ORALPEACE
Clean&Moisture

Japanese innovative bacteriocin
(lactic acid bacteria antibacterial peptide)
safety chemical-free oral-care gel/liquid
made from 100% plant-based food ingredients

ORALPEACE Clean & Moisture (oral care gel, mouth spray & wash) is an oral care product containing the patented lactic acid bacteria antibacterial peptide (bacteriocin) formulation “Neonisin-e®︎”.

It was invented through more than 20 years of research into lactic acid bacteria biotechnology to control bacteria by Professor Kenji Sonomoto, who has a doctorate in engineering and has served as professor emeritus at National Kyushu University, president of the Japan Lactic Acid Bacteria Society, and president of the Japanese Society of Bioengineering.

“Neonisin-e®” is a patented formulation created from nisin, an antibacterial peptide (bacteriocin) that has been approved as a food by health organizations around the world, and is used to treat oral infections such as Streptococcus mutans, Pg bacteria, Candida bacteria, Escherichia coli, and Staphylococcus aureus. It instantly approaches the bacteria that cause problems at ultra-low concentrations, more so than conventional antibiotics, synthetic bactericides, and phytotoxic antibacterial agents. However, toothpaste and oral care products are 100% food ingredients and chemical-free (no chemical ingredients) that are safe to swallow.

Japan’s cutting-edge lactic acid bacteria antibacterial peptide research and green technology have solved the conflicting issues that could not be overcome with conventional chemical technology: “effectiveness against causative bacteria at ultra-low concentrations, high biodegradability, and safety.”

It is an oral hygiene brand born in Japan that is kind to the body and nature, and is in a new era of environmentally friendly development, creating new possibilities for the sustainable development of humanity through an invention that is unique in the world.

The project members were inspired by the birth of a child with a disability and by witnessing the oral problems of his father, who was battling terminal cancer.

In response to the needs of medical and nursing care settings for people who have difficulty gargling, spitting, and oral care, they want to use ingredients that are safe to absorb into the body and do so without burdening them.

Industry-academia-government collaboration with Kyushu University Graduate School of Agriculture, Kagoshima University Graduate School of Medical and Dental Sciences, National Center for Geriatrics and Gerontology, Oral Disease Research Department, etc.

Projects ranging from basic research to clinical applications are made up of medical, engineering, agricultural, dental, pharmaceutical, medical, dentist, veterinarian, dental hygienist, nurses, caregivers, speech therapists, etc.

Developed in 2013 after more than 10 years of research, based on cutting-edge lactic acid bacteria biotechnology research conducted through industry-academia-government collaboration at Japanese national research institutes.

Through technological innovation originating in Japan, we are improving the oral environment of many people around the world, leading to healthier lives and extending healthy lifespans.

Reducing the burden on daily medical care and caregivers, reducing nursing care costs that approach 10 trillion yen annually in Japan alone, preventing infection and aggravation through oral care.

Through our business, we create jobs for people with disabilities across the country who have low incomes in our main business, promote sustainable initiatives aimed at increasing their income, and engage in social activities through our business, such as supporting disaster-stricken areas and protecting the beautiful global environment.

We has won various awards including the Yokohama Business Grand Prix Grand Prize, the Japan Venture Award Grand Prize, the Japan Agricultural Science and Technology Award, the Good Design Award, and the Social Products Award.

It has been adopted by medical institutions and ICUs across Japan, including general hospitals, dental clinics, and pharmacies, including the National Research Center for Child Health and Development, Tokyo Medical and Dental University Hospital, and the University of Tokyo Hospital.

In addition, it is safe to swallow, can be used without water, is highly biodegradable, and is gentle on the body and the environment, making it suitable not only for the elderly and those fighting diseases.

Useful for people who are concerned about their family’s health, those who do not want to ingest chemical ingredients, infants, pregnant women, breastfeeding mothers, disaster-stricken areas where water use is limited, outdoor activities such as mountain climbing, and pets that are important family members.

Our products are not only available at welfare facilities nationwide, but also at department stores such as Isetan,GoodDesignStoreTOKYO, and Hands, as well as advanced select shops nationwide.

Furthermore, as an innovative made-in-Yokohama-Japan product, it is exported to 15 countries around the world, including Europe and America, and is loved by people all over the world.

In December 2020, it was selected by the Japan Aerospace Exploration Agency (JAXA) to be installed on the International Space Station (ISS), and will be used to maintain the health of astronauts while living in space. We also support expansion.

With this one item, you can use daily oral care and tooth brushing to clean your mouth, moisturize your mouth, prevent bad breath, periodontal care, tongue care, mucous membrane care, prevent cavities, massage your mouth, and dry your mouth. At the same time, we provide total care, including mouse prevention, saliva support, aspiration lung trouble prevention, infection and aggravation prevention care, and beautiful and healthy teeth.

Based on the research results of Japan’s national universities, we will respond to the needs of people who care about their health, the needs of medical and nursing care settings, the oral hygiene needs of the world in the era of the new coronavirus, and the new tooth brushing and oral care needs of humans in the age of living in space.

Streptococcus mutans in the oral cavity, Pg bacteria, bacteria that cause periodontal problems, Escherichia coli, bacteria that cause aspiration lung problems, bacteria that cause bad breath, Candida bacteria, etc.

More than conventional antibiotics, synthetic bactericides, and phytotoxic antibacterial agents,

While instantly approaching with ultra-low concentration,

When swallowed, it is quickly broken down and digested into amino acids in the intestinal tract.

Protects intestinal flora, which is the source of immunity, without sterilizing it.

Safe with no side effects

Contains “Neonisin-e®”, a patented lactic acid bacterium peptide formulation produced by lactic acid bacteria derived from clean plant foods, discovered in “okara” produced in Fukuoka Prefecture.

All products are domestically produced with highly traceable safe ingredients, water and plant-derived ingredients, food ingredients, and organic ingredients, so they taste delicious.

Contains a moisturizer that enhances the cleaning action of saliva, prevents stains (pigments) from adhering, and maintains white teeth.

Prevents bad breath by moisturizing the oral cavity, which tends to dry out from breathing through the mouth while wearing a mask.

Contains no abrasives so it won’t scratch your precious enamel, prevent hypersensitivity, and won’t damage ceramic teeth.

It polishes well without using any foaming agents, leaving little residue.

A major feature of ORALPEACE is that it won’t upset your stomach even if you apply or spray it on your mouth to prevent bacterial growth and dry mouth while you sleep.

Chemical-free, realized through technological innovation and green technology from Japanese industry, academia, and government.

Also, since no alcohol (ethanol) is added, everyone can use it.

It does not contain fluorine (a titanium corrosive component), so it can be used on implants.

It can also be used in disaster-stricken areas and spacecraft where water availability is limited.

Contains no synthetic disinfectants or chemical substances that are difficult to decompose.

It does not accumulate in the body, and even if it is discharged into the natural environment, it is quickly biodegraded by microorganisms and does not affect the beautiful natural microbial ecosystem of soil and water.

It is also an environmentally friendly SDGs-compliant product that does not pollute the oceans where it is washed away and keeps the earth beautiful.

To someone you love.

People who are concerned about their family’s health and want safety in what they eat and put in their mouths on a daily basis. People who are concerned about daily health and preventive care.

For elderly people who need care who have difficulty gargling or spitting, who are worried about aspiration or swallowing, people who are battling illness, and in medical and nursing care settings.

Infants who swallow toothpaste, people who are sensitive to chemical ingredients, and people who are pregnant, breastfeeding, or trying to conceive.

For those who are hypersensitive to chemical components, and those who are trying to prevent future hypersensitivity/allergies and avoid accumulation of chemical components in the body.

Moisturizes dry mouth caused by aging or side effects of medications. To prevent lung problems caused by aspiration.

For the first tooth brushing of a baby whose teeth have begun to grow. Also for pets, who are important family members. Also suitable for vegans.

Also suitable for disaster sites where water is valuable, outdoors, and life in space. Also for those who want to protect the beautiful environment of the earth.

Also, oral care can be used to prevent viral infections.

The spray can be used to easily treat bad breath, cavities, periodontal conditions, moisturizing, and lung troubles such as aspiration. You can also dissolve it in water and gargle as a mouthwash.

For your mouth and throat during cold season. Preventive care for your baby when going out. Also for easy care of bedridden people and children who have fallen asleep.

Products that are kind to your body and the earth and can be used every day by the whole family.

It’s also a product that makes you feel good.

FOR WHO?

  • Low saliva
  • The mouth is rough
  • For electric toothbrush
  • I have trouble in my mouth
  • People who have dry oral cavity
  • For newborns For baby tooth care
  • I’m dry and hard to talk
  • I want to keep my mouth healthy
  • I want to care for something safe
  • I have less saliva and I am thirsty
  • I want to keep it clean at bedtime
  • People who want fresh oral condition
  • People with difficulty to gargle and spit
  • People who have white moss on their tongue
  • I do not want to take chemically synthesized ingredients
  • I have a sticky mouth when I wake up in the morning
  • People who want to keep the oral clean and moist during bedtime
  • I like people who have clean teeth and mouth
  • I care about what I use on my skin and body
  • I want my irreplaceable family to stay healthy
  • Looking for effective oral care products in nursing homes
  • I want to brush my teeth in the mountains and natural places
  • I want to efficiently carry out oral care for a large number of people
  • I take a good look at the ingredient list of the product and choose the one to eat
  • I want to use the products in reliable hospitals, dental clinics, department stores, etc.
  • Concerns about ingestion and transdermal absorption of chemically synthesized components
  • Mouth is the entrance to all illnesses, I love loving oral care products that I really want my family to use with peace of mind
  • I want to use oral care products that are gentle to the body and mind as an important substance that forms the body and mind.
  • We would like to recommend patients not only low value-added products that are cheap, but also high-value-added oral care products that help reduce total expenditure for health.
  • Sticky mouth
  • I care about what I eat
  • Daily oral care is difficult
  • I swallow my toothpaste
  • People who worry about bad breath
  • I’m worried about bad breath
  • I have difficulty gargle/exhale
  • I like the natural and gentle taste
  • I worry about swallowing/aspiration
  • People who use electric toothbrush
  • I don’t want to sharpen tooth enamel
  • I have difficulty swallowing food
  • People who want to keep their oral healthy
  • People who are likely to swallow dental care product
  • People who worry about accidentally ingestion
  • I want to use it for visiting dentistry and nursing care
  • I don’t want my child to take chemical ingredients
  • I have a great burden on oral care for my family
  • I feel value and empathy for social brands
  • I don’t know what oral care product to use in the ward
  • I think it is important to protect the environment of the earth
  • I like products that make me feel good when picked up or taken
  • I want to use it in a water-free environment at the time of a disaster
  • I am looking for an oral care product that meets the needs of medical and nursing care
  • I want to use oral care products based on solid research and evidence
  • I am glad to have a safe oral care product that complies with international organic certification standards.
  • I trust products researched and developed by medical doctors, dentists, engineering doctors, agricultural doctors, dentists, etc.
  • I trust oral care products with a scientific approach through joint research with research institutions such as national universities
  • Baby tooth-care
  • I want to use it in space
  • I tend to have dry mouth
  • I’m thirsty because of side effects
  • Pregnant women, lactating women
  • I like eco-friendly products
  • I care about my family’s health
  • I want to use it in visiting dentistry
  • I want to use safe oral care products
  • The tongue is white and dirty
  • I want to reduce the burden of care
  • People who allergic to chemical ingredients
  • People who often with phlegm in the throat
  • I do not want to take chemical substances every day
  • During disaster or water shortages environment
  • I want to use it in a disaster or in an environment without water
  • I swell my mouth with anti-cancer drugs
  • I want my parents to be healthy and live longer
  • I like products designed to enhance everyday life
  • I’m worried about bad breath when I wake up in the morning
  • I think a good product isn’t just about advertising and claims
  • Products with academic research background are preferred
  • I want to choose a product whose ability is recognized around the world
  • Want to use oral care products using patented research and technology
  • I want a product that can feel the effect even if it is a food ingredient or a safe ingredient.
  • I prefer oral care products that I use daily to patients, as well as products that contribute to society.
  • It would be great if there were reasonably-priced oral care products that were both effective and safe and did not burden the household.
  • Daily oral care is more difficult than purchasing a product. If so, effective oral care products are better to use

PRODUCT FEATURES

Daily oral care with this product only

  • ORALPEACE cleans the oral cavity, moisturizes it & maintains a healthy condition.
  • ORALPEACE is degraded & digested in the body if it is swallowed.
  • Toothbrushing, cleaning, prevention of bad breath & moisturization of the oral cavity only with this product.
  • In pursuit of unprecedented safety and clinical effects, research and development by world-leading technology.
  • The lactic acid bacterium bacteriocin patented formulation “Neonisin-e®*” is mixed to meet the needs of clinical sites such as medical care and nursing care.
  • Toothbrushing, cleansing, prevention of tooth decay, periodontal care, prevention of bad breath, moisturizing in the mouth is this one.
  • No abrasive compound. Beautiful white teeth by brushing without removing enamel.
  • Suitable for those who have a rough mouth and who are sensitive to chemical synthesis.
  • For elderly people who require nursing care, people with severe physical and intellectual disabilities, infants and young children, and those who are concerned about accidental ingestion.

Daily oral care at ease

  • Chemosynthetic ingredient-free & available for infants, elderly people, pregnant women as well as lactating mothers.
  • For sensitive persons with rough skin in the oral cavity & persons who do not like chemosynthetic ingredients.
  • For people for whom there is concern about accidental ingestion & swallowing such as elderly people requiring nursing care, people experiencing severe disability and infants.
  • Alcohol free with chemical components realized by technological innovation of Japanese industry, academia and government.
  • 100% natural ingredients, chemical-free. A safe ingredient for people who care about food.
  • Lactic acid bacteria used as raw materials also utilize bacteria that live in plants (food).
  • Suitable for elderly people, those who are fighting illness, newborns to pregnant women, and those who are breastfeeding.
  • Uses only plant-derived foods and organic ingredients that are safe to swallow.
  • Should it be swallowed, it will decompose and digest in the body. Even during a disaster without water.
  • Natural and gentle taste that does not affect the taste.

Daily oral care that is not a burden

  • Simple care by anybody at any time, even if there is no water and the mouth cannot be rinsed.
  • ORALPEACE contains a lactobacillus peptide preparation, Neonisin-e®*, and reduces the burden of oral care.
  • Oral care keeps your mouth clean, moisturized and healthy.
  • In a short time without trouble. You and your children. It also reduces the burden on patients, medical care, caregivers, and families.
  • Easy care for anyone, no water, no rinse.
  • Reducing the burden at a reasonable price.
  • Highly biodegradable, leaving no footprint in the environment such as camping and mountaineering.
  • When camping, climbing mountains & during disasters when water is not available.

* Cleaning aid

Product Line up

Japanese innovative bacteriocin(lactic acid bacteria antibacterial peptide)
safety chemical-free oral-care gel made from 100% plant-based food ingredients

A 21st century toothpaste and oral care gel containing “Neonisin-e®*” that is easy, safe and effective for oral care, and is kind to the body and the environment.

With this one item, you can perform daily oral care and tooth brushing to clean your mouth, moisturize your mouth, prevent bad breath, periodontal care, tongue care, oral massage, mucous membrane care, prevent cavities, and dry your teeth. We provide total care at the same time, including mouse prevention, aspiration prevention, and infection prevention care.

Neonisin-e®* (Patent No. 5750552), a patented lactic acid bacteriocin formulation derived from plant foods, spreads throughout the mouth, teeth, interdental areas, periodontal areas, and tongue, cleaning areas that are difficult to reach with tooth brushing alone. Moisturizes the oral cavity and keeps it healthy.

Contains “Neonisin-e®*” to prevent cavities and bad breath and provide periodontal care.

Brushing whitens your teeth and freshens your breath.

Oral care prevents lung problems caused by aspiration, and keeps the oral cavity, which tends to become dry, moisturized and healthy.

It polishes thoroughly without using foaming agents, abrasives, or irritating ingredients, leaving little residue and leaving you with a refreshing and refreshing feeling.

Especially before going to bed, we recommend cleaning between your teeth using an interdental brush or floss while keeping it in your mouth.

If possible, clean your tongue with a tongue brush (or a toothbrush).

It is also effective to spread a small amount over the entire mouth, teeth, interdental areas, periodontal areas, and tongue after rinsing.

It spreads well and has a refreshing aftertaste.

A major feature of ORALPEACE is that it won’t upset your stomach even if you apply it to your mouth and sleep to prevent bacterial growth and dry mouth.

The next day after carefully caring for your mouth with Oral Peace and resting, you will notice a change in your bad breath and the freshness of your mouth when you wake up.

When your mouth feels good, the air, water, food, and alcohol taste better.

Have a nice and healthy day!

Delicious, natural, gentle and refreshing taste

Clean & Moisture Toothbrushing & Oral Care Gel

  • Content : 80 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), xanthan gum* (thickener), plum fruit extract* (patented formulation “Neonisin-e®” aid, cleaning aid, product) (preservation aid), Caesarpinia spinosa gum* (thickener), peppermint oil*** (product preservation aid, flavoring agent), spearmint oil*** (product preservation aid, flavoring agent), damask rose flower Oil*** (patented formulation “Neonisin-e®︎” auxiliary agent, product preservation performance aid, flavoring agent) *Plant-derived **Plant-derived lactic acid bacteria-derived ***Organic ingredients

●A delicious and refreshing taste of gentle natural mint. For daily tooth brushing and oral care for the whole family. For oral care in medical and nursing care settings. It can be safely used by everyone from newborns to the elderly.

Delicious, Juicy yuzu (Japanese citrus) and lemon taste Baby&Children-friendly taste

Clean & Moisture Orange Toothbrushing & Oral Care Gel

  • Content : 80 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), xanthan gum* (thickener), plum fruit extract* (patented formulation “Neonisin-e®” aid, cleaning aid, product) Preservation performance aid), Caesarpinia spinosa gum* (thickening agent), orange oil* (flavoring agent), lemon peel oil* (flavoring agent), yuzu peel oil* (flavoring agent), peppermint oil*** (product) Preservation performance aid, flavoring agent), damask rose flower oil*** (patented formulation “Neonisin-e®︎” aid, product preservation performance aid, flavoring agent) *Plant-derived **Derived from vegetable lactic acid bacteria ***Organic ingredients

●The juicy flavor of yuzu and orange is popular among children and women who don’t like mint flavor. Natural flavor with no chemical additives that will please even children who hate brushing their teeth. Also suitable for newborns’ first tooth brushing and oral care. It can be used by the whole family, from babies to the elderly.

Delicious, cool and refreshing taste Clean and refreshing, prevents bad breath

Clean & Moisture Mint Toothbrushing & Oral Care Gel

  • Content : 80 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), xanthan gum* (thickener), plum fruit extract* (patented formulation “Neonisin-e®” aid, cleaning aid, product) (preservation performance aid), Caesarpinia spinosa gum* (thickener, derived from legumes), Mentha oil*** (product preservation performance aid, flavoring agent), Spearmint oil*** (product preservation performance aid, flavoring agent) ), damask rose flower oil*** (patented formulation “Neonisin-e®︎” auxiliary agent, product preservation performance aid, flavoring agent) *Plant-derived **Plant-derived lactic acid bacteria-derived ***Organic ingredients

●It has a cool and refreshing mint flavor that is popular among people who are not satisfied with the refreshing feeling of original (green) or orange. It does not contain any abrasives and can be used as a toothpaste gel to prevent sensitivity and is gentle on the gums, oral mucosa, and enamel.

Japanese innovative bacteriocin(lactic acid bacteria antibacterial peptide)
safety chemical-free oral-care liquid made from 100% plant-based food ingredients

A 21st century toothpaste and oral care gel containing “Neonisin-e®*” that is easy, safe and effective for oral care, and is kind to the body and the environment.

A high-performance oral care spray containing “Neonisin-e®*” that allows easy oral care for people who are busy, going out, sleeping, or bedridden.

Through technological innovation and green technology from industry, academia, and government, we pursue effectiveness against trouble-causing bacteria and safety when swallowed.

