mouth which is inclined to alkali.

Tartar is a plaque that is a collection of bacteria that is calcified by alkali and causes dental caries and periodontal disease.

There is also the expectation that “the neutralization of the mouth, which is inclined to be acidic by diet, may promote remineralization of teeth and prevent tooth decay”, but in reality remineralization is performed by saliva minerals.

Caries do not occur because the inside of the mouth becomes acidic, but the teeth are melted by the acid produced by the dental caries that live in the mouth to decompose sugar.

Ordinary weak acidity in the oral cavity does not activate dental caries (it cannot be inactivated even by tilting it to alkaline), so there is no point in temporarily tilting the oral cavity to alkali. There was a clinical problem that the bacteria could not be eliminated (oral mucosa and skin tissues were damaged before that), but the risk of tartar was increased.

Finally, the point is that “strong stimulation with alkali damages the oral mucosa.”

When treated with a strong alkali, it becomes the same as reduced bleach and strong alkaline ionized water, and strong alkali can sterilize general bacteria and inactivate viruses.

Strong alkalis are as good as disinfectants for medical equipment and kitchens, just like disinfectants such as chlorine and hypochlorous acid. However, there is a problem that it causes damage when used on the body of people who are composed of various bacteria.

Although strong alkali sterilizes bacteria, chemical damage destroys the proteins that make up the oral mucosa, damages the gum tissue and periodontal skin tissue, and damages the oral mucosa, deteriorating the oral condition.

When making skeletal specimens of animals because of their characteristics of destroying skin tissues and proteins, they are boiled with sodium hydrogen carbonate (baking soda).

Also, if you add baking soda to oil-dirty kitchen utensils, clogged ceramic filters, and parts of cars and motorcycles, the oil and protein will be decomposed and it will be very clean. Please try.

And regarding the effect data on bacteria and viruses, in experiments such as petri dishes, we can get data that reducing bleach and strong alkaline ion electrolyzed water can kill various bacteria and viruses.

However, in the actual oral clinic, the concentration cannot be maintained by being diluted with saliva (the skin damage is large if it is not diluted with saliva), and the reality is that the same clinical effect as the experimental data on petri dishes cannot be expected.

From the above, there was an oral clinical problem that strong alkali had more side effects than action and could not be used for babies and infants with weak oral mucosa, elderly people, fighters, and people who care about salt and are healthy.

Therefore, ORAL PEACE is a prescription that does not contain it.

However, if you like sodium bicarbonate (baking soda, abrasives, alkalis), baking soda for food is sold at supermarkets, so please use it with caution.

ORALPEACE is made from only food ingredients that are safe to eat, and we do not mix non-food abrasives (compounds, stone powder, etc.).

Abrasives (compounds, stone powder, etc.) can be whitened by scraping the tooth surface, but they have the following side effects.

Enamel does not return to the original state if it is cut too much.

It becomes hypersensitive due to excessive shaving.

Accumulates on the periodontium.

We do not have the following abrasives in ORALPEACE.

Calcium carbonate (raw powder for drawing white lines on playground, raw material for chalk)
Sodium hydrogen carbonate (baking soda)
Mud (clay and montmorillonite)
Micro beads (plastic powder)

ORALPEACE can be used safely with only edible ingredients, and it is also suitable for whitening teeth by carefully brushing teeth for a certain period of time without damaging enamel and dentin, and for use with electric toothbrushes.

ORALPEACE can also be applied to the oral cavity as a moisturizing gel for the oral cavity.

Regarding “keeping teeth white”, our research team recommends the following methods.

Instead of shaving away the enamel and dentin of your important teeth with an “abrasive” to make your teeth look white (which was the standard in the past), perform daily home maintenance by careful brushing.

To have a whitening treatment in a clinic once a year or once every few months.

We believe that it is a reasonable way to keep your beautiful white teeth, both effective and safe, just like removing stains on your skin.

Synthetic preservatives such as methylparaben, butylparaben, propylparaben, also known as paraoxybenzoate, are not added at all.

In addition, we do not use other synthetic preservatives that are used in place of parabens in our oral pieces.

All ingredients of ORALPEACE are as shown on the package.

Please check the effects, side effects, and environmental effects of synthetic preservatives on the Internet yourself.

Not using

Phenoxyethanol is a synthetic preservative/preservative that is increasingly being used as a substitute for consumers who do not like parabens.

It is chemically synthesized in the presence of an alkali metal hydroxide or alkali metal borohydride by hydroxyethylation of phenol (a colorless needle-shaped crystal made from coal tar, which is used for preserving and disinfecting).

In Japan and the European Union, the amount of phenoxyethanol is strictly limited for cosmetics for skin, and up to 1% can be added to the product.

However, it is a banned ingredient for use in food.

(Paraben is allowed to be used in food.)

Even for cosmetics for the skin, the inclusion of phenoxyethanol is prohibited by international organic product certification standards.

