(JP) 「ISETAN HOME HOTEL」にて「オーラルピース」がご紹介

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2020/08/05 (Wednesday)

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(JP) 「ポビドンヨード」と「ネオナイシン-e」の違いについて

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2020/07/22 (Wednesday)

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(JP) 新製品 「オーラルピース クリーン&ホワイト」日本・海外市場で同時発売へ

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2020/07/03 (Friday)

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Regarding the container of ORAL PEACE

ORALPEACE tubes are available in aluminum tube type and laminated tube type.

The plastic tube/container type (made of plastic, the contents that come out are returned, and the amount of the contents that can be seen through the sun can be seen through) is said to be “very cheap” and “open with one hand” There are merits.

However, it has a demerit that “it is not confidential and it easily rots, and it is necessary to use a lot of synthetic preservatives.” Not used with ORALPEACE.

The advantage of the aluminum tube type is that it “has high airtightness and light-shielding properties, and the contents that have been left out once do not return.”

On the other hand, it has the disadvantages of being “unusable” such as “cannot be opened with one hand”, “sometimes overloaded”, and “tube breaks”.

Since the debut of ORALPEACE in 2013, aluminum tubes have been used so far because they are highly sensitive and are best suited for oral pieces that do not use synthetic preservatives.

However, in daily use at medical and nursing care sites and at home, we received many comments regarding inconvenience (cannot be opened with one hand, aluminum is cut, contents cannot be cut out to the end, etc.). ..

On the other hand, the laminated tube type that we started to use in ORALPEACE in 2017 adopted the latest technology, “Aluminum Barrier Lamination (ABL)”, and is a material with layers of “PB, PET, aluminum, PB” stacked from the outside.

By sandwiching the aluminum layer in the laminate, the airtightness and light-shielding properties equivalent to those of aluminum tubes can be ensured, and compared to plastic tubes, the contents do not volatilize and the contents can be protected.

It is more convenient to meet the demand for ease of use at medical/nursing sites and homes while maintaining the functionality of aluminum tubes without deterioration even after being left for 6 months in a aging test (temperature 40 degrees, humidity 75% etc.) The characteristics of conventional aluminum tubes are fully ensured as it was developed with consideration given to its characteristics.

Although the cost of the container is high, it is a tube that combines the advantages of the functionality of the aluminum tube and the ease of use of the plastic tube.

ORALPEACE reflects the voices of many patients and consumers, and we would like to not only research and develop the ingredients but also utilize the latest technology for packaging.

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2020/06/24 (Wednesday)

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Articles on Oral Peace’s entry into the European market in “WWD Beauty”

【Articles on Oral Peace’s entry into the European market in “WWD Beauty”】

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ORAL PEACE posted in “WWD Beauty”

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2020/06/11 (Thursday)

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[An article was published in the Japan Economic Newspaper about the launch of “ORALPEACE” in the European market]

“ORALPEACE” finally obtained official export sales authorization in the European market and started market expansion
-Official export to EU and local sales approval obtained, launched in September 2020-

ORALPEACE project has received official export and local sales approval to the EU and will start official sales in the European market from September 2020.

The EU has various strict regulations regarding the import and local sale of cosmetics, including the regulation of ingredients and the establishment of local managers.

Furthermore, regarding the submission of product information to the EU Commission, the “Cosmetics Regulations 1223/2009 (Cosmetics Regulations)” are stipulated in detail.

Exporting oral care products from Japan has been a significant barrier to entry for small Japanese social venture companies.

This time, I met a great European entrepreneur and partner, and received a lot of support, and I realized the effort.

Similar to the markets in the United States, Mexico, China, Hong Kong, Taiwan, Malaysia, Singapore and Australia, where we are already developing business, we manufacture products at laboratories and factories in Japan and export from Yokohama Port.

In Europe, there is a strong consumer awareness of what can be put in the mouth, and there is also a great deal of interest in environmental impact. In addition, the emergence of the coronavirus has raised awareness of oral hygiene in people. Therefore, the local release of “ORAL PEACE” was highly anticipated.

Therefore, local sales in Europe of “ORAL PEACE” with the following characteristics, which was realized by biotechnology research of Japanese industry-academia-government collaboration that has never existed before, can be a great consumer benefit.

