Organizations: TRIFE Inc., Yasashii Laboratory Inc., Kyushu University (ORALPEACE Project)
Initiative Name: Development and commercialization of a safe oral care agent using lactic acid bacteria bacteriocin and nisin (innovative oral care products adopted in space to reduce global caregiving burdens and create jobs for people with disabilities)
TRIFE Inc. (Headquarters: Minami-Nakadori, Naka-ku, Yokohama; Otsu Building ; Representative: Daisuke Teshima) has been awarded the Encouragement Prize in the “2025 STI for SDGs Award” hosted by the National Research and Development Agency Japan Science and Technology Agency (JST).
This award recognizes outstanding initiatives that leverage Science, Technology, and Innovation (STI) to address societal challenges. Our project—“Innovative oral care products adopted in space to reduce caregiving burdens worldwide and create jobs for people with disabilities”—was highly evaluated.
This marks the first such achievement in oral care products and the dental field.
- ORALPEACE and SDGs
- JST “2025 STI for SDGs Award” Page
- Japan Science and Technology Agency Report, Issue 1805, October 16, 2025 (Reiwa 7) – Announcement of 2025 “STI for SDGs” Award Recipients


【Award Summary】
2025 “STI for SDGs” Award Encouragement Prize Organizer: National Research and Development Agency Japan Science and Technology Agency (JST) Organizations: TRIFE Inc., Yasashii Laboratory Inc., Kyushu University (ORALPEACE Project) Initiative Name: Development and commercialization of a safe oral care agent using lactic acid bacteria bacteriocin and nisin (innovative oral care products adopted in space to reduce global caregiving burdens and create jobs for people with disabilities)















【Social Background of the ORALPEACE Project】
ORALPEACE is an oral care product made solely from water and plant-derived ingredients, incorporating the patented lactic acid bacteria peptide formulation “Neonisin-e®”, invented through industry-academia-government collaboration with Kyushu University using STI (Science, Technology, and Innovation) from Japan’s national research institutions and adopted in space.
It demonstrates excellent efficacy against bacteria causing oral issues and is digestible and degradable in the body even if accidentally swallowed or aspirated—making it ideal for those who have difficulty spitting.
Unlike conventional oral care products, it can be safely used by people of all ages—from newborns to pregnant women and the elderly—even in water-scarce environments, making it optimal for disaster preparedness. In evacuation shelters where routine oral care is challenging, it helps reduce risks such as aspiration pneumonia.
Japan, the world’s most aged society, currently has approximately 7 million elderly requiring care, with annual caregiving costs exceeding 10 trillion yen—projected to reach 25 trillion yen by 2040. This growing burden on caregivers is a major social issue. Globally, aging is expected to become an even larger challenge, with the population aged 65 and older projected to exceed 1.5 billion by 2050.
Japan’s Ministry of Health, Labour and Welfare promotes oral care to extend healthy life expectancy and reduce the approximately 10-year gap between average lifespan and healthy lifespan (i.e., caregiving period). Initiatives include preventing oral frailty and the 8020 campaign (retaining 20 teeth by age 80), linking oral health to conditions like Alzheimer’s.
However, hundreds of people die daily in Japan from aspiration pneumonia caused by oral bacteria, with increasing cases of cavities, periodontal disease, bad breath, and aspiration-related lung issues among the elderly. Caregivers and families face heavy burdens in providing safe and effective oral care, alongside the strain of repeated hospital admissions due to aspiration pneumonia.
The ORALPEACE Project—initiated by a group of parents of children with disabilities—goes beyond innovative product development. It creates jobs for people with disabilities nationwide through core business activities (production, distribution, sales) and addresses the “post-parental care” challenge (SDGs)—a Japan-origin STI for SDGs initiative.
Innovative Oral Care Products for Extending Global Healthy Lifespan and Creating Jobs for People with Disabilities
ORALPEACE is a swallowable oral care product featuring the patented Neonisin-e® formulation derived from lactic acid bacteria. It targets bacteria causing oral issues, aiming to reduce caregiving burdens and costs—currently exceeding 10 trillion yen annually in Japan (projected to reach 25 trillion yen by 2040, with the global 65+ population exceeding 1.5 billion by 2050).
Proven Results:
- Adoption in space validates the credibility of Japan’s national research institution-derived STI, directly linked to job creation and profit-sharing for people with disabilities.
- Over 10 years, distributed over 3,000 yen to 3,000+ individuals with disabilities.
- Cumulative 2 million units shipped, expanded to 15 countries worldwide, and adopted in medical institutions and local governments.