Easy oral care, mouth moisturizing, and bad breath prevention for bedridden people and children who have fallen asleep during busy times. We pioneered a new product category in the world called “oral care when going out,” which is difficult to gargle or spit out.

As a product that aims to balance safety and functionality, it can also be used as a high-performance oral care spray when going out during the coronavirus pandemic.

With this one item, you can perform daily oral care and tooth brushing to clean your mouth, moisturize your mouth, prevent bad breath, periodontal care, tongue care, oral massage, mucous membrane care, prevent cavities, and dry your teeth. We provide total care at the same time, including mouse prevention, aspiration prevention, and infection prevention care.

Neonisin-e®* (Patent No. 5750552), a patented lactic acid bacteriocin formulation derived from plant foods, is distributed throughout the mouth, teeth, interdental areas, periodontal areas, and tongue, reaching areas that are difficult to reach with tooth brushing alone. Care helps keep teeth clean, prevents cavities and bad breath, provides periodontal care, and moisturizes the oral cavity to keep it healthy.

Spray directly into your mouth, then dilute with water and gargle as a mouthwash. Leaves you with a refreshing and refreshing feeling.

Especially before going to bed, we recommend cleaning between your teeth using an interdental brush or floss while keeping it in your mouth. If possible, clean your tongue with a tongue brush (or a toothbrush).

It is also effective to spread a small amount over the entire mouth, teeth, interdental areas, periodontal areas, and tongue after rinsing.

The next day after carefully caring for your mouth with Oral Peace and resting, you will notice a change in your bad breath and the freshness of your mouth when you wake up.

Also, if you spray it on saline and use it when gargling your nose, it will cleanse the nasal cavity and pharynx, so please try it.

When you refresh, your mouth and mind will be refreshed.

Have a nice and healthy day!

Delicious, natural, mild and refreshing taste

Clean & Moisture Spray Oral hygiene & moisturizing liquid

  • Content : 30 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), plum fruit extract* (patented formulation “Neonisin-e®︎” aid, cleaning aid, product preservation performance aid), peppermint oil *** (product preservation performance aid, flavoring agent), spearmint oil*** (product preservation performance aid, flavoring agent), damask rose flower oil*** (patented formulation “Neonisin-e®︎” aid, product preservation performance) Auxiliary, flavoring agent) *Plant-derived **Plant-derived lactic acid bacteria-derived ***Organic ingredients

●A delicious and refreshing taste of gentle natural mint. For oral care in medical and nursing care settings. Can be used by the whole family.

Delicious, juicy yuzu (Japanese citrus) and lemon taste

Clean & Moisture Spray Orange Oral hygiene & moisturizing liquid

  • Content : 30 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), plum fruit extract* (patented formulation “Neonisin-e®︎” aid, cleaning aid, product preservation performance aid), orange oil* (flavoring agent), lemon peel oil* (flavoring agent), yuzu peel oil (flavoring agent), peppermint oil*** (product preservation performance aid, flavoring agent), damask rose flower oil*** (patented formulation “Neonisin”) -e®︎” auxiliary agent, product preservation performance aid, flavoring agent) *Plant-derived **Plant-derived lactic acid bacteria-derived ***Organic ingredients

●The juicy flavor of yuzu and orange is popular among children and women who don’t like mint flavor. Also for preventive care of babies.

Delicious, cool and fresh taste

Clean & Moisture Spray Mint Oral hygiene & moisturizing liquid

  • Content : 30 g (for about 2 months)

All ingredients

Glycerin* (moisturizer), water, lactic acid coccus culture extract** (Main ingredient of the patented formulation “Neonisin-e®︎”, invented in industry-academia collaboration with Kyushu University, the world’s only colorless, transparent, tasteless, odorless, and highly Stable “Highly Purified Nisin A”, cleaning aid, product preservation performance aid), plum fruit extract* (patented formulation “Neonisin-e®︎” aid, cleaning aid, product preservation performance aid), peppermint oil *** (product preservation performance aid, flavoring agent), damask rose flower oil*** (patented formulation “Neonisin-e®︎” aid, product preservation performance aid, flavoring agent) *Plant-derived **Derived from vegetable lactic acid bacteria * **Organic ingredients

● A cool and refreshing mint flavor that is popular with those who like minty refreshing feeling.

Designed by Noriteru Minezaki ((Studio))

The following ingredients are not used

ORALPEACE do not contain the following ingredients:

×Ingredients that are not approved for food that can be taken into the mouth
×Alcohol (ethanol, cause of dry mouth/avoidable for infants)
×Petroleum-derived ingredients
×Chemical substances
×Forever Chemical (PFAS)
×Cyanide(potassium cyanide, etc., poisonous substance, substance not permitted for food, substance prohibited from being released into the environment in ppm units)
×Potassium thiocyanate(Thyroid side effects, hazardous substance, substance prohibited from being mixed into food or released into the environment in ppm units, regulated by the U.S. Environmental Protection Agency in 2011, regulated by the European Union in 2014, and regulated by the Japan Ministry of Health, Labor and Welfare for hypothyroidism in 2021, the Japan Ministry of the Environment will classify it as an endocrine organ disruptor and prepare for regulations.)
×Hydrogen peroxide(deleterious substance, residual unlicensed substance in food, prohibited in Japanese toothpaste products in ppm units)×Enzymes such as lactoperoxidase and glucose oxidase that cause a chemical reaction with hydrogen peroxide and thiocyanate in the oral cavity to generate cyanide and sterilize E. coli(Thyroid side effects, Japan Ministry of Health, Labor and Welfare and Ministry of the Environment impact risk)
×Potassium iodide (Iodine, disinfectant, risk of side effects such as iodine poisoning and thyroid dysfunction)
×Formaldehyde (poisonous substance, bactericidal agent, there are cases where it is added to imported products in ppm units for antibacterial purposes due to carryover of preservatives from raw materials)
×Synthetic fungicides that disrupt the intestinal flora, which is the source of immunity, and are toxic in nature when released into the environment
×Synthetic disinfectants such as cetylpyridinium chloride (also known as cetylpyridinium chloride, CPC), benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, IPMP (isopropylmethylphenol), triclosan, methyl salicylate, lauroylsarcosine salt (LSS), etc.
×Chlorine, chlorine dioxide (CIO2), sodium chlorite, sodium hypochlorite, chlorine gas, etc. (deleterious substances, dangerous substances, bleach, pool disinfectants)
×Na hydroxide/K hydroxide (deleterious substance, caustic soda/potassium, strong alkali, biohazardous, corneal damage observed with 2% solution, prohibited substance remaining in food)
× Strong alkaline electrolyzed water (although it is water, it is strongly alkaline and there is a risk of damaging the oral cavity and visceral mucosa and diluting stomach acid if swallowed accidentally, so it is not used for oral care in medical care settings)
×Water-soluble synthetic polymers such as carbomer, sodium polyacrylate, and hydroxyethyl cellulose (liquid microplastics, may impede skin breathing, and are difficult to decompose in the environment as nanoplastics, posing risks to seafood and the body)
×Fluoride (European Union suggests an impact on children’s IQ and reproductive function; in the United States, the safe exposure limit for fluoride is 0.12 mg/kg body weight/day)
×Titanium dioxide, TI dioxide, titanium oxide, TI oxide (coloring agent, bleach, suspected of carcinogenicity, French government has banned its inclusion in food from 2020)
×Phosphorus (phosphates such as polyphosphoric acid, metaphosphoric acid, pyrophosphoric acid, bleach)
×Aspartame (artificial sweetener, WHO suggested it may be carcinogenic in 2023)
×Artificial sweeteners such as sorbitol, sucralose, maltitol, erythritol, and saccharin sodium (effects on intestinal bacteria, etc.)
×Xylitol (effect on intestinal bacteria)
×Paraben (paraoxybenzoic acid ester, methylparaben, butylparaben)
×Phenoxyethanol (synthetic preservative, substance not permitted for food)
×Sodium benzoate (synthetic preservative)
×Sorbic acid potassium (synthetic preservative)
×Pentylene glycol (synthetic preservative)
×Glycine (preservative/food additive chemically synthesized from formaldehyde and hydrogen cyanide)
×Poly-ε-lysine (polylysine, an antibiotic analog produced by fungi-like actinomycetes, preservative and food additive)
×Synthetic surfactants and foaming agents such as sodium lauryl sulfate, lauryl glucoside, cocamidopropyl betaine, and sodium cocoyl glutamate that pose risks of swallowing and environmental pollution.
×Soap base, soap such as coconut oil fatty acid K, olive fatty acid K, etc., foaming agent
×Abrasives (stones, microplastic beads, mud, salt, etc.) that can be swallowed, accumulate in the gums, or abrade too much enamel and risk hypersensitivity.
×Calcium carbonate (Ca carbonate, large-particle abrasive, limestone powder, powder for drawing white lines on playgrounds, raw material for chalk), zeolite (zeolite), sodium bicarbonate (baking soda), coral powder, shells, Abrasives (compound, stone powder, etc.) such as mud (clay, montmorinite), charcoal, microbeads (plastic), etc.
×Large amounts of hydroxyapatite (risk of absorbing and sterilizing microorganisms in septic tanks and sewage treatment plants when discharged into the environment; risk of environmental pollution when discharged into the natural world)
×Strong synthetic fragrances and chemical fragrances that can disguise signs of illness such as bad breath (treatment of the affected area is necessary for health)
×Chemical substances whose names are hidden and only written as “fragrances” and “preservatives” (medicinal and quasi-drugs are not required to list all ingredients, and display names and INCI names can be hidden)
×Synthetic fragrances and flavors such as grape and cola made from chemicals
×Solubilizers such as PEG (polyethylene glycol) and propanediol
×BG (butylene glycol) ×PG (propylene glycol)
×EDTA-2Na × etidronic acid × phytic acid × nanoparticles
×Synthetic colorants made from petroleum tar raw materials such as Blue No. 1 and Yellow No. 2
×Metals such as copper and silver, heavy metals, heavy metals
×Poisonous components of animals and plants (natural poisons) × Aconite (alkaloids)
×Essential oils and resins with distilled and concentrated plant toxicity ×Tea tree essential oil
×Hinokitiol (teratogenic risk, avoid for pregnant women and girls)
×Pine tar × Japanese cedar resin × Mastic resin × Eucalyptus essential oil × Wintergreen essential oil × St. John’s wort essential oil
×Yucca Schidigera extract (complex mixture of compounds, 2021 EU/European Food Safety Authority has determined that the effects of triterpenoid saponin and steroid saponin mixture (thyrotoxicity and male reproductive toxicity), serious skin and eye (suggests irritation and effects on aquatic organisms)
×Indigestible dextrin × Catechin × Tea leaves × Caffeine × Salt/Sea salt
×Insects, larvae, caterpillars, insect eggs, insect-derived raw materials × Honey, propolis × Saliva × Body fluids × Feces
×Animal-derived materials that sacrifice the tiny lives of other animals, such as bird eggs and animal placentas
×Animal-derived lactic acid bacteria (lactic acid bacteria derived from human/animal feces, intestinal tract, oral bacteria, dental plaque, etc. are not used)
×Lactic acid bacteria itself (no combination of live bacteria or dead bacteria, no evidence data on the immediate effect of lactic acid bacteria itself on oral bacteria)
×Limited natural biological raw materials such as corals in the marine environment
×Chemical substances that are toxic to the natural environment and biological ecosystems in the rivers and soil where they are discharged, and that indirectly affect human health from edible seafood and agricultural products.
×Chemical substances that the World Health Organization is considering regulating in the future due to their negative effects on the human body and the environment

*When purchasing products for the mouth of children, family members, or patients, please be sure to check the “all ingredients” (all ingredients contained in each product) of each product before making your selection. We recommend it.

*Also, some Internet search services are capable of various information manipulations such as SEO to prevent consumers from knowing the truth, so the same content can be used on new AI question answering services, etc. We encourage you to investigate the truth for yourself.

* Cleaning aid

How to use

Clean & Moisture (gel)

As a toothpaste gel

As with normal toothpaste, take an appropriate amount on your toothbrush after waking up, after eating, and before going to bed so that the gel spreads throughout your mouth, between your teeth, and your gums. Then brush it carefully. After brushing, lightly rinse.

Since it contains no foaming agent, it can also be used for careful brushing, electric toothbrush, and deciduous care.

Especially before going to bed, we recommend that you use an interdental brush or floss to clean the spaces between your teeth while still in your mouth. If possible, clean your tongue with a tongue brush (a toothbrush is fine). After rinsing, it is also effective to apply a small amount of gel over the entire mouth, teeth, interdental space, periodontium, and tongue again.

The day after resting after carefully taking care of your mouth with an oral piece, you will be able to feel the change in breath and mouth breath when you wake up.

As an oral care gel

Carefully check the condition of your mouth.
If you have a dry mouth, use water to moisten your mouth. It is effective to use “Clean & Moisture Spray” for dry stains.
When the dirt becomes soft, take an appropriate amount of Clean & Moisture on a care sponge brush etc. to clean the inside of the oral cavity.

As an oral moisturizing gel

After oral care and brushing, take an appropriate amount on a clean finger or sponge brush and apply it evenly in the oral cavity.
If the inside of the mouth becomes dry, the causative bacteria in the mouth will grow and cause troubles. Let’s keep moisturizing.
During bedtime, saliva is reduced and the causative bacteria in the oral cavity grow. It is more effective when applied before bedtime at night when the saliva is low and the mouth is dry.

As a tongue care gel

Gently clean your tongue with a soft or tongue brush.
Since it contains no abrasives or foaming agents, it can clean the tongue coating without damaging the taste buds or changing the taste, preventing bad breath.

Oral care videos for healthcare professionals and caregivers

「”Gum and oral massage method using oral pieces”」
 
Yoshida Dental Product News No. 224
Clinical Practice Techniques Prevention / PMTC
Target group: dentist, dental hygienist, nurse, caregiver, speech therapist, caregiver
Image courtesy of Kayo Uchida Dental Hygienist

Clean & Moisture (spray)

As mouth spray

“When you can’t gargle right away” or in crowds. For preventive measures for babies. When you are worried about your mouth or when you want to moisturize, push it directly into your mouth as a mouth spray.

It doesn’t bother you to swallow only the food ingredients. It is also convenient to use in the precious outdoors of water. It does not leave a footprint on the environment when it is exhaled. You can use it on your throat during cold season.

In addition, especially before going to bed, we recommend that you use an interdental brush or floss to clean the spaces between your teeth with the oral piece in your mouth. If possible, clean your tongue with a tongue brush (a toothbrush is fine).

After rinsing, it is also effective to spread a small amount over the entire mouth, teeth, teeth, periodontium and tongue.

The day after resting after carefully taking care of your mouth with an oral piece, you will be able to feel the change in breath and mouth breath when you wake up.

As a mouth wash

Dilute about 3 pushes in about 20 ml of water in a cup and rinse for 30 seconds in the mouth.
It can also be used for cleaning dentures.

As an oral care spray

For oral care, you can use it directly to clean the dry side of the oral cavity or when you need easy oral care.
Regular spraying before going to bed or for bedridden people is also an easy way to use without taking hands.

Especially during sleep, it is a time when the causative bacteria in the mouth increase. Spraying before bedtime is also effective.

As a moisturizing spray

After oral care and brushing, spray into the oral cavity.
If the inside of the mouth becomes dry, the causative bacteria in the mouth will grow and cause troubles. Let’s keep moisturizing.
During bedtime, saliva is reduced and the causative bacteria in the oral cavity grow. When saliva is low and mouth is dry, it is more effective to use at night before bedtime.

As a tongue care spray

Spray on your mouth and gently clean your tongue with a soft or tongue brush.
You can clean the tongue coating without damaging the taste buds or changing the taste, and prevent bad breath.

MEDIA  INFORMATION

Other videos and articles can be viewed online.

Q  &  A

First is the confirmation of “all ingredients”.

Whenever you buy a product that puts in your “mouth”, which is the entrance to all your important physical and health needs to build your body and mind,
We recommend that you check the “all ingredients” of each product yourself before making a selection.

You can find “all ingredients” on the Internet and on product packaging.

In many cases, consumers are often distracted by the “non-essential nature of the product.”

However, in the world of science, research, and manufacturing, all new research and technological innovations and efforts for safety that are the background of products result in the achievement of “all ingredients”.

When selecting a product, it is most important to check the “all ingredients” and determine the essence of the product.

Second is the confirmation of “research background” and “results”.

What kind of project members, universities/graduate schools and research institutes are you conducting research (national institutions or private institutions/public competitive institutions with international competitiveness)?

What kind of career and profile does the technology/product have been researched and developed by a researcher (a researcher who has international competitiveness in his/her institution or specialized field)?

What are they studying for?

And does the research/technology have innovation and objective advantages (such as “patents”, “papers”, “awards”, and “newspapers”)?

“Research background” and “data”, “papers” and “patents”, “awards” and “media publications” for each product can be easily searched on the Internet.

In order to select a product, it is important to identify what kind of research institute, researchers, involved members, etc. are engaged in the “research background” and what “results” are obtained as a result.

Thirdly, what kind of newspapers, televisions, and other news media, and public media, such as magazines, handle these research results and products?

Is it a research result or product that has value as news that is treated as an article rather than an advertisement by a reliable news agency or public media?

News reporters receive and exhaust press releases from numerous research institutions and companies every day.

What is reported through a reporter’s filter is a major factor for many non-specialty consumers to judge whether research results with new social usefulness or products with unprecedented value.

Fourthly, what kind of medical institution/store is selected and in what countries are they sold and used?

At highly reliable medical institutions and stores such as department stores, there are medical staff and buyers who select products to handle.

They choose various products in the world at their own risk and choose products that patients and customers can proceed with confidence in their hospitals and stores.

With so many things and information overflowing all over the world, there are shops with high-quality stores that consumers can definitely buy here.

It means that the products selected by those medical institutions and department stores are the products that should be recommended to important patients and customers by the filters of discerning buyers who are overlooking the products of the world.

In addition to the official local sale of products in one country as well as in countries around the world, strict approval by the health authorities of each country is required.

The products that are officially sold locally are the products that have been carefully examined in their respective countries and judged to be used as those that contribute to the health of the people.

What kind of medical institution/administrative/public institution, what kind of store department and store are the products selected and handled?

Is it a product that is sold all over the world? And is it a product that is needed by many people around the world?

For many consumers who do not have specialized knowledge, it is important to keep calmly aware of the handling and sales results of the product in order to distinguish it from other products in the world, the essence of the product, the superiority of research and technology, and the product to choose. It will be a factor to judge.

Finally, it is confirmation of “sociality”.

Whether the product/business depends on the selection and is good not only for yourself but also for society and others, is it a product that gives priority to human health and environmental consideration, is it a product for mere commercial purposes, or is social It is important to check if the product you are working on and so on.

We are now in an era where the actual conditions and management attitudes of the above companies can be easily searched on Wikipedia.

It is important for medical professionals and consumers to judge not only the product specifications themselves, but also the “sociality” of products and companies.

Nowadays, various information is overflowing, and companies and products are also overflowing. In order to protect the health of ourselves, families and patients, we need to identify the essence and select products.

Currently, oral care products (antibacterial and moisturizing) on the global market are broadly classified into the following categories:

①Products made with artificial sweeteners, preservatives, synthetic polymers, and flavorings to make tooth brushing easier(No antibacterial properties)
●“Sweet gels and liquids”
(base material, ingredients: artificial sweeteners such as aspartame, sorbitol, sucralose, maltitol, erythritol, sodium saccharin, water-soluble synthetic polymers such as carbomer, sodium polyacrylate, hydroxyethyl cellulose, Liquid plastics, synthetic fragrances, synthetic preservatives such as parabens, phenoxyethanol, sodium benzoate, potassium sorbate, BG, PG, etc.)

Furthermore, in addition to the base material of ①,

②Contains synthetic disinfectants, chlorine, bleach, surfactants, other chemicals and compounds, and antibiotics for the purpose of killing oral bacteria.
Chemical gels and liquids
(key ingredients: CPC, IPMP, chlorhexidine gluconate, benzethonium chloride, benzalkonium chloride, LSS, triclosan, salicylic acid, yucca extract, phenol, cresol, hydrogen peroxide, chlorine, chlorine dioxide, phosphates, iodine, formaldehyde, ammonia, cyanide/cyanic acid, pesticides/insecticide ingredients, etc.)

