ORALPEACE” is a lactic acid bacterium bacteriocin that is invented in collaboration with research institutes such as Kyushu University and National Center for Longevity Medicine, and is made from foods and organic ingredients that are safe to swallow while approaching the bacteria that cause oral problems. An oral hygiene agent containing the formulation “Neonisin-e®”.

It is a product originally developed for elderly people who need nursing care, who suffer from oral and periodontal troubles and aspiration pneumonia, those who are unable to gargle or spit, and those who do not want to take chemical components such as infants and pregnant women.

Since its launch in July 2013, in addition to medical institutions and home use, research results and technologies that meet the needs of the environment where water usage is limited and outdoor where no chemical components are required, and its business Received numerous awards such as Yokohama Business Grand Prix Grand Prix, Japan Venture Award Grand Prize, Good Design Award, Japan Agricultural Society Technology Award for social activities such as job creation and income generation for people with disabilities.

In addition, the Konamoto earthquake, Chiba typhoon disaster, and other disaster-stricken areas throughout Japan continued, and in February 2020 when the global pandemic of the new coronavirus (COVID-19) began, the coronavirus anchored at the local Yokohama port. We also carry out support activities to provide free of charge to 3,600 crew members of the group-infected cruise ship “Diamond Princess”.

The new type of coronavirus that scared the world has made people around the world aware of the importance of preventing infection every day.

Now that a vaccine has not been developed, in addition to basic infection prevention such as wearing a mask and washing hands and mouth, “keeping the mouth clean”, which is the “entrance of the virus”, prevents a reduction in infection risk and avoids aggravation. Care has been widely disseminated through various media.

In addition, “ORALPEACE Clean & Moisture” (oral hygiene and moisturizer) is responding to the health needs of consumers around the world in recent years, “What is safe to put in your mouth, which is the entrance to your body and all your health.” , The oral hygiene and oral care products that are required by people all over the world because of the characteristics that have been created by responding to the clinical needs to effectively suppress the bacteria in the oral cavity.

Over the past 7 years, the ORALPEACE project has been working on research results and technological innovation of the lactic acid bacterium bacteriocin patented technology “Neonisin-e®”, which was invented in collaboration with national research institutes. We place the highest priority on “life-threatening” for people who have trouble with lung problems due to sexuality, and have refrained from using it for “beauty” applications such as “whitening teeth”.

As human products, we concentrate our research resources mainly on “Clean & Moisture” which is an oral hygiene and moisturizer.

Responding to oral problems, fighting illnesses and high-risk patients, gargling and non-exhaling elderly and infants, health-conscious people and pregnant women, and other pets, and having a significant impact on microbial ecosystems during disasters We have a history of focusing on providing oral care products for the outdoor natural environment.

Since our launch seven years ago, we have been required to provide products for “whitening teeth” and “beauty”, but our research team prioritizes the needs of “life-threatening” and “health” from its business background. We couldn’t find any significance as a project in responding to the needs of “whitening teeth” and “beauty”, and the research and development and sales of “Toothpaste powder” to whiten teeth, which is flooded with many products around the world.

However, the consciousness of people all over the world is currently undergoing a major paradigm shift from “to cope after getting sick” to “to take preventive care every day to prevent getting sick”.

In addition, university professors, doctors, and project members of social entrepreneurs are also involved in protecting the lives of loved ones from unknown dangers through support activities for a new coronavirus outbreak cruise ship at Yokohama Port. We should re-recognize that preventive care and health maintenance should be given the highest priority rather than the response from.

However, under the current circumstances, it is effective to keep hygiene and moisturizing in the oral cavity and to carry out thorough preventive care on busy days, and to purchase new oral hygiene agents and oral care products, because the burden increases. The situation remains that preventive care has not spread to many people.

However, the vast majority of people around the world brush their teeth daily and take care of their mouth. In addition, more than 90% of the toothpaste and oral care products market is “tooth brushing products”, and the need for “whitening teeth” is the mainstream.

