ORALPEACE for Pet does not contain potassium thiocyanate for the following reasons.

The “potassium thiocyanate” you are asking about seems to be a chemical substance that is useful as a “raw material for plating,” “a raw material for the production of synthetic resins,” “agrochemicals,” “insecticides,” etc.

The purpose of its inclusion in oral care products seems to be to combat oral bacteria, but since it is a chemical that also affects the human body, we cannot confirm that it has been approved for inclusion in human food. I think there may be issues with edible consumption and accidental ingestion.

According to literature on the Internet, the enzyme causes a chemical reaction in the presence of thiocyanate, generates ions, and exhibits antibacterial activity. However, the “thiocyanic acid and its salts” used have problems with their effects on humans and aquatic organisms in the environment.

(Source: Advanced Utilization of Milk P375 Reference)

There is a method that uses chemical reactions of enzymes to sterilize and preserve milk. The antibacterial effect is due to the lactoperoxidase activity of the enzyme contained in milk. The enzyme decomposes hydrogen peroxide in milk into water and active oxygen, and the active oxygen generated here is converted into thiocyanate ion (SCN), which is present in small amounts in milk. -) is said to be oxidized into hypothiocyanate ion (OSCN-) through a chemical reaction. This hypothiocyanate ion is said to exhibit antibacterial activity against some Gram-negative bacteria such as Escherichia coli by inactivating the SH enzyme within the bacterial cells. (However, it has a narrow antibacterial range and does not show antibacterial activity against other Gram-negative bacteria and Gram-positive bacteria such as caries bacteria.)

For the antibacterial activity of lactoperoxidase to work efficiently, approximately 12 ppm of thiocyanate ions and approximately 8 ppm of hydrogen peroxide are required for the chemical reaction, but only 1 to 10 ppm of thiocyanate ions are present in milk. First, it is necessary to add thiocyanate ions and hydrogen peroxide.

However, Japan’s Ministry of Health, Labor and Welfare does not by law permit the addition or residual presence of thiocyanic acid or hydrogen peroxide in food or milk, even in trace amounts of ppm (1 part per million, 1 ppm = 0.0001%). Therefore, in Japan, the antibacterial effect of lactoperoxidase, which is the addition of potassium thiocyanate, cannot be used to sterilize and preserve milk, or to prevent E. coli contamination. (Hydrogen peroxide is carcinogenic, but easily decomposed, and if it does not ultimately remain in food, the law has been revised to permit its use in sterilization, bleaching, etc.)

https://otemae.repo.nii.ac.jp/record/1979/files/2000_jc_h359-392_yagi.pdf

In addition, the International Dairy Federation states that lactoperoxidase/thiocyanate/hydrogen peroxidase (lactoperoxidase system) is a chemical means of preserving raw milk when refrigeration conditions cannot be secured, such as in developing countries in tropical regions. Milk quality can be temporarily controlled during milk storage and transportation to processing plants. In 1991, the Codex Alimentarius Alimentarius Alimentarius, an intergovernmental organization established by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO), decided to In countries where refrigeration is not possible, the use of peroxidase systems is permitted, but any trade in milk treated with lactoperoxidase systems is subject to mutual agreements between the parties without prejudice to third countries. It is recommended that this should be done based on the following. However, decomposition products of chemical activators such as cyanic acid may be a concern. Continuous consumption of high or even low concentrations can have an adverse effect on the health of consumers. The conclusion is that developing countries, especially small-scale village dairy producers in regions with temperate or tropical climates without refrigeration, should consider the use of chemicals that stimulate the effects of lactoperoxidase systems. There may be no other option than using an activator. This method is a low-cost option that provides a source of income for farmers and maintains the quality of nutritious food. However, in order to maintain the positive image of dairy products among consumers and to increase the consumption of milk and dairy products in all parts of the world, this option should be used only when no other options are available. There is. (Source: International Dairy Federation Lactoperoxidase IDF Fact Sheet January 2013)

https://www.j-milk.jp/jidf/wp-content/uploads/2017/02/j-The-Lactoperoxidase.pdf

*While cyanide is generally bactericidal, it is also highly toxic. Cyanide contains cyanide ions (CN^-), which affect the respiratory chain of cells and inhibit oxygen utilization, resulting in cell death. Therefore, when used in proper concentrations, cyanide can kill bacteria and other microorganisms. However, it is also harmful to humans and animals, so care must be taken. (Source: ChatGTP)

Furthermore, we were unable to confirm any clinical efficacy data or academic papers on potassium thiocyanate against oral bacteria that cause plaque, tartar, and periodontal problems in humans and animals.

“Potassium thiocyanate” appears to be a chemical substance that is not approved as a food in Japan.

List of food additives in Japan (Source: Japan Food Additives Association)

Existing additives (revised on February 26, 2020) Designated additives (revised on March 1, 2020)

https://www.jafaa.or.jp/tenkabutsu01/tenkaichiran

Japan’s Ministry of Health, Labor and Welfare has classified potassium thiocyanate as a “dangerous substance” that must not be put into the mouth or taken continuously.

“Potassium thiocyanate”

Source: Ministry of Health, Labor and Welfare

https://anzeninfo.mhlw.go.jp/anzen/gmsds/333-20-0.html

[Summary of hazards]

Health hazards Acute toxicity (oral) Category 4

Specific target organ/systemic toxicity (repeated exposure) Category 1 (thyroid)

Hazardous to the environment Acute hazard to the aquatic environment Category 3

[Label element]

Pictogram or Symbol Exclamation Mark Health Hazard

Signal word: danger

Hazard statement: Harmful if swallowed

Thyroid damage due to long-term or repeated exposure

Harmful to aquatic life

【Safety measure】

Wash hands thoroughly after handling.

Do not eat, drink or smoke when using this product.

Do not breathe dust, fumes, vapors or spray.

Avoid release to the environment.