Therefore, phenoxyethanol is not added to ORALPEACE, which is an oral care product that can be taken orally and absorbed by the mucous membranes in infants and pregnant women.

Carryover ingredients that are not included in the ingredients of overseas products, such as preservatives as impurities contained in the product, which are not stated in the labeling of all ingredients, are prevented from being mixed in under the strict production control system in Japan.

Unlike overseas, it does not contain formaldehyde, which is strictly prohibited in Japan.

Many toothpaste products are white pastes because they contain many abrasives (compounds and stone powders) and foaming agents (soaps and surfactants).

However, in the case of a semi-transparent gel that does not turn white with a mild mixture of abrasives and foaming agents, if you add a component called “titanium oxide” as a coloring agent, the transparent one becomes a pure white paste.

“Titanium oxide” is made from minerals, but the World Health Organization points out that it is “carcinogenic”.

Since January 2020, France has banned the production and sale of food products containing “titanium oxide”.

ORALPEACE is a formulation that does not contain “titanium oxide” because it is made from only food ingredients that are safe to swallow.

ORALPEACE for Pet does not contain “Yucca schidigera extract”.

Saponin, which is found in plants such as European soapwort, is a naturally occurring compound and surfactant that foams like shampoo and uses its surfactant action to destroy bacteria and sterilize water and oil. It emulsifies and is said to have the effect of improving the shelf life of products.
In 2021, the European Food Safety Authority recommends Yucca schidigera extract (a complex mixture of various compounds, the main components being steroidal saponins and triterpenoid saponins, but other components present in the extract cannot be identified) as a fungicide. However, there is insufficient information to support the effectiveness of the extract as a bactericidal agent, while the effects of the triterpenoid saponins contained in the extract on human health and animal health (thyrotoxicity and (male reproductive toxicity) and effects on aquatic organisms in the environment, and the whole mixture (including unidentified substances in the ingredients) of Yucca Schidigera extracts suggests serious irritation to the skin and eyes. doing.
Due to the above issues, we currently do not require the formulation of ORALPEACE for Pet to contain Yucca schidigera extract.
If you like Yucca schidigera extract, you can purchase it online, so please be careful about your skin and eyes and avoid releasing it into the environment as it may affect aquatic life. We would appreciate it if you could consider the clinical use for oral ingestion, tooth brushing, and oral care for your family, children, pet dogs, and cats.
Source: Cabinet Office Food Safety Commission Food safety related information details November 26, 2021
The European Food Safety Authority (EFSA) publishes the results of discussions between European Union (EU) member states and EFSA regarding the basic substance authorization application for Yucca Schidigera extract in a technical report.


Not blended.

We ask each customer to research on the Internet the effects of preservatives (sodium benzoate) on dogs and cats, which are small organs that cannot be gargled or spit out.

As you might be concerned, sodium benzoate is considered to be a more repellent ingredient for cats than it is for dogs, so if you are concerned about its effects on your cats, please check past research data.

External survey results
Twenty-eight cats ingesting a diet containing 2.39% benzoic acid exhibited symptoms of toxicity, including nervousness, agitation, loss of balance and vision. Sensitivity in cats is due to defective glucuronide production, and toxicity occurs at doses above 0.45 g/kg for single doses and 0.2 g/kg for repeated doses. (Bedford & Clark, 1971)
A study was conducted in which 17 dogs were fed sodium benzoate or benzoic acid at a rate of 1000 mg/kg for over 250 days (Rose et al., 1913).

For details (cited: external survey data)

No animal-derived ingredients are used.

We do not use any ingredients derived from animals, ingredients produced from the placenta of humans or domestic animals such as cows, pigs, sheep and horses, ingredients produced from animal eggs, and ingredients produced by culturing animal cells.

Also, we are not conducting animal experiments.

Regarding product manufacturing, we aim to create products that do not sacrifice the lives of animals.

We do not use ingredients such as cultivated bacteria ingested from dental plaque, excrement or plaque of humans or animals, or animal-derived bacteriocin, which is not approved as food.

First of all, as for plant extracts and essential oils, most of the raw materials in the world can be easily purchased at the essential oil shops on the Internet, so if you are expecting the effect of plant essential oils or herbal extracts on oral clinic, you can buy each raw material. We recommend that you try the effects of yourself.

ORALPEACE does not contain various plant essential oils or herbal extracts for antibacterial purposes.

The reason is as follows.

Plant essential oils and plant extracts have a sales promotion effect that makes consumers expect some effects when a large number of ingredients are added to products.

However, in reality, there was a problem that the expected clinical effects could not be obtained when added to oral care products.

For skin cosmetics, essential oils and plant extracts are predominantly used as fragrances, and vegetable oils are formulated as oils.

However, the problem is that oral care products that do not require fragrance or oil have almost no clinically expected effects.

It is necessary to increase the concentration in order to obtain some effect, but this will affect the taste and aroma, resulting in a taste that cannot be put into the mouth.

On the other hand, there was a problem that it would have a negative effect on safety if the amount of the formulation did not affect the taste.