③ For the purpose of sterilizing oral bacteria, products that contain saliva components such as glucose oxidase and chemically react with saliva components in ppm units (thiocyanate) to generate cyanide in the oral cavity.
● “Thiocyanate gel and liquid”
(key ingredients: glucose oxidase, lactoperoxidase, potassium thiocyanate, sodium thiocyanate, hydrogen peroxide)

④For the purpose of sterilizing oral bacteria, it contains strong alkalis with a pH of 10 or higher (K hydroxide, caustic potassium, sodium hydroxide, caustic soda) and electrolyzed alkaline water.
●“Strong alkaline gel and liquid”
(key ingredients: potassium hydroxide, caustic potash, sodium hydroxide, caustic soda, alkaline electrolyzed water, pH adjustment strong alkaline agent, salt)

⑤Contains alcohol (ethanol), natural toxin antibacterial ingredients (plants/organisms), lactic acid bacteria themselves, heavy metals, etc. based on the effect on oral bacteria.
●”Gel and liquid containing naturally derived ingredients”
(key ingredients: grain ethanol, hinokitiol, catechin, mastic resin, St. John’s wort essential oil, wintergreen essential oil, tea tree essential oil, plant extract, koji extract, Chinese herbal medicine, alkaloids, propolis, yogurt, lactic acid bacteria themselves, lactic acid bacteria culture extract, mold products, silver and zinc, etc.)

⑥ Contains lactic acid bacteria antibacterial peptide for the purpose of cleaning oral bacteria.
●“Lactic acid bacteria antibacterial peptide gel and liquid”
(key ingredient: lactic acid bacteria antibacterial peptide)

It is said that there are 6 categories as above.

Until the 2010s, before the coronavirus pandemic, category 3, which also included products for human use, accounted for a large share, but the formulation changed in 2015 in response to the European Union (EU) regulations on chemical substances in 2014. As a result, it has become a ① category, and the share of ① is increasing, and since 2020, the miscellaneous goods industry and mail order businesses have entered the ④ category one after another, and the ④ category is also growing. Regarding ② and ⑤, the main products are human products, and although there are sub-line players, they are on the decline.

The exact market size of each category, future growth potential, health/environmental/business risks, position map of each brand, market share, and market trends 30 years from now are currently under investigation, but health and environmental protection are important. In the 21st century, there will be a generational shift to alternative green technologies, and category 6 will become mainstream.

DTC World Pets product review 2024 Health and Environment

It is a coined word that combines oral and peace.

It is said that about 700 kinds of bacteria are always present in the oral cavity, and they maintain a balanced and healthy condition.

If this calm balance is disturbed and the total number of bacteria increases too much, you will end up in an unhealthy state and get sick.

Therefore, we named it “ORALPEACE” in the sense that “it maintains a peaceful state in the oral cavity with safe ingredients.”

It also expresses peace of mind, family health and peace.

Yes, it is made in Japan.

Like medical products , ORALPEACE is produced cleanly in a factory dedicated to cutting-edge oral care that is strictly controlled under Japan’s Pharmaceutical Affairs Law, and during the distribution process, it is kept clean and safe as something to be put in the mouth. We strive to deliver the products so that they can be used at hospitals and at home.

As mentioned above, we are working hard every day to meet the “clean Japanese quality” you mentioned.

For any other questions, please see our Frequently Asked Questions.

Thank you for your continued support of the ORALPEACE project.

The major differences are:

“It contains the patented formulation “Neonisin-e®”.”

“We are conducting research to respond to bacteria that cause oral problems with safe ingredients.”

Safe to swallow, 100% naturally derived, only food ingredients, organically certified toothpaste, oral care products can be made without the need for basic research or patented technology at national universities or research institutes.

Regarding ORALPEACE, we think that it is almost the same as other safety-promoting oral care products unless “Neonisin-e®︎” is added.

Gels with similar shapes can be easily and inexpensively made at home if you purchase the materials at online shops.

[How to make a toothpaste gel]

In the case of “Toothpaste Gel”, refer to the ingredients of your favorite product and refer to the ingredients of glycerin (moisturizer) and mint essential oil or orange essential oil (preferably organic certified) and thickener xanthan gum at online shops etc. If you purchase it and mix it at home, you can make a toothpaste gel with 100% food ingredients that are safe ingredients made only from food ingredients.

If you want sweetness for children, xylitol, which is an alternative sweetener for sugar, is also sold at online shops, so you can mix it.

Also, if you want to see if lactic acid bacteria (itself) actually has an effect or effect on the oral cavity and teeth, mix the yogurt supernatant (lactic acid bacteria fermentation extract/whey) or yogurt itself (live lactic acid bacteria) I think that is also good.

If the lactic acid bacteria contained in the product are alive, it is possible to make it by culturing and fermenting the bacteria from milk at the home in a yogurt maker.
(Products such as yogurt that are sold in refrigerated storage without preservatives and bactericides. Products that are distributed at room temperature will ferment and decay when lactic acid bacteria are alive. It is inactive because it is sterilized by mixing with a strong alkali, and the lactic acid bacteria have been killed and left behind.)

[How to make natural toothpaste (abrasive)]

In the case of “natural toothpaste”, similarly, calcium carbonate, Ca carbonate (abrasive, limestone powder, white line powder on the playground, raw material for chalk), glycerin (moisturizer), and mint essential oil (with organic certification) Is preferred), and you can easily make natural toothpaste powder by purchasing it at an online shop or drug store and mixing it with water at home.

In addition, you can get your favorite plant extract, essential oil, xylitol, propolis, sodium hydrogen carbonate (baking soda, polishing action, strong alkali), salt (polishing action, preservative), other polishing agents, etc. at the online shop. It is an ingredient that is easy to obtain, so I think you can try mixing it.

You can purchase undiluted solutions of almost all of the above materials and various ingredients and extracts that have been appealed as key ingredients of cosmetics at online shops.

I think that it is a good opportunity to actually try on your own oral cavity and teeth and judge for yourself what kind of effect these ingredients can be expected and realized clinically in the oral cavity and teeth. ..

The above is not a patentable ingredient, so anyone can mix it to make a toothpaste gel or paste.

However, in order to respond to the needs of the new 21st century and to cope with bacteria causing troubles in the oral cavity in clinical settings of medical care and nursing care, a patent for lactic acid bacteria antibacterial peptide invented in joint research with Kyushu University etc. over 10 years The formulation “Neonisin-e®” (cleaning aid) is a research result/invention that plays a major clinical role that could not be realized with conventional ingredients of natural origin.

To experience the difference, use an interdental brush or floss to clean the spaces between your teeth with the oral piece in your mouth before bedtime, and use a tongue brush (a toothbrush may be used) to clean your tongue. After cleaning and rinsing again, we recommend that you spread a small amount over the entire mouth, teeth, interdental space, periodontium, and tongue.

The next day after carefully taking care of your mouth and resting, you will be able to experience the changes in bad breath and mouth refreshment when you wake up.

We believe that ORALPEACE has no new significance for humankind as a product unless it contains “Neonisin-e®”.

The major differences are as follows.

Regarding research on response to bacteria causing oral problems,

“Use of lactic acid bacterium antibacterial peptide “Neonisin-e®︎” instead of conventional synthetic bactericides and alcohols”

“The product is made only from food ingredients that are considered safe even if swallowed.”

“Chemical synthetic ingredients such as synthetic bactericides and alcohol are not added to the product”

We are responding to the new world-wide medical and nursing care clinical needs and consumer needs, bacteria that cause oral problems.

“I want to use ingredients that are safe to swallow,”

“I would like to use a safe antibacterial agent that replaces conventional synthetic antibacterial agents, alcohol (ethanol), and highly concentrated plant antibacterial agents with side effects.”

In order to respond to the aging of the world and the paradigm shift towards the consumer’s safety and health consciousness, a century after the birth of toothpaste, the lactic acid bacterium antibacterial peptide “Neonisin- e®” research.

ORALPEACE is a new product invented and developed in Japan in the 21st century for the following people.

Worried about problems in the oral cavity,
I’m careful about what I eat,
We are committed to family health and prevention,
Want to avoid daily oral intake of chemical ingredients,
Pregnant woman/lactating
I don’t like additives or synthetic fungicides,
Elderly people and illnesses requiring nursing care who have difficulty gargle or spit and accidentally swallow the product,
Infants,
Pets,
And I do not want to destroy the natural environment with persistent chemical products.

And ORALPEACE is a product for people all over the world who really need ORALPEACE not only to pursue the superiority of the product but also to sympathize with the background of the brand and contribute to society through the business.

A naturally derived oral care formulation invented in Japan.

For details, please see the “Neonisin®” website.

The “selection points for oral care products, oral hygiene agents, oral moisturizers, oral moisturizers, and oral care products” that are expected to have the function of simultaneously moisturizing while providing oral care are as follows.

First and foremost, try the tasting yourself. With this, you can understand most of the differences, such as “feeling whether it is a safe ingredient even if swallowed as it is” “feeling whether it feels good or bad when put in the mouth” “real feeling of effect of using” I will.

Secondly, it may be important to confirm whether or not “ingredients that are expected to have safe antibacterial properties even if swallowed” are included.

In order not to increase bacteria causing troubles in the oral cavity, mere moisturizers (gels such as glycerin and hyaluronic acid) cannot meet the needs of clinical sites, and “a product containing an antibacterial agent that is safe to swallow” is the oral cavity. It is considered highly useful in terms of cleanliness, moisturizing, and keeping cleanliness.

The third major point is the patient’s feeling of use.

Materials that contain a large amount of chemical components such as synthetic thickeners and synthetic polymers, which are not food products, have low raw material costs, but have problems in terms of usability and water solubility. In other words, it feels like a foreign body in your mouth and you feel uncomfortable. For example, it feels like vaseline, lard and paint cling to your mouth all the time.

You can also check the water solubility of each product at home.

Put a small amount of the product you want to compare with a petri dish (a small plate is also acceptable).

Then add water and leave for about 1 hour.

Finally, flush the water and watch the condition of the remaining wetting agent.

If it remains unmelted, it will feel like sticking to the upper jaw. There is a type that remains almost as it is even if water (saliva) is attached, to a type that naturally spreads and spreads with water (saliva) thinly and moisturizes like Oral Peace Clean & Moisture.

Substances that are difficult to dissolve that contain a large amount of chemical raw materials are difficult to digest in the human body and decompose by microorganisms in the intestinal tract, and also difficult to biodegrade by microorganisms even if they are discharged to the natural world.

Whether it does not melt in saliva and feels like it remains in the mouth, or it spreads well in the mouth and is moisturized without any discomfort is better for myself, my family, and patients. We recommend that you choose the best product.

It is important to thoroughly understand the research and development background of each product and the characteristics such as feeling of use, and select the product that meets the needs of users.

ORALPEACE has been developed with the aim of making it a product that can be used by infants, the elderly who need care, elderly people who are difficult to gargle and vomiting, fighting persons and people with disabilities.

Originally, we have spent a lot of time researching and developing foods that human beings have eaten since ancient times, and products that use only plant-derived food ingredients whose safety has been verified by insurance organizations around the world.

Therefore, we do not use chemically synthesized ingredients, petroleum-derived ingredients, or even plants that have no edible history.

Even if it is recognized as a raw material for food, it was developed with the policy of not adding chemical synthetic components or petroleum-derived components.

Regarding the antibacterial peptide (bacteriocin) that may be produced by the compounded lactic acid bacteria component, those that have not been approved as food or food additives after undergoing safety verification by the World Health Organization or the Japanese Ministry of Health, Labor and Welfare Is not used at all.

There are various kinds of “lactic acid bacteria” that you can eat.

Lactic acid bacteria taken from plaque in the mouth of people who cannot brush their teeth but have caries or periodontal disease, and lactic acid bacteria ingested from other people’s mouth or excrement are unapproved substances as food. ..

The only ingredients used in ORALPEACE are those approved by WHO, GRAS certified in the United States, and approved by Japan’s Ministry of Health, Labor and Welfare as foods.

Regarding antibacterial peptides (bacteriocin), we also avoid blending non-approved food products.

Not used

ORALPEACE is made from water and all-edible plant-derived food ingredients.

ORALPEACE is a product newly developed for elderly people requiring nursing care, fighting patients, infants, etc. who have difficulty in gargle and vomiting. It was created with a lot of effort and more than 10 years.

All ingredients, except water, are made from plant-derived food ingredients. It is made entirely of plant materials that are sustainable and environmentally friendly, rather than limited fossil materials such as petroleum.

Synthetic agents derived from petroleum such as cetylpyridinium chloride (also known as cetylpyridinium chloride/CPC), benzethonium chloride, chlorhexidine gluconate, IPMP (isopropylmethylphenol), and triclosan, which are chemically synthesized from light oil, etc., are not added.

The above are extremely powerful bactericides, and the Ministry of Health, Labor and Welfare strictly limits the compounding percentage in products, and there are side effects to the action.

However, in practice, among the petroleum-based synthetic bactericides, it has been recognized in the world’s research that a concentration of 0.1% or more is effective, but in one country, the concentration recognized in product formulations is 0.05% or less. As a product, it is difficult to expect actual clinical effects.

On the other hand, side effects such as taste disorders and black hair tongue may occur due to long-term use even at low concentrations where no effect can be expected, and there have been difficult problems with actual clinical use.

For details on the synthetic fungicides derived from petroleum, their effects, side effects, and their environmental impact, please do your own research on the Internet.

Not compounded.

Alcohol (ethanol) is not added so that it can be used by infants, those who do not want to take alcohol, and those who are dry.

Alcohol has the effect of clearing the inside of the mouth and not spoiling the product, but it may cause damage to the oral mucous membranes, thirst in the mouth, and dry teeth in the oral cavity. There are side effects that can cause trouble.

Therefore, it is unblended in ORALPEACE.

If you like alcohol (ethanol), we would appreciate it if you could get a high-frequency alcohol product from a pharmacy or a liquor store and use it with ORALPEACE.

Do you mix bleaching agents such as chlorine, chlorine dioxide (CIO2), sodium chlorite, sodium hypochlorite, chlorine-based gas, etc.?

ORALPEACE does not contain bleach, chlorine, chlorine dioxide (CIO2), which is a deleterious substance used for disinfecting and disinfecting pools, sodium chlorite, sodium hypochlorite, chlorine-based gas, etc. ..

ORALPEACE has devoted a great deal of time to research and development aiming at products that can be used by elderly people, fighters and people with disabilities who require nursing care, which makes it difficult to gargle and spit.

Please investigate the effects, side effects, and effects on the human body of chlorine and chlorinated gases on the Internet by yourself.

All components of ORALPEACE are made from plants (food) except water.

It is made entirely of plant materials that are sustainable and environmentally friendly, rather than limited fossil materials such as petroleum.

Also, ORAL PEACE is a product that you can put into your mouth.

Regarding the lactic acid bacteria used during the production of “Neonisin-e®”,

Not “animal-derived fungus” that lives in “excretion” in the intestinal tract of “animal”, which is found from human or animal feces, etc.

We use “Lactococcus lactis”, which is a “plant” found in “Tofu” from Japan and a “plant-derived fungus” that lives in “food”.

Not compounded.

ORALPEACE contains the bacteriocin preparation “Neonisin-e®︎” (cleaning aid), which is a highly purified lactic acid bacterium peptide produced by lactic acid bacteria.

Regarding the clinical effects of adding “lactic acid bacteria” itself to oral care products, we would like to ask you to visit the website of “Neonisin” for the past problems by research institutions around the world.

In addition, there is a big problem that “a product containing lactic acid bacteria” and the following ingredients “cannot be combined together”.

“Antibacterial substances” and “preservatives” “alcohol (ethanol)” “synthetic germicide” “sodium hydrogen carbonate (baking soda/alkali)” etc.

Because, “antibacterial substances” such as lactic acid bacterium bacteriocin, “preservatives” such as paraben, phenoxyethanol, sodium benzoate, K sorbate, alcohol (ethanol), “synthetic germicides” and “sodium hydrogen carbonate (sodium bicarbonate/alkali)” )” is for killing the “lactic acid bacteria” mixed together.

Also, if you want to use oral care products that can be stored and used at room temperature instead of refrigerated storage like yogurt, it is necessary to sterilize because “lactic acid bacteria” will perish if they are alive.

Therefore, a product that contains both “lactic acid bacteria” and “antibacterial substances” is said to have “combined both components that evoke the effect.”
Actually, “lactic acid bacteria” have been killed by “antibacterial substances” etc., and there was a problem that it became meaningless in use and clinical.

ORALPEACE contains “Neonisin-e®︎”, which is a purified peptide produced by lactic acid bacteria, and does not contain “lactic acid bacteria” itself.

ORALPEACE does not contain lactic acid bacteria itself, but “Neonisin-e®︎” is produced from lactic acid bacteria.

The lactic acid bacteria used for the production are explained below.

Even if you say “lactic acid bacteria” that you can eat, their habitat and origin are various.

Even if you say “lactic acid bacteria” with a good image, it will be completely different depending on the bacterial species and strain.

There are also lactic acid bacteria derived from the ground, rivers, insects and animals, and humans. There are also lactic acid bacteria that live in the intestinal tract (feces) and excrement of animals, and in blister and sludge.

There are also lactic acid bacteria found in plaque accumulated in the mouth of people who cannot brush their teeth but have caries or periodontal disease, and lactic acid bacteria found in the feces and dirt of other people.

In fact, the strains of adult feces and dental plaque are often stronger than the bacteria of infants and children’s feces and dental plaque, and the product contains bacteria isolated from adult human feces and dental plaque. The reality is that they are often used.

However, until now, in the practical application of lactic acid bacteria research by research institutes all over the world, yogurt, beverages and oral products produced by fermenting feces and plaque of other people have been consumer-oriented and are themselves, families, children and patients. There was a big problem that I didn’t want to put it in your mouth.

Regarding the antibacterial peptide (bacteriocin) that may be mixed in the “fermented products” of the bacteria derived from feces and dental plaque, there is a possibility that the habitat of the bacteria may be effective against miscellaneous bacteria. Antibacterial peptides (bacteriocin) other than “A” are unapproved substances that have not been verified for safety by WHO, the world health organizations, or the Japanese Ministry of Health, Labor and Welfare.

The lactic acid bacterium “Lactococcus lactis” contained in ORALPEACE is a lactic acid bacterium discovered in “Tofu”, a clean and safe food produced in Japan.

And for decades, a lactic acid bacterium that lives in plant-derived foods that mass-produces lactobacillus antibacterial peptide “Nisin A”, which has been licensed all over the world. It is a research result.

The lactic acid bacteria used in ORALPEACE are clean and safe lactic acid bacteria found in foods derived from edible plants called tofu, so you can safely put them in your mouth.

For the type and origin of lactic acid bacteria that you put in your mouth, we recommend that you check the name of each bacterium on the Internet.

Not used at all.

As mentioned above, this point is a major advantage of ORALPEACE in the world due to the background of long and deep research including the world’s leading researchers in lactic acid bacteriocin research.

ORALPEACE is a product that you can put in your mouth.

Not “animal-derived fungus” that lives in “excretion” in the intestinal tract of “animal”, which is found in the feces of humans and livestock

Regarding the lactic acid bacteria used during the production of “Neonisin-e®”,

We use “Lactococcus lactis” which is a “plant” found in Japanese “tofu” and a “plant-derived fungus” that lives in “food”.

For the type and origin of lactic acid bacteria that you put in your mouth, we recommend that you check the name of each bacterium on the Internet.

The labeling of “Neonisin-e®︎” is “Lactic acid bacteria culture extract”, “Plum fruit extract”, and “Damask rose oil”.

This is because “Neonisin-e®︎” is a mixture of the above ingredients.

Ordinary “lactic acid bacterium culture/fermented extract” is a liquid obtained by fermenting lactic acid bacteria, and in many cases, it is like the supernatant of yogurt. And many things such as water, impurities, and salt are turbid in the fermented liquid.