[First aid measures]

If swallowed: Call a doctor if you feel unwell.

Rinse mouth.

If you feel unwell, seek medical advice and treatment.

[Chemical name or common name]

potassium thiocyanate

Other names Potassium rhodanide, Potassium sulfocyanide

[Molecular formula (molecular weight)]

KSCN (97.18)

[CAS number]

333-20-0

[Official Gazette Publication Number (Chemical Substances Control Law/Safety and Safety Law)]

(1)-152

[Expected acute symptoms and delayed symptoms]

Ingestion: confusion, convulsions, nausea, vomiting, weakness

[Specific hazards]

It is non-combustible and will not burn itself but may decompose when heated producing corrosive and/or toxic fumes. In the event of a fire, irritating, corrosive and toxic gases may be generated.

[Environmental precautions]

Should not be released into the environment.

[Possibility of hazardous reactions]

The substance decomposes producing highly toxic fumes (sulfur compounds, nitrogen oxides, cyanides). Reacts violently with strong oxidants. Strong cooling effect when in contact with water.

[Hazardous decomposition products]

Very toxic fumes (sulfur compounds, nitrogen oxides, cyanides)

[Acute toxicity]

Oral rat LD50 value: 854 mg/kg (RTECS (2007): Original document Journal of the American Pharmaceutical Association, Scientific Edition. Volume 29,152 (1940)). “See also other thiocyanates for health hazards” (GHS classification: Category 4)

[Specific target organ/systemic toxicity (repeated exposure)]

Although there is no data on this substance, thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))

[Environmental impact information]

・Ecotoxicity

Hazardous to the aquatic environment (acute hazard) 96-hour LC50 for fish (rainbow trout) = 52.5 mg/L (ECETOC TR91, 2003). (GHS classification: Category 3)

– Hazardous to the aquatic environment (long-term hazard) Acute toxicity category 3, non-rapidly degradable (BIOWIN), 124-day NOEC (reproduction) for fish (rainbow trout) = 1.1 mg/L. (GHS classification: Not classified)

[Disposal precautions]

Residual waste Before disposal, carry out treatments such as detoxification, stabilization, and neutralization to the extent possible to reduce the level of hazards.

When disposing of the product, follow relevant laws and regulations and local government standards.

If an industrial waste disposal company licensed by the prefectural governor or a local government is in charge of the disposal, the disposal is outsourced to them. 　

[Contaminated containers and packaging]

Clean and recycle containers or dispose of them appropriately in accordance with relevant laws and local government standards. When disposing of an empty container, completely remove the contents.

[Transportation precautions]

Do not transport with food or feed.

A yellow card must be maintained during transportation.

“Potassium thiocyanate” is present in Japan’s natural environment, even if it is invisible or odorless and is present in very small amounts in ppm units (1/1 million, 1ppm = 0.0001%), it is prohibited to be released. (Ministry of Health, Labor and Welfare) and Japanese law stipulates that it must not be detected (quantification limit 0.1 mg/L, Ministry of the Environment).

Ministry of the Environment Basis for setting environmental standard items, etc.

Total cyanide (thiocyanate)

https://www.env.go.jp/council/09water/y095-05/mat05.pdf

After the war, from the 1930s to the 1930s, in the industrial area of the downtown area where there were many plating factories, there were pollution problems such as cyanide poisoning by craftsmen and dumping into rivers, lakes, and the sea, which wiped out fish, shellfish, and algae, making fishing grounds unusable. In the past, administrative personnel at ward offices and other offices have worked on health education for workers, water purification and coordination of issues with artisanal fisheries, and industrial promotion and health coordination with local residents.

A notable example is that even a small amount of cyanide-containing wastewater from a plating factory can cause fish death.

Source: Industrial Wastewater and Fisheries Chemistry and Biology 1962

https://www.jstage.jst.go.jp/article/kagakutoseibutsu1962/1/1/1_1_24/_pdf/-char/ja

In recent years, the Ministry of the Environment has been conducting an environmental survey of “thiocyanate” in Japan’s environment, and concentrations exceeding standard values have been detected in various places, creating a problem.

Ministry of the Environment 2018 detailed environmental survey results “thiocyanic acid and its salts (CAS registration number: 463-56-9, etc.)” https://www.env.go.jp/chemi/kurohon/2019/shosai/2_0.pdf (P120)

[2018 survey medium: water quality]

Reason for request:

Copper thiocyanate is designated as a Priority Assessment Chemical Substance under the Chemical Substances Control Law, and it is necessary to consider designating it as a Class 2 Specified Chemical Substance, but as there is no research record in recent years, priority should be given to investigating the actual status of environmental residue. This was because it was necessary to conduct research and understand the actual situation in the environment. Note that copper thiocyanate was not used in the analysis method applied in this study.

Since thiocyanate ions can only be measured, in this study, we conducted a survey to measure the total amount of thiocyanate and its salts. 


Survey details and results:
<Water quality>
Regarding water quality, 2018 was the first time for this survey, and 24 points were investigated, and the lower limit of detection was 1.1 ng/L, and it was detected at all 24 points, and the detected concentration was 2.5 to 120 ng/L. It was in the range of L.

[Reference: Regarding thiocyanic acid and its salts]・Application:
The main uses of sodium thiocyanate are as a solvent for acrylic fibers, dyes, herbicides, and pharmaceuticals. 

The main uses of potassium thiocyanate are synthetic resins, insecticides and fungicides, dye synthesis, photographic aids, reagents, and plating. 

The main uses of copper thiocyanate are ship bottom paints, antifungal agents, insecticides, copper plating, lubricating oil additives, photosensitizers, color formers for recording paper, and toothpaste. 

The main use of mercuric thiocyanate is as an analytical reagent. 

The main uses of ammonium thiocyanate are synthetic resins, hydrogen peroxide stabilizers, dyeing aids, photography, fertilizers, and herbicides. 