Even though it is derived from plants, there are many ingredients that have evolved to avoid living organisms, such as hinokitiol and tea catechin, that have not been fully verified as safe substances for living organisms and the human body.

Since plant essential oils and plant/herb extracts have not been the foods that humans have always liked since ancient times, we do not use them in ORALPEACE.

If antibacterial properties are expected, the antibacterial activity of “Neonisin-e®” is several thousand times that of plant essential oils and plant extracts. In other words, the same effect can be obtained with a few thousandths.

ORALPEACE is blended with plum fruit extract for “Neonisin-e®”, Damask rose essential oil, and mint essential oil for refreshing feeling.

It contains the minimum amount of plant essential oils and extracts that are essential for expecting clinical effects.

If you like vegetable essential oils and herbal extracts, please procure them from herbs and essential oil shops and use them together with ORALPEACE.

Not compounded.

It is the same reason as hinokitiol, high-concentration catechin, mastic resin, and pine resin.

This is because there is a problem that side effects are greater than effects on humans and pets.

Since many plants do not become extinct by being eaten by insects and herbivores, they have developed and evolved toxicity and repellency against living organisms, and survived the severe survival race of this earth for millions of years.

Plants that are highly toxic cannot be eaten by humans, just as insects and herbivores cannot.

Plants such as vegetables and fruits that humans can eat are limited to a very small number of plants on earth, as there are very few plants that can be eaten in natural forests.

However, vegetables and fruits that are safe to eat as they are, as well as most of the plants in the garden or familiar to you, have the power to kill bacteria and organisms at home by boiling them to a high concentration.

In a simple example, fungi and viruses do not propagate in the essential oil of plant distillation.

In addition, it is possible to obtain data that a highly concentrated component of a plant extract that seems to be safe to eat will inactivate bacteria and viruses in experiments in petri dishes.

However, if a plant that seems safe as it is is made into a substance with a high concentration to kill bacteria and organisms, side effects on humans and pets that are organisms are large, and it is difficult to put it in the mouth. There was a big problem that it could not be tasted as an oral care product, the amount of the mixture that could be expected to be effective could not be put into the mouth, and the actual product was meaningless unlike the image.

From the above, there has been a worldwide demand for the development of natural preparations that exhibit bactericidal effects even at extremely low concentrations.

It is not mixed at all.

For the health of pets who cannot gargle or spit,

At Oralpeace, we avoid adding chemical substances (synthetic fragrances and synthetic preservatives) that are labeled as “fragrances.”

Also, the cause of bad breath in dogs and cats is periodontal disease caused by oral bacteria, mainly periodontal disease (dogs are said to be less prone to tooth decay).

Using “fragrance” to disguise the odor caused by physical illness or illness means leaving the cause of the illness untreated.

Using scented chemical products like deodorants in a dog’s mouth may be good for humans because it covers up the odor.

However, for our beloved pets, Oralpeace believes that it is more important to cure periodontal disease, which is the root cause of bad breath, to feed delicious food with healthy teeth, and to help them live long, healthy lives. Masu.

For pets, even if they are suffering from an illness or condition, they are fooled by the scent and are not treated properly, and even though they cannot gargle or vomit and have small organs, they are not given odor-eliminating fragrances that contain additives and chemical ingredients. Although being forced to drink is a human convenience, I feel a little sorry for them as they are all animals.

Oral pieces containing neonisin-e, which were created based on research results to approach the bacteria that cause bad breath, periodontal disease, and tartar in the oral cavity, are designed to treat affected areas that cause physiological bad breath due to periodontal pus in your dog or cat. Our policy is not to include fragrances or synthetic fragrances that mislead you with scent.

If you like flavorings, we would appreciate it if you could purchase food flavorings etc. from our online shop and use them.

ORALPEACE does not contain artificial sweeteners or food additives such as “sorbitol,” “maltitol,” “erythritol,” “sucralose,” “saccharin,” and “aspartame.”

Artificial sweeteners have been used since the 1980s due to their advantages such as zero calories, hundreds to tens of thousands of times sweeter than sugar, cheaper than synthetic sugar, and the ability to make products at a lower cost. There has been increasing debate.

If you are interested in the composition of artificial sweeteners, confirming their safety and risks, or the latest opinions from the World Health Organization (WHO), please feel free to check out news reports on the Internet, etc. .

ORALPEACE is a product with excellent “biodegradability”.

Since it is made from only plant-derived food ingredients, if it is discharged to the environment after its function is completed, it will be quickly metabolized and reused in the natural ecosystem, and the characteristics of the environment and the risk of pollution are extremely low. ..

It is truly an environmentally friendly oral care product.

On the other hand, many petroleum-derived synthetic bactericides, antibiotics, concentrated plant antibacterial agents, etc. have the characteristic of being “hard to decompose”, and even if they decompose, the decomposed products show toxicity in the natural world. There is also something to do.

Since its toxic effect is strong and long-lasting, it is feared that it will adversely affect the natural ecosystem, especially the microbial ecosystem.