If effective oral care is realized at the same time as “tooth brushing” that many people do every day, it will change the current situation, accelerate the spread of preventive care to more people, reduce the risk of infection and the risk of seriousness. I thought that it would lead to the avoidance of and protect as many lives as possible all over the world.

In addition to the existing “Clean & Moisture” aimed at “oral hygiene” and “moisturizing,” a new “whitening function” for teeth, which is required for daily brushing, has been added. Achieving “cleanliness”, “moisturizing” and “whitening” at the same time, “realizing daily tooth brushing and preventive care at the same time”, and “balancing both health and beauty” in an all-in-one new coronavirus era The social utility of oral hygiene and oral care products.

From the above background, not only products that deal with high-risk people who cannot gargle or spit or those who have a disease, we can easily realize “preventive care” and accelerate the spread of preventive care. Judging that the use of research results and technology contributes to the health of the people and people around the world and is “life-threatening”, and that it has significance to be worked on as a project, research and development of new products It has begun.

The premise for the development of new products is to maintain the original concept of “oral piece, which is made with safe ingredients that can be swallowed while approaching the bacteria causing troubles in the oral cavity”, in addition to the “cleanliness” and “moisturizing” so far. A new function “Keep white and beautiful” is added. It is the creation of oral hygiene and oral care products with new value in the world that can easily realize preventive care at the same time as daily tooth brushing.

In addition, we focused on Japanese dentin, which has a thin enamel and tends to become hypersensitive due to tooth brushing, and created a whitening product that allows “care for each tooth”.

In order to deliver it to many people around the world as soon as possible, we are working hard on research and development day and night to develop new oral hygiene and oral care products with gel formulations that are unprecedented for the new corona age.

“Neonisin-e®” is produced from over 10 years of lactic acid bacterium biotechnology research through industry-academia collaboration with Kyushu University Graduate School of Agriculture, Kagoshima University Graduate School of Medical and Dental Sciences, and National Longevity Medical Center, Department of Oral Diseases. Lactobacillus bacteriocin preparation derived from plant lactic acid bacteria.

Focusing on the excellent power of the natural lactic acid bacterium bacteriocin, it is an oral-peace-proprietary ingredient evolved and developed from “Nisin A”, which was discovered in cheese in England in 1928 as a safe antibacterial substance for the human body.

The bacteriocin “Nisin-A” produced by lactic acid bacteria found in “Tofu”, a clean and safe food from Kyushu, and plum extract from Kishu are mixed with Damask rose essential oil from Bulgaria.

It has been found to be extremely useful against bacteria that cause problems in the oral cavity, and is being used as an oral care preparation in a new era.

Although it is naturally derived, it has an extremely low concentration that instantly and firmly approaches the causative bacteria in the oral cavity, and even if swallowed, it is decomposed and digested as an amino acid in the body. (Patent No. 5750552)

It is calcium hydroxide phosphate/hydroxyapatite, which is the main component of the tissues such as teeth and bones, and the main constituent of hard tissues such as teeth and bones of humans and other vertebrates. 60% of human bones and 97% of tooth enamel consist of hydroxyapatite.

In the medical field, artificial bones, artificial teeth, artificial joints, etc. mainly intended to be transplanted into the human body by using the same chemical composition as human bones and teeth and utilizing high biocompatibility with bones. Is being put to practical use as a biomaterial.

By burying artificial bone made of hydroxyapatite in the defective portion of the bone, new bone covers the surface and the bone is absorbed and formed repeatedly, and it is replaced with autogenous bone over a long period of time.

The hardness is 5 when the enamel of the tooth is 6 to 7, hydroxyapatite is 5 and is a softer substance than the enamel, and from the effect of repairing bone, it can be expected to have an effect of also repairing scratches on the tooth surface ..

Hydroxyapatite is also approved as a safe food to eat, and there are also supplements.

It also has the function of adsorbing stains such as stains (pigments).