・Production volume/Import volume:
FY2017: Manufacture/import less than 1,000t (value published as a result of general chemical substance notification under the Chemical Substances Control Law)
・Distribution prediction by medium:
Thiocyanic acid: water 39.5%, sediment 0.08%, air 21.2%, soil 39.2%
Copper thiocyanate (I): water 33.7%, sediment 0.0737%, air 2.65%, soil 63.6%
・Acute toxicity, etc.:
Sodium thiocyanate: LD50 (dose that causes 50% mortality) = 232 mg/kg rat (oral) iv) LD50 = 362 mg/kg mouse (oral) LDLo = 600 mg/kg guinea pig (oral) iv LDLo = 750 mg/kg rabbit (oral)
Ammonium thiocyanate: LD50=24.5mg/kg mouse (oral) iv) LD50=46mg/kg rat (oral) iv)
Mercury(II) thiocyanate: LD50=24.5mg/kg mouse (oral) LD50=46mg/kg rat (oral)
・Ecological impact:
Thiocyanate: 96h-LC50 (50% mortality concentration) = 0.09 mg/L: Grass shrimp (Palaemonetes pugio) 96h-LC50 = 0.15 mg/L: Fathead minnow (Pimephales promelas)
Copper thiocyanate: PNEC= 0.0000031mg/L (Reason: 96h-LC50 (Rainbow trout lethal) = 0.031mg/L, assessment coefficient 10,000)
・Regulations
[Chemical Substances Control Law] Law (revised on May 20, 2009) Article 2, Paragraph 5, Priority Assessment Chemical Substances (142 Copper(I) thiocyanate)

 

The details of “potassium thiocyanate” as a chemical substance are as follows.
　

What is “thio”:
Thio is a prefix that means sulfur. A chemical compound containing “sulfur”. A linked form used especially for special compounds in which an oxygen atom is replaced with a sulfur atom.
“Thiocyanate” is a similar chemical substance in which “oxygen” of “cyanate ion [OCN]-” is replaced with “sulfur” through a chemical reaction.

What is “cyan (CN)”:
1. A highly poisonous, colorless gas with a distinctive odor. When dissolved in water, it produces hydrogen cyanide (cyanic acid gas) and cyanic acid.
2 Blue. Blue is the primary color in paints, printing inks, etc. It has a greenish blue color. (Source: Weblio)
https://www.weblio.jp/content/%E3%82%B7%E3%82%A2%E3%83%B3

What is “cyanic acid (CNHO)”:
It is a compound represented by the molecular formula CNHO. Structural isomers include isocyanic acid (H-N=C=O) and thunderic acid (HO-N=C:). However, cyanic acid is tautomeric with isocyanic acid, and they continue to mutually convert and are in an equilibrium state. (Source: Wikipedia) https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8

What is “potassium (K)”:
Alkali metal, one of the typical elements. Potassium is an element with atomic number 19. Also called “potassium” or “potash”. The element symbol is K. It is an essential element for living things. It is a silver-white metal with a specific gravity of 0.86, which is lighter than water, the second lightest after lithium, and is a soft metal that can be easily cut with a knife. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%AB%E3%83%AA%E3%82%A6%E3%83%A0

What is “cyanide (potassium cyanide, etc., CN)”:
A name referring to a salt having cyanide ion (CN-) as an anion. Also called cyanide, cyanide, cyanide, and cyanide. Cyanide compounds, as “potassium cyanide” is famously known, are generally toxic to the human body, and even small amounts can cause death. In order to protect the developing fruits and seeds from being eaten by herbivores due to the struggle for survival, amygdalin, a poison contained in green plums, etc. (spreading seeds) is also a cyanide compound. As the fruit ripens, amygdalin is broken down into hydrogen cyanide (cyanic acid gas), benzaldehyde (an aromatic component common to almonds, apricot kernels, and loquats), and glucose by the enzyme emulsin contained in plants. disappears. The “cyanic acid” generated at this time also disappears through volatilization and decomposition. Processing also promotes decomposition. Processed products such as ripe fruit pulp and pickled plums are safe to eat if consumed in normal amounts. Amygdalin itself is non-toxic, but when ingested orally, it is broken down in the body by emulsin, a safe enzyme also found in plants, and β-glucosidase, a safe enzyme found in human intestinal bacteria, resulting in a chemical reaction. It is said to generate dangerous hydrogen cyanide (cyanic acid gas). It is safely broken down in very small amounts, but if a certain amount is ingested, it will cause toxic symptoms such as vomiting, facial flushing, diarrhea, and headaches, and if large amounts are ingested, it will cause confusion, coma, and even death, so be careful. is required. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E7%89%A9

What is “thiocyanic acid (HSCN)”:
Thiocyanic acid is a type of inorganic acid with the chemical formula HSCN. Also called “rhodanic acid”. It is an unstable colorless liquid and a relatively strong acid. It exists as a mixture with its tautomer, isothiocyanic acid (HN=C=S). In the synthetic production method of thiocyanate, lead(II) thiocyanate is liberated by reacting hydrogen sulfide. When ammonia and carbon disulfide react, an ammonium salt of thiocyanate is produced. Some N-esters of thiocyanate (isothiocyanates) are used as insecticides. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8

What is “sodium thiocyanate (thiocyanate/NaSCN)”:
It is a sodium salt of thiocyanate with the chemical formula NaSCN. At room temperature, it is a colorless, hygroscopic crystal or white powder that is soluble in water, ethanol, and acetone. It is toxic, with an LD50 of 764 mg/kg when administered orally to rats. When ingested, it affects the central nervous system, causing symptoms such as vomiting, diarrhea, weakness, confusion, and convulsions. Although it is nonflammable, it decomposes when heated, producing toxic gas (cyanic acid gas) containing sulfur oxides, nitrogen oxides, sodium oxide, and cyanide. Reacts violently with acids, strong bases and oxidizing agents. It is used as a reagent, color film developer, herbicide, and solvent in the production of acrylic fibers. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E5 %A1%A9

