ORALPEACE Launches Fluoride-Free Tooth Gel for Babies and Children Worldwide
In Response to U.S. Fluoride Regulations, Providing Safe Oral Care for Your Child’s Future
~ For You and Your Baby’s Future, For the Peace of Mind of Your Entire Family ~
Chemical-Free Oral Care Powered by Japanese Space Technology
Product Specifications
Product Name: ORALPEACE Baby Children’s Tooth Gel
Origin: Yokohama, Japan
Volume: 80g (approximately 2.5 months’ supply)
Ingredients: Glycerin (plant-derived moisturizer), water, lactic acid bacteria culture extract (cleaning aid), xanthan gum (plant-derived thickener), plum fruit extract (cleaning aid), Caesalpinia spinosa gum (plant-derived thickener), orange oil (flavor), yuzu peel oil (flavor), peppermint oil (cleaning aid, flavor), damask rose flower oil (cleaning aid)
Texture: Colorless, transparent gel (no dyes)
Flavor: Natural, fruity taste from plant-derived ingredients, gentle for newborns (free of chemicals, synthetic preservatives, sweeteners, fragrances, abrasives, foaming agents, alcohol, fluoride, or animal-derived ingredients)
Price: Japan: ¥1,200 (~$8.3, tax excluded)
Launch Date: Mid-June 2025
Fluoride Regulation in the U.S. and the Shift to Fluoride-Free Products
On September 24, 2024, the U.S. District Court in California (Judge Edward Chen) ordered the U.S. Environmental Protection Agency (EPA) to strengthen regulations on fluoride in drinking water due to potential risks of IQ decline in children (（https://www.reuters.com/world/us/epa-must-address-fluoridated-waters-risk-childrens-iqs-us-judge-rules-2024-09-25/）。
This ruling is based on an August 2024 report from the U.S. National Toxicology Program（https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/fluoride）, which evaluated 72 studies and found that 19 high-quality studies suggest fluoride concentrations of 1.5mg/L (1.5ppm) or higher may be linked to IQ decline (NTP). However, data on effects at the U.S. recommended level (0.7mg/L) remain limited, and the World Health Organization (WHO) and American Dental Association (ADA) currently support fluoride’s efficacy in preventing tooth decay at recommended levels.
Following this ruling, municipalities in states like Florida, Tennessee, and Utah have begun discontinuing fluoride addition to water supplies. On May 13, 2025, the U.S. Food and Drug Administration (FDA) announced the withdrawal of ingestible fluoride prescription products for children, citing potential risks to infants, including impacts on gut flora and cognitive development（FDA Begins Action To Remove Ingestible Fluoride Prescription Drug Products for Children from the Market）. This is critical information for parents prioritizing safety during early childhood.
Conversely, investors anticipating a rise in dental caries due to fluoride restrictions have driven up stock prices for dental equipment and material manufacturers, as reported by Nikkei. This shift has prompted a return to core dental practices, such as sugar intake guidance, brushing instruction, and cavity treatment, benefiting the dental industry overall.
Latest Updates on U.S. Fluoride Regulations: https://ORALPEACE.com/news/news-news/33862
Expectations in the U.S.
“With recent court rulings highlighting the neurotoxic risks of fluoride for fetuses and infants in cavity prevention, prioritizing patient safety with the ‘do not use if in doubt’ principle is crucial. Developing safe oral care for vulnerable pregnant women and young children through innovative research is vital. ORALPEACE, leveraging patented technology from Japanese national universities used in space exploration, combines scientifically proven safety and efficacy, offering a trusted choice for parents concerned about their children’s intellectual development.” (U.S. parenting community)
Global Fluoride-Free Toothpaste Market Growth and Timing
This product launch aligns with the growing global fluoride-free toothpaste market. Research indicates the market exceeded $6.3 billion (approximately ¥976.5 billion) in 2024, with a projected compound annual growth rate (CAGR) of 5.67% from 2025 to 2034, reaching $10.94 billion (approximately ¥1.6957 trillion) by 2034 (https://www.expertmarketresearch.com/reports/fluoride-free-toothpaste-market）. Other studies estimate the market at $5–7 billion (¥775–¥1,085 billion) in 2023, with a CAGR of 5–6% by 2030 (Toothpaste Market). The children’s fluoride-free segment is expanding rapidly, driven by parental demand for safe ingredients, with health-conscious consumers leading the trend. （Fluoride Free Toothpaste Market Share & Analysis 2034（Toothpaste Market Size, Share, Trends & Growth Report [2032] https://www.fortunebusinessinsights.com/toothpaste-market-104484）
These trends show innovators worldwide shifting to fluoride-free options, reflecting a preference for natural, safe ingredients independent of regulatory changes. “ORALPEACE Baby Children’s Tooth Gel” anticipates this shift, offering a groundbreaking, abrasive-, foaming agent-, and chemical-free product with proven safety and efficacy, providing a new choice for parents aspiring for their children’s future success.