After conducting various verifications of ingredients that achieve both safety and effect, we decided to combine them with “ORALPEACE Clean & White,” which required a whitening function for teeth.

“ORALPEACE Clean & White” gel contains a proper amount of a very small amount of hydroxyapatite, aiming for a formulation that is gentle on the tooth enamel. (Photo source: Wikipedia)

Organic mint essential oil used for oral peas is the birthplace of slow food and barolo wine, and it is a herb farm in Piedmont, Italy, which is described as “bravissimo” among the world’s herb producing areas. It uses essential oils that are carefully grown under organic farming methods.

Furthermore, it has the oldest history in the world and has obtained the strict organic certification standard “DEMETER” certification.

Biodynamic farming (organic farming) was systematized by the anthropologist Dr. Rudolf Steiner in Germany, where soil pollution had advanced due to the spread of chemical fertilizers and pesticides before and after the First World War.

Dr. Steiner returns ancient farming methods that match the European climate based on the phases of the moon (the lunar calendar) that have been transmitted to Europe, such as the South Tyrol region on the Swiss border, since ancient times, and do not rely on pesticides and chemical fertilizers that have side effects to remediate soil. By trying to recover the original immunity of microorganisms and plants, we tried to overcome the food crisis of that time.

For hundreds of years since ancient times in the harsh regions of Europe’s nature, the unique farming work that was carried out from the days of sowing the seeds of snow to the days of harvesting the autumn in order to obtain food that survived the harsh winter was created according to the phases of the moon. According to the calendar, we went and examined the best dates and times.

It is said that in certain areas, days such as cutting hair and baking bread were fixed.

In addition to using pesticides and chemical fertilizers as organic farming methods, we focus on the effects of celestial bodies on life on Earth, and incorporate the rhythm of the universe based on the operation of the sun, moon, and stars.

The rhythms of the universe and the celestial bodies and the phases of the moon are deeply related to the ebb and flow of the sea tides and the biorhythm of women, and it is also said to be the original rhythm of humans.

In the homeland of Europe and Italy, it inherits the history of medicinal herb cultivation from ancient monasteries and is produced by the hands of an Italian family, spending more than 5 times as much as ordinary chemical farming and twice as much as ordinary organic farming. Organic essential oils have a completely different power and aroma than those of other production areas and climates.

It is natural that pesticide-free cultivation is a product you can eat every day, and biodynamic mint essential oil is full of energy and vitality woven by the rhythm of the celestial body and the earth of Europe, and in our casual daily brushing time, It will deliver the love and kindness that speaks to the body and body from Piedmont, Italy.

What is currently attracting attention in the field of infectious diseases is “why can oral care and preventive care prevent or reduce viral infection?”

Viruses, including influenza viruses, have a structure in which a gene called nucleic acid is encapsulated in a protein called capsid (Note: New Coronavirus (COVID-19) is also wrapped in another protein called envelope). Bacteria in the oral cavity also have a protein-degrading enzyme called protease.

In an unsanitary oral environment, many bacteria are present in the oral cavity, and many proteinases come into contact with viral capsids and envelopes.

As a result, capsids and envelopes of some viruses, including influenza virus, are broken down by proteolytic enzymes and popped off, making it easier for the virus to enter the mucosal cells, mainly the oral mucosa.

This is the reason why it becomes difficult to establish influenza virus infection if the bacterial flora in the oral cavity is kept normal and the amount of bacteria is reduced. If the oral cavity is left unclean, the amount of protease and other substances will increase, which may lead to the onset and severity of the virus.

A study conducted by a university institution found that cleaning oral cavity with oral care reduced the infection rate of influenza virus to 1/10, and the relationship between viral infection and keeping oral cavity clean was obtained. It is recognized.

“Neonisin-e®︎” contains lactic acid bacterium antibacterial bacteriocin preparation derived from “Okara” which is an edible food, and its benefits have been clarified in the data of Kagoshima University School of Dentistry.