Environmental Impact: Certified with the Acorn Mark and fully biodegradable.
Future Plans: Initiate local production and support abroad, delivering impact across 11 SDGs (1/3/4/8/9/10/12/13/14/15/17) as a Japan-model initiative.
ORALPEACE leverages Japan’s national research institution-derived lactic acid bacteria biotechnology—adopted in space—to provide convenient, safe, and effective oral care. It reduces caregiving burdens, benefits health and the environment, and increases support for people with disabilities as sales grow—a Japan-origin STI for SDGs model.
Key Features of ORALPEACE:
- Contains patented Neonisin-e® lactic acid bacteria bacteriocin formulation, adopted on the International Space Station (ISS).
- Acts instantly at ultra-low concentrations against bacteria causing oral issues.
- Digestible if swallowed; biodegradable if discharged into the environment.
- Chemical-free, revolutionary oral care product.
For bedridden elderly or people with disabilities unable to rinse or spit, conventional sterilizers can cause stomach upset, while water or moisturizers alone increase risks of aspiration pneumonia and oral diseases. In Japan, hundreds die daily from aspiration pneumonia, contributing to caregiver burden (both professional and family) and healthcare costs (over 10 trillion yen annually, projected to 25 trillion yen by 2040, with global 65+ population exceeding 1.5 billion by 2050).
Through Japan’s national STI and diverse partnerships, ORALPEACE reduces caregiving burdens in the world’s most aged nation, creates jobs for people with disabilities via business, protects the environment, and supports disaster-affected areas—contributing to global social challenges from Japan.
The ORALPEACE Project utilizes STI (Science, Technology, and Innovation) with the patented Neonisin-e® formulation for swallowable antibacterial oral care.
Its selective bacteria-suppressing technology earned trust as an oral care product for astronauts in extreme environments and is now expanding to medical and municipal sectors.
In 2025, local deployment begins in the U.S., expanding job support for people with disabilities through technological innovation—contributing to SDG 9 (Industry, Innovation, and Infrastructure).
This project—based on ISS-adopted technology—is a unique, integrated SDGs model from Japan, the world’s most aged society, combining aspiration prevention for the elderly with support for people with disabilities, safe oral care, job creation, and environmental consideration.
Using Japan-origin STI adopted in space, this initiative tackles global aging challenges (projected 1.5 billion+ people aged 65+ by 2050), universal support for people with disabilities, and planetary environmental pollution.
From Japan—the world’s most aged nation—we deliver cutting-edge national research technology to those in need worldwide, co-creating a better future.
ORALPEACE: A CSV Model Linking Japan’s National STI to Profit-Sharing
- Swallowable × Selective Antibacterial Japan-origin STI, directly tied to sales-driven profit allocation.
- Third-party validations: ISS adoption (space technology), KIS certification (government standard).
- 10 years: Cumulative 2 million units, 50+ facilities, 3,000+ people with disabilities, over 30 million yen distributed.
- Expanded to over 500 medical institutions and specialty stores nationwide, 15 countries globally, and space.
- Achieves both efficacy, safety, and low environmental impact (biodegradable, Acorn Mark).
- Contributes effectively to 11 SDGs (1/3/4/8/9/10/12/13/14/15/17) through core business-driven job creation for people with disabilities and cross-sector partnerships.
Inclusivity:
STI-based safe oral care directly connects to job creation for people with disabilities and extended healthy lifespan for the elderly.
Solution Architecture:
STI → Research (Kyushu University × Yasashii Laboratory) → Productization (Neonisin-e®) → Type-B Employment (production, shipping, promotion) → Profit Allocation → Medical/Municipal Adoption → Trust & Sales → Donations & Reinvestment (A self-sustaining social enterprise for people with disabilities, independent of subsidies or donations).
Collaboration Framework:
Universities/research institutes, medical professionals, space agencies, government, employment support/guardianship organizations, international partners, pro bono experts. Professional collaboration, leadership, and team management are key.
Implementation:
Divided operations: Production (Niigata), Shipping (Tokyo), Promotion (Kyoto), Sales (Nationwide). 10 years, 50+ facilities, 3,000+ individuals, 30 million+ yen distributed. Full traceability.
Governance:
Medical evidence, third-party evaluations (KIS/ISS/awards), biodegradability, and Acorn Mark ensure environmental accountability.
KPIs:
Employment numbers/wages & allocations, medical adoption facilities, aspiration pneumonia indicators, environmental impact, research reinvestment.
Next Steps:
International expansion via local production × employment; expansion into caregiving and infant/toddler sectors.
