The Power of Nature Approaching Bacteria.

ORALPEACE is an oral care product made solely from water and plant-derived ingredients, incorporating the patented lactic acid bacteria peptide formulation “Neonisin-e®” derived from natural sources.

It has been recognized for its excellent efficacy against bacteria causing oral troubles, and since it is digested and broken down in the body even if accidentally swallowed or aspirated, it can be recommended for those who have difficulty spitting it out.

Unlike conventional oral care products, it can be used safely by a wide range of age groups—from newborns to pregnant women and the elderly—even in environments without water, making it ideal for disaster preparedness. In evacuation shelters where routine oral care becomes difficult, it helps reduce the risk of aspiration pneumonia and other issues.

In Japan, the country with the world’s most advanced aging population, there are currently about 7 million elderly individuals requiring care, with annual caregiving costs exceeding 10 trillion yen and projected to swell to 25 trillion yen by 2040. This is becoming a major social issue alongside the increasing burden on caregivers. As a universal challenge for humanity worldwide, similar aging problems are forecasted on an even larger scale globally in the future (with the global population aged 65 and over exceeding 1.5 billion by 2050).

The Ministry of Health, Labour and Welfare is actively promoting oral care to extend healthy life expectancy and reduce the approximately 10-year gap between average lifespan and healthy lifespan (i.e., the caregiving period). This includes preventing oral frailty through proper oral care, the 8020 campaign (aiming to retain 20 teeth by age 80) based on the correlation between the number of teeth and Alzheimer’s disease, and efforts to extend healthy lifespan while reducing caregiving burdens.

However, in Japan, hundreds of people die daily from aspiration pneumonia, and the number of elderly individuals suffering from cavities, periodontal disease, bad breath, and aspiration-related lung troubles caused by proliferating bacteria in the oral cavity is increasing. The burden of oral care performed by caregivers or family members at care sites is heavy, and the reality is a desire for safe, simple, and effective care methods.

In Japan, now the world’s leading nation in elderly population, at oral hygiene and care sites for those requiring care—such as the elderly, cancer patients, people with disabilities, or the injured—there is a need for solutions addressing bacteria that cause oral troubles like oral candidiasis, aspiration pneumonia, periodontal disease, cavities, bad breath, and stomatitis.

This meets the 21st-century invention needs for oral hygiene moisturizers that: “kill bacteria while being safely digested and decomposed if swallowed,” “protect the intestinal flora,” and “are 100% biodegradable even when discharged into the environment.”

By applying research technology (STI) from Japan’s national research institutions, a new era of toothpaste and oral care products has been created for all humanity.

Based on over 20 years of research in lactic acid bacteria biotechnology to “control bacteria with bacteria,” led by Dr. Kenji Sonomoto, Professor Emeritus of Kyushu University, who served as Professor in the Microbial Engineering Research Division, Department of Bioscience and Biotechnology, Graduate School of Agriculture at Kyushu University; President of the Japan Society for Lactic Acid Bacteria; and President of the Society for Biotechnology, Japan—this invention incorporates the patented lactic acid bacteria antibacterial peptide (bacteriocin) formulation “Neonisin-e.”

“Neonisin-e®,” a patented formulation derived from nisin—the world’s only antibacterial peptide (bacteriocin) approved for food use—approaches trouble-causing bacteria in the oral cavity, such as mutans streptococci, P. gingivalis, Candida, E. coli, and Staphylococcus aureus, at ultra-low ppb concentrations in an instant, far surpassing conventional antibiotics or synthetic bactericides.

It is a toothpaste and oral care product that is 100% safe food ingredients even if swallowed, chemical-free, plant-based, and 100% biodegradable.

This resolves the conflicting challenges that old chemical technologies could not overcome—”effectiveness against causative bacteria at ultra-low concentrations combined with high biodegradability and safety”—through cutting-edge lactic acid bacteria antibacterial peptide research and green technology from Japan’s national research institutions.

Born from an invention unmatched anywhere in the world, it creates new possibilities for humanity’s sustainable development. This is an environmentally considerate oral care brand for a new era that is gentle on both the body and nature, expanding from Japan to about 15 countries worldwide, including Europe.

Since 2022, it has been selected for inclusion on the International Space Station (ISS) in collaboration with JAXA (Japan Aerospace Exploration Agency). We are developing space toothpaste like ORALPEACE for space and space cosmetics like FACEPEACE, as Japan’s first venture in personal care products for space. Toward the era of human space development by 2050, we have begun small challenges as a space-related company. Since the 2010s, we have been supporting the health maintenance of astronauts in extreme conditions and humanity’s advancement into space.

From Japan—the world’s leading nation in elderly population and a global leader in science and technology—we aim to share the results of this 21st-century sustainable green technology, which balances clinical effectiveness, safety, and low environmental impact, with many people around the world facing difficulties as soon as possible, through a sincere social contribution business filled with love to help the vulnerable.

Creating Jobs for People with Disabilities through Innovative Oral Care Products
ORALPEACE Project

We are a Japanese biotechnology venture that has pioneered the medical and healthcare applications of lactic acid bacteria antibacterial peptides (bacteriocins), using bacteria to control bacteria for the first time in the world.

Through collaboration among researchers, clinicians, engineers, and government bodies, we have developed innovative, plant-based oral care products that are safe to swallow, pursuing both clinical efficacy and safety to contribute to human progress. These products support the oral health of people worldwide, from infants to the elderly, promoting daily health, extending healthy lifespans through oral care and prevention, and advancing humanity’s development in the era of space living.

Rooted in a volunteer organization supporting people with disabilities, including parents of children with disabilities, we strive to create jobs for people with disabilities across Japan who face limited income opportunities, addressing the issue of their support after the passing of their parents. We also tackle sustainable social contributions, such as reducing the growing burden on medical and caregiving professionals due to global aging, supporting disaster-affected areas, and protecting the Earth’s environment through green technology.

As a social venture led by those directly affected by these societal challenges, we are also, since 2022, the world’s first venture developing personal care products for space. By harnessing the collective wisdom and technology of humanity, we research, develop, and manufacture products essential for human life in space, taking on the cutting edge of science.

The increasing environmental destruction and disasters on Earth, along with the urgent need for CO2 reduction and water conservation to combat global warming, and the onset of space exploration as a path for humanity’s future, are becoming realities that cannot wait. These challenges require global collaboration, uniting diverse wisdom and leveraging cutting-edge technology to overcome.

ORALPEACE meets the need for both efficacy and safety through advanced lactic acid bacteria research and biotechnology from Japan’s national research institutions (STI). The ORALPEACE Project aims to realize a society where individuals support one another in times of need. Professionals from various fields unite, and with the support of many, we are expanding this love-driven initiative from Japan—the world’s leading aging nation and a global leader in science and technology—to the world and into space.

“ORALPEACE is not just toothpaste.
It’s a movement — from Japan to the stars, for the ones closest to your heart.”

“ORALPEACE is not just oral care.
It’s love, in a tube — from Earth to the Moon.”

What we aim to deliver is healthy and happy days for families: the joy of living with the most important people in your life, the courage to overcome any challenge for loved ones, and irreplaceable moments. We aspire to share this vision with people across Japan and around the world.

We warmly invite you to join us as partners in supporting this project, working together to shape the future.

Thank you for your support of the ORALPEACE Project.

ORALPEACE project