On the other hand, “Lactobacillus culture extract” used in “Neonisin-e®” is very different from other fermentation broths, and only the antibacterial peptide “Nisin A” produced by lactic acid bacterium from the fermentation broth fermented It will be isolated and highly purified by biotechnology.

It is “highly purified nisin A” as a highly pure lactic acid bacterium antimicrobial peptide liquid that can be extracted from a normal lactic acid bacterium fermentation liquor in an amount of only about 1/10, manufacturing costs and labor are more than 10 times.

Highly purified “Nisin A” has a 100 times or more difference in purity, degree of purification, stability and effect from the fermentation liquid of normal lactic acid bacteria.

The patented ingredient “Neonisin-e®︎”, which has been researched and developed through industry-academia collaboration with Kyushu University, etc., has the same label name as other “lactic acid bacterium culture/fermentation extract” “enzyme” etc. However, the reality is that the dimensions are completely different.

ORALPEACE does not contain Forever Chemical (PFAS), which has been strongly suspected of being linked to cancer and fetal growth disorders, and whose regulations have been significantly tightened, including complete banning.

For more information about “Forever Chemicals (PFAS),” which is now a worldwide problem for all of humanity, please check the news reports on the Internet and TV, and be mindful of the health of your children and other important family members. Thank you very much.

Now in the 21st century, where the destruction of the earth’s environment and the health risks to humankind have become more apparent, we are living in a world where the effects of persistent substances developed and utilized in the 1900s (that are not biodegradable by bacteria in the natural world and that can be absorbed into the human body, the internal organs of living things, soil, and water) Since the 2010s, it has become clear that chemicals (forever concentrated and accumulated) pose serious risks to humanity, including health damage, environmental destruction, and contamination of food and drinking water.

ORALPEACE does not contain potassium thiocyanate for the following reasons.
 
The “potassium thiocyanate” you are asking about seems to be a chemical substance that is useful as a “raw material for plating,” “a raw material for the production of synthetic resins,” “agrochemicals,” “insecticides,” etc.

The purpose of its inclusion in oral care products seems to be to combat oral bacteria, but since it is a chemical that also affects the human body, we cannot confirm that it has been approved for inclusion in human food. I think there may be issues with edible consumption and accidental ingestion.
 
According to literature on the Internet, the enzyme causes a chemical reaction in the presence of thiocyanate, generates ions, and exhibits antibacterial activity. However, the “thiocyanic acid and its salts” used have problems with their effects on humans and aquatic organisms in the environment.
  
(Source: Advanced Utilization of Milk P375 Reference)
There is a method that uses chemical reactions of enzymes to sterilize and preserve milk. The antibacterial effect is due to the lactoperoxidase activity of the enzyme contained in milk. The enzyme decomposes hydrogen peroxide in milk into water and active oxygen, and the active oxygen generated here is converted into thiocyanate ion (SCN), which is present in small amounts in milk. -) is said to be oxidized into hypothiocyanate ion (OSCN-) through a chemical reaction. This hypothiocyanate ion is said to exhibit antibacterial activity against some Gram-negative bacteria such as Escherichia coli by inactivating the SH enzyme within the bacterial cells. (However, it has a narrow antibacterial range and does not show antibacterial activity against other Gram-negative bacteria and Gram-positive bacteria such as caries bacteria.)
For the antibacterial activity of lactoperoxidase to work efficiently, approximately 12 ppm of thiocyanate ions and approximately 8 ppm of hydrogen peroxide are required for the chemical reaction, but only 1 to 10 ppm of thiocyanate ions are present in milk. First, it is necessary to add thiocyanate ions and hydrogen peroxide.

However, Japan’s Ministry of Health, Labor and Welfare does not by law permit the addition or residual presence of thiocyanic acid or hydrogen peroxide in food or milk, even in trace amounts of ppm (1 part per million, 1 ppm = 0.0001%). Therefore, in Japan, the antibacterial effect of lactoperoxidase, which is added with potassium thiocyanate, cannot be used to sterilize and preserve milk or to prevent E. coli contamination. (Hydrogen peroxide is carcinogenic, but easily decomposed, and if it does not ultimately remain in food, the law has been revised to permit its use in sterilization, bleaching, etc.)
https://otemae.repo.nii.ac.jp/record/1979/files/2000_jc_h359-392_yagi.pdf
 
In addition, the International Dairy Federation states that lactoperoxidase/thiocyanate/hydrogen peroxidase (lactoperoxidase system) is a chemical means of preserving raw milk when refrigeration conditions cannot be secured, such as in developing countries in tropical regions. Milk quality can be temporarily controlled during milk storage and transportation to processing plants. In 1991, the Codex Alimentarius Alimentarius Alimentarius, an intergovernmental organization established by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO), decided to In countries where refrigeration is not possible, the use of peroxidase systems is permitted, but any trade in milk treated with lactoperoxidase systems is subject to mutual agreements between the parties without prejudice to third countries. It is recommended that this should be done based on the following. However, decomposition products of chemical activators such as cyanic acid may be a concern. Continuous consumption of high or even low concentrations can have an adverse effect on the health of consumers. The conclusion is that in developing countries, especially small-scale dairy producers operating in villages in areas with temperate or tropical climates without refrigeration, it is important to There may be no other option than using an activator. This method is a low-cost option that provides a source of income for farmers and maintains the quality of nutritious food. However, in order to maintain a positive image of dairy products among consumers and to increase the consumption of milk and dairy products in all parts of the world, this option should only be used when no other options are available. There is. (Source: International Dairy Federation Lactoperoxidase IDF Fact Sheet January 2013)
https://www.j-milk.jp/jidf/wp-content/uploads/2017/02/j-The-Lactoperoxidase.pdf

*While cyanide is generally bactericidal, it is also highly toxic. Cyanide contains cyanide ions (CN^-), which affect the respiratory chain of cells and inhibit oxygen utilization, resulting in cell death. Therefore, when used in proper concentrations, cyanide can kill bacteria and other microorganisms. However, it is also harmful to humans and animals, so care must be taken. (Source: ChatGTP)

Furthermore, we were unable to confirm any clinical efficacy data or academic papers on potassium thiocyanate against oral bacteria that cause plaque, tartar, and periodontal problems in humans and animals.

“Potassium thiocyanate” appears to be a chemical substance that is not approved as a food in Japan.

List of food additives in Japan (Source: Japan Food Additives Association)
Existing additives (revised on February 26, 2020) Designated additives (revised on March 1, 2020)
https://www.jafaa.or.jp/tenkabutsu01/tenkaichiran

Japan’s Ministry of Health, Labor and Welfare has classified potassium thiocyanate as a “dangerous substance” that must not be put into the mouth or taken continuously.

“Potassium thiocyanate”
Source: Ministry of Health, Labor and Welfare
https://anzeninfo.mhlw.go.jp/anzen/gmsds/333-20-0.html
[Summary of hazards]Health hazards Acute toxicity (oral) Category 4
Specific target organ/systemic toxicity (repeated exposure) Category 1 (thyroid)
Hazardous to the environment Acute hazard to the aquatic environment Category 3
[Label element]Pictogram or Symbol Exclamation Mark Health Hazard
Signal word: danger
Hazard statement: Harmful if swallowed
Thyroid damage due to long-term or repeated exposure
Harmful to aquatic life
【Safety measure】
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
Do not breathe dust, fumes, vapors or spray.
Avoid release to the environment.
[First aid measures]If swallowed: Call a doctor if you feel unwell.
Rinse mouth.
If you feel unwell, seek medical advice and treatment.
[Chemical name or common name]potassium thiocyanate
Other names Potassium rhodanide, Potassium sulfocyanide
[Molecular formula (molecular weight)]KSCN (97.18)
[CAS number]333-20-0
[Official Gazette Publication Number (Chemical Substances Control Law/Safety and Safety Law)](1)-152
[Expected acute symptoms and delayed symptoms]Ingestion: confusion, convulsions, nausea, vomiting, weakness
[Specific hazards]It is non-combustible and will not burn itself but may decompose when heated producing corrosive and/or toxic fumes. In the event of a fire, irritating, corrosive and toxic gases may be generated.
[Environmental precautions]Should not be released into the environment.
[Possibility of hazardous reactions]The substance decomposes producing highly toxic fumes (sulfur compounds, nitrogen oxides, cyanides). Reacts violently with strong oxidants. Strong cooling effect when in contact with water.
[Hazardous decomposition products]Very toxic fumes (sulfur compounds, nitrogen oxides, cyanides)
[Acute toxicity]Oral rat LD50 value: 854 mg/kg (RTECS (2007): Original document Journal of the American Pharmaceutical Association, Scientific Edition. Volume 29,152 (1940)). “See also other thiocyanates for health hazards” (GHS classification: Category 4)
[Specific target organ/systemic toxicity (repeated exposure)]Although there is no data on this substance, thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))
[Environmental impact information]・Ecotoxicity
Hazardous to the aquatic environment (acute hazard) 96-hour LC50 for fish (rainbow trout) = 52.5 mg/L (ECETOC TR91, 2003). (GHS classification: Category 3)
– Hazardous to the aquatic environment (long-term hazard) Acute toxicity category 3, non-rapidly degradable (BIOWIN), 124-day NOEC (reproduction) for fish (rainbow trout) = 1.1 mg/L. (GHS classification: Not classified)
[Disposal precautions]Residual waste Before disposal, treat it as much as possible to make it harmless, stabilize it, neutralize it, etc. to reduce its hazardous level to a low level.
When disposing of the product, follow relevant laws and regulations and local government standards.
If an industrial waste disposal company licensed by the prefectural governor or a local government is in charge of the disposal, the disposal is outsourced to them.  
[Contaminated containers and packaging]Clean and recycle containers or dispose of them appropriately in accordance with relevant laws and regulations and local government standards. When disposing of an empty container, completely remove the contents.
[Transportation precautions]Do not transport with food or feed.
A yellow card must be maintained during transportation.
  

“Potassium thiocyanate” is present in Japan’s natural environment, even if it is invisible and odorless, and even in extremely small amounts in the ppm unit (1/1 million, 1ppm = 0.0001%), it is prohibited to be released. (Ministry of Health, Labor and Welfare) and Japanese law stipulates that it must not be detected (quantification limit 0.1 mg/L, Ministry of the Environment).

Ministry of the Environment Basis for setting environmental standard items, etc.
Total cyanide (thiocyanate)
https://www.env.go.jp/council/09water/y095-05/mat05.pdf

After the war, from the 1930s to the 1930s, in the industrial area of the downtown area where there were many plating factories, there were pollution problems such as cyanide poisoning by craftsmen and dumping into rivers, lakes, and the sea, which wiped out fish, shellfish, and algae, making fishing grounds unusable. In the past, administrative personnel at ward offices and other offices have worked on health education for workers, water purification and coordination of issues with artisanal fisheries, and industrial promotion and health coordination with local residents.

A notable example is that even a small amount of cyanide-containing wastewater from a plating factory can cause fish death.
Source: Industrial Wastewater and Fisheries Chemistry and Biology 1962
https://www.jstage.jst.go.jp/article/kagakutoseibutsu1962/1/1/1_1_24/_pdf/-char/ja

In recent years, the Ministry of the Environment has been conducting an environmental survey of “thiocyanate” in Japan’s environment, and concentrations exceeding standard values have been detected in various places, creating a problem.

Ministry of the Environment 2018 detailed environmental survey results “thiocyanic acid and its salts (CAS registration number: 463-56-9, etc.)” https://www.env.go.jp/chemi/kurohon/2019/shosai/2_0.pdf (P120)

[2018 survey medium: water quality]Reason for request:
Copper thiocyanate is designated as a Priority Assessment Chemical Substance under the Chemical Substances Control Law, and it is necessary to consider designating it as a Class 2 Specified Chemical Substance, but as there is no research record in recent years, priority should be given to investigating the actual status of environmental residue. This was because it was necessary to conduct research and understand the actual situation in the environment. In addition, copper thiocyanate is treated as ion thiocyanate in the analysis method applied in this study.

Since it is possible to measure only the amount of thiocyanic acid and its salts, in this study, we conducted a survey in which the total amount of thiocyanic acid and its salts was measured. 


Survey details and results:
<Water quality>
Regarding water quality, 2018 was the first time for this survey, and 24 points were investigated, and the lower limit of detection was 1.1 ng/L, and it was detected at all 24 points, and the detected concentration was 2.5 to 120 ng/L. It was in the range of L.

[Reference: Regarding thiocyanic acid and its salts]・Application:
The main uses of sodium thiocyanate are as a solvent for acrylic fibers, dyes, herbicides, and pharmaceuticals. 

The main uses of potassium thiocyanate are synthetic resins, insecticides and fungicides, dye synthesis, photographic aids, reagents, and plating. 

The main uses of copper thiocyanate are ship bottom paints, antifungal agents, insecticides, copper plating, lubricating oil additives, photosensitizers, color formers for recording paper, and toothpaste. 

The main use of mercuric thiocyanate is as an analytical reagent. 

The main uses of ammonium thiocyanate are synthetic resins, hydrogen peroxide stabilizers, dyeing aids, photography, fertilizers, and herbicides. 

・Production volume/Import volume:
FY2017: Manufacture/import less than 1,000t (value published as a result of general chemical substance notification under the Chemical Substances Control Law)
・Distribution prediction by medium:
Thiocyanic acid: water 39.5%, sediment 0.08%, air 21.2%, soil 39.2%
Copper thiocyanate (I): water 33.7%, sediment 0.0737%, air 2.65%, soil 63.6%
・Acute toxicity, etc.:
Sodium thiocyanate: LD50 (dose that causes 50% mortality) = 232 mg/kg rat (oral) iv) LD50 = 362 mg/kg mouse (oral) LDLo = 600 mg/kg guinea pig (oral) iv LDLo = 750 mg/kg rabbit (oral)
Ammonium thiocyanate: LD50=24.5mg/kg mouse (oral) iv) LD50=46mg/kg rat (oral) iv)
Mercury(II) thiocyanate: LD50=24.5mg/kg mouse (oral) LD50=46mg/kg rat (oral)
・Ecological impact:
Thiocyanate: 96h-LC50 (50% mortality concentration) = 0.09 mg/L: Grass shrimp (Palaemonetes pugio) 96h-LC50 = 0.15 mg/L: Fathead minnow (Pimephales promelas)
Copper thiocyanate: PNEC= 0.0000031mg/L (Reason: 96h-LC50 (Rainbow trout lethal)=0.031mg/L, assessment coefficient 10,000)
・Regulations
[Chemical Substances Control Law] Law (revised on May 20, 2009) Article 2, Paragraph 5, Priority Assessment Chemical Substances (142 Copper(I) thiocyanate)

 

The details of “potassium thiocyanate” as a chemical substance are as follows.
 

What is “thio”:
Thio is a prefix that means sulfur. A chemical compound containing “sulfur”. A linked form used especially for special compounds in which an oxygen atom is replaced with a sulfur atom.
“Thiocyanate” is a similar chemical substance in which “oxygen” of “cyanate ion [OCN]-” is replaced with “sulfur” through a chemical reaction.

What is “cyan (CN)”:
1. A highly poisonous, colorless gas with a peculiar odor. When dissolved in water, it produces hydrogen cyanide (cyanic acid gas) and cyanic acid.
2 Blue. Blue is the primary color in paints, printing inks, etc. It has a greenish blue color. (Source: Weblio)
https://www.weblio.jp/content/%E3%82%B7%E3%82%A2%E3%83%B3

What is “cyanic acid (CNHO)”:
It is a compound represented by the molecular formula CNHO. Structural isomers include isocyanic acid (H-N=C=O) and thunderic acid (HO-N=C:). However, cyanic acid is tautomeric with isocyanic acid, and they continue to mutually convert and are in an equilibrium state. (Source: Wikipedia) https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8

What is “potassium (K)”:
Alkali metal, one of the typical elements. Potassium is an element with atomic number 19. Also called “potassium” or “potash”. The element symbol is K. It is an essential element for living things. It is a silver-white metal with a specific gravity of 0.86, which is lighter than water, the second lightest after lithium, and is a soft metal that can be easily cut with a knife. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%AB%E3%83%AA%E3%82%A6%E3%83%A0

What is “cyanide (potassium cyanide, etc., CN)”:
A name that refers to a salt that has cyanide ion (CN-) as an anion. Also called cyanide, cyanide, cyanide, and cyanide. Cyanide compounds, as “potassium cyanide” is famously known, are generally toxic to the human body, and even small amounts can cause death. In order to protect the developing fruits and seeds from being eaten by herbivores due to the struggle for survival, amygdalin, a poison contained in green plums, etc. (spreading seeds) is also a cyanide compound. As the fruit ripens, amygdalin is broken down into hydrogen cyanide (hydrogen gas), benzaldehyde (an aromatic component common to almonds, apricot kernels, and loquats), and glucose by the enzyme emulsin contained in plants. disappears. The “cyanic acid” generated at this time also disappears through volatilization and decomposition. Processing also promotes decomposition. Processed products such as ripe fruit pulp and pickled plums are safe to eat if consumed in normal amounts. “Amygdalin” itself is non-toxic, but when ingested orally, it is broken down in the body by emulsin, a safe enzyme found in plants, and β-glucosidase, a safe enzyme found in human intestinal bacteria, resulting in a chemical reaction. It is said to generate dangerous hydrogen cyanide (cyanic acid gas). It is safely broken down in very small amounts, but if a certain amount is ingested, it will cause toxic symptoms such as vomiting, facial flushing, diarrhea, and headaches, and if large amounts are ingested, it may cause confusion, coma, and even death, so be careful. is required. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E7%89%A9

What is “thiocyanic acid (HSCN)”:
Thiocyanic acid is a type of inorganic acid with the chemical formula HSCN. Also called “rhodanic acid”. It is an unstable colorless liquid and a relatively strong acid. It exists as a mixture with its tautomer, isothiocyanic acid (HN=C=S). In the synthetic production method of thiocyanate, lead(II) thiocyanate is liberated by reacting hydrogen sulfide. When ammonia and carbon disulfide react, an ammonium salt of thiocyanate is produced. Some N-esters of thiocyanate (isothiocyanates) are used as insecticides. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8

What is “sodium thiocyanate (thiocyanate/NaSCN)”:
It is a sodium salt of thiocyanate with the chemical formula NaSCN. At room temperature, it is a colorless, hygroscopic crystal or white powder that is soluble in water, ethanol, and acetone. It is toxic, with an LD50 of 764 mg/kg when administered orally to rats. When ingested, it affects the central nervous system, causing symptoms such as vomiting, diarrhea, weakness, confusion, and convulsions. Although it is nonflammable, it decomposes when heated, producing toxic gas (cyanic acid gas) containing sulfur oxides, nitrogen oxides, sodium oxide, and cyanide. Reacts violently with acids, strong bases and oxidizing agents. It is used as a reagent, color film developer, herbicide, and solvent in the production of acrylic fibers. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E5 %A1%A9

What is “potassium thiocyanate (KSCN)”:
Potassium thiocyanate is a deliquescent crystalline solid. It dissolves well in water, and the resulting aqueous solution becomes very cold as it absorbs heat. Also soluble in ethanol and acetone. It is a chemical substance obtained by melting potassium cyanide and elemental sulfur, or by reacting ammonium thiocyanate and potassium hydroxide. Japan’s Ministry of Health, Labor and Welfare has designated it as a hazardous material. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E3%82%B7%E3%82%A2%E3%83%B3%E9%85%B8%E3 %82%AB%E3%83%AA%E3%82%A6%E3%83%A0

“Sodium thiosulfate (Na2S2O3)”
It is a sodium thiosulfate salt with the chemical formula Na2S2O3. Like sodium sulfite and sodium hyposulfite, it has bleaching and antioxidant effects, so it is used as a food additive in some countries. However, this is not allowed in Japan. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%83%81%E3%82%AA%E7%A1%AB%E9%85%B8%E3%83%8A%E3%83%88%E3 %83%AA%E3%82%A6%E3%83%A0

“Potassium cyanide (KCN)”
Potassium cyanide, also known as potash cyanide or potash cyanide, is synonymous with poison, but is an industrially important inorganic compound. It is designated as a poisonous substance as “cyanide” under the Poisonous and Deleterious Substances Designation Ordinance. (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E3%82%AB%E3%83%AA%E3 %82%A6%E3%83%A0

“Hydrogen cyanide (cyanic acid gas/HCN)”
Poisonous gas. Hydrogen cyanide, also known as methanenitrile, formonitrile, and formic acid nitrile, is a highly toxic substance. Its aqueous solution is weakly acidic and is called hydrocyanic acid (cyanic acid gas). Cyanide is hydrolyzed by cyanide glycosides by enzymes such as β-glucosidase found in animal intestinal bacteria, producing sugars, aldehydes, and hydrogen cyanide (cyanic acid gas). (Source: Wikipedia)
https://ja.wikipedia.org/wiki/%E3%82%B7%E3%82%A2%E3%83%B3%E5%8C%96%E6%B0%B4%E7%B4%A0

Additionally, when released into the environment, there is a risk that hypochlorous acid and thiocyanate will undergo a chemical reaction, resulting in the production of cyanide (poisonous gas) that is not anticipated or intended by the company.