What is “potassium thiocyanate (KSCN)”:
Potassium thiocyanate is a deliquescent crystalline solid. It dissolves well in water, and the resulting aqueous solution becomes very cold due to heat absorption. Also soluble in ethanol and acetone. It is a chemical substance obtained by melting potassium cyanide and elemental sulfur, or by reacting ammonium thiocyanate and potassium hydroxide. Japan’s Ministry of Health, Labor and Welfare has designated it as a hazardous material. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E3 %82%AB%E3%83%AA%E3%82%A6%E3%83%A0

“Sodium thiosulfate (Na2S2O3)”
It is a sodium thiosulfate salt with the chemical formula Na2S2O3. Like sodium sulfite and sodium hyposulfite, it has bleaching and antioxidant effects, so it is used as a food additive in some countries. However, this is not allowed in Japan. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E7%A1%AB%E9%85%B8%E3%83%8A%E3%83%88%E3 %83%AA%E3%82%A6%E3%83%A0

“Potassium cyanide (KCN)”
Potassium cyanide, also known as potash cyanide or potash cyanide, is synonymous with poison, but is an industrially important inorganic compound. It is designated as a poisonous substance as “cyanide” under the Poisonous and Deleterious Substances Designation Ordinance. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E3%82%AB%E3%83%AA%E3 %82%A6%E3%83%A0

“Hydrogen cyanide (cyanic acid gas/HCN)”
Poisonous gas. Hydrogen cyanide, also known as methanenitrile, formonitrile, and formic acid nitrile, is a highly toxic substance. Its aqueous solution is weakly acidic and is called hydrocyanic acid (cyanic acid gas). Cyanide is hydrolyzed by cyanide glycosides by enzymes such as β-glucosidase found in animal intestinal bacteria, producing sugars, aldehydes, and hydrogen cyanide (cyanic acid gas). (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E6%B0%B4%E7%B4%A0

Additionally, when released into the environment, there is a risk that hypochlorous acid and thiocyanate will undergo a chemical reaction, resulting in the production of cyanide (poisonous gas) that is not expected or intended by companies.

Due to the death of fish in Tokyo Bay, the chemical (sodium hypochlorite) used to remove nitrogen from factory wastewater remained in the treatment tank and reacted with thiocyanide in the wastewater, resulting in the production of cyanogen. ” was generated (“hypochlorous acid (NaClO) + thiocyanic acid (HSCN) → cyanide (CN)”) 2022 Chiba Prefecture

https://www.pref.chiba.lg.jp/suiho/press/2022/koitogawa-mizu.html
https://www.pref.chiba.lg.jp/suiho/press/2022/koitogawa-mizu35.html
　

Symptoms of chronic poisoning due to cyanide (CN):
Feeling of helplessness, headache, dizziness, nervousness

Irritability, hair loss, skin diseases, weight loss, loss of appetite, loss of energy
　

Safety evaluation of “cyanide (CN)” in oral intake (soft drink)
Ministry of Health, Labor and Welfare Food Safety Commission Special Investigation Committee on Chemical Substances and Contaminants August 2010
https://www.fsc.go.jp/iken-bosyu/pc3_kagaku_osen_cyan_220819.pdf
　
　

Reproductive and developmental toxicity and repeated dose toxicity of “potassium thiocyanate (KSCN)” (external research experiment): http://www.jpec.gr.jp/detail=normal&date=safetydata/ta/dati3.html

Toxicity evaluation of “potassium thiocyanate (KSCN)” in animals (1954-1997)
● Repeated dose toxicity
・As a result of oral administration of potassium thiocyanate to rats for 4 or 11 months, an increase in thyroid weight and a decrease in thyroxine levels were observed. (Philbrick et al, 1979) The same study showed spinal cord lesions including disruption of the myelin sheath.
・As a result of intraperitoneal administration of 50 to 850 mg/kg of potassium thiocyanate, brain damage was observed in 10% of rats. (Rose et al, 1954)
●Reproductive and developmental toxicity
– When potassium thiocyanate was orally administered to pregnant mothers, goiter was observed in the neonates. (Rudert & Oliver, 1976) RTETECS, 1997)
・When potassium thiocyanate was administered intravenously to mother mice and rats, transfer of thiocyanate to the fetus was confirmed. (Moedder, 1980)
– When 0.1-0.5% potassium thiocyanate was orally administered to female rats during pregnancy and 2 weeks after delivery, growth inhibition was observed in the newborns. (Pyska, 1977)
・High doses of 5-10 g/100 g affected the reproductive ability of female rats. (Olusi, 1979)
　

Thiocyanates that also exist in nature
Be careful not to eat too much of kale, which is said to be a super healthy ingredient. This is because it is said to have a serious effect on the thyroid gland. Kale contains a substance called “thiocyanate,” and if you consume too much of it, it may affect the function of iodine, a mineral that is a component of thyroid hormone, and may cause decreased thyroid function. It is said that there is. (Source: COSMOPOLITAN)
https://www.cosmopolitan.com/jp/beauty-fashion/health/tips/a861/7-all-natural-foods-that-can-totally-mess-you-up/#link1
　　
According to a report by the German Federal Institute for Risk Assessment, the cause of reduced iodine absorption in the thyroid is a substance called “thiocyanate” found in “cabbage” and “radishes.” Corn and millet contain cyanogenic glycosides, which are converted to thiocyanates in the body. (Source: Food Safety Information (Chemical Substances) No. 8/ 2020. 04. 15 National Institute of Health Sciences)
https://www.nihs.go.jp/dsi/food-info/foodinfonews/2020/foodinfo202008ca.pdf

Foods containing cyanide
Avoid eating loquat seed powder (Source: Ministry of Agriculture, Forestry and Fisheries, January 15, 2021) https://www.maff.go.jp/j/syouan/seisaku/foodpoisoning/naturaltoxin/loquat_kernels .html?utm_source=dlvr.it&utm_medium=twitter