Expansion in Japan and Global Markets
In Japan, high-fluoride toothpastes are widely recommended, but U.S. court rulings and discussions are spreading via news and X, reaching educated, health-conscious parents with global exposure. This may boost demand for fluoride-free products during pregnancy and infancy. ORALPEACE will launch in Japan from mid-June 2025 to meet these needs, offering a new option for parents prioritizing their children’s intellectual development and future success amid ongoing fluoride safety debates.
Sales Channels: Nationwide dental clinics, obstetrics/gynecology and pediatric hospitals, family clinics, urban department stores, luxury baby stores, high-end hotels, membership clubs, resort hotels, luxury retailers, first-class in-flight services, lifestyle shops, design stores, select shops, women’s and children’s apparel stores, premium supermarkets, organic food and cosmetic stores, early education centers, tutoring schools, preschools, private kindergartens, international schools, libraries, bookstores, science museums, planetariums, space shops, art museums, museum shops, yoga studios, high-end gyms, spas, salons, bridal facilities, outdoor shops, campgrounds, pop-up stores, hometown tax shops, parent-child event novelties, ORALPEACE Store, Amazon, child support organizations, and regional disability employment facilities.
Globally, starting in the U.S., we will expand to Europe (Germany, France, UK), Latin America (Mexico, Guatemala, Brazil, Argentina), and Asia (Singapore, Taiwan, Malaysia, Thailand). Using Japan’s national research institute-developed lactic acid bacteria biotechnology, we offer new choices and peace of mind for families’ most precious babies to knowledge-driven, innovative parents worldwide prioritizing intellectual development and healthy growth.
Social Background and Mission
Globally, autism spectrum disorder (ASD) and other developmental disorders are on the rise, with 2022 research estimating a prevalence of 1% (1 in 100 children), impacting millions (Autism Research). This trend highlights the need for safe, effective oral care products that pose no risk to children’s health and development.
The ORALPEACE Project, founded 20 years ago by parents of children with disabilities (including management consultants and designers), stems from a volunteer organization focused on developing and selling products for people with disabilities. Our mission is to create jobs for individuals with disabilities and address the “after parents are gone” challenge through innovative oral care. We contribute to a future where all children can lead healthy, happy lives through advanced science and compassionate business.
About ORALPEACE
ORALPEACE is a Japanese oral care brand dedicated to safety and efficacy. Using the patented “Neonisin-e” formulation, developed with Kyushu University, Kagoshima University, and the National Center for Geriatrics and Gerontology, we offer chemical-free products. We also promote job creation for people with disabilities, disaster relief, and environmental protection, striving for a sustainable society.
About Neonisin-e®
“Neonisin-e®” is a plant-based lactic acid bacteria peptide formulation from collaborative research with Kyushu University, Kagoshima University, and the National Center for Geriatrics and Gerontology. Derived from lactic acid bacteria in Fukuoka Prefecture’s “okara” (soy pulp), it targets oral bacteria like mutans, Pg, periodontal, E. coli, aspiration pneumonia, odor, and Candida at ultra-low concentrations. Safe when swallowed, it digests into amino acids in the intestines. It earned the 2019 Japan Society for Bioscience, Biotechnology, and Agrochemistry Technology Award (Patent No. 6523473) (https://neonisin.jp/en/).
ORALPEACE Development History (Excerpt)
December 2012: Announced “Neonisin” invention (Kyushu University Press Club).
June 2013: Launched ORALPEACE Project for disability job creation.
July 2013: Launched “ORALPEACE Clean & Moisture” gel/spray for elderly care.
February 2014: Won Grand Prize and Audience Award at Yokohama Business Grand Prix.
February 2015: Won Grand Prize at JAPAN Venture Awards, leading Japan’s ventures.
April 2015: Patented “Neonisin” and earned European organic certification.
March 2016: Launched chemical-free “ORALPEACE for Pet.”
July 2017: Launched “Neonisin-e” for oral Candida (Yokohama Port Opening Memorial Hall).
October 2017: First oral care product to win Good Design Award 2017.
September 2018: Entered Europe, expanding to 15 countries.
March 2019: Received Japan Society for Bioscience Technology Award.
May 2019: Launched biodegradable “ORALPEACE Outdoor Adventure.”
February 2020: Donated ORALPEACE to 3,600 Diamond Princess passengers/crew.
June 2021: Launched “ORALPEACE Clean & White” and “BODYPEACE Premium Hand Cream.”
November 2021: JAXA selected ORALPEACE for International Space Station.
May 2022: Launched “ORALPEACE Space Toothpaste” and “FACEPEACE Space Cosmetics.”
June 2025: Launched “ORALPEACE Baby Children’s Tooth Gel” in response to U.S. fluoride rulings, starting global rollout from the U.S.
Video Introduction: ORALPEACE Videos https://youtu.be/ByuIqlJHxl4?si=SHxM9kqukpApP41b
Contact Information
Trife Inc. ORALPEACE Project
Website: ORALPEACE https://oralpeace.com/en/
Address: 4-43 Minami-Nakadori, Naka-ku, Yokohama, Japan
We urge media, reporters, and writers who care about our future children to share this news with pregnant women, fathers, mothers, and families. By highlighting risks to fetal and infant intellectual development, we empower informed choices to protect precious children. Your support is vital for their future.