【Key Highlights】
- News Video Collection: 3-minute visualization of STI social implementation sites. → https://www.youtube.com/playlist?list=PLBegZ2BmeuTIaOS55wJXZSj7G_-VmPOAF
- Space Adoption: Proof of Japan-representative STI.
- NHK World Broadcast: International recognition.
- Members & Stakeholders: ~100 experts across research, medicine, government, and affected communities. Multi-sector collaboration.
- KIS Certification: Kawasaki City government standard for environment, safety, and social impact.
- Job Creation: Global precedent for STI social implementation with people with disabilities.
- Springer Case Study: Featured in international academic publisher textbook—proof of reproducibility and social significance.
- Project Story (12 Episodes): 10-year journey. Ensures continuity and transparency. Contributes to future generations.
【Summary】
Social Challenges (Elderly Aspiration, Disability Employment, Chemical Pollution) → Neonisin-e® → Products + Training + Jobs → Adoption / Employment / Distribution → Health↑, Income↑, Environmental Impact↓ → Inclusion / Sustainability
In One Sentence: “A structural solution where product sales growth directly increases wages for people with disabilities and health outcomes.”
Backed by KIS (government standard) × ISS (space technology) × Springer (international business), this swallowable antibacterial agent reduces aspiration pneumonia through burden-free oral care for caregivers and families, with disability employment and allocations scaling with sales. (11 SDGs addressed by the Oral Peace Project)
Next: Local deployment abroad × environmental protection and education support. Demonstrate scalability by horizontally expanding Japan’s space-adopted STI for SDGs “social implementation” worldwide.
【Reference Information】
- ORALPEACE Homepage: https://oralpeace.com/
- ORALPEACE and SDGs: https://trife.co.jp/sdgs/
- ORALPEACE Project – Job Creation for People with Disabilities Nationwide: https://oralpeace.com/business
- ORALPEACE Project News Video Collection: https://www.youtube.com/playlist?list=PLBegZ2BmeuTIaOS55wJXZSj7G_-VmPOAF
- ORALPEACE Project Members: https://oralpeace.com/member
- Our Mission (Presentation Deck): https://oralpeace.com/mission
- ORALPEACE Space Project: https://oralpeace.com/space-project
- ORALPEACE Project Disaster Support Activities: https://oralpeace.com/tag/%E7%81%BD%E5%AE%B3%E6%94%AF%E6%8F%B4%E6%B4%BB%E5%8B%95
- ORALPEACE Media Coverage: https://oralpeace.com/category/news
- ORALPEACE Project Activity Blog: https://oralpeace.com/category/blog
- ORALPEACE Research Papers: https://oralpeace.com/library
- NHK World Interview: https://youtu.be/ByuIqlJHxl4?si=3GYrzkyXdzv2X_Va
- Feb 2014: Yokohama Business Grand Prix – Grand Prize (Sponsored by Yokohama Foundation for Enterprise Management Support) → https://oralpeace.com/blog/928
- Feb 2015: JAPAN Venture Awards 2015 – Grand Prize (Sponsored by Small and Medium Enterprise Agency) → https://oralpeace.com/news/announcement/2028
- 2019: Japan Society for Bioscience, Biotechnology, and Agrochemistry Technology Award → https://oralpeace.com/blog/8535
- 2014: Selected for Yokohama City Market Development Support Project (Social Issue Solution Type)
- 2015: Selected for Yokohama City Promising Business Plan Subsidy
- 2016: Selected as one of “10 People Changing Japan’s Future” by Japan Foundation Social Innovator Grant
【Social Challenges Addressed】
Through safe oral care products, this initiative tackles four key issues:
- Provision of safe oral care products
- Reduction of elderly caregiving burden and health maintenance for infants and humanity
- Job creation for people with disabilities
- Environmental protection and disaster area support
【Top 5 Prioritized SDGs】
- SDG 3 (Health): Innovative chemical-free, swallowable oral care reduces caregiving burden/costs, extends healthy lifespan for the elderly, and ensures safety for pregnant women (fetus) and infants.
- SDG 8 (Decent Work): Creates jobs and social participation for people with disabilities via nationwide employment facilities, addressing low income and post-parental care challenges.
- SDG 6 (Clean Water): Enables oral care in water-scarce environments (space/disasters). Chemical-free, non-polluting to rivers/seas. Supports disaster areas.
- SDG 9 (Innovation): Developed swallowable safe oral care using lactic acid bacteria-derived nisin A. Selected by JAXA for ISS in 2021.