“Immediately sterilizing the causative bacteria in the oral cavity with ultra-low concentration, it is made of only food and organic ingredients and safe to swallow, and even if it is vomited into the environment, it is quickly biodegraded and does not burden the microbial ecosystem.”

We will continue to make efforts to deliver ORAL PEACE to the world as soon as possible for many people who are in trouble.

ORALPEACE Product Overview:

An oral hygiene product containing the world-leading patented formulation “Neonisin-e”, which has an excellent bactericidal effect against bacteria causing troubles in the oral cavity but is safe to swallow and has a low environmental load.

Made from 100% natural ingredients based on the world’s most advanced lactic acid bacterium biotechnology research with Kyushu University and the National Center for Longevity Medical Research, etc., for the needs of oral care that is safe even if absorbed by the body.

Another characteristic of this project is the Social Contribution (CSV) project, which is run by a project supporter consisting of 2 employees and more than 100 professionals in each industry, and creates jobs and income for people with disabilities throughout the country.

Won “Yokohama Business Grand Prix 2014 Grand Prize”, “Japan Venture Award 2015 Grand Prize”, “Nippon Foundation Social Innovator 2016”, “2018 Japan Agricultural Chemistry Technology Award”, etc., the world’s largest academic publication in 2019 It was also featured in Springer’s book Entrepreneurship in the Asia-Pacific: Case Studies.

Currently, it is offered to 10 countries as a global oral hygiene brand from Yokohama, Japan.

In February of this year, we also provided free of charge to 3,600 crew members of the “Diamond Princess”, a coronavirus outbreak cruise ship anchored at Yokohama Port.

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2020/03/25 (Wednesday)

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Let’s protect the family from the new coronavirus (COVID-19)

Now that no vaccine has been developed, people with illness, elderly people, infants, and other people who are at high risk of being infected should use various methods to prevent the disease and protect the lives of important family members.

Thoroughly take preventive measures such as thoroughly washing hands, gargle, boosting immunity, getting enough nutrition and sleep, staying away from crowded areas, do not touch your face with your hands, put on a mask, etc. We also need to bring together wisdom from all over the world to overcome this human crisis.

By the way, the other day, I also announced my opinion on toothpaste / oral care and viruses, and I would like to inform you about the possibility of “virus measures by oral care”.

A virus cannot live by itself, but propagates through bacteria. It then enters the respiratory tract and body through all entrances to the body, the mouth and nose.

However, it seems that little is known that oral health is associated with more severe viral infections.

Miscellaneous bacteria in the mouth excrete enzymes such as protease and neuraminidase as their metabolites. Proteases destroy proteins, and in a dirty state, viruses are more likely to enter through weak areas of the mucous membrane.

In a survey by the Dental Association, it was reported that thorough brushing of teeth and oral care and cleansing of the oral cavity drastically reduced the influenza incidence to 1/10.

Unlike the influenza virus, the new coronavirus (COVID-19) is unknown to humankind and a countermeasure has not been established, but it is considered to be a preventive measure.

It is important to keep your mouth clean by brushing your teeth and taking oral care. It has been suggested that oral care and tooth brushing with the lactic acid bacterium antibacterial peptide preparation “Neonisin-e” can reduce bacteria in the oral cavity and clean it.

In addition, when going out, I would like to try to prevent infections when I go out, where people gather, trains and buses, and when I meet people who are coughing after talking to many people. But there are also times when you can’t gargle right away.

In such cases, the usefulness of the “ORALPEACE Spray” product has been suggested. Lactobacillus antibacterial peptide formulation “Neonisin-e” is made from naturally derived food ingredients, plants and water, so it is safe to spray and swallow.

From the above, I would like to be aware of the health of the “mouth”, which is the entrance to all of the body, and try to keep the oral cavity clean by brushing teeth and taking oral care more than usual.

Until vaccines are developed, it is important to gather information on preventive measures announced by researchers and research institutions around the world and take preventive measures as much as possible in order to protect the lives of important family members. It is considered.

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2020/03/10 (Tuesday)

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A View on Coronavirus and ORALPEACE / Oral Care

[Remarks on new coronavirus (COVID-19) and ORALPEACE / oral care]

This is a reprint from the ORALPEACE project supporter Dr. Tanaka regarding the relationship between oral care and viral infection prevention. We hope that our long-standing research team on lactic acid bacteria antimicrobial peptides and clinical research will be of little help to the health of many people in times of emergency.