Recently, in developed countries and around the world, the problem that persistent plastic waste has a negative impact on marine ecosystems has become a hot topic, and containers with low risk of environmental pollution and switching to plastic with good biodegradability have become popular. There is a great worldwide interest in raw materials that excel in biodegradability in harmony with the environment, such as alternatives to.

It is easy to imagine that in the future, these environmentally-friendly directions will not reverse, and that in the future, new eco-friendly products that are kind to the earth, highly sustainable, and beneficial to humankind will replace the mainstream of the world. I can do it.

ORALPEACE are not made from petroleum, which is a limited fossil raw material, but can be made from lactobacilli that live in plant-derived okara and edible plants, which are highly sustainable and have a low environmental impact. There is also.

Against this background, we hope that many people will use Oral Peace to leave a beautiful earth for the next generation.

Until now, many people have used search sites to find out how to check the safety and environmental impact of ingredients contained in toothpaste, oral care, and oral care products.
However, in the past, some search sites used various techniques such as reverse SEO by sales companies and agents to subordinate and hide the true information, preventing consumers from seeing anything inconvenient. Consumers are not informed of the truth, competitors continue to advertise to other brands, competitors do reverse SEO, and advertising of deceptive products is left unattended, causing great damage to Japanese consumers. There are negative impact, such as leaving malicious reviews and suggestions contaminated for a long period of time, and prioritizing profit acquisition and neglecting to protect Japanese consumers and businesses and ethical corporate behavior and response. Social problems are occurring.
Up until now, search sites have provided wonderful services that have greatly advanced humanity and enjoyed great benefits, but recently, due to manipulation by malicious parties, the current situation has deteriorated. I would like to express my deepest gratitude and hope for a better response.
AI question and answer services that have recently appeared are characterized by AI compiling a large amount of information and providing accurate answers, which has the advantage of being less likely to provide biased information like search sites.
If you want to find out the dangers of an ingredient you want to investigate, in addition to the conventional search services, we recommend that you use the AI question answering service, which makes it easier to get real answers, to get real information.
I think you will be able to find the truth that has never been found on conventional search sites.

Please try it once. Best regard.

ORALPEACE is a component that can be swallowed as it is, has high biodegradability, and needs for medical and nursing care in order to avoid the risk of aspiration of the oral cavity moisturizing agent on the nasopharynx and tongue, which may cause aspiration in the lungs. In order to meet the requirements, we spent a lot of time carefully selecting the ingredients and developing highly water-soluble and biodegradable products.

Generally, it is possible to increase the viscosity of gel by adding synthetic polymers, polymer compounds, synthetic thickeners, etc.

However, in that case, there will be problems in the use of elderly people, infants and infants who are not good at gargling and vomiting, pregnant women who do not want to take chemically synthesized components, and discharge into the natural environment.

In addition, when foods with a thickening effect such as agar are added, the problem of easy spoilage emerges, and the problem that synthetic preservatives and alcohol (ethanol) must be added will arise.

The moisturizing and thickening components of the oral peas are made of plant-derived glycerin and xanthan gum, which are highly water-soluble and are kept hygienic and used in foods.

Formulating with only water and plant-derived ingredients, it is difficult to balance the water-solubility/biodegradability of the product and the viscosity that is easy to handle, and as a result of repeated trial and error, the viscosity of water and plant-derived ingredients is increased to a certain degree. We have succeeded in commercialization with a fine prescription balance and a unique manufacturing method.

However, glycerin has the property of taking in water from the atmosphere, so that natural soap containing a large amount of glycerin will dissolve in a humid bathroom.

If you do not close the cap properly after use, or leave it in a humid place for a long time, it may take in moisture from the atmosphere and become loose. Also, if there is a lot of water on the toothbrush or hand, it will be difficult to put it on because it leans down.

Therefore, in order to keep the viscosity so that it is easy to pick up, please consider how to use it, such as tightly closing the cap after use, not storing it in a highly humid place, taking a dry brush or picking it up with your hand. I would appreciate it.

No plastic tube is used.

ORALPEACE tube packages are available in aluminum tube type and laminated tube type.

Plastic tube/container type (made of plastic only, contents that popped out will return, air will enter the container where the contents have disappeared, there will be gaps, the amount of the contents that can be seen through the sun will be transparent) , “Very low cost”, “It can be opened with one hand”, but it has “low confidentiality and easy to rot and needs to be mixed with a large amount of synthetic preservatives”. There is a demerit that “the component of is easy to deteriorate.”

For the above reasons, we are not using it in oral pieces made of delicate ingredients such as food and organic ingredients.

The advantage of the aluminum tube type is that it “has high airtightness and light-shielding properties, and the contents that have been put out once will not return.” On the other hand, it has the disadvantages of being “unusable”, such as “cannot be opened with one hand”, “sometimes overloaded”, and “tube breaks”.