“Inorganic cyanide compounds” Effects on human health (Summary) P52
Accumulation in the blood or other tissues after oral ingestion of inorganic cyanide compounds has not been confirmed, but the metabolite “thiocyanate ion” is known to have a cumulative effect, causing thyroid toxicity such as thyroid adenoma and cretinism. . The long-term toxic effects on the thyroid gland are presumed to be due to the metabolite “thiocyanate ion.” Cyanide binds to Fe3+ ions in cytochrome oxidase in tissue cells and to proteins such as hemoglobin in red blood cells. Inhibition of cytochrome oxidase prevents the oxidation of reduced cytochrome c, stopping cellular enzyme utilization and leading to cell death. Hydrogen cyanide and cyanide compounds are mainly metabolized by rhodanese present in the liver into “thiocyanate ions” and excreted in the urine. Chronic effects of inorganic cyanide include headaches, dizziness, nervous anxiety, weakness, decreased vision, slurred speech, gastrointestinal disturbances, and enlarged thyroid gland. The effects of long-term exposure on the thyroid gland are probably due to inhibition of iodine uptake into the thyroid gland by the metabolite thiocyanate ion. (Source: Initial Risk Assessment Report for Chemical Substances “Inorganic Cyanide Compounds” National Institute of Technology and Evaluation, October 2008)
https://www.nite.go.jp/chem/chrip/chrip_search/dt/pdf/CI_02_001/risk/pdf_hyoukasyo/108riskdoc.pdf

Danger of cyanide
Chronic systemic cyanide poisoning can occur but is rarely recognized because of the gradual onset of disability and symptoms consistent with other diagnoses. The reported symptoms are similar to those seen when thiocyanate is used as a drug, thus explaining the chronic disease caused by cyanide due to excess thiocyanate in the extracellular fluid. It has been suggested that this is possible. Symptoms of chronic disease have been reported in electroplaters and silver polishers after several years of exposure. The most notable were weakness in the arms and legs, headaches, and thyroid disease. These findings have also been reported as “complications of thiocyanate therapy.” (Source: International Labor Organization Encyclopedia of Occupational Safety and Health)
https://www.iloencyclopaedia.org/ja/part-xviii-10978/guide-to-chemicals/item/1038-cyano-compounds

　
Evaluation, classification, and regulation of “potassium thiocyanate” by international health organizations
World Health Organization International Chemical Safety Program International Chemical Concise Assessment Document IPCS UNEP/ILO/WHO
Concise International Chemical Assessment Document No61 Hydrogen Cyanide and Cyanides: Human Health Aspects (2004) World

Hydrogen cyanide and cyanide: effects on human health
https://www.nihs.go.jp/hse/cicad/full/no61/full61.pdf
Thiocyanic acid classification display
https://www.ilo.org/dyn/icsc/showcard.display?p_lang=ja&p_card_id=1671&p_version=2
　

Regulatory trends for “potassium thiocyanate (KSCN)” in Europe

In 2013, the European Food Safety Authority (EFSA) disapproved “potassium thiocyanate.”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
https://www.fsc.go.jp/fsciis/foodSafetyMaterial/show/syu03900400149
On 19 June 2013, the European Food Safety Authority (EFSA) published conclusions on the risk assessment of potassium thiocyanate (approved 19 October 2012, page 46). Safety to humans and animals, safety from environmental emissions could not be guaranteed, data gaps regarding physical and chemical properties and concerns in the mammalian toxicology section were identified. Due to the lack of toxicity and exposure data regarding the LP-system (Lactoperoxidase System) mixture, a risk assessment for users, workers, and bystanders cannot be conclusively completed. If the definition of this reaction mixture residue is unknown and toxicity reference values are not available, a consumer risk assessment cannot be carried out. Also insufficient to perform an environmental exposure assessment. Although we believe that the active ingredient potassium thiocyanate has an effective bactericidal effect, the qualitative effects of the compound (cyanide) and its decomposition/conversion products formed from the reaction mixture with naturally occurring enzymes and hydrogen peroxide are uncertain. and quantitative environmental exposure assessments are lacking. Additionally, in the ecotoxicology section, data deficiencies were identified to submit screening studies for non-target terrestrial plants for representative field use.

In 2014, the European Union (EU) disapproved “potassium thiocyanate”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
https://www.fsc.go.jp/fsciis/foodSafetyMaterial/show/syu03970210305
On February 6, 2014, the European Union (EU) published in the Official Gazette Commission Implementing Regulation (EU) No 108/2014 disapproving potassium thiocyanate. The applicant withdrew the application after the Food Safety Authority (EFSA) identified several data gaps on potassium thiocyanate that required additional data, including safety.

　
Potassium thiocyanate (KSCN) is being regulated in Europe, and Japan’s Ministry of the Environment is also preparing to legalize it as an “endocrine organ disruptor.”

Ministry of the Environment “Report related to endocrine disrupting effects of thiocyanic acid and its salts 2021”
Materials from the 1st Study Group on Endocrine Disrupting Effects of Chemical Substances in FY2021
Thiocyanic acid and its salts have been shown to have effects on the hypothalamus-pituitary-thyroid axis in animal test reports, and androgenic or anti-androgenic effects, effects on thyroid hormone synthesis ability, and in vitro test reports. It shows an effect on thyroid hormone synthesis ability by activating peroxidase, shows an effect on the hypothalamus-pituitary-thyroid axis in human administration studies, and shows an effect on the hypothalamus-pituitary-thyroid axis in an epidemiological survey. As it has been suggested that it exhibits anti-parathyroid hormone-like effects, it can be used as a test substance for endocrine disrupting effects (P25).