Considering the mechanism above, if oral care/preventive care reduces bacteria in the oral cavity, it may help reduce the risk of viral infection (although new coronavirus is an unknown virus) and the risk of aggravation. There is.

Although it has not been medically verified that the new coronavirus suppresses the establishment of infection via the oral mucosa, from the viewpoint of the risk/benefit ratio that medical evidence (evidence) already exists for oral bacterial control. However, it is considered that prevention of infection by oral care/preventive care is meaningful.

First of all, the reason why teeth are yellower than the “original color” is largely due to the following reasons.

① Coloring (coffee, tea, red wine, curry, foods with synthetic colors and stains attached by mouthwash, tobacco tar),
② Tooth brushing too much (“Abrasive” “Paste type toothpaste” gradually thins the enamel and the underlying dentine becomes transparent and becomes yellow),
③ Dry mouth (dry mouth reduces the cleaning effect of saliva, and stains that are originally washed away adhere),
④Changes due to aging (with aging, the color of dentin becomes darker and looks yellow. With more years of polishing, the enamel becomes thinner and looks more yellow),
⑤ Adhesion of tooth decay and tartar,
⑥ Teeth without nerves,
⑦ Discoloration due to illness,

is. And there are roughly three ways to whiten your teeth.

① Remove stains on the surface of the teeth to remove the stains and make the person’s original teeth white.
② “bleach and whiten teeth as much as possible” using chemicals such as hydrogen peroxide,
③Put veneer of desired color on the surface of teeth and make it “white” by “changing to your desired color”

Regarding② “whitening teeth as much as possible”, bleaching agents such as hydrogen peroxide are very irritating, and unlike Japan, oral care products are not approved in Japan. Considering daily absorption of chemical components through mucous membranes, the use of bleach in the oral cavity for several decades at home every day poses a health problem.

Also, it is not easy to do at home to “change to your desired color” such as “white” in ③, and covering the surface of the tooth may interfere with remineralization of the tooth, so at the dental clinic. We recommend the following procedure.

Those who want to make their teeth whiter than their original color, those who want to change to their favorite color such as “pure white”, those who want to cure discoloration of teeth due to aging or disease, and discoloration of tooth decay or nerves. It is advisable to consult a specialist such as a dentist for treatment instead of making an amateur decision.

As for “tobacco tar” caused by smoking, since it is “tar” that is harder to remove than wine or curry stains, “tar tar” or “abrasive” should be used to remove the tar, or if the enamel is thin, it is dental. We recommend “bleaching” with a drug at a doctor’s office.

As a result of various examinations and verifications regarding “to remove stains and make the person’s original whiteness” that can be done every day even at home, for those who do not smoke and especially those who are hyperesthesia Considered better.

● “Abrasive” “Paste type toothpaste”
● “Foam toothpaste”
● “Chemically synthesized toothpaste”
● “Dentifrice containing alcohol (ethanol)”

First of all, you can easily whiten your teeth by using “abrasives” and “paste-type toothpaste”, but the enamel of your teeth is gradually damaged by daily use, and the teeth become yellow due to over-shaping. This can lead to things and hyperesthesia.

Abrasives are “calcium carbonate” (Ca carbonate, limestone powder, white line powder on the playground, raw material for chalk) “sodium hydrogen carbonate” (Na bicarbonate, baking soda) “salt” “charcoal” (charcoal) “Zeolite” (zeolite) “micro beads” (plastic particles), etc.

When polishing with an “abrasive” or “paste-type toothpaste”, the enamel may be gradually scraped and thinned, and dentin may become transparent and the teeth may become yellow.

Even with substances (abrasives) that are softer than tooth enamel, in combination with the hardness of the toothbrush and the strength of brushing, there are many cases where even hard enamel is scraped off by daily polishing for many years.

Like skin and hair, a person’s “tooth” is as different as their individuality. The same dentifrice is not suitable for all people, and in the future era it will be important to carry out each type of “dental care”.