Since the debut of the ORALPEACE in 2013, we have been using it since aluminum tubes are highly sensitive and are ideal for oralpieces that do not use synthetic preservatives.

However, in daily use at medical and nursing care sites and at home, we received many comments regarding the inconvenience (cannot be opened with one hand, aluminum will be cut, contents will not be exhausted to the end, etc.). ..

On the other hand, the laminated tube type, which we started to use in 2017, adopts the latest technology “Aluminum Barrier Lamination (ABL)” and is a material with layers of “PB, PET, aluminum, PB” stacked from the outside. ..

By sandwiching the aluminum layer in the laminate, it is possible to ensure the same level of airtightness and light shielding as an aluminum tube, and it has the property of protecting the contents without volatilizing the contents compared to a plastic tube.

It is more convenient to meet the demand for ease of use at medical/nursing sites and at home while maintaining the functionality of the aluminum tube without deterioration even after being left for 6 months in a aging test (temperature 40 degrees, humidity 75% etc.) The characteristics of conventional aluminum tubes are fully ensured as it was developed with consideration given to its characteristics.

Although the cost of the container is high, it is a tube that combines the functionality of aluminum tubes with the ease of use of plastic tubes.

At ORALPEACE , we would like to reflect the opinions of many patients and consumers and not only to research and develop the ingredients, but also to utilize the latest technology for packaging.

You can check the quality of the tube/container by taking into consideration the tube/container of the oral care product and checking the inside by opening the tube/container with scissors after use.

We recommend you to check by yourself.

Materials that can be said to be almost handmade, such as fermented lactic acid bacteria extract and expensive plant-derived raw materials, which are developed by investing a great deal of time and effort in basic research and technology development of new ingredients by research institutions The oral piece used is a very time-consuming and costly product.

In fact, unlike oral toothpaste, which is made by mixing cheap stone powder and synthetic surfactant in a tube and filling it in a tube, basic research produces original ingredients, blends expensive organic ingredients, and agitates/fills. Production control, packaging and box materials, patent control, pharmaceutical control, support for facilities for people with disabilities, creative, public relations, distribution to high-quality department stores, etc. Oral care products that seem to be considered do not have to be cheap, and it takes the same effort and cost as lotions and beauty liquids of several thousand yen to 10,000 yen or more made in the same process at the same factory. ..

However, the concept of the oral piece is to offer the product at a reasonable price while pursuing the effect and safety of the product.

Good products include price. With the goal of setting a reasonable price for households that can be used on a daily basis, all of our factories and distribution partners are making various efforts and efforts to develop products from scratch in order to achieve products at that price.

Honestly pursuing the ideal price for daily oral care products and the appropriate price for the product content, and aiming for a more affordable price for those who love oral pieces through corporate efforts We are.
(For 80g of Clean & Moisture Gel, 15ml per 1ml.)

Now is the time when the world can share knowledge on the Internet. You can easily check the ingredients contained in toothpaste/oral care products, their prices, and the research background of the products.

Even if you choose to purchase oral care products, check the “all ingredients” displayed on the product package without taking into account the effect expression and the suggested price that the seller sings. We ask you to search the ingredients online, check the research background of the product, whether the product is valuable to the price, and what kind of corporate attitude you are conducting research and production in manufacturing. We recommend that you make a judgment and make a smart choice.

In the future, ORALPEACE will continue to sincerely strive to create better value-added and better products for those who feel value and empathy for this research, products, and businesses. Thank you for your cooperation.

The ORALPEACE planning and development member was the pioneer in 2005 developing the first organic brand with organic certification such as oral care, body care and hair care, and has developed many organic certified brands.

What are natural organic products made for overseas consumers who are highly conscious of family health and environmental issues?
Uses plant materials that can be produced sustainably without using fossil (petroleum) materials. Plants use endless organic cultivation and wild craft materials. Chemically synthesized ingredients and additives that have an impact on the human body and environment. I think that the aim is to create a product with the concept of not using etc.

ORALPEACE have also been developed by members who have been involved in the planning and development of various organic products and oral care products based on European organic standards for more than 15 years, and are still certified plants based on international organic product standards. It is produced in.

Regarding the organic product certification mark, until 2017, Oral Piece also acquired the European organic certification for each product and marked the product with the mark. However, the claims from the certification company (certification business group) are large, and the listing of the certification mark is not as effective as expected, and the payment to the certification company and the product without making the decision to convert the certification cost to the consumer price. We have decided to stop posting on the website and continue to only manufacture products that comply with the certification standards.

In other words, the oral pieces are of the same quality as the organic certified products in the world.

However, there is a reality that organic and natural products, herbs and herbal medicines have not been able to meet the needs of various diseases that are diversifying as therapeutic agents.

In order to meet the medical and health needs of the new era, “addition of products” that contains a large number of various plant extracts that are expected to have the same effect as before, and “subtraction that uses as few chemical synthetic ingredients as possible for health” Aiming for “multiplication” to a completely different dimension in “product manufacturing”, basic research that responds to modern clinical issues by fusing R&D with Japan’s advanced science and medical technology based on biotechnology of the new era, It can be said that they are challenging the development of patented technology and the production of products in a new era.