* “Endocrine disruptors” are chemical substances that affect the “endocrine system” and have a negative impact on human health and the environment.
*The endocrine organs of the human body include the pituitary gland, thyroid, adrenal glands, ovaries, testes (front), pineal gland, brain, liver, heart, pancreas, “Kidney” etc. These “endocrine organs” secrete appropriate amounts of hormones at appropriate times that correspond to the development and development of the human body.

Ministry of the Environment Reliability evaluation and test implementation status regarding endocrine disrupting effects of chemical substances
“Thiocyanate and its salts”
2021 Reliability evaluation completed (first stage biological testing currently being conducted or scheduled to be conducted)
https://www.env.go.jp/chemi/end/substances.html

Reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021, P16~) https://www.env.go.jp/chemi/%E8%B3%87%E6 %96%991-2.pdf

Excerpt: Literature reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021) https://www.env.go.jp/content/000081308.pdf
　　
Chemical reaction between enzyme and thiocyanate (HSCN)

The milk sterilization method used involves a chemical reaction (peroxidase activity) between a harmless enzyme and a small amount of thiocyanic acid (HSCN), which deactivates the SH enzyme within the cells of some Gram-negative bacteria such as Escherichia coli, resulting in an antibacterial effect. An active ion (OSCN-) is generated, which can sterilize some Gram-negative bacteria such as Escherichia coli in invisible amounts of ppm (1/1,000,000, 1 ppm = 0.0001%) (thiocyanate-added milk India P18 ) produce an effect.

However, in the 2020s, the effects on the human body (endocrine organ disruption effects such as inhibiting the intake of iodine from the thyroid and lowering the production capacity of hormones such as thyroxine at very small amounts of ppm) have become clear. In 2015, Japan’s Ministry of the Environment identified thiocyanic acid (HSCN) and its salts as potential test substances for endocrine disrupting effects (P25), and the first biological tests are currently underway or scheduled.

Regarding environmental impacts and regulations, Japan’s Ministry of Health, Labor and Welfare states that thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). ). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))
“Potassium thiocyanate (KSCN)” must not be released into the beautiful natural environment of Japan in ppm units (1 part per million, 1ppm = 0.0001%), and the Ministry of the Environment has announced that it must not be released into Japan’s beautiful natural environment in soil, rivers, lakes, seawater, etc. The law stipulates that total cyanide (CN) must not be detected (detection limit 1.1 (ng/L)).

It contains enzymes that are harmless as a single substance, which are contained in microscopic amounts of ppm (ppm = 0.0001%) in milk and saliva, and a less toxic cyanide substance called thiocyanate, which is also contained in milk and saliva. By administering an increased amount of an enzyme that is harmless to the chemical reaction partner alone, a chemical reaction (The LP-system, lactoperoxidase or glucose oxidase reaction) is caused in the oral cavity, producing cyanide, which causes Escherichia coli among Gram-negative bacteria. Although cyanide has an antibacterial action mechanism that can kill some oral bacteria (it is not effective against Gram-positive bacteria such as Streptococcus mutans, which causes dental caries), and other Gram-negative bacteria, cyanide can also be used in humans and animals. It has the side effect of disrupting endocrine organs, such as inhibiting iodine intake and affecting thyroid hormone production and reproductive function.It also has clinical effects on the concentration of cyanide generated in the body, effects on the thyroid and kidneys in the human body, and environmental emissions. In recent years, health organizations around the world have become concerned about the health risks of the antibacterial mechanism of action (the LP-system, lactoperoxidase and glucose oxidase reactions), as safety data regarding the effects of antimicrobials are not available, and regulations are progressing.

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Based on the above, “potassium thiocyanate (KSCN)” is a very useful chemical substance for “manufacturing raw materials for synthetic resins,” “raw materials for plating,” “agrochemicals,” “insecticides,” etc., but it is not suitable for oral ingestion or food formulation. Recently, it has become clear that it has an effect on endocrine organs such as the thyroid gland and reproductive function, including the risk of causing hypothyroidism in dogs and cats, the risk of affecting reproductive function, and the fact that it is excreted into the natural environment through urination. Impact on aquatic organisms and soil microbial ecosystems, marine products and vegetables, impact on nearby residents, farmers, and fishermen, impact on Japanese food, risk of impact on thyroid function, risk of declining birthrate among Japanese people It is inferred that issues related to health and environmental compliance, such as risks to compliance with laws and regulations stipulated by the Ministry of Health, Labor and Welfare and the Ministry of the Environment, have begun to be understood in the 2020s, when medical science and technology have advanced.

From the development of human science to the world’s first products using cutting-edge research technology, times and social needs change, the generations of scientists and researchers and the countries they live in change, and the population and needs change. New technological innovations are born in the country.
　
We respect the pioneering products and the scientists who developed them through chemical technology in the 20th century, and the research and products that have been helpful in the development of many human beings can be said to have shaped today’s humanity and the earth. You can call it an invention.
　
Then, in the 21st century, humans are evolving little by little, and with the development of medicine and science, new issues such as effectiveness, side effects, and environmental burden are becoming clearer.
　
We have also entered the age of the Internet, where consumers around the world can access a variety of new and correct information.

We have entered an era in which consumers choose products with safe and reliable ingredients for their loved ones, and demand that producers disclose all ingredients honestly and with traceability.

In recent years, chemicals with concerns about their safety, such as Forever Chemical, an endocrine disruptor that has become a problem for humanity as a whole, have the potential to take away health and happiness, and the risk of burdening medical costs has led to a change in the latest prescriptions. Responding to consumers’ health needs for improvement (I am sorry that it is difficult to fully promote the safety of products for those who use them as health products.Also, even in trace amounts, they may be released into the environment through urination, causing Ogawa I’m also concerned about the impact on killifish and red dragonflies, aquatic life and seafood from nearby rivers and the sea, vegetables and rice, children playing in rivers and the sea, fishing and clam-gathering, swimming and surfing, and my descendants living in Japan. companies are focusing on product development.