Due to the death of fish in Tokyo Bay, the chemical (sodium hypochlorite) used to remove nitrogen from factory wastewater remained in the treatment tank and reacted with thiocyanide in the wastewater, resulting in the production of cyanogen. ” was generated (“hypochlorous acid (NaClO) + thiocyanic acid (HSCN) → cyanide (CN)”) 2022 Chiba Prefecture

https://www.pref.chiba.lg.jp/suiho/press/2022/koitogawa-mizu.html
https://www.pref.chiba.lg.jp/suiho/press/2022/koitogawa-mizu35.html
 

Symptoms of chronic poisoning due to cyanide (CN):
Feeling of helplessness, headache, dizziness, irritability, hair loss,

Skin diseases, weight loss, loss of appetite, loss of energy
 

Safety evaluation of “cyanide (CN)” in oral intake (soft drink)
Ministry of Health, Labor and Welfare Food Safety Commission Special Investigation Committee on Chemical Substances and Contaminants August 2010
https://www.fsc.go.jp/iken-bosyu/pc3_kagaku_osen_cyan_220819.pdf
 
 

Reproductive and developmental toxicity and repeated dose toxicity of “potassium thiocyanate (KSCN)” (external research experiment): http://www.jpec.gr.jp/detail=normal&date=safetydata/ta/dati3.html

Toxicity evaluation of “potassium thiocyanate (KSCN)” in animals (1954-1997)
● Repeated dose toxicity
・As a result of oral administration of potassium thiocyanate to rats for 4 or 11 months, an increase in thyroid weight and a decrease in thyroxine levels were observed. (Philbrick et al, 1979) The same study showed spinal cord lesions including disruption of the myelin sheath.
・As a result of intraperitoneal administration of 50 to 850 mg/kg of potassium thiocyanate, brain damage was observed in 10% of rats. (Rose et al, 1954)
●Reproductive and developmental toxicity
– When potassium thiocyanate was orally administered to pregnant mothers, goiter was observed in the neonates. (Rudert & Oliver, 1976) RTETECS, 1997)
・When potassium thiocyanate was administered intravenously to mother mice and rats, transfer of thiocyanate to the fetus was confirmed. (Moedder, 1980)
– When 0.1-0.5% potassium thiocyanate was orally administered to female rats during pregnancy and 2 weeks after delivery, growth inhibition was observed in the newborns. (Pyska, 1977)
・High doses of 5-10 g/100 g affected the reproductive ability of female rats. (Olusi, 1979)
 

Thiocyanates that also exist in nature
Be careful not to eat too much of kale, which is said to be a super healthy ingredient. This is because it is said to have a serious effect on the thyroid gland. Kale contains a substance called thiocyanate, and if you consume too much of it, it can affect the function of iodine, a mineral that is a component of thyroid hormone, and may cause a decline in thyroid function. It is said that there is. (Source: COSMOPOLITAN)
https://www.cosmopolitan.com/jp/beauty-fashion/health/tips/a861/7-all-natural-foods-that-can-totally-mess-you-up/#link1
  
According to a report by the German Federal Institute for Risk Assessment, the cause of decreased thyroid absorption of iodine is a substance called thiocyanate, which is found in cabbage and radish. Corn and millet contain cyanogenic glycosides that are converted to thiocyanate in the body. (Source: Food Safety Information (Chemical Substances) No. 8/ 2020. 04. 15 National Institute of Health Sciences)
https://www.nihs.go.jp/dsi/food-info/foodinfonews/2020/foodinfo202008ca.pdf

Foods containing cyanide
Avoid eating loquat seed powder (Source: Ministry of Agriculture, Forestry and Fisheries, January 15, 2021) https://www.maff.go.jp/j/syouan/seisaku/foodpoisoning/naturaltoxin/loquat_kernels .html?utm_source=dlvr.it&utm_medium=twitter

“Inorganic cyanide compounds” Effects on human health (Summary) P52
Accumulation in the blood or other tissues after oral ingestion of inorganic cyanide compounds has not been confirmed, but the metabolite “thiocyanate ion” is known to have a cumulative effect, causing thyroid toxicity such as thyroid adenoma and cretinism. . The long-term toxic effects on the thyroid gland are presumed to be due to the metabolite “thiocyanate ion.” Cyanide binds to Fe3+ ions in cytochrome oxidase in tissue cells and to proteins such as hemoglobin in red blood cells. Inhibition of cytochrome oxidase prevents the oxidation of reduced cytochrome c, stopping cellular enzyme utilization and leading to cell death. Hydrogen cyanide and cyanide compounds are mainly metabolized by rhodanese present in the liver into “thiocyanate ions” and excreted in the urine. Chronic effects of inorganic cyanide include headaches, dizziness, nervous anxiety, weakness, decreased vision, slurred speech, gastrointestinal disturbances, and enlarged thyroid gland. The effects of long-term exposure on the thyroid gland are probably due to inhibition of iodine uptake into the thyroid gland by the metabolite thiocyanate ion. (Source: Initial Risk Assessment Report for Chemical Substances “Inorganic Cyanide Compounds” National Institute of Technology and Evaluation, October 2008)
https://www.nite.go.jp/chem/chrip/chrip_search/dt/pdf/CI_02_001/risk/pdf_hyoukasyo/108riskdoc.pdf

Danger of cyanide
Chronic systemic cyanide poisoning can occur but is rarely recognized because of the gradual onset of disability and symptoms consistent with other diagnoses. The reported symptoms are similar to those seen when thiocyanate is used as a drug, thus explaining the chronic disease caused by cyanide due to excess thiocyanate in the extracellular fluid. It has been suggested that this is possible. Symptoms of chronic disease have been reported in electroplaters and silver polishers after several years of exposure. The most notable were weakness in the arms and legs, headaches, and thyroid disease. These findings have also been reported as “complications of thiocyanate therapy.” (Source: International Labor Organization Encyclopedia of Occupational Safety and Health)
https://www.iloencyclopaedia.org/ja/part-xviii-10978/guide-to-chemicals/item/1038-cyano-compounds

 
 
Evaluation, classification, and regulation of “potassium thiocyanate” by international health organizations
World Health Organization International Chemical Safety Program International Chemical Concise Assessment Document IPCS UNEP/ILO/WHO
Concise International Chemical Assessment Document No61 Hydrogen Cyanide and Cyanides: Human Health Aspects (2004) World

Hydrogen cyanide and cyanide: effects on human health
https://www.nihs.go.jp/hse/cicad/full/no61/full61.pdf
Thiocyanic acid classification display
https://www.ilo.org/dyn/icsc/showcard.display?p_lang=ja&p_card_id=1671&p_version=2
 

Regulatory trends for “potassium thiocyanate (KSCN)” in Europe

In 2013, the European Food Safety Authority (EFSA) disapproved “potassium thiocyanate.”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
https://www.fsc.go.jp/fsciis/foodSafetyMaterial/show/syu03900400149
On 19 June 2013, the European Food Safety Authority (EFSA) published conclusions on the risk assessment of potassium thiocyanate (approved 19 October 2012, page 46). Safety to humans and animals, safety from environmental emissions could not be guaranteed, data gaps regarding physical and chemical properties and concerns in the mammalian toxicology section were identified. Due to the lack of toxicity and exposure data regarding the LP-system (Lactoperoxidase System) mixture, a risk assessment for users, workers, and bystanders cannot be conclusively completed. If the definition of this reaction mixture residue is unknown and toxicity reference values are not available, a consumer risk assessment cannot be carried out. Also insufficient to perform an environmental exposure assessment. Although we believe that the active ingredient potassium thiocyanate has an effective bactericidal effect, the qualitative effects of the compound (cyanide) and its decomposition/conversion products formed from the reaction mixture with naturally occurring enzymes and hydrogen peroxide and quantitative environmental exposure assessments are lacking. Additionally, in the ecotoxicology section, data deficiencies were identified to submit screening studies for non-target terrestrial plants for representative field use.

In 2014, the European Union (EU) disapproved “potassium thiocyanate”
(Source: Cabinet Office Food Safety Commission Food Safety Information System)
https://www.fsc.go.jp/fsciis/foodSafetyMaterial/show/syu03970210305
On February 6, 2014, the European Union (EU) published in the Official Gazette Commission Implementing Regulation (EU) No 108/2014 disapproving potassium thiocyanate. The applicant withdrew the application after the Food Safety Authority (EFSA) identified several data gaps on potassium thiocyanate that required additional data, including safety.

 
Potassium thiocyanate (KSCN) is being regulated in Europe, and Japan’s Ministry of the Environment is also preparing to legalize it as an “endocrine organ disruptor.”

Ministry of the Environment “Report related to endocrine disrupting effects of thiocyanic acid and its salts 2021”
Materials from the 1st Study Group on Endocrine Disrupting Effects of Chemical Substances in FY2021
Thiocyanic acid and its salts have been shown to have effects on the hypothalamus-pituitary-thyroid axis in animal test reports, and androgenic or anti-androgenic effects, effects on thyroid hormone synthesis ability, and in vitro test reports. It shows an effect on thyroid hormone synthesis ability through peroxidase activation, and in human administration studies, it shows an effect on the hypothalamus-pituitary-thyroid axis.In an epidemiological survey, it shows an effect on the hypothalamus-pituitary-thyroid axis. As it has been suggested that it exhibits anti-parathyroid hormone-like effects, it can be used as a test substance for endocrine disrupting effects (P25).

* “Endocrine disruptors” are chemical substances that affect the “endocrine system” and have a negative impact on human health and the environment.
*The endocrine organs of the human body include the pituitary gland, thyroid, adrenal glands, ovaries, testes (front), pineal gland, brain, liver, heart, pancreas, “Kidney” etc. These “endocrine organs” secrete appropriate amounts of hormones at appropriate times that correspond to the development and development of the human body.

Ministry of the Environment Reliability evaluation and test implementation status regarding endocrine disrupting effects of chemical substances
“Thiocyanate and its salts”
2021 Reliability evaluation completed (first stage biological testing currently being conducted or scheduled to be conducted)
https://www.env.go.jp/chemi/end/substances.html

Reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021, P16~) https://www.env.go.jp/chemi/%E8%B3%87%E6 %96%991-2.pdf

Excerpt: Literature reliability evaluation results regarding endocrine disrupting effects of “thiocyanic acid and its salts” (Source: Ministry of the Environment 2021) https://www.env.go.jp/content/000081308.pdf
  
of milk using a chemical reaction between enzymes and thiocyanic acid (HSCN)

As a sterilization method, a chemical reaction (peroxidase activity) between a harmless enzyme and a small amount of thiocyanate (HSCN) is used to deactivate the SH enzyme in the cells of some Gram-negative bacteria such as Escherichia coli and produce ions that exhibit antibacterial activity. (OSCN-) is generated, producing an effect that can sterilize some Gram-negative bacteria such as Escherichia coli at an invisible ppm level (1/1 million, 1 ppm = 0.0001%) (thiocyanate-added milk India P18) .

However, in the 2020s, the effects on the human body (endocrine organ disruption effects such as inhibiting the intake of iodine from the thyroid and lowering the production capacity of hormones such as thyroxine at very small amounts in ppm) have become clear, and in 2021 In 2015, Japan’s Ministry of the Environment identified thiocyanic acid (HSCN) and its salts as potential test substances for endocrine disrupting effects (P25), and the first biological tests are currently underway or scheduled.

Regarding environmental impacts and regulations, Japan’s Ministry of Health, Labor and Welfare states that thiocyanate is known to inhibit iodine uptake in the thyroid gland and exhibit thyrotoxicity (CICADs(J) 61 (2004), ATSDR (2006)). ). Additionally, thiocyanate is a major metabolite of cyanide, and thyroid dysfunction and goiter have been reported due to occupational exposure to cyanide (CICADs(J) 61 (2004), ATSDR (2006)). (GHS classification: Category 1 (thyroid))
“Potassium thiocyanate (KSCN)” must not be released into the beautiful natural environment of Japan in ppm units (1 part per million, 1ppm = 0.0001%), and the Ministry of the Environment has announced that it must not be released into Japan’s beautiful natural environment in soil, rivers, lakes, seawater, etc. The law stipulates that total cyanide (CN) must not be detected (detection limit 1.1 (ng/L)).

It contains enzymes that are harmless as a single substance, which are contained in microscopic amounts of ppm (ppm = 0.0001%) in milk and saliva, and a less toxic cyanide substance called thiocyanate, which is also contained in milk and saliva. By administering an increased amount of an enzyme that is harmless to the chemical reaction partner alone, a chemical reaction (The LP-system, lactoperoxidase or glucose oxidase reaction) is caused in the oral cavity, producing cyanide, which causes Escherichia coli among Gram-negative bacteria. Although cyanide has an antibacterial action mechanism that can kill some oral bacteria (it is not effective against Gram-positive bacteria such as Streptococcus mutans, which causes dental caries), and other Gram-negative bacteria, cyanide can also be used in humans and animals. It has the side effect of disrupting endocrine organs, such as inhibiting iodine intake and affecting thyroid hormone production and reproductive function.It also has clinical effects on the concentration of cyanide generated in the body, effects on the thyroid and kidneys in the human body, and environmental emissions. In recent years, health organizations around the world have become concerned about the health risks of the antibacterial mechanism of action (the LP-system, lactoperoxidase and glucose oxidase reactions), as no safety data is available regarding the effects of the drug, and regulations are being advanced.

Based on the above, “potassium thiocyanate (KSCN)” is a very useful chemical substance for “manufacturing raw materials for synthetic resins,” “raw materials for plating,” “agrochemicals,” “insecticides,” etc., but it is not suitable for oral ingestion or food formulation. Recently, it has become clear that the thyroid gland has an effect on endocrine organs such as the thyroid gland, and on reproductive functions, including the risk of causing hypothyroidism and the risk of affecting the reproductive function. impact on the microbial ecosystem, marine products and vegetables, impact on nearby residents, farmers and fishermen, impact on people’s food, risk of impact on thyroid function, risk of declining birthrate among people, impact on the Ministry of Health, Labor and Welfare, etc. It is inferred that issues related to health and environmental compliance, such as risks to compliance with laws and regulations stipulated by the Ministry of the Environment, have begun to be understood in the 2020s, when medical science and technology have advanced.
  

From the development of human science to the world’s first products using cutting-edge research technology, the times and social needs change, the generations of scientists and researchers and the countries they live in change, and the population and needs increase. New technological innovations are born in the country.
 
We respect the pioneering products and the scientists who developed them through chemical technology in the 20th century, and the research and products that have been helpful in the development of many human beings can be said to have shaped today’s humanity and the earth. You can call it an invention.
 
Then, in the 21st century, humans are evolving little by little, and with the development of medicine and science, new issues such as effectiveness, side effects, and environmental burden are becoming clearer.
 
We have also entered the age of the Internet, where consumers around the world can access a variety of new and accurate information.

We have entered an era in which consumers choose products with safe and reliable ingredients for their loved ones, and demand that producers disclose all ingredients honestly and with traceability.

In recent years, chemicals with concerns about their safety, such as Forever Chemical, an endocrine disruptor that has become a problem for humanity as a whole, have the potential to take away health and happiness, and the risk of burdening medical costs has led to a change in the latest prescriptions. Responding to consumers’ health needs for improvements (I am sorry that it is difficult to fully promote safety for those who use the product as a health product.Also, even in trace amounts, Ogawa may be released into the environment through urination.) I’m also concerned about the impact on killifish and red dragonflies, aquatic life and seafood from nearby rivers and the sea, vegetables and rice, children playing in rivers and the sea, fishing and clam-gathering, swimming and surfing, and my descendants living near place. companies are focusing on product development.

For the sake of the health of their families, consumers are also responsible for carefully examining safety and environmental toxicity, and if possible, developing new formulations, and making sure that all ingredients and purpose of the formulation are clearly disclosed and easy to understand for consumers. A manufacturer of specialized oral care formulations that clearly shows the developer’s face and can be trusted, including in the ingredients section of the site, and whose medical basis and safety can be trusted, with a doctor of dentistry specializing in oral medicine involved in research and development. Explore oral care products and more.

We would like to take this opportunity to examine various compounded chemicals, their development background, year of prescription development, experimental data, and clinical trials, to clarify that there may be old products from before the green innovation era that do not meet 21st century medical standards, safety, and environmental protection standards. I think it would be a good idea to look into efficacy data, safety evaluation data, etc.

Endocrine disrupting chemicals, which have been considered dangerous in Europe, have only recently begun to attract attention in Japan, starting in the 2020s when Japan’s birthrate was declining.

As a trusted brand, we provide information such as “all ingredients and purpose of blending,” “mechanism of action and risk of side effects,” “efficacy and safety data,” and “risk of environmental emissions” for the sake of our customers’ precious families. In today’s world, consumers and patients need honest ingredients that are clearly visible and easy to understand when purchasing, and that are clearly displayed on each page of online shopping sites. It is considered to be absolutely important for the trust of customers, the health of their families, and the future survival of their businesses.

In addition, we also provide experimental data, clinical data (effect data in the oral cavity of actual animals), academic papers, explanations of the mechanism of action, explanations of side effects, and safety data regarding the actual effects of the product (whether it works or not). (Are there side effects or not?), etc., and the existence of evidence (scientific evidence). We protect the lives and health risks of beloved dogs, cats, medical professionals, patients and their families, and people all over the world, and the reliability of brands and companies, as well as managers, directors, researchers, regulatory affairs personnel, and business personnel. Also, as an outside collaborator and a person with a family, I believe that this is an important and important thing that has a great social responsibility.

For consumers, it has a serious impact not only on their own health but also on the environment. Products that do not comply with laws and regulations on the market not only increase the burden on the surrounding environment, but also harm the lives of nearby residents. It can also have negative health effects. In that case, ultimately the consumer who uses the product is also responsible. Therefore, European consumer organizations are raising awareness that it is important for consumers to not only think about themselves, but also to adopt environmentally friendly consumption practices that do not endanger the lives and health of nearby residents and the entire nation.

Since the 2000s, when the world’s aging population and environmental destruction have become more serious, the green technology of the 21st century has achieved a balance between oral action and safety when swallowed, something that traditional chemical technology from the 1900s could not overcome. “Ultra-low concentration has thousands of times more effect” ・“Protection of antibacterial activity and the natural environment of rivers and oceans and biological ecosystems when discharged into the environment” ・“Medical costs and healthcare are increasing with the declining birthrate and aging population” In the 1900s, in order to overcome the contradictory issue of “reducing the burden on people,” in Japan, where the population is aging, research was carried out for more than 30 years at Kyushu University’s Faculty of Agriculture, Faculty of Agriculture, a national research institution. This is an alternative green technology from the 2000s that realized a generational shift from the 2000s, and the world’s most cutting-edge microbial biotechnology research, as well as research on lactic acid bacteria antibacterial peptides that are made from food raw materials and are safe to swallow.