Specifically, it is necessary to create products that do not use petroleum-derived ingredients even if they are raw materials that can be used in food, and do not use chemically-synthesized ingredients or alcohol (ethanol) even if they are natural or plant-derived Naturally, in addition to the above, the lactic acid bacterium bacterium derived from plants, which is kind to animals and the global environment, was invented over 10 years with the aim of achieving both efficacy and safety through industry-academia collaboration with advanced research institutions. The major difference is that it is an oral care product for the global market that originates from Japan, which is a research and technology-based nation, and contains the syn drug “Neonisin-e”.

It is also a big difference that it is a social product that is trying to utilize the research and technology not only for commercial purposes but for the creation of jobs for people with disabilities in vulnerable places around the world.

ORALPEACE is a product and business that was created in consideration of an important family. I’m sure that everyone will be able to convey that feeling through the product.

We hope that many people will use ORALPEACE.

Thank you for your continued support of ORALPEACE Project.

In modern science,

1. “All human indigenous bacteria cannot be classified as good or bad”

2. “There is no technology that can classify the same creatures as good or evil and control/reduce only one or raise/increase only one”

There is a thing.

It is said that about 500 kinds of bacteria, including those that have not yet been named, live in our oral cavity up to 1 trillion.

In modern modern science, identification of bacteria that cause tooth decay and periodontal disease among the indigenous bacteria in the oral cavity is progressing, but 
 all bacteria in the oral cavity including those that have no name The fact is that the separation of good bacteria and bad bacteria has not actually been done.

In the oral cavity, even indigenous bacteria, which are considered to be good, may have a bad effect depending on the situation (also called opportunistic bacteria), and on the contrary, it is described as a bad one that causes tooth decay and periodontal disease. It has not been scientifically ruled out that indigenous bacteria can also perform good functions such as suppressing bacterial invasion from the outside.

 In other words, there are no evidences regarding the judgment of good or evil of indigenous bacteria・Because it has not been clarified.

Next, bacteria are classified as Gram-positive bacteria, Gram-negative bacteria, fungi, etc., and are not classified as good bacteria or bad bacteria.
The latest technology to sort the same organisms as good and bad There is no point.

Like humans, animals, insects, and living things, if you use “poisons”, “insecticides”, and “bactericides”, good and bad people, good animals and bad animals, beneficial insects and pests The indigenous bacteria that form, the bait bacteria and viruses, and the good bacteria and the bad bacteria “act on both at the same time and both.”

The opposite is the same, but since the recent boom in lactic acid bacteria has increased the focus on “bacteria” in the beauty industry, focusing on “beneficial bacteria” and “beautiful skin bacteria” that have a good effect on the human body, the “beneficial bacteria” Even if you want to grow or increase “Beautiful skin bacteria”, “all bacteria including bad bacteria” will increase at the same time.

The following are the current findings in the world’s most advanced lactic acid bacteria research, that is, research on probiotics and lactic acid bacteria antibacterial peptides (bacteriocins).

The antibacterial substances and antibacterial peptides (bacteriocins) produced by lactic acid bacteria vary depending on the type, but there are many antibacterial spectra (ranges) ranging from narrow to wide.

For example, “Nisin A”, which was discovered for the first time in the world and is most famous, has the broadest antibacterial spectrum among lactic acid bacteriocins and controls most Gram-positive bacteria.

On the other hand, bacteriocin, which has a narrow antibacterial spectrum, controls only certain Gram-positive bacteria (Gram-positive bacteria closely related to the production bacteria).

It can be said that this is “a certain bacterium or bacteriocin controls by selecting a specific bad bacterium”, but unfortunately it also works with closely related Gram-positive bacteria. I will.

Among the closely related bacteria of Gram-positive bacteria, Streptococcus mutans which is a bad bacterium that causes tooth decay and selects “only”, “single action” bacteria, substances, and bacteriocins are still found in the world. not.

It is impossible to get rid of only “bad bacteria” among all bacteria.

On the contrary, it is impossible to nourish “good bacteria”, “beautiful skin bacteria” and “only” to give them an advantage and increase “good bacteria”, “beautiful skin bacteria” and “only”.

Health and beauty/moisturizing effect in the oral cavity by growing and increasing “beneficial bacteria” and “beautiful skin bacteria” by paying attention to the existence and effects of “good bacteria” and “beautiful skin bacteria” in the oral cavity and skin I understand that you want to ask for, but unfortunately, you also increase “bad bacteria.”

As an example, if nutrients such as “oligosaccharides” that lactic acid bacteria prefer are given to “good bacteria” and “beautiful skin bacteria”, they will also be nutritious to “bad bacteria”, and at the same time as “good bacteria” and “beautiful skin bacteria” Will increase in the same way.