- SDG 12 (Responsible Consumption): Develops biodegradable, chemical-free, carbon-neutral products. Promotes sustainable production/consumption awareness. (11 SDGs addressed by the ORALPEACE Project)
【STI Utilized】
- Rapid screening of high-nisin-producing lactic acid bacteria
- Mass production and advanced purification of nisin
- Development and commercialization of natural antibacterial agents using nisin
- Support for job creation and social participation of people with disabilities via developed products (ORALPEACE Project)
- Development of oral care products usable in water-restricted environments (space/disasters) and disaster support activities
【Project Details】
ORALPEACE develops and provides swallowable safe oral care products through green technology collaboration with Japan’s national research institutions, addressing oral care challenges for the elderly, people with disabilities, and infants. Uses proprietary Neonisin-e®—chemical-free and environmentally friendly.
【Organizational Structure】
Collaboration among corporate/university researchers, medical experts, welfare facilities, and disability employment support centers—from R&D to manufacturing and sales. People with disabilities engage in production and logistics, enabling employment and social participation.
【Science & Technology Utilized】
Neonisin-e®, co-developed with Kyushu University, offers high antibacterial efficacy from natural ingredients and is effective in preventing aspiration pneumonia. Chemical-free formulation is validated for safety to body and environment.
【Social Impact】
Reduces aspiration pneumonia mortality risk, creates jobs for people with disabilities, lowers environmental impact. Adopted in medical/welfare facilities nationwide; expanding domestically and internationally.
【SDGs Contribution & Approach】
Under the “Leave No One Behind” principle, contributes to SDGs 3, 8, 12, and others. Sustainability integrated from product design to distribution and employment. 11 SDGs addressed.
【Storytelling】
Founded by parents of children with disabilities concerned for their future, this bio × social venture—with broad support—consistently addresses social challenges through R&D, disability social participation, elderly health, and environmental care.
【Future Plans】
Expand domestically and internationally. Strengthen ties with municipalities and medical/welfare sectors for broader adoption in elderly facilities, disability support, and home care. Continue awareness and training programs.
Overseas: Target aging regions. Build local supply chains with partners. Plan U.S. market entry by 2026 with localized packaging and information.
Expand Neonisin-e® applications to infection prevention and eco-friendly hygiene products, creating cross-sector social solutions.
Focus on Fluoride Regulations: Respond to U.S. fluoride restrictions and Europe’s chemical regulations. Position Neonisin-e® as a fluoride-free cavity prevention alternative. Develop safe products for infants, children, and pregnant women. Deliver fluoride-free, chemical-free, high-efficacy prevention globally.
【2030 Vision: ORALPEACE Project】
ORALPEACE provides 100% natural, swallowable oral care using Japan’s national lactic acid bacteria antibacterial peptide Neonisin-e®—safe from infants to the elderly, fully biodegradable. As a social product supporting the vulnerable and an Acorn Point product by METI, it reduces environmental impact.
By 2030, aim for a society balancing health and environment. Create jobs for people with disabilities via core business, solve post-parental care issues, embody STI for SDGs with Japan’s national research innovation, and expand globally as Japan’s leading SDGs initiative.
【2030 Social Vision】
- Healthy Oral Environment (SDG 3): Safe products for aspiration-risk elderly and infants. Universal access to proper oral care by 2030.
- Eco-Friendly Consumption (SDG 12): Biodegradable products reduce persistent chemicals and plastic waste. Environmentally conscious oral care becomes standard by 2030, advancing circular economy.
- Global Co-Creation (SDG 17): Collaborate with space agencies; leverage ISS track record. Partner with NGOs/companies to spread safe oral care worldwide.
- Fluoride Regulation Response: Fluoride-free products support cavity prevention for mothers and infants. Expand to 50+ countries.
- Disability Support via Core Business: Embody Japan-origin STI for SDGs through disability support and environmental protection. Expand globally as Japan’s representative SDGs initiative.
【Initiatives】
- Product Distribution: Low-cost supply to developing countries.
- Education & Awareness: Promote oral health importance.
- Technological Innovation: Pursue lower environmental impact.
- Social Contribution: Advance disability employment.
【STI Utilization】
Neonisin-e®—Japan’s national safe antibacterial technology for cavity/periodontal prevention. Validated in space via international space agency collaboration. Contributes to SDGs via STI as revolutionary technology for humanity.
By 2030, ORALPEACE realizes family-wide health and environmental protection. Complies with U.S./EU chemical/fluoride regulations, delivering safe oral care globally.
Through core business-driven job creation and economic independence for people with disabilities post-parental care, expand projects worldwide with empathetic local partners—including parents of children with disabilities—using Japan’s cutting-edge national STI to build a future society that saves the vulnerable globally.