Discovered as a safe antibacterial substance in cheese by British dairy farmers in the 1920s, it has a wide range of excellent antibacterial properties at ultra-low concentrations in ppb units (1/1 billion, 1/1,000th of ppm, 1ppb = 0.001ppm) Nisin, a lactic acid bacteria antibacterial peptide (protein) that has been considered as safe as salt and spices around the world since the 1980s due to its safe activity and mechanism of action, has been confirmed to be the safest in the world, and is now available in Japan. Approximately 100 years later, in 2009, it was finally approved as a food by the Ministry of Health, Labor and Welfare. While the approval of nisin as a food product was not progressing in Japan, its social usefulness was recognized and research was progressing on applications such as oral care preparations that are safe for elderly people to swallow. “Neonisin-e®︎” is the result of research that has brought about an innovation that expands the spectrum to include Gram-negative bacteria and Candida bacteria, which is impossible with other methods.

The research results of neonisin, which paved the way for the world’s first practical application of lactic acid bacterium antibacterial peptides for medical and healthcare applications and obtained a patent in 2016, are a major social issue for caregivers in Japan, the world’s oldest nation. In addition to helping reduce the burden on patients and improving patient quality of life, it has also made small contributions to humanity, such as being used at disaster sites and on the International Space Station, becoming popular around the world, and winning various awards. It can be said to be a research result by a Japanese national institution that is extremely useful for elderly people in need of care, infants, people who have difficulty gargling or spitting due to illness or disability, pets, etc.