For the sake of the health of their families, consumers are also responsible for carefully examining safety and environmental toxicity, and if possible, developing new formulations, and making sure that all ingredients and purpose of the formulation are not concealed and are easy to understand for consumers. The developer’s face is clearly visible and trustworthy, and the medical basis and safety of the doctor of dentistry, who specializes in oral medicine for animals including humans, is involved in the research and development. Explore oral care products from oral care formulation manufacturers, etc.

We would like to take this opportunity to examine various compounded chemicals, their development background, year of prescription development, experimental data, and clinical trials, to clarify that there may be old products from before the green innovation era that do not meet 21st century medical standards, safety, and environmental protection standards. I think it would be a good idea to look into efficacy data, safety evaluation data, etc.

Endocrine disrupting chemicals, which have been considered dangerous in Europe, have only recently begun to attract attention in Japan, starting in the 2020s when Japan’s birthrate was declining.

As a trusted brand, we provide information on “all compounded ingredients and their purpose,” “action mechanism and risk of side effects,” “efficacy and safety data,” and “risk of environmental emissions,” etc., for the sake of our customers’ precious little families. In today’s world, consumers and patients need honest ingredients that are clearly visible and easy to understand when making a purchase, and that is clearly displayed on each page of online shopping sites. This is considered to be absolutely important for the trust of our customers, the health of our beloved dogs and cats, and the future survival of our business.

In addition, we also provide experimental data, clinical data (effect data in the oral cavity of actual animals), academic papers, explanations of the mechanism of action, explanations of side effects, and safety data regarding the actual effects of the product (whether it works or not). (Are there side effects or not?), etc., and the existence of evidence (scientific evidence). We protect the lives and health risks of our beloved dogs, cats, medical professionals, patients and their families, and people all over the world, the reliability of brands and companies, managers, directors, researchers, regulatory affairs personnel, and business personnel. Also, as an outside collaborator and a person with a family, I believe that this is an important and important thing that has a great social responsibility.

For consumers, it has a serious impact not only on their own health but also on the environment. Products that do not comply with laws and regulations on the market not only increase the burden on the surrounding environment, but also harm the lives of nearby residents. It can also have negative health effects. In that case, ultimately the consumer who uses the product is also responsible. Therefore, European consumer organizations are raising awareness that it is important for consumers to not only think about themselves, but also to adopt environmentally friendly consumption practices that do not endanger the lives and health of nearby residents and the entire nation.

Since the 2000s, when the world’s aging population and environmental destruction have become more serious, the green technology of the 21st century has achieved a balance between oral action and safety when swallowed, something that traditional chemical technology from the 1900s could not overcome. “Several thousand times more effective at an ultra-low concentration” ・“Protection of antibacterial activity and the natural environment of rivers and seas and biological ecosystems when discharged into the environment after fulfilling its role” ・“Medical costs and health care increasing with the declining birthrate and aging population” In the 1900s, in order to overcome the contradictory issue of “reducing the burden on people,” in Japan, where the population is aging, research was carried out for more than 30 years at Kyushu University’s Faculty of Agriculture, Faculty of Agriculture, a national research institution. This is an alternative green technology from the 2000s that realized a generational shift from the 2000s, and the world’s most cutting-edge microbial biotechnology research, as well as research on lactic acid bacteria antibacterial peptides that are made from food raw materials and are safe to swallow.

Discovered as a safe antibacterial substance in cheese by British dairy farmers in the 1920s, it has a wide range of excellent antibacterial properties at ultra-low concentrations in ppb units (1/1 billion, 1/1,000th of ppm, 1ppb = 0.001ppm) Nisin, a lactic acid bacteria antibacterial peptide (protein) that has been considered as safe as salt and spices around the world since the 1980s due to its safe activity and mechanism of action, has been confirmed to be the safest in the world, and is now available in Japan. Approximately 100 years later, in 2009, it was finally approved as a food by the Ministry of Health, Labor and Welfare. While the approval of nisin as a food product was not progressing in Japan, its social usefulness was recognized and research was progressing on applications such as oral care formulations that are safe for elderly people to swallow. “Neonisin-e®︎” is the result of research that has brought about an innovation that expands the spectrum to include Gram-negative bacteria and Candida bacteria, which is impossible with other methods.

The research results of neonisin, which paved the way for the world’s first practical application of lactic acid bacterium antibacterial peptides for medical and healthcare applications and obtained a patent in 2016, are a major social issue for caregivers in Japan, the world’s oldest nation. In addition to helping to reduce the burden on patients and improve patients’ QOL, they have also made small contributions to humanity, such as being used at disaster sites and on the International Space Station, spreading around the world, and winning various awards. It can be said to be a research result by a Japanese national institution that is extremely useful for elderly people in need of care, infants, people who have difficulty gargling or spitting due to illness or disability, pets, etc.

In order to meet the needs of advanced pet owners around the world, who are raising their pets as important family members like their own children as the birthrate declines and the population ages, we develop new products for the 21st century that contribute to the development of humanity. In order to ensure that pets who love research results can also enjoy them, we have Japanese human-grade safety and efficacy, innovative patentability that realizes low environmental impact, and are used by many people around the world at an honest and reasonable price. Aiming to create the best oral care products for pets, we are working with leading experts in lactic acid bacteria biotechnology research, such as Doctors of Engineering, Doctors of Agriculture, and Doctors of Dentistry, as well as doctors, veterinarians, pharmacists, breeders, groomers, and pet companies that are oral peace partners around the world. Oral Peace Four Pets was born after a lot of time and effort was put into the research team.

From the above issues, we believe that we should love our pets as part of our family, like our own children, and that what we put in our mouths should also be eaten by humans.

ORALPEACE for Pet, which has been researched with the aim of making it food-grade safe and protecting Japan’s beautiful natural environment and marine products from dangerous chemical contamination, is formulated with potassium thiocyanate (KSCN). This is a prescription that does not require.