Too much shaving will pass the white teeth and turn yellow and cause hyperesthesia. The scratches created by the abrasive are more likely to develop into caries.

Damaged enamel can be remineralized and repaired by 1.5 ℓ to 2 ℓ saliva secreted per day, but it cannot be repaired if it is damaged too much. Please be careful as important teeth that have been ground too much cannot be restored.

Those who are worried may be able to scrape off the enamel even if the compounding purpose is not indicated as an “abrasive”. Therefore, “Ca carbonate (limestone)” “Na bicarbonate (baking soda)” “Zeolite ( I think it is necessary to check whether or not “zeolite””, “micro beads (plastic)”, “salt”, etc. are mixed.

Although you can “brush your teeth” with “abrasives” and “paste-type toothpaste”, it may damage the taste buds, and may cause damage to the tongue, gums, inside cheeks, upper jaw, oral mucosa, etc. “Oral care” becomes difficult.

As a result, you may have to buy a new product for “oral care”, which is a burden to your household, it may be an obstacle to be placed in a limited space, and you may lose the aesthetics of the interior. ..

Next, the reasons for not using “dentifrice with foaming agent” are as follows.

“Effervescent agents” means “synthetic surfactants” such as “sodium lauryl sulfate” “lauryl glucoside” “cocamidopropyl betaine” “Na cocoyl glutamate”, “soap base” “coconut oil fatty acid K” “olive fatty acid” “Soap” such as “K”. At first, the history of toothpaste was only “polishing powder”, but about 100 years ago, paste containing a foaming agent appeared.

“Synthetic surfactants” and “soaps” may be added because they give a feeling of brushing teeth due to foaming and can emulsify the components water and oil (surface active). However, brushing teeth does not mean decomposing the oil stains in the mouth and teeth, so it is considered that foaming agents such as “synthetic surfactants” and “soaps” are virtually unnecessary. I will.

Brushing your teeth with “synthetic surfactant” or “soap” is the same as brushing your teeth with shampoo or solid soap at home, so I think you can try it. I also think that it is not very pleasant to lather the brim or plaque and spread it in your mouth.

On the other hand, there is a possibility that side effects may occur, instead of expecting a little effect. If you use a dentifrice with a “foaming agent”, it’s much better if you rush and strongly polish before foam overflows from the mouth, or if the foam overflows is the end (time limit). I think there are many. If you rush and polish strongly, the enamel will be further scraped off with an “abrasive”, which may cause yellowing of the teeth and hypersensitivity.

If the mouth soon becomes full of bubbles and overflows from the mouth, it will be impossible to carefully brush each tooth, tooth gap, and periodontal tooth and polish it. As a result, there is always the possibility of being left unpolished, resulting in caries, periodontal disease, tartar deposition and bad breath.

Next, the reasons for not using “dentifrice containing chemically synthesized ingredients” are as follows.

Although it is not well known, it is said that the absorption and ingestion of chemical components from the oral mucosa is 10 to 20 times that of the skin. Absorption of chemical components from the oral mucosa into the body during tooth brushing several times daily for decades should be avoided as much as possible for those who are concerned about food and health, pregnant women, women and infants.

Next, the reason why we do not use “dentifrice containing alcohol (ethanol)”.

In the process of evolution, humans and animals have acquired the physiological action of cleaning and keeping teeth clean without brushing them. The important thing to do that is saliva. “Saliva” plays an important role in washing away dirt and preventing it from sticking to your teeth.

However, if the mouth is dry, the cleaning effect of saliva will be weakened, and stains and tartar, which should not adhere, will adhere. Therefore, in order to keep teeth white, “moisturizing” in the oral cavity is also important, and especially for those with a small amount of saliva, we believe that the use of “alcohol (ethanol)-containing toothpaste” that can cause dry mouth should be avoided. I will.

The same thing can be said of tooth stains on the astringency of tea in cups and the burns on frying pans. Detergent (foaming agent/surfactant) and alcohol (ethanol) are not very effective for tea astringent and kogye that do not fall off even after washing.