In light of the above issues, ORALPEACE , which has been researched with the aim of making food-grade food-grade food-safe foods for people to put in their mouths, and protecting Japan’s beautiful natural environment and marine products from hazardous chemical contamination, has been named thiocyanic acid. The formulation does not require the addition of potassium (KSCN).

~~~

To be honest, until recently, we, the research members, were unaware of the progress in regulating potassium thiocyanate (KSCN) by the Japanese Ministry of the Environment. I only realized this after receiving many inquiries from customers. No one really knew. This is the latest issue that humanity as a whole was unaware of, and even expert scientists and strategists were unaware of. We sincerely apologize for the inconvenience, as our research team’s global research efforts were not successful.
 
Regarding oral care products, in response to European Union (EU) regulations in 2014, brand ownership changed and a new global distribution system was established, and from 2015 onwards, a complete formulation change was made to improve the mechanism of action. It was reborn as a new, simple oral moisturizing product brand that eliminates the antibacterial effect on oral bacteria, and has smoothly penetrated the market.However, as an animal product, there are no regulations by the Ministry of Health, Labor and Welfare or the Ministry of the Environment, and conventional cyanide products have been used. Some antibacterial mechanisms of action based on thiocyanate peroxidase activity (thiocyanate peroxidase activity) remain unchanged as we head into the 2020s.

We have been using this pioneering 20th century chemical technology for many years with our own pets. The side effects that have been pointed out in the 2020s are cutting-edge research results that have finally become clear due to advances in human science, and the benefits outweigh the risks that were previously unknown (poor temperate regions Humankind has enjoyed benefits that outweigh the side effects (just as children in developing countries in the region are able to survive hunger and survive by relying on milk as a source of nutrition). Regarding this, as I mentioned at the beginning, I will never forget my gratitude and respect to the pioneering scientists.  

As a businessman, I have always struggled with the gap between the sales, marketing, and management departments, which are close to consumers, and the research and development department, and have experienced much pain in the friction between them. There have been times when front-line department members have overcome various risks that were not pointed out to them by the R&D department by worrying and trying to resolve them. The research side is often forced to comply with the reckless demands of the front department.

As a researcher myself, I believe that side effects require actual clinical experiments and animal experiments, and the results vary depending on the person, individual, and various conditions, so they are not something that can be obtained easily and in practice. We need to make sure that consumers, sales, marketing departments, and management departments understand that it is difficult to obtain clear answers clinically. In reality, it is difficult to understand the correlation on a case-by-case basis.
 
However, this time, we need to discuss the side effects and environmental burden of chemical substances, which have recently begun to be pointed out around the world, and work together to create choices that will create a better future. However, rather than blaming yourself or someone else for your past, I think this action will lead to good things for future consumers, collaborators, and ourselves.

As researchers, we respect and collaborate in each other’s fields of expertise, and this time, WHO, FAO, Codex Alimentarius Commission, the European Union (EU), the International Dairy Federation, the Ministry of Health, Labor and Welfare, and the Ministry of the Environment have collaborated to discuss the impact on health and the natural environment. We need to involve many colleagues in conducting deeper research into chemical substances and mechanisms of action that suggest safety, proving their safety one by one, and working together to overcome new challenges one by one. We believe that this is the real thrill of research, and that it is a breakthrough and a valuable challenge that will produce true inventions and innovations, and dispel the concerns of people around the world.

When it comes to research that is beneficial to humanity as a whole, in order to overcome various difficulties, everyone should open their hearts honestly and transcend interests between universities and companies without criticizing or protecting themselves. I think it would be wonderful for these Japanese researchers to work together and work together to develop a mechanism of action that has proven safety for the body and low environmental impact for the benefit of humanity all over the world.
 
To that end, our research team will work together to prove the safety and low environmental impact of this mechanism of action, and we believe that helping each other will be a breakthrough for us as researchers.
 
In this time when many people are hurt by disasters and wars, I believe that if we all start moving in a better direction, even little by little, and even from today to tomorrow, we can join hands and change the future for the better. think.
  
Families will be healthy, nature will be beautiful, the latest research efforts will be appreciated, companies will trust us, and business will continue to be beautiful. You can change it from today to tomorrow. Every day is a challenge with change, and continuing to improve on it is through research and corporate efforts, and the number of customers and colleagues who do research together will increase.
  
World health organizations, the Japanese Ministry of Health, Labor and Welfare, and the Ministry of the Environment investigated facts that we did not know on our own and taught us about the risks. At first I was confused, but I took a deep breath, changed my mind, and thought about the best direction. Check with your own eyes the safety of the products you use. We will communicate this risk to the relevant departments and work together to refine new technology to meet the new era. We will work together to prove safety and evolve through friendly competition.

Through the power of science and research, we will use the power of science and research to help people around the world who are struggling to survive despite difficulties due to illness, disability, injury, aging, etc. In front of that ultimate love for humanity, competition between researchers and companies, scrambling for profits, criticism, and self-protection are petty and vain. Excellent minds come together to advance research that will remain in human history, transcending even conflicts of interest.

I believe that the gradual awareness of humanity as a whole and the step-by-step progress we make each day will change the future of this earth and humanity for the better.

Our research team has taken the courage to provide the latest information on chemical substances that health organizations around the world are warning about, and we hope that this information will contribute to the future choices of many people, and that even one person will be aware of it. I would be happy if you could obtain this.

In addition, many oral piece users and professionals contact our research team with their opinions on individual ingredients that are not included in oral pieces, but if possible, please check the details on the Internet etc. Thank you for your understanding.

The ingredients that were not selected simply did not match the concept we were aiming for, and we are not in a position to answer the pros and cons of past diverse research orientations. For the health of your precious family, we believe that it is important to carefully examine the ingredients based on your own value standards.

If you are a researcher and are having trouble finding clinical data or proof of the safety of the ingredients and mechanism of action, or the low environmental impact, please feel free to contact our research team. If you are in the sales or marketing department and are having trouble reaching out to the research department, we would be happy to hear from you.

Change the future with inventions that contribute to the development of humanity. If we all work together, we can definitely find a way. Love creates a beautiful future.
 
ORALPEACE for your loved ones

Thank you for your continued support of the ORALPEACE Project.

It is not included.

If you like iodine, use the brown mouthwash containing povidone-iodine, being careful about swallowing and side effects on your thyroid.

Not compounded.

Sodium hydrogen carbonate (baking soda) is an alkaline substance that has the effect of floating dirt and destroying and decomposing fats and oils and proteins.

In addition, the particles are large and difficult to dissolve in water, which makes them useful as an abrasive for kitchens.

Toothpaste containing sodium hydrogen carbonate (baking soda, polishing agent, alkali) was born about 100 years ago and can be easily made with baking soda in the kitchen.

However, there are various problems that are not recommended for use in tooth brushing and oral care in the modern oral clinics around the world.

First of all, the point that “the teeth are scraped by the polishing action”.

Sodium hydrogencarbonate (baking soda, abrasives, alkalis) is a substance that has a very strong polishing action, as it is also included in cleansers that remove stubborn dirt.

The American Dental Association (ADA) does not recommend sodium bicarbonate (baking soda) for the following reasons:

Particles of sodium hydrogen carbonate (baking soda) are said to be coarser and larger than any of the abrasive components of commercially available dentifrices, which is the same as brushing teeth with a file or cleanser.

After daily polishing, the enamel is scraped off every day, and symptoms of hypersensitivity will eventually occur, prone to tooth decay, pigments will easily remain on the scratches on the tooth surface and cause yellowing, and eventually dentin inside Is visible, and the teeth are gray, over white.

And the tooth that has been scraped will not return to the original, so be careful.

Next, it is “inducing excessive intake of salt”.

Sodium hydrogen carbonate (baking soda, abrasives, alkalis) is composed of sodium compounds as well as salts.

The amount of sodium hydrogen carbonate (baking soda, abrasives, alkalis) that can be taken daily by healthy people is less than 5 grams.

If you accidentally swallow it with toothpaste or gargling with sodium hydrogen carbonate (baking soda, abrasives, alkalis), you will ingest too much salt. Also, salt will be absorbed from the mucous membranes of the oral cavity without swallowing.

In particular, caution is required for those with impaired kidney/cardiopulmonary function, those with salt or sodium restriction, those with high blood pressure, and those with restricted salt intake due to chronic illness.

Also, it is not good for healthy people to increase their salt intake. Excessive salt intake leads to symptoms of metabolic disorders such as swelling and alkalosis.

Secondly, “alkaline tilt in the mouth causes tartar to adhere”.

The human body’s oral cavity has the physiological function of keeping the same weak acidity as the skin, keeping the PH in the mouth constant, suppressing the action of causative bacteria, and promoting the remineralization action of teeth.

Humans’ mouth is kept weakly acidic by saliva, but tartar is more likely to adhere to the mouth which is inclined to alkali.

Tartar is a plaque that is a collection of bacteria that is calcified by alkali and causes dental caries and periodontal disease.

There is also the expectation that “the neutralization of the mouth, which is inclined to be acidic by diet, may promote remineralization of teeth and prevent tooth decay”, but in reality remineralization is performed by saliva minerals.

Caries do not occur because the inside of the mouth becomes acidic, but the teeth are melted by the acid produced by the dental caries that live in the mouth to decompose sugar.

Ordinary weak acidity in the oral cavity does not activate dental caries (it cannot be inactivated even by tilting it to alkaline), so there is no point in temporarily tilting the oral cavity to alkali. There was a clinical problem that the bacteria could not be eliminated (oral mucosa and skin tissues were damaged before that), but the risk of tartar was increased.

Finally, the point is that “strong stimulation with alkali damages the oral mucosa.”

When treated with a strong alkali, it becomes the same as reduced bleach and strong alkaline ionized water, and strong alkali can sterilize general bacteria and inactivate viruses.

Strong alkalis are as good as disinfectants for medical equipment and kitchens, just like disinfectants such as chlorine and hypochlorous acid. However, there is a problem that it causes damage when used on the body of people who are composed of various bacteria.

Although strong alkali sterilizes bacteria, chemical damage destroys the proteins that make up the oral mucosa, damages the gum tissue and periodontal skin tissue, and damages the oral mucosa, deteriorating the oral condition.

When making skeletal specimens of animals because of their characteristics of destroying skin tissues and proteins, they are boiled with sodium hydrogen carbonate (baking soda).

Also, if you add baking soda to oil-dirty kitchen utensils, clogged ceramic filters, and parts of cars and motorcycles, the oil and protein will be decomposed and it will be very clean. Please try.

And regarding the effect data on bacteria and viruses, in experiments such as petri dishes, we can get data that reducing bleach and strong alkaline ion electrolyzed water can kill various bacteria and viruses.

However, in the actual oral clinic, the concentration cannot be maintained by being diluted with saliva (the skin damage is large if it is not diluted with saliva), and the reality is that the same clinical effect as the experimental data on petri dishes cannot be expected.

From the above, there was an oral clinical problem that strong alkali had more side effects than action and could not be used for babies and infants with weak oral mucosa, elderly people, fighters, and people who care about salt and are healthy.

Therefore, ORAL PEACE is a prescription that does not contain it.

However, if you like sodium bicarbonate (baking soda, abrasives, alkalis), baking soda for food is sold at supermarkets, so please use it with caution.

ORALPEACE is made from only food ingredients that are safe to eat, and we do not mix non-food abrasives (compounds, stone powder, etc.).

Abrasives (compounds, stone powder, etc.) can be whitened by scraping the tooth surface, but they have the following side effects.

Enamel does not return to the original state if it is cut too much.

It becomes hypersensitive due to excessive shaving.

Accumulates on the periodontium.

We do not have the following abrasives in ORALPEACE.

Calcium carbonate (raw powder for drawing white lines on playground, raw material for chalk)
Sodium hydrogen carbonate (baking soda)
Zeolite
Mud (clay and montmorillonite)
Charcoal
Micro beads (plastic powder)

ORALPEACE can be used safely with only edible ingredients, and it is also suitable for whitening teeth by carefully brushing teeth for a certain period of time without damaging enamel and dentin, and for use with electric toothbrushes.

ORALPEACE can also be applied to the oral cavity as a moisturizing gel for the oral cavity.

Regarding “keeping teeth white”, our research team recommends the following methods.

Instead of shaving away the enamel and dentin of your important teeth with an “abrasive” to make your teeth look white (which was the standard in the past), perform daily home maintenance by careful brushing.

To have a whitening treatment in a clinic once a year or once every few months.

We believe that it is a reasonable way to keep your beautiful white teeth, both effective and safe, just like removing stains on your skin.

The mechanism of hypersensitivity is mainly caused by shaving the “dentin” at the boundary between teeth and gums with toothpaste containing “abrasives (compound, stone powder, charcoal, etc.)”.

The whitish part that covers the teeth as a whole is called “enamel”, and the part that is slightly darker at the boundary between the teeth and the gingiva is called “dentin”.

If you rub the “dentin” strongly with a toothbrush, the dentin is relatively soft, so it will be scraped earlier than the “enamel” and will look like a wave-cut rock.

In addition, there are small holes (dentin tubules) in the “dentin”, from which the stimulus is directly transmitted to the nerves, so the cold ones are particularly soaked.

The gums and alveolar bone also go down due to periodontal disease. In addition, toothpaste containing “abrasives (compound, stone powder, charcoal, etc.)” will make you hypersensitive if you remove “dentin” and “enamel”.

In other words, every day, we shave our precious teeth with toothpaste containing “abrasives (compound, stone powder, charcoal, etc.)” to make ourselves hypersensitive.

Also, if you use toothpaste containing “foaming agent (surfactant/soap)”, you will be rushing to brush before the bubbles overflow from your mouth.

“Abrasives (compound, stone powder, charcoal, etc.)” will further scrape your teeth if you rush and polish strongly.

The key to daily beautiful tooth care is to gently polish with a toothbrush gel containing no abrasive and foaming agent and a good toothbrush with a light force.

In brief, it is thought that if you take each product with your finger and touch it, it will be “gritty” and “grainy” will have a relatively strong polishing action.

In addition, we will also introduce “Comparison, selection, and selection of tooth polishing powder, dentifrice, oral care product tooth polishing effect, polishing strength and weakness” that can be easily done at home.

Place aluminum foil on a cutting board, put something you want to compare on it, and polish it with your fingers.

For those with strong polishing power, the aluminum will be scraped off, the paste gel will turn gray, and the scraped aluminum on tissues can be removed.

Therefore, by seeing how much aluminum can be abraded, it is possible to know the presence or absence of polishing action and the strength of polishing power.

If you are worried about “abrasive-free”, “soft abrasive” or “natural organic”, there is a difference in polishing power, so we recommend you to check it yourself.

From the type that is made mainly of abrasives, which polishes and scrapes teeth, it is possible to use “Aural Piece Clean & White”, an abrasive that can be used for prevention of hyperesthesia and for people with thin enamel. There are various types of products such as “Oral Peace Clean & Moisture” which are not included at all.

It is important to thoroughly understand the research and development background and intention of those products, and the characteristics of the products, and to select the most suitable one for yourself, your family, and your patients.

Not compounded.

Synthetic surfactants for decomposing oil and surfactants and foaming agents such as soap are not used in ORALPEACE.

This is because it is not necessary to clean the oil in the mouth and it is not food.

Please check the effects, side effects, and environmental effects of synthetic surfactants on the Internet yourself.

Not compounded.

“Lauryl glucoside”, a nonionic surfactant, is a synthetic raw material that is often used in shampoos as an inexpensive synthetic surfactant.

Not used for ORALPEACE.

For the same reason as the synthetic surfactants above, we have not added any to ORALPEACE.

Soap may be added because it gives a feeling of brushing the teeth due to foaming and can emulsify the water and oil components of the toothpaste.

However, soaps and foams that decompose oil are not required for cleaning the mouth, and soaps, coconut oil fatty acid K, olive fatty acid K, and other soaps and foaming agents are not included because they are not foods.

Brushing your teeth with soap is the same as brushing your teeth with solid soap at home. You can try.

Synthetic preservatives such as methylparaben, butylparaben, propylparaben, also known as paraoxybenzoate, are not added at all.

In addition, we do not use other synthetic preservatives that are used in place of parabens in our oral pieces.

All ingredients of ORALPEACE are as shown on the package.

Please check the effects, side effects, and environmental effects of synthetic preservatives on the Internet yourself.

Not using

Phenoxyethanol is a synthetic preservative/preservative that is increasingly being used as a substitute for consumers who do not like parabens.

It is chemically synthesized in the presence of an alkali metal hydroxide or alkali metal borohydride by hydroxyethylation of phenol (a colorless needle-shaped crystal made from coal tar, which is used for preserving and disinfecting).

In Japan and the European Union, the amount of phenoxyethanol is strictly limited for cosmetics for skin, and up to 1% can be added to the product.

However, it is a banned ingredient for use in food.

(Paraben is allowed to be used in food.)

Even for cosmetics for the skin, the inclusion of phenoxyethanol is prohibited by international organic product certification standards.

Therefore, phenoxyethanol is not added to ORALPEACE, which is an oral care product that can be taken orally and absorbed by the mucous membranes in infants and pregnant women.

Not using

Please check the effects, side effects, and environmental effects of sodium benzoate on the Internet for yourself.

Not using

Please check the effects, side effects, and environmental effects of potassium sorbate on the Internet yourself.

Carryover ingredients that are not included in the ingredients of overseas products, such as preservatives as impurities contained in the product, which are not stated in the labeling of all ingredients, are prevented from being mixed in under the strict production control system in Japan.

Unlike overseas, it does not contain formaldehyde, which is strictly prohibited in Japan.

Not mixed at all.

As food additives, phosphates such as polyphosphoric acid, metaphosphoric acid, pyrophosphoric acid, etc. used for ham and salami binding reinforcing agents, emulsifiers, swelling agents, etc. have a bleaching effect and may be used for toothpaste products. There is.

However, ORALPEACE does not use phosphorus phosphate because it aims to make products that can be used by infants, those who are not good at chemically synthesized components, fighting illnesses and elderly people requiring nursing care.

Please check the effects, side effects, and environmental effects of phosphorus and phosphate on the Internet yourself.

Not used

ORAL PEACE is all seasoned with natural plant essential oils.

For flavors such as “grape”, “strawberry”, “melon”, and “cola”, it is not possible to make them with natural essential oils and extracts, but they are chemically synthesized synthetic flavors (flavors).

Natural flavors and tastes are limited to the essential oils of plants such as “mint” and fruits such as “citrus”.

ORALPEACE uses only mint and citrus essential oils for taste.

We do not mix chemical substances (synthetic fragrances or synthetic preservatives) that are labeled as “fragrance”.

Many toothpaste products are white pastes because they contain many abrasives (compounds and stone powders) and foaming agents (soaps and surfactants).

However, in the case of a semi-transparent gel that does not turn white with a mild mixture of abrasives and foaming agents, if you add a component called “titanium oxide” as a coloring agent, the transparent one becomes a pure white paste.

“Titanium oxide” is made from minerals, but the World Health Organization points out that it is “carcinogenic”.

Since January 2020, France has banned the production and sale of food products containing “titanium oxide”.

ORALPEACE is a formulation that does not contain “titanium oxide” because it is made from only food ingredients that are safe to swallow.

Since ORALPEACE aims to be a product that can be used with peace of mind even for infants, honey and propolis are not added.

In addition, there are some reports of antibacterial action such as Manuka honey, but there have been a number of issues with the use of honey and propolis as hygiene agents, which are expected to have antibacterial properties.

First of all, its antibacterial property is about 1/1,000 or less than that of lactic acid bacteria peptides, similar to that of essential oils and extracts of plants such as herbs.

In other words, it is difficult to take a large amount of honey propolis and carry it if you expect the same benefits that you can achieve even with a very small amount if you do not take 1,000 times as much, and you can take a high concentration of plant essential oils and extracts Is dangerous and expensive.

In addition, the main ingredients of honey are sugars called “glucose” and “fructose”, which can cause caries as a side effect.

For these reasons, honey propolis is not added to ORALPEACE.

If you like honey propolis, please check your age and sugar intake, be careful of caries, and use it together with ORALPEACE.

No animal-derived ingredients are used.

We do not use any ingredients derived from animals, ingredients produced from the placenta of humans or domestic animals such as cows, pigs, sheep and horses, ingredients produced from animal eggs, and ingredients produced by culturing animal cells.

Also, we are not conducting animal experiments.

Regarding product manufacturing, we aim to create products that do not sacrifice the lives of animals.

We do not use ingredients such as cultivated bacteria ingested from dental plaque, excrement or plaque of humans or animals, or animal-derived bacteriocin, which is not approved as food.

Not compounded.

The antibacterial activity of “Neonisin-e®” is about 1,000 times that of hinokitiol. In other words, the same effect can be obtained with an amount of 1/1000.

Hinokitiol is a repellent component created by cypresses (trees) in the hot and humid forests to resist insects, microorganisms and mold, and is used for preventing termites on pillars, preserving rice, and bath tubs that easily mold. I came.

However, in order to exert its effect on bacteria, it has to be concentrated to increase the concentration, and even if it is usually harmless, a high concentration poses a risk of malformation (teratogenicity) in rat experiments. There was a problem with its use on women.

In addition, in the case of high concentration, it has the strength of peeling the laminate tube, so it is not added to ORALPEACE.

If you like Hinokiol, we would appreciate it if you can get it at an essential oil shop and use it together with ORALPEACE.

For the same reason as Hinokitiol, it is not added.

The antibacterial activity of “Neonaisin-e®” is about 3,000 times that of catechin. In other words, the same effect can be obtained with an amount of 1/3,000.

Tea has been consumed by humans since ancient times as a healthy food.

Normal concentration is good, but in order to exert an effect on bacteria, it has to be concentrated to increase the concentration, and at high concentration, the Canadian Health Organization announces a concern about liver function, It is important to know the correct volume without side effects.

If you get the wrong amount of good things, it becomes bad. Everything needs a proper amount.

Therefore, tea catechin is not added to oral pieces.

If you like tea catechin, we recommend that you take it from tea or beverage products.

First of all, as for plant extracts and essential oils, most of the raw materials in the world can be easily purchased at the essential oil shops on the Internet, so if you are expecting the effect of plant essential oils or herbal extracts on oral clinic, you can buy each raw material. We recommend that you try the effects of yourself.

ORALPEACE does not contain various plant essential oils or herbal extracts for antibacterial purposes.

The reason is as follows.

Plant essential oils and plant extracts have a sales promotion effect that makes consumers expect some effects when a large number of ingredients are added to products.

However, in reality, there was a problem that the expected clinical effects could not be obtained when added to oral care products.

For skin cosmetics, essential oils and plant extracts are predominantly used as fragrances, and vegetable oils are formulated as oils.

However, the problem is that oral care products that do not require fragrance or oil have almost no clinically expected effects.

It is necessary to increase the concentration in order to obtain some effect, but this will affect the taste and aroma, resulting in a taste that cannot be put into the mouth.

On the other hand, there was a problem that it would have a negative effect on safety if the amount of the formulation did not affect the taste.

Even though it is derived from plants, there are many ingredients that have evolved to avoid living organisms, such as hinokitiol and tea catechin, that have not been fully verified as safe substances for living organisms and the human body.

Since plant essential oils and plant/herb extracts have not been the foods that humans have always liked since ancient times, we do not use them in ORALPEACE.

If antibacterial properties are expected, the antibacterial activity of “Neonisin-e®” is several thousand times that of plant essential oils and plant extracts. In other words, the same effect can be obtained with a few thousandths.

ORALPEACE is blended with plum fruit extract for “Neonisin-e®”, Damask rose essential oil, and mint essential oil for refreshing feeling.

It contains the minimum amount of plant essential oils and extracts that are essential for expecting clinical effects.

If you like vegetable essential oils and herbal extracts, please procure them from herbs and essential oil shops and use them together with ORALPEACE.

A component called dipotassium glycyrrhizinate, which is obtained from licorice, is expected to suppress skin inflammation.

However, it is not used in ORALPEACE because it is not used for skin inflammation in clinical settings in dentistry and oral surgery.

Although it has been approved for addition to foods, licorice is not a food that humans have liked and loved since ancient times, so it is not used in ORALPEACE because it has a bad taste.

If you like dipotassium glycyrrhizinate (licorice extract), licorice extract is sold at online shops, so please use it together with ORALPEACE.

As a side effect, dipotassium glycyrrhizinate (licorice extract) has the function of accumulating salt in the body, so it is recommended to refrain from those with kidney disease. Please use it with caution.

For the same reason as hinokitiol, tea catechin, and other plant extracts, it is not added.
Not compounded.

It is the same reason as hinokitiol, high-concentration catechin, mastic resin, and pine resin.

This is because there is a problem that side effects are greater than effects on humans and pets.

Since many plants do not become extinct by being eaten by insects and herbivores, they have developed and evolved toxicity and repellency against living organisms, and survived the severe survival race of this earth for millions of years.

Plants that are highly toxic cannot be eaten by humans, just as insects and herbivores cannot.

Plants such as vegetables and fruits that humans can eat are limited to a very small number of plants on earth, as there are very few plants that can be eaten in natural forests.

However, vegetables and fruits that are safe to eat as they are, as well as most of the plants in the garden or familiar to you, have the power to kill bacteria and organisms at home by boiling them to a high concentration.

In a simple example, fungi and viruses do not propagate in the essential oil of plant distillation.

In addition, it is possible to obtain data that a highly concentrated component of a plant extract that seems to be safe to eat will inactivate bacteria and viruses in experiments in petri dishes.

However, if a plant that seems safe as it is is made into a substance with a high concentration to kill bacteria and organisms, side effects on humans and pets that are organisms are large, and it is difficult to put it in the mouth. There was a big problem that it could not be tasted as an oral care product, the amount of the mixture that could be expected to be effective could not be put into the mouth, and the actual product was meaningless unlike the image.

From the above, there has been a worldwide demand for the development of natural preparations that exhibit bactericidal effects even at extremely low concentrations.

Not compounded.

The function of “Neo Nisin-e®” is about 1,000 times that of tea tree. In other words, with the amount of 1/1000, the same effect can be obtained without side effects.

Tea tree is native to Australia and has developed a repellent component (toxicity) because it is inedible by insects and animals. The concentrated sap and essential oil have antibacterial properties until they kill organisms.

However, people such as babies, pets, and pregnant women should be careful about daily oral intake.

Tea tree oil contains varying amounts of skin irritants (1,8-cineole), and products with high levels of this compound may cause skin irritation, contact dermatitis and allergic reactions in some people. May be seen. Oxidized tea tree oil (the essential oil that was in contact with air) is said to be more likely to cause an allergic reaction than fresh tea tree oil.

Also, tea tree oil should not be drunk.

It causes poisoning, primarily in children, causing drowsiness, disorientation, rash and ataxia (loss of control of arm and leg muscles, loss of balance and coordination). There have been reports of cases of falling into a coma after drinking 1/2 cup of tea tree oil.

Furthermore, in the United States, in the 1990s, there was a case in which the animals became sick after feeding a product containing essential oil distilled from tea tree leaves at a high concentration to the National Animal Poison Control Center. It was As a result of the verification, in the United States, the blending ratio of tea tree essential oil for cat products should be 1.0% or less.

Essential oils that are concentrated in the phytotoxic components of tea tree, which has a bactericidal effect on organisms as organisms, are also organisms when incorporated into oral care products, and various microorganisms also have side effects on the human body in the intestinal tract.

In addition, it is not a food that humans have eaten since ancient times, but an ingredient whose safety to the human body has not been academically guaranteed.

Therefore, it is not added to oral products intended to be used in mouth-worn products, elderly people with disabilities, persons with disabilities, those with fighting illness, infants and pregnant women.

If you like tea tree essential oil, we would appreciate it if you can get it at an essential oil shop and use it for aromatherapy.

Q. Are metals such as copper and silver and heavy metals (heavy metals) included?

Not mixed at all.

Q. Is all ingredients displayed?

Oral Peace describes all ingredients in an easy-to-understand manner for consumers.

For quasi-drugs, it may be possible to list only the components or main components that are required to be described and omit the detailed name of the additive.However, we want consumers to know everything about oral pieces. All components are listed.

Also, carry-over ingredients are not included.

We would be grateful if you could check all ingredients to see which ingredients are included in the product.

In addition, when purchasing a product to be taken by mouth, we recommend that you make sure that you check the “all ingredients” (all ingredients that are contained) of each product on the Internet etc. before selecting.

ORALPEACE is made with only food-approved ingredients that are safe to swallow, and because it is a product that can be used with peace of mind every day from newborns to the elderly and pets, no fluorine is added.

In Europe, many consumers do not like to take fluoride.

We thought that it is better not to add fluorine to the dentifrice, but to have a dental coat apply firmly at the dental clinic when a fluorine coat is needed to strengthen the teeth.

Fluorine is allowed to be added to commercial products up to 1500ppm in Japan, but the effect changes depending on the concentration in saliva.

If you think that fluoride is needed to strengthen the tooth structure, we recommend that you carefully apply the treatment by a dentist or dental hygienist at the dental clinic.

Not compounded.

Xylitol is a sweetener that replaces sugar and does not feed on dental caries, but there is a problem that diarrhea occurs if it is consumed too much. Therefore, we have decided not to add it to ORALPEACE.

If you like xylitol, we recommend taking it from gums.

Does not include salt, sea salt, mineral salts, sodium hydrogen carbonate (baking soda).

Although salt is useful as a preservative for products, some people do not like to ingest salt directly from the oral mucosa.

ORALPEACE is researching and developing a preservation technology that does not rely on salt, alcohol (ethanol) or synthetic preservatives, even though it is 100% food material.

If you like salt, please use commercially available salt with ORALPEACE.

We regularly inspect radioactive materials. The factory is located in the southern part of Japan. Please use with confidence.
1. Oralcare product is something most of us use 365 days.

Oral mucosa is said to have 10 to 20 times more of percutaneous absorption than of skin. It is our policy that as a component of oral care product, we do not use/compound ingredients that are not safe to eat.

2.This is because the concept is that the oral pieces contain no food ingredients that are safe to eat.