It is actually difficult to fix new bacteria such as “beneficial bacteria” and “skin-cleansing bacteria” to the human body, and it is not possible to nourish only the “beneficial bacteria” and “skin-cleansing bacteria” that are indigenous to each person. In the end, it means that the bacterial flora composed of “beneficial bacteria”, “beautiful skin bacteria”, “bad bacteria”, etc. will not change, and if you give nutrition, “bad bacteria”, which has a relatively strong power, will also become healthy, We may also expand our power.

In other words, it is impossible for the human body to “control only by selecting bad bacteria” and “increasing only good bacteria and beautiful skin bacteria” with the latest science and technology.

The human beings on earth are the same as we humans, but they support each other, complement each other, act and live together, and coexist in balance.

All of them do not exist insignificantly, and in the situation where their respective functions and interactions are not elucidated in science, it is impossible to distinguish everything from good and evil, and it is not possible to distinguish superiority and inferiority. is.

Even in the same human being, it has been reported that the composition of salivary bacteria varies depending on ethnicity, family, and each person depending on heredity and living environment. For each person, more than several hundred types of oral bacteria are good or bad. It cannot be said that it can be separated into fungi.

The bacteria and flora that we have in the oral cavity, skin, and intestines are not those that we have from birth, but the bacteria and flora that are inherited from parents such as cheek rubbing and saliva contact from an early childhood. It can be said that genetically optimal bacteria protect the body.

Like human beings, living things have good and bad sides for a specific person or society, but they are born and exist because they are necessary, and live and coexist with their individual characteristics.

Invisible to our eyes, it is the same organism, bacteria.

The oral cavity suffers from trouble because it is one of the Gram-positive bacteria, Cariestobacilli, that lives in the mouth as an indigenous bacterium and does not usually cause any problems (it does something useful). Produce acid from food waste and sugar as food to cause dental caries, periodontal disease bacteria that are one of the Gram-negative bacteria “excessively increase” between the teeth to form biofilms, and cause inflammation of the gums. The cause is that it becomes dirty and the total number of bacteria “excessively increases” and flows into the lungs.

Oral care with oral pieces helps to keep the oral health and peace of mind by approaching trouble-causing bacteria that are present as oral bacteria and cause “too many” problems.

For details, please see the collection of papers.

As the price of various products increased, the “reasonability” (image of acceptable price) felt by consumers of “toothpaste” was very low.

The reason is that the prices of calcium carbonate and baking soda in the ingredients are low, consumers know it, and the past “toothpaste” producers were very honest, serious about consumers.

In addition, due to deflation that lasted for many years (economic uncertainties associated with falling prices), many producers around the world have taken on new research and research compared to producers in other growth fields such as ICT and biotechnology. It is also possible that this is the result of choosing a strategy of low profit and high sales, which is mass production/mass sale of low value-added and low-priced products, rather than creation of high value-added products through technological innovation.

Many consumers in this economy, especially before the epidemic of the new coronavirus, are more likely to buy a consumer good without technological innovation than investing in family health and reducing total spending due to high added value. Purchasing is a priority because we want to reduce spending, and there was a situation in which low-priced consumer goods were favored.

However, recently, even for manufacturing companies, the number of customers and the number of sales points will not increase as the population and product usage amount/scene will increase, and market share of counterfeit products of other companies will be put on the market due to low cost for research and development, and share due to low price advantage In the erosion battle of increasing sales by depriving customers, the physical strength such as sales maintenance and employee salaries is reaching the limit, and the price range is increased by repricing products to higher prices and strengthening branding to improve the customer unit price. Is progressing.

ORALPEACE is an oral hygiene agent that aims to create new markets by creating unprecedented high added value through technological innovation invented by research at university institutions in order to meet new world needs. Will be.

ORALPEACE is one of the world’s largest oral care products markets, born in 2013 in Japan, which has the highest elderly ratio in the world. “The elderly, pregnant women, vulnerable people such as infants, those who care about the health and natural environment of their families. It is a super niche market product specialized for.

The market is small in the world, and many companies are left behind niche markets where they do not start investing in new R&D or entering the market.

This is because the lifetime value (LTV/customer lifetime value) is low, the economic efficiency is low, and the business feasibility is low, that is, the company does not profit.

In Japan alone, more than 1.3 million people, mainly elderly people, die each year due to old age or illness.

This means that the number of domestic users who need oral peace will continue to decline by more than 1.3 million people each year.

However, even though the market is small, there are people left behind in the world who are in trouble, such as the elderly, fighters, infants and people who are not good at chemical ingredients.

Oral care products are the oral care products for people left behind in the world.

It is a product that was newly researched and developed by a research institute of a national university, giving priority to the health and happiness of many families without giving priority to corporate profits and economic efficiency.

In other words, in terms of business, the main business of Oral Peace itself is not an economic/profit activity, but a social contribution activity/CSR (Corporate Social Responsibility) that is somehow economically balanced. It is a CSV (Creating Shared Value) model that is completely independent and rare in the world.