 

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To be honest, until recently, we, the research members, were unaware of the progress in regulating potassium thiocyanate (KSCN) by the Japanese Ministry of the Environment. I only realized this after receiving many inquiries from customers. No one really knew. This is the latest issue that humanity as a whole was unaware of, and even expert scientists and strategists were unaware of. We sincerely apologize for the inconvenience, as our research team’s global research efforts were not successful.

Regarding oral care products for human use, in response to the European Union (EU) regulations in 2014, brand ownership changed and a new global distribution system was adopted, and from 2015 onwards, the formulations were completely changed and the corresponding effects were changed. It has been reborn as a new, simple oral moisturizing product brand that eliminates antibacterial action and antibacterial effects on oral bacteria, and has smoothly penetrated the market. Some antibacterial mechanisms of action based on cyanide (thiocyanate peroxidase activity) remain unchanged as we head into the 2020s.

We have been using this pioneering 20th century chemical technology for many years with our own pets. The side effects that have been pointed out in the 2020s are cutting-edge research results that have finally become clear due to advances in human science, and the benefits outweigh the risks that were previously unknown (poor temperate regions Humankind has enjoyed benefits that outweigh the side effects (just as children in developing countries in the region are able to survive hunger and survive by relying on milk as a source of nutrition). Regarding this, as I mentioned at the beginning, I will never forget my gratitude and respect to the pioneering scientists. 　

As a businessman, I have always struggled with the gap between the sales, marketing, and management departments, which are close to consumers, and the research and development department, and have experienced much pain in the friction between them. There have been times when front-line department members have overcome various risks that were not pointed out to them by the R&D department by worrying and trying to resolve them. The research side is often forced to comply with the reckless demands of the front department.

As a researcher myself, I believe that side effects require actual clinical experiments and animal experiments, and the results vary depending on the person, individual, and various conditions, so they are not something that can be obtained easily and in practice. We need to make sure that consumers, sales, marketing departments, and management departments understand that it is difficult to obtain clear answers clinically. In reality, it is difficult to understand the correlation on a case-by-case basis.
　
However, this time, we need to discuss the side effects and environmental burden of chemical substances, which have recently begun to be pointed out around the world, and work together to create choices that will create a better future. However, rather than blaming ourselves or someone else for the past, I think this action will lead to good things for future consumers, collaborators, and ourselves.

As researchers, we respect and collaborate in each other’s fields of expertise.This time, WHO, FAO, Codex Alimentarius Commission, the European Union (EU), the International Dairy Federation, the Ministry of Health, Labor and Welfare, and the Ministry of the Environment have collaborated to collaborate and respect each other’s fields of expertise. We need to involve many colleagues in conducting deeper research into chemical substances and mechanisms of action that suggest safety, proving their safety one by one, and working together to overcome new challenges one by one. We believe that this is the real thrill of research, and that it is a breakthrough and a valuable challenge that will produce true inventions and innovations, and dispel the concerns of people around the world.

When it comes to research that is beneficial to humanity as a whole, in order to overcome various difficulties, everyone should open their hearts honestly and transcend conflicts of interest between universities and companies, without criticism or self-protection. I think it would be wonderful for these Japanese researchers to work together and work together to develop a mechanism of action that has proven safety for the body and low environmental impact for the benefit of humanity all over the world.
　
To that end, our research team will work together to prove the safety and low environmental impact of this mechanism of action, and we believe that helping each other will be a breakthrough for us as researchers.
　
In this time when many people are hurt by disasters and wars, I believe that if we all start moving in a better direction, even little by little, and even from today to tomorrow, we can join hands and change the future for the better. think.
　　
Families will be healthy, nature will be beautiful, the latest research efforts will be appreciated, companies will be trusted, and business will continue to be beautiful. You can change it from today to tomorrow. Every day is a challenge with change, and continuing to improve on it is through research and corporate efforts, and the number of customers and colleagues who do research together will increase.
　　
World health organizations, the Japanese Ministry of Health, Labor and Welfare, and the Ministry of the Environment investigated facts that we did not know on our own and taught us about the risks. At first I was confused, but I took a deep breath, changed my mind, and thought about the best direction. Check with your own eyes the safety of the products you use. We will communicate this risk to the relevant departments and work together to refine new technology to meet the new era. We will work together to prove safety and evolve through friendly competition.

Through the power of science and research, we will use the power of science and research to help people around the world who are struggling to survive despite difficulties due to illness, disability, injury, aging, etc. In front of that ultimate love for humanity, competition between researchers and companies, scrambling for profits, criticism, and self-protection are petty and vain. Excellent minds come together to advance research that will remain in human history, transcending even conflicts of interest.

I believe that the gradual awareness of humanity as a whole and the step-by-step progress we make each day will change the future of this earth and humanity for the better.

Our research team has taken the courage to provide the latest information on chemical substances that health organizations around the world are warning about, and we hope that this information will contribute to the future choices of many people, and that even one person will be aware of it. I would be happy if you could obtain this.

In addition, many oral piece users and professionals contact our research team with their opinions on individual ingredients that are not included in oral pieces, but if possible, please check the details on the Internet etc. Thank you for your understanding.

The ingredients that were not selected simply did not match the concept we were aiming for, and we are not in a position to answer the pros and cons of past diverse research orientations. For the health of your precious family, we believe that it is important to carefully examine the ingredients based on your own value standards.

If you are a researcher and are having trouble with clinical data and proof of the safety of the ingredients and mechanism of action, as well as the low environmental impact, please feel free to contact our research team. If you are in the sales or marketing department and are having trouble reaching out to the research department, we would be happy to hear from you.

Change the future with inventions that contribute to the development of humanity. If we all work together, we can definitely find a way. Love creates a beautiful future.

ORALPEACE for your loved ones

Thank you for your continued support of the ORALPEACE Project.