As a component that is rubbed daily into the oral mucosa, which is said to have 10 to 20 times the percutaneous absorption of skin.

No, ORALPEACE do not and will not conduct animal testing.

It is also our policy not to use any ingredients/components which requires animal testing into ORALPEACE products.

Since ORALPEACE does not contained alcohol and chemical ingredients, it is suitable for infants, pregnant women, breastfeeding women and the elderly people.
ORALPEACE can be used with confidence because it is made with safe ingredients. It is safe to swallow.
ORALPEACE aims to make products for people who are not good at chemically synthesized ingredients and who do not want to take them.

However, there are as many cases of hypersensitivity reactions and allergies as there are in the world population.

If you are unsure, it is a very simple method, but we recommend that you do the patch test yourself, including other products.

Allow the product to soak in the adhesive bandage, apply it to the skin, and wait for a certain period of time to see the situation. It is considered that products that are allergic to redness do not fit your body, and you may decide to refrain from using them. The oral cavity and the skin are basically different, but this is an example of a simple method.

Since it does not contain fluorine, which is a titanium corrosion component, it can also be used by implanters.
The storage period before opening is 3 years, and it is recommended to use up within 3 months after opening.

In addition, considering the risk of storage and use in places with high temperature and humidity and poor hygiene environment, we recommend that you use the product within 3 months after opening. As long as the hygiene condition is maintained in normal use, there is no problem with using the product for more than 3 months after opening.

ORALPEACE is a product with excellent “biodegradability”.

Since it is made from only plant-derived food ingredients, if it is discharged to the environment after its function is completed, it will be quickly metabolized and reused in the natural ecosystem, and the characteristics of the environment and the risk of pollution are extremely low. ..

It is truly an environmentally friendly oral care product.

On the other hand, many petroleum-derived synthetic bactericides, antibiotics, concentrated plant antibacterial agents, etc. have the characteristic of being “hard to decompose”, and even if they decompose, the decomposed products show toxicity in the natural world. There is also something to do.

Since its toxic effect is strong and long-lasting, it is feared that it will adversely affect the natural ecosystem, especially the microbial ecosystem.

Recently, in developed countries and around the world, the problem that persistent plastic waste has a negative impact on marine ecosystems has become a hot topic, and containers with low risk of environmental pollution and switching to plastic with good biodegradability have become popular. There is a great worldwide interest in raw materials that excel in biodegradability in harmony with the environment, such as alternatives to.

It is easy to imagine that in the future, these environmentally-friendly directions will not reverse, and that in the future, new eco-friendly products that are kind to the earth, highly sustainable, and beneficial to humankind will replace the mainstream of the world. I can do it.

ORALPEACE are not made from petroleum, which is a limited fossil raw material, but can be made from lactobacilli that live in plant-derived okara and edible plants, which are highly sustainable and have a low environmental impact. There is also.

Against this background, we hope that many people will use Oral Peace to leave a beautiful earth for the next generation.

Areas where sewers are not maintained are easy to understand, but the wastewater they produce is either discharged into a natural river as it is, or after being cleaned in a septic tank, it is discharged into the river.

In the case of natural rivers, many microorganisms that live in water play their roles to form the environment.

Microorganisms live in the septic tank, and the microorganisms eat the dirty water that washed their bodies and dishes to biodegrade it and clean the water.

The same is true for cities, where the wastewater discharged by the sewer is collected at a sewage treatment plant, where it is biodegraded by microorganisms to purify the water.

Synthetic petroleum-derived germicides and synthetic preservatives that sterilize bacteria in the oral cavity, synthetic surfactants and synthetic fragrances, and toothpastes containing tree resin and high-concentration sap are difficult to biodegrade. In other words, the microorganisms cannot eat, and they also kill the microorganisms.

Therefore, there are many cases where the use of oral care products containing chemically synthesized ingredients is prohibited during mountain huts, campgrounds, and mountain climbing.

To give an example that is easy for many people to understand, the water discharged from a sewage treatment plant may have smelled of a synthetic fragrance that is not biodegradable, and I have experienced it in nearby rivers or the sea. Naturally, odorless and persistent chemical components are also naturally released.

It is easy to imagine what will happen to the global environment where they live, the organisms that live in water, and the seafood they eat every day if many people use it repeatedly in the sewage every day.

It is also important for the health of ourselves and children that they are kind to the microorganisms that biodegrade their dirty water.

In developed countries, attention is being paid to “highly biodegradable products” that do not affect the microbial ecosystem even for oral care products that are discharged into the environment.

In the world, the time has changed when many people began to notice the following things. It is important not only for the convenience and profits of the company, but also for their own health and to leave this inherited beautiful green earth to the generations of children.

ORALPEACE is a component that can be swallowed as it is, has high biodegradability, and needs for medical and nursing care in order to avoid the risk of aspiration of the oral cavity moisturizing agent on the nasopharynx and tongue, which may cause aspiration in the lungs. In order to meet the requirements, we spent a lot of time carefully selecting the ingredients and developing highly water-soluble and biodegradable products.

Generally, it is possible to increase the viscosity of gel by adding synthetic polymers, polymer compounds, synthetic thickeners, etc.

However, in that case, there will be problems in the use of elderly people, infants and infants who are not good at gargling and vomiting, pregnant women who do not want to take chemically synthesized components, and discharge into the natural environment.

In addition, when foods with a thickening effect such as agar are added, the problem of easy spoilage emerges, and the problem that synthetic preservatives and alcohol (ethanol) must be added will arise.

The moisturizing and thickening components of the oral peas are made of plant-derived glycerin and xanthan gum, which are highly water-soluble and are kept hygienic and used in foods.

Formulating with only water and plant-derived ingredients, it is difficult to balance the water-solubility/biodegradability of the product and the viscosity that is easy to handle, and as a result of repeated trial and error, the viscosity of water and plant-derived ingredients is increased to a certain degree. We have succeeded in commercialization with a fine prescription balance and a unique manufacturing method.

However, glycerin has the property of taking in water from the atmosphere, so that natural soap containing a large amount of glycerin will dissolve in a humid bathroom.

If you do not close the cap properly after use, or leave it in a humid place for a long time, it may take in moisture from the atmosphere and become loose. Also, if there is a lot of water on the toothbrush or hand, it will be difficult to put it on because it leans down.

Therefore, in order to keep the viscosity so that it is easy to pick up, please consider how to use it, such as tightly closing the cap after use, not storing it in a highly humid place, taking a dry brush or picking it up with your hand. I would appreciate it.

No plastic tube is used.

ORALPEACE tube packages are available in aluminum tube type and laminated tube type.

Plastic tube/container type (made of plastic only, contents that popped out will return, air will enter the container where the contents have disappeared, there will be gaps, the amount of the contents that can be seen through the sun will be transparent) , “Very low cost”, “It can be opened with one hand”, but it has “low confidentiality and easy to rot and needs to be mixed with a large amount of synthetic preservatives”. There is a demerit that “the component of is easy to deteriorate.”

For the above reasons, we are not using it in oral pieces made of delicate ingredients such as food and organic ingredients.

The advantage of the aluminum tube type is that it “has high airtightness and light-shielding properties, and the contents that have been put out once will not return.” On the other hand, it has the disadvantages of being “unusable”, such as “cannot be opened with one hand”, “sometimes overloaded”, and “tube breaks”.

Since the debut of the ORALPEACE in 2013, we have been using it since aluminum tubes are highly sensitive and are ideal for oralpieces that do not use synthetic preservatives.

However, in daily use at medical and nursing care sites and at home, we received many comments regarding the inconvenience (cannot be opened with one hand, aluminum will be cut, contents will not be exhausted to the end, etc.). ..

On the other hand, the laminated tube type, which we started to use in 2017, adopts the latest technology “Aluminum Barrier Lamination (ABL)” and is a material with layers of “PB, PET, aluminum, PB” stacked from the outside. ..

By sandwiching the aluminum layer in the laminate, it is possible to ensure the same level of airtightness and light shielding as an aluminum tube, and it has the property of protecting the contents without volatilizing the contents compared to a plastic tube.

It is more convenient to meet the demand for ease of use at medical/nursing sites and at home while maintaining the functionality of the aluminum tube without deterioration even after being left for 6 months in a aging test (temperature 40 degrees, humidity 75% etc.) The characteristics of conventional aluminum tubes are fully ensured as it was developed with consideration given to its characteristics.

Although the cost of the container is high, it is a tube that combines the functionality of aluminum tubes with the ease of use of plastic tubes.

At ORALPEACE , we would like to reflect the opinions of many patients and consumers and not only to research and develop the ingredients, but also to utilize the latest technology for packaging.

You can check the quality of the tube/container by taking into consideration the tube/container of the oral care product and checking the inside by opening the tube/container with scissors after use.

We recommend you to check by yourself.

When developing a product that uses a lot of water, such as mouthwash, if it is not a very small amount of a single-use type, in order to prevent water from spoiling by long-term storage at room temperature and to prevent spoilage by suppressing the growth of various bacteria (antiseptic・Because of the preservation) issues arise.

To make products such as toothpaste and mouthwash, synthetic preservatives (paraben/aka paraoxybenzoic acid, sodium benzoate, sorbic acid K, phenoxyethanol, PG/aka propylene glycol, BG/aka Butylene glycol, etc.), alcohol (ethanol), synthetic bactericide (CPC, also known as cetylpyridinium chloride, chlorhexidine gluconate, benzethonium chloride, etc.), strong alkaline water, etc. will need to be added.

In order to be established as a product, it is necessary to sterilize the microorganisms and bacteria in the product container with a synthetic preservative and a sterilizing agent to make it aseptic and to be able to store it. It requires a lot of synthetic preservatives and synthetic fungicides.

ORALPEACE do not contain lactic acid bacteria themselves (both live and dead), but contain purified peptides produced by lactic acid bacteria. Therefore, synthetic preservatives and fungicides were added at the same time. Although it does not lose the activity and effect of the contents by sterilizing live bacteria, if a synthetic preservative or bactericide is added, infants and the elderly who are not good at gargle and vomiting, pets, chemically synthesized ingredients There are problems with the use of pregnant women who do not want to ingest the product and the use as an oral moisturizer.

Therefore, we have devoted a lot of effort and time to the development and research of new products that meet the needs of people who are in trouble around the world.

Liquid type clean & moisture spray that can be used as mouthwash, reduces water content, does not require synthetic preservatives, synthetic bactericides, alcohol (ethanol), and can be stored with naturally derived ingredients. It is a container that cannot be touched from the outside (hard to be contaminated).

If you would like to use it as a mouthwash for mouthwash, we would appreciate if you could use it at home by spraying clean and moisturizing spray on water and diluting it to increase the water content.

Materials that can be said to be almost handmade, such as fermented lactic acid bacteria extract and expensive plant-derived raw materials, which are developed by investing a great deal of time and effort in basic research and technology development of new ingredients by research institutions The oral piece used is a very time-consuming and costly product.

In fact, unlike oral toothpaste, which is made by mixing cheap stone powder and synthetic surfactant in a tube and filling it in a tube, basic research produces original ingredients, blends expensive organic ingredients, and agitates/fills. Production control, packaging and box materials, patent control, pharmaceutical control, support for facilities for people with disabilities, creative, public relations, distribution to high-quality department stores, etc. Oral care products that seem to be considered do not have to be cheap, and it takes the same effort and cost as lotions and beauty liquids of several thousand yen to 10,000 yen or more made in the same process at the same factory. ..

However, the concept of the oral piece is to offer the product at a reasonable price while pursuing the effect and safety of the product.

Good products include price. With the goal of setting a reasonable price for households that can be used on a daily basis, all of our factories and distribution partners are making various efforts and efforts to develop products from scratch in order to achieve products at that price.

Honestly pursuing the ideal price for daily oral care products and the appropriate price for the product content, and aiming for a more affordable price for those who love oral pieces through corporate efforts We are.
(For 80g of Clean & Moisture Gel, 15ml per 1ml.)

Now is the time when the world can share knowledge on the Internet. You can easily check the ingredients contained in toothpaste/oral care products, their prices, and the research background of the products.

Even if you choose to purchase oral care products, check the “all ingredients” displayed on the product package without taking into account the effect expression and the suggested price that the seller sings. We ask you to search the ingredients online, check the research background of the product, whether the product is valuable to the price, and what kind of corporate attitude you are conducting research and production in manufacturing. We recommend that you make a judgment and make a smart choice.

In the future, ORALPEACE will continue to sincerely strive to create better value-added and better products for those who feel value and empathy for this research, products, and businesses. Thank you for your cooperation.

The ORALPEACE planning and development member was the pioneer in 2005 developing the first organic brand with organic certification such as oral care, body care and hair care, and has developed many organic certified brands.

What are natural organic products made for overseas consumers who are highly conscious of family health and environmental issues?
Uses plant materials that can be produced sustainably without using fossil (petroleum) materials. Plants use endless organic cultivation and wild craft materials. Chemically synthesized ingredients and additives that have an impact on the human body and environment. I think that the aim is to create a product with the concept of not using etc.

ORALPEACE have also been developed by members who have been involved in the planning and development of various organic products and oral care products based on European organic standards for more than 15 years, and are still certified plants based on international organic product standards. It is produced in.

Regarding the organic product certification mark, until 2017, Oral Piece also acquired the European organic certification for each product and marked the product with the mark. However, the claims from the certification company (certification business group) are large, and the listing of the certification mark is not as effective as expected, and the payment to the certification company and the product without making the decision to convert the certification cost to the consumer price. We have decided to stop posting on the website and continue to only manufacture products that comply with the certification standards.

In other words, the oral pieces are of the same quality as the organic certified products in the world.

However, there is a reality that organic and natural products, herbs and herbal medicines have not been able to meet the needs of various diseases that are diversifying as therapeutic agents.

In order to meet the medical and health needs of the new era, “addition of products” that contains a large number of various plant extracts that are expected to have the same effect as before, and “subtraction that uses as few chemical synthetic ingredients as possible for health” Aiming for “multiplication” to a completely different dimension in “product manufacturing”, basic research that responds to modern clinical issues by fusing R&D with Japan’s advanced science and medical technology based on biotechnology of the new era, It can be said that they are challenging the development of patented technology and the production of products in a new era.

Specifically, it is necessary to create products that do not use petroleum-derived ingredients even if they are raw materials that can be used in food, and do not use chemically-synthesized ingredients or alcohol (ethanol) even if they are natural or plant-derived Naturally, in addition to the above, the lactic acid bacterium bacterium derived from plants, which is kind to animals and the global environment, was invented over 10 years with the aim of achieving both efficacy and safety through industry-academia collaboration with advanced research institutions. The major difference is that it is an oral care product for the global market that originates from Japan, which is a research and technology-based nation, and contains the syn drug “Neonisin-e”.

It is also a big difference that it is a social product that is trying to utilize the research and technology not only for commercial purposes but for the creation of jobs for people with disabilities in vulnerable places around the world.

ORALPEACE is a product and business that was created in consideration of an important family. I’m sure that everyone will be able to convey that feeling through the product.

We hope that many people will use ORALPEACE.

Thank you for your continued support of ORALPEACE Project.

In modern science,



1. “All human indigenous bacteria cannot be classified as good or bad”



2. “There is no technology that can classify the same creatures as good or evil and control/reduce only one or raise/increase only one”



There is a thing.

It is said that about 500 kinds of bacteria, including those that have not yet been named, live in our oral cavity up to 1 trillion.



In modern modern science, identification of bacteria that cause tooth decay and periodontal disease among the indigenous bacteria in the oral cavity is progressing, but 
 all bacteria in the oral cavity including those that have no name The fact is that the separation of good bacteria and bad bacteria has not actually been done.



In the oral cavity, even indigenous bacteria, which are considered to be good, may have a bad effect depending on the situation (also called opportunistic bacteria), and on the contrary, it is described as a bad one that causes tooth decay and periodontal disease. It has not been scientifically ruled out that indigenous bacteria can also perform good functions such as suppressing bacterial invasion from the outside.

 In other words, there are no evidences regarding the judgment of good or evil of indigenous bacteria・Because it has not been clarified.

Next, bacteria are classified as Gram-positive bacteria, Gram-negative bacteria, fungi, etc., and are not classified as good bacteria or bad bacteria.
The latest technology to sort the same organisms as good and bad There is no point.

Like humans, animals, insects, and living things, if you use “poisons”, “insecticides”, and “bactericides”, good and bad people, good animals and bad animals, beneficial insects and pests The indigenous bacteria that form, the bait bacteria and viruses, and the good bacteria and the bad bacteria “act on both at the same time and both.”

The opposite is the same, but since the recent boom in lactic acid bacteria has increased the focus on “bacteria” in the beauty industry, focusing on “beneficial bacteria” and “beautiful skin bacteria” that have a good effect on the human body, the “beneficial bacteria” Even if you want to grow or increase “Beautiful skin bacteria”, “all bacteria including bad bacteria” will increase at the same time.

The following are the current findings in the world’s most advanced lactic acid bacteria research, that is, research on probiotics and lactic acid bacteria antibacterial peptides (bacteriocins).




The antibacterial substances and antibacterial peptides (bacteriocins) produced by lactic acid bacteria vary depending on the type, but there are many antibacterial spectra (ranges) ranging from narrow to wide.



For example, “Nisin A”, which was discovered for the first time in the world and is most famous, has the broadest antibacterial spectrum among lactic acid bacteriocins and controls most Gram-positive bacteria.



On the other hand, bacteriocin, which has a narrow antibacterial spectrum, controls only certain Gram-positive bacteria (Gram-positive bacteria closely related to the production bacteria).



It can be said that this is “a certain bacterium or bacteriocin controls by selecting a specific bad bacterium”, but unfortunately it also works with closely related Gram-positive bacteria. I will.



Among the closely related bacteria of Gram-positive bacteria, Streptococcus mutans which is a bad bacterium that causes tooth decay and selects “only”, “single action” bacteria, substances, and bacteriocins are still found in the world. not.

It is impossible to get rid of only “bad bacteria” among all bacteria.

On the contrary, it is impossible to nourish “good bacteria”, “beautiful skin bacteria” and “only” to give them an advantage and increase “good bacteria”, “beautiful skin bacteria” and “only”.

Health and beauty/moisturizing effect in the oral cavity by growing and increasing “beneficial bacteria” and “beautiful skin bacteria” by paying attention to the existence and effects of “good bacteria” and “beautiful skin bacteria” in the oral cavity and skin I understand that you want to ask for, but unfortunately, you also increase “bad bacteria.”

As an example, if nutrients such as “oligosaccharides” that lactic acid bacteria prefer are given to “good bacteria” and “beautiful skin bacteria”, they will also be nutritious to “bad bacteria”, and at the same time as “good bacteria” and “beautiful skin bacteria” Will increase in the same way.

It is actually difficult to fix new bacteria such as “beneficial bacteria” and “skin-cleansing bacteria” to the human body, and it is not possible to nourish only the “beneficial bacteria” and “skin-cleansing bacteria” that are indigenous to each person. In the end, it means that the bacterial flora composed of “beneficial bacteria”, “beautiful skin bacteria”, “bad bacteria”, etc. will not change, and if you give nutrition, “bad bacteria”, which has a relatively strong power, will also become healthy, We may also expand our power.




In other words, it is impossible for the human body to “control only by selecting bad bacteria” and “increasing only good bacteria and beautiful skin bacteria” with the latest science and technology.

The human beings on earth are the same as we humans, but they support each other, complement each other, act and live together, and coexist in balance.

All of them do not exist insignificantly, and in the situation where their respective functions and interactions are not elucidated in science, it is impossible to distinguish everything from good and evil, and it is not possible to distinguish superiority and inferiority. is.



Even in the same human being, it has been reported that the composition of salivary bacteria varies depending on ethnicity, family, and each person depending on heredity and living environment. For each person, more than several hundred types of oral bacteria are good or bad. It cannot be said that it can be separated into fungi.



The bacteria and flora that we have in the oral cavity, skin, and intestines are not those that we have from birth, but the bacteria and flora that are inherited from parents such as cheek rubbing and saliva contact from an early childhood. It can be said that genetically optimal bacteria protect the body.




Like human beings, living things have good and bad sides for a specific person or society, but they are born and exist because they are necessary, and live and coexist with their individual characteristics.

Invisible to our eyes, it is the same organism, bacteria.



The oral cavity suffers from trouble because it is one of the Gram-positive bacteria, Cariestobacilli, that lives in the mouth as an indigenous bacterium and does not usually cause any problems (it does something useful). Produce acid from food waste and sugar as food to cause dental caries, periodontal disease bacteria that are one of the Gram-negative bacteria “excessively increase” between the teeth to form biofilms, and cause inflammation of the gums. The cause is that it becomes dirty and the total number of bacteria “excessively increases” and flows into the lungs.




Oral care with oral pieces helps to keep the oral health and peace of mind by approaching trouble-causing bacteria that are present as oral bacteria and cause “too many” problems.




For details, please see the collection of papers.

While the prices of various products have been rising, the “affordability” (image of an acceptable price) that consumers felt for “toothpaste” was very low.

This is because the ingredients, calcium carbonate and baking soda, are cheap and consumers know this, and companies that have produced toothpaste have been very honest and serious with consumers.

In addition, amidst deflation (economic uncertainty accompanied by falling prices) that has continued for many years, many manufacturing companies around the world have been unable to pursue new research or develop new technologies, compared to companies in other growth fields such as ICT and biotechnology. This may be the result of choosing a low-margin, high-sales strategy of mass production and mass sales of simple, low-value-added, low-priced products rather than creating high-value-added products through technological innovation.

In this economy, especially before the coronavirus pandemic, many consumers would rather invest in their family’s health or reduce their total expenses through high added value than to invest in consumer goods without technological innovation. The desire to keep expenses down has become an important point in purchasing, and there is a current situation in which low-priced consumer goods are favored.

However, recently, even for manufacturing companies, the population, the amount of products used, and the situations in which they are used have not increased, and the number of customers and number of sales have been limited, and they have been able to market imitation products of other companies without spending research and development costs, and share their market share due to their low price advantage. In a war of attrition to increase sales by taking away customers, we are reaching our physical limits in terms of maintaining sales and paying employees, so we are repricing our products to higher prices and increasing our price range by strengthening our branding in order to increase the average spend per customer. is progressing.

ORALPEACE is an oral hygiene product that aims to create unprecedented high added value and create a new market through technological innovations invented through research at universities and other institutions in order to meet new needs around the world. It becomes.

ORALPEACE was born in 2013 in Japan, where the elderly population is the highest in the world, and is one of the most popular products in the global oral care product market. This is a super niche market product that specializes in.

It is a small market in the world, and many companies are left behind in niche markets where they do not invest in new R&D or enter the market.

This is because the lifetime value (LTV/customer lifetime value) is low, the economic efficiency is low, and the business viability is low, in other words, the company is not profitable.

In Japan alone, more than 1.3 million people, mainly elderly people, die from old age or disease every year.

This means that the number of users in Japan who require oral peace continues to decrease by more than 1.3 million people every year.

However, even though the market is small, there are people around the world who are in trouble and are left behind, such as the elderly, people fighting diseases, infants, and people who are not comfortable with chemical ingredients.

ORALPEACE is an oral care product for those who are left behind in this world.

This product was newly researched and developed by a research institute at a national university, giving top priority to the health and happiness of many families, rather than corporate profits or economic efficiency.

In other words, from a business perspective, ORALPEACE’s main business itself is not an economic or profit-making activity, but rather an economically balanced social contribution activity and CSR (Corporate Social Responsibility). This means that it is a completely independent CSV (Creating Shared Value) model, which is rare in the world.

As a business, it is a social enterprise in which it is difficult to pursue economic efficiency, but due to a serious research background, we are the only oral hygiene agent in the world that is “specialized in oral care for elderly and vulnerable people”. It has no social benefit.

It is a new value for humanity: “It instantly attacks bacteria that cause problems in the oral cavity at an ultra-low concentration, is moisturizing, is safe to swallow, is highly biodegradable, and has a low environmental impact.”

Currently, we are small and have not been able to convey this new invention and value to people around the world, but in 100 years, the orientation of people around the world will definitely shift in this direction, not just for the elderly and the weak. I can imagine it going.

The reason why lactic acid bacteria antibacterial peptides (bacteriocins) have been applied to the field of hygiene and created new value for humankind is through the efforts of serious researchers at research institutes such as Kyushu University in Japan, who are risking their lives to conduct research every day. This is the result of hard work.

This is a world-class technological innovation created by a Japanese research institution that created a new market that did not exist before and provided new benefits to humanity.

The technological innovations created by this Japanese research institution may seem small now, but over time, it can be said to be a made-in-Japan technology that will gain attention around the world.

Therefore, it takes a lot of time and money to conduct basic research and development to provide essential value.

In fact, ORALPEACE differs from toothpaste, which is a mixture of cheap stone powder and synthetic surfactants packed into tubes, in that it involves basic research, production of unique raw materials, blending of expensive organic raw materials, stirring, filling, and Low cost in terms of category, such as production management, packaging and box materials, patent management, pharmaceutical management, support for support facilities for people with disabilities, creative, public relations, distribution to high-quality department stores, consumer/customer support, etc. Oral care products that seem to be cheap are not cheap; they require the same amount of time and effort as lotions and serums that cost several thousand yen to over 10,000 yen and are made in the same factory and in the same process. .

(Thus, since the production price of the product itself is high, mass retailers are required to compete with low prices, invest in advertising, make a profit of more than 60% of the retail sales price, and if the product does not sell, must return all products to the manufacturer and receive a refund.) )

In addition, the market and production volume of the product is limited, and since most of the products are manufactured by hand by Japanese people, it takes a lot of effort and cost to produce each item.

In addition, for many cosmetics and consumer goods, distribution costs such as materials such as boxes and containers and retailer profits are higher than the contents, making it difficult to evaluate the research and technology behind the products economically.

However, since the recent coronavirus outbreak, we have learned more about the importance of oral hygiene as preventive care and health maintenance, the mucous membrane absorption of chemicals contained in oral care products, and the impact on the microbial ecosystem when released into the environment. Many people have noticed that consumer awareness of oral care products is rapidly changing.

ORALPEACE Clean & Moisture gel costs 1,200 yen for about 2 months.

That means 600 yen per month and 20 yen per day.

When you say 600 yen,

For many people,

Bank transfer fees and overtime fees, monthly charges for mobile phones, WIFI, and internet services, small lunch and dinner party fees, wine and alcohol, electricity and gas fees, daily food and snack fees, expressway fees and gasoline fees, Parking fees, train fees, coffee and cigarette fees, electricity fees, WIFI fees, mobile phone fees for viewing this website, etc.

and,

People who are worried about aspiration or accidental ingestion, who are in need of nursing care who are not good at gargling or spitting it out, or who are battling illness.

Those who take care of their family’s health and seek safety in what they eat and put in their mouths, those who are trying daily health and preventive care, infants, pregnant women, and valuable disasters in water, beautiful natural Those who want to use oral care products in

For,

Other expenses related to maintaining health, prices of organic vegetables and ingredients with few additives, prices of health foods and supplements, expenses for sports and gyms, medical expenses and medicine expenses when you get sick, cosmetics and shampoo expenses, etc. Daily anxiety about various things…

Even when compared to

Through joint research with Kyushu University Graduate School of Agriculture, Kagoshima University Graduate School of Medical and Dental Sciences, National Geriatrics Center, Oral Disease Research Department, etc.

Researched and developed over 10 years,

Made in Japan, made almost entirely by hand from materials and raw materials by people who live and have families in Japan.

You can enjoy the unprecedented value of “instantly attacking bacteria that cause problems in the oral cavity, moisturizing, and being safe to swallow, being highly biodegradable, and having a low environmental impact.”

Packaged in designed boxes and tubes, they will be displayed at hospitals, dental clinics, and department stores across the country, and your purchase will also contribute to society.

Above all, I use it for the health and happiness of my precious family, and I also invest in my own health so that I don’t cause any trouble to my family until my last day.

1,200 yen (600 yen per month),

Don’t you think it’s reasonable? (lol)

ORALPEACE are available at affordable prices for those who value their family’s health and happy days.

We will continue to work diligently on manufacturing, so we appreciate your continued support.

For other questions, please see the page below.

“Frequently Asked Questions”

If you have any questions that are not included in the “Frequently Asked Questions”, please feel free to contact us using the contact form.

We also welcome messages about projects, research and products.

We would appreciate it if you could feel free to contact us using the contact form.

We look forward to your continued support of the ORALPEACE Project.

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We would be happy if everyone could improve their life with oral peace by adding the tags #oralpeace and #oralpeace and be connected to PEACE all over the world.

Best regard!!