To remove tea and astringent, I think that abrasives (compound, stone powder), polishing sponge, and steel wool are often used. You can easily remove dirt and scorching by rubbing with an abrasive or a file, but the surface will be covered with small scratches.

Even an abrasive (stone powder) that should be harder than a metal such as iron will scratch a lot of metal while rubbing it with a brush.

In addition, the new scratches that you made become dirty and become dirty easily, and eventually you get dirty, dirty, and the bacteria easily propagate on the wound, and it becomes a dirty state. Also, if the surface is shaved too much to make it white, the base will come out and it will be impossible to repair. And if you don’t scratch it in the first place, it will be less likely to get dirty.

On the other hand, if you use chemicals such as bleach, the chemicals will penetrate even small scratches and the cups and pans will turn white immediately. However, a drug that has the strength of turning a black one into a white one is highly irritating, and there is a problem in using it with bare hands every time considering the safety to the human body. It is not very good for your health if you don’t wash it well and keep your family eating tea and food using cups and frying pans with chemicals and chemically synthesized ingredients attached to them every day.

The same can be said for the teeth, mouth, and human body.

Based on the above premise, “The most effective and efficient from the viewpoint of risk/benefit, in order to prevent excessive enamel scraping and mucous membrane absorption of chemical components by everyday laymen, and to maintain the original healthy health and beautiful mouth and teeth.・The research team believes that “healthy and reasonable methods” are as follows.

“Daily oral care is a gel formulation product that contains a formulation that responds to bacteria that cause problems in the oral cavity and that is gentle to the body and safe to absorb into the body. , Maintain the tooth surface clean by thoroughly brushing it, and moisturize the oral cavity to enhance the saliva cleansing action and prevent pigmentation. Effective and safe whitening treatment based on medical viewpoints by dentists in the clinic.”

As with normal toothpaste, take an appropriate amount on your toothbrush after waking up, after eating, and before going to bed so that the gel spreads throughout your mouth, between your teeth, and your gums. Then brush it carefully. After brushing, lightly rinse. For cleaning the teeth and tongue with floss etc. A fresh breath of organic mint from Piedmont, Italy. A refreshing and refreshing feeling lasts.

Since it contains no foaming agent, it can also be used for careful brushing, electric toothbrush, and deciduous care.

In addition, especially before going to bed, we recommend that you use an interdental brush or floss to clean the spaces between your teeth while still in your mouth. If possible, clean your tongue with a tongue brush (a toothbrush is fine).

It is also effective to apply “Clean & Moisture Gel” or “Clean & Moisture Spray” to the entire mouth, teeth, interdental space, periodontium and tongue after rinsing.

The day after taking a rest after carefully taking care of your mouth with an oral piece, you will be able to feel the bad breath and the refreshing feeling of your mouth when you wake up.

Take an appropriate amount on a soft toothbrush and gently clean the tongue, gums, and oral mucosa.

Since it contains no abrasives or foaming agents, it can clean the tongue coating and oral cavity without damaging the mucous membranes and taste buds and changing the taste sensation, and prevents bad breath.

“Clean & White” is a combination of “Oral Peace Clean & Moisture” with “Hydroxyapatite” which is a cleaning agent for teeth, and can simultaneously brush teeth, moisturize (measure against dry mouth) and tongue/gum/mucosal care. Although it is a product, “hydroxyapatite” may remain in the mouth when applied.

“Hydroxyapatite” is a bone component and is a food, so it is safe to swallow it, but it is better to rinse your mouth.

If you want to focus on oral mucosal care and moisturizing, we recommend “Oral Peace Clean & Moisture”, which specializes in oral care and moisturizing.

“Clean & White” has a mint flavor so that even adults can feel refreshed.

We recommend “Clean & Moisture Orange” or “Clean & Moisture Original (Green)” for newborns and children who do not like mint taste.