As a business, it is a social business in which it is difficult to pursue economic efficiency, but due to a serious research background, there is no other oral hygiene agent in the world that specializes in oral care for people including the elderly and the weak. Has no social benefit.

It is a new value for human beings: “While you can instantly approach the bacteria that cause problems in the oral cavity at ultra-low concentration, you can also moisturize and feel safe when swallowed, with high biodegradability and low environmental impact.”

Although it is small now, we have not been able to convey this new invention and value to people all over the world, but 100 years from now, not only for the elderly and the vulnerable, but definitely for the people of the world to shift their orientation in this direction. You can imagine it going.

In this way, the application of lactic acid bacterium antibacterial peptide (bacteriocin) to the field of hygiene has created new value for humankind. Serious researchers from research institutes such as Kyushu University in Japan research daily with a bet on their lives. It is a result of hard work.

And it will be the world’s technological innovation created by a Japanese research institute that created a new market and provided new benefits to humanity that never existed before.

I think the technological innovation created by this Japanese research institute feels small now, but it can be said that it is a technology in maid-in-Japan that is getting more attention in the world over time.

Therefore, it takes a lot of time and money for basic research and development to provide essential value.

In fact, unlike oral toothpaste, which is made by mixing cheap stone powder and synthetic surfactant in a tube and filling it in a tube, basic research produces original ingredients, blends expensive organic ingredients, and agitates/fills. Production control, packaging and box materials, patent control, pharmaceutical control, support for facilities for people with disabilities, creative, public relations, distribution to high-quality department stores, etc. Oral care products that seem to be considered do not have to be cheap, and it takes the same effort and cost as lotions and beauty liquids of several thousand yen to 10,000 yen or more made in the same process at the same factory. ..

(Thus, because the production price of the product itself is high, low-price competition, advertising drops, retail store profits of 60% or more of the over-the-counter sales price, and if all items are not sold back to the manufacturer Is a difficult product.)

In addition, the product market and production volume are limited, and it is very laborious and costly to produce each piece because it is manufactured by the Japanese people by hand.

And in many cosmetics and consumer goods, materials such as boxes and containers have higher distribution costs such as profits from retail stores, and the reality is that the research and technology behind them are not evaluated economically.

However, since the recent coronavirus damage, the importance of oral hygiene as preventive care and health maintenance, mucosal absorption of chemical substances contained in oral care products, and the impact on the microbial ecosystem when discharged into the environment, Many people have noticed that consumer awareness of oral care products is changing rapidly.

ORALPEACE For Pet gel costs 1,200 yen for about 2 months.

That means 600 yen per month and 25 yen per day.

6000 yen

For many,

Bank transfer fees and overtime fees, monthly charges for mobile phones, WIFI and internet services, small lunches and meals, wine and alcohol, electricity and gas, daily meals, snacks, high speeds and gasoline, Parking fee, train fee, coffee and cigarette fee, electricity fee, WIFI fee, mobile phone fee, etc.


Those who are concerned about aspiration/drinking, who are not good at gargling and vomiting, who are in need of nursing care or who are fighting illness,
Those who are careful about the health of their families and who demand safety in what they eat and drink daily, those who keep in mind their daily health and preventive care, infants and pregnant women, and beautiful nature in the event of precious water disasters. Those who want to use oral care products in


Other costs for maintaining health, prices of ingredients with low organic vegetables and additives, prices of healthy foods and supplements, costs for sports and gyms, medical expenses when you get sick, medication costs, cosmetics and shampoo fees, I am worried about various things everyday…

Compared to

Through joint research with Kyushu University Graduate School of Agriculture, Kagoshima University Graduate School of Medical and Dental Science, National Center for Longevity Medical Research, Department of Oral Diseases, etc.

Researched and developed over 10 years,

Made in Japan, which is made by hand from materials and raw materials by people who live in Japan and have a family,

You can enjoy the unprecedented value of “being instantly approaching the bacteria causing the trouble in the oral cavity, it can also moisturize and is safe to swallow, has high biodegradability and has a low environmental load”.

Entering the designed boxes and tubes, they are lined up in hospitals, dental clinics, and department stores nationwide, and purchasing makes a social contribution.

Above all, to use for the health and happiness of the important family, and to invest in your own health so as not to disturb your family until the last day,

1,200 yen (600 yen a month),

Don’t you think it’s reasonable? (Lol)

ORALPEACE is in pursuit of affordable prices for those who feel value in family health and happy days.

For other questions, please see the page below.

“Frequently Asked Questions”

If you have any questions that are not included in the “Frequently Asked Questions”, please feel free to contact us using the contact form.

We also welcome messages about projects, research and products.

We would appreciate it if you could feel free to contact us using the contact form.

We look forward to your continued support of the ORALPEACE Project.


Search for #oralpeace, #oralpeace tags on Instagram to see oralpieces around the world.

We would be happy if everyone could improve their life with oral peace by adding the tags #oralpeace and #oralpeace and be connected to PEACE all over the world.

Best regard!!