Usually, the dentist, otolaryngologist, head and neck surgeon will often consult the oral cavity. I will give my opinion as one of the otolaryngologists of the ORALPEACE support member.

I think that what is recently attracting attention in the field of infectious diseases is “why can brushing and oral care prevent or reduce viral infection?”

Viruses, including influenza viruses, have a structure in which a gene called nucleic acid is encapsulated in a protein called capsid (Note: New Coronavirus (COVID-19) is also wrapped in another protein called envelope).

Bacteria in the intestinal tract, including the oral cavity, also have a protein-degrading enzyme called protease.

In an unsanitary oral environment, many bacteria are present in the oral cavity, and many proteinases come into contact with viral capsids and envelopes.

As a result, capsids and envelopes of some viruses, including the influenza virus, are degraded by proteolytic enzymes, causing them to pop, which makes it easier for the virus to enter the mucosal cells, mainly the oral mucosa.

This is the reason why it is difficult to establish influenza virus infection when the bacterial flora in the oral cavity is kept normal and the amount of bacteria is reduced.

It may be more likely to enter the digestive tract mucosa, but as an otolaryngologist, I do not have enough knowledge on this point.

However, many intestinal bacteria have proteinases, and keeping the intestinal bacteria normal seems to be recommended from the viewpoint of preventing viral infection.

The conclusion comes to the end and is tedious and apologetic, but ORALPEACE is mainly based on the lactobacillus antibacterial bacteriocin preparation derived from “Okara” which is an edible food called “Neonisin-e”, and its safety and antibacterial action. Is also revealed in data from the Faculty of Dentistry at Kagoshima University.

The reason why it is okay to swallow is that it is made from only the lactic acid bacterium bacteriocin preparation derived from the food “Okara” and water and plant (food) ingredients.

And even considering the above mechanism, the risk of viral infection (although new coronavirus (COVID-19) is unknown as described below) is reduced if oral bacteria are reduced by ORALPEACE and tooth brushing / oral care. May help.

Like this time, I think the chance of getting an unknown virus on a large-scale cruise ship such as the Diamond Princess carrying 3,700 people is the first time, at least in the modern world where there is a record.

It has not been medically verified that the new coronavirus (COVID-19) suppresses infection through the oral mucosa.

However, at least it is a risk that even if you consider it because it is a product that can be swallowed without exhaling even on a cruise ship that may lack drinking water, and that there is already some medical evidence for suppressing oral bacteria (evidence). From the viewpoint of benefit ratio, I think that prevention of infection by ORALPEACE and oral hygiene is significant.


* The new coronavirus (COVID-19) is unknown, and it is thought that there are differences from the existing viruses. However, we would be grateful if people with illnesses, the elderly, infants and young children who seem to be at high risk can take possible preventive measures and save their lives. This comment is published not as a medical practice but as a view that contributes to the health of the people in an emergency.

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2020/03/04 (Wednesday)

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About preventive measures for babies and children

Everyone is worried about your baby or child going out.

I think many moms are having trouble with hand washing, alcohol disinfection, gargling and masking.

Sometimes I have to go through the crowd, and I eat a lot of things.

In such a case, using ORALPEACE spray on your baby’s or children’s mouth and throat may be one of the preventive measures.

It is not possible to inactivate the new coronavirus, but if you clean your mouth and reduce the enzyme that spreads the virus, you can reduce the virus infection rate such as influenza by 1/10 There are research presentations.

ORALPEACE is researched and developed by Kyushu University in Japan, and it is safe to swallow, yet contains “Neonisin-e *” that suppresses the action of bad bacteria in your mouth, 100% edible ingredients, organic oral care. ..

It is an oral hygiene agent used in ICU of Japan National Center for Child Health and Development (formerly National Children’s Hospital).

Since synthetic bactericides, preservatives and other chemically synthesized components, alcohol (ethanol), honey and propolis are not used, they can be used by newborns. Delicious fruity mandarin orange flavor.

While keeping basic precautions such as boosting immunity, staying out of the crowd, putting on a mask, and cleaning your hands, you should also keep your mouth clean.

Until the vaccine is developed, I would like to protect my small life with various preventive measures against new coronavirus (COVID-19).

Researchers, clinicians and other ORALPEACE project members are working on research and information dissemination every day with the help of their own research and technology to contribute to protecting the health of everyone and their irreplaceable families.


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