【Reference SDGs】
- SDG 1: End extreme poverty, ensure social protection and equal opportunity.
- SDG 3: Strengthen prevention, treatment, and welfare; extend healthy lifespan for all ages.
- SDG 4: Free, inclusive education and lifelong learning.
- SDG 8: Safe, fair work, youth employment, innovation for sustainable growth.
- SDG 9: Resilient infrastructure, R&D for inclusive, sustainable industrialization. Sustainable, safe, eco-friendly oral care via space technology without relying on finite resources or chemicals.
- SDG 10: Reduce income/opportunity gaps and discrimination; promote social inclusion.
- SDG 12: Resource efficiency, waste/chemical management for sustainable consumption/production.
- SDG 13: Reduce greenhouse gases, enhance resilience via climate education and funding.
- SDG 14: Prevent marine pollution/overfishing; preserve ecosystems and coasts.
- SDG 15: Conserve forests, soil, biodiversity; combat desertification/chemical pollution.
- SDG 17: Multi-stakeholder partnerships to support all goals.
【Selection Committee Comments】
Organizations: TRIFE Inc., Yasashii Laboratory Inc., Kyushu University Initiative Name: Development and commercialization of a safe oral care agent using lactic acid bacteria bacteriocin and nisin
<Initiative Overview>
Through industry-academia collaboration, developed a swallowable, low-environmental-impact oral care product using lactic acid bacteria-derived antibacterial peptide nisin A. Extends healthy lifespan and reduces caregiving burden in aging societies. Also creates jobs for people with disabilities through manufacturing and sales.
<Award Rationale>
This initiative leverages industry-academia research on lactic acid bacteria antibacterial peptides to develop innovative oral care products and builds a disability support model through business. The product “ORALPEACE” uses Neonisin-e®—effective against oral bacteria, safe if swallowed, and environmentally friendly—contributing to reduced caregiving burden. It also creates sustainable jobs for people with disabilities tailored to each facility.
The selection highly valued the unique perspective and compelling story of professionals solving family-facing challenges with their expertise. In an aging society, it addresses multifaceted issues—reducing on-site caregiving burden/costs, extending healthy lifespan, and supporting people with disabilities. It contributes to SDGs 3, 6, 8, 9, 12 without undermining other goals—deemed worthy of the Encouragement Prize.
※ Reference: https://oralpeace.com/
<Chair’s Message (Excerpt)>
We introduced the Encouragement Prize this year to recognize initiatives with high potential for future social impact—such as early-stage startups or initial social implementation of university/corporate R&D. Even if just beginning, we aim to accelerate SDGs progress by spotlighting activities with assured future impact. → https://www.jst.go.jp/ristex/sdgs-award/about/message.html
【Words of Gratitude】
Since 2001, starting from a parents’ group for children with disabilities, over 100 pioneering members—social entrepreneurs, NGO staff, medical professionals, activists in social, environmental, and welfare fields—have collaborated. They merged with researchers from national institutions like Kyushu University Faculty of Agriculture and the National Center for Geriatrics and Gerontology, alongside dentists, dental hygienists, caregivers, and the medical/dental community. Together, we have explored comprehensive solutions to family-surrounding social issues. (11 SDGs addressed)
The ORALPEACE Project leverages world-leading lactic acid bacteria biotechnology STI from Kyushu University—adopted in space and representative of Japan. Implemented as a self-sustaining social enterprise independent of donations or public funds, the innovative, swallowable, eco-friendly oral care product ORALPEACE actively supports:
- Oral frailty prevention and the 8020 campaign promoted by the Ministry of Health, Labour and Welfare to extend healthy lifespan (reducing the ~10-year caregiving period).
- Reduction of annual caregiving costs exceeding 10 trillion yen (projected 25 trillion yen by 2040; global 65+ population 1.5 billion+ by 2050).
- Shift of young workers from elderly care to growth sectors.
- Contribution to manned space development (Artemis program, etc.).
- Disaster area support.
- Reduction of chemical environmental pollution.
Beyond STI-driven innovation, it creates a CSV model linking core business (production, distribution, sales) to job creation for people with disabilities—expanded to 15 countries. Not corporate philanthropy, but a social project delivering direct, high-impact contributions to humanity.
This Encouragement Prize will enhance recognition among domestic and international governments and municipalities, promote adoption in caregiving/medical/pediatric settings, expand to dental clinics, pregnant women, and infants, increase disaster stockpile use, boost income for people with disabilities via facility sales, facilitate global partner searches and local social enterprise deployment, resolve domestic imitation issues, and amplify Japan’s space-adopted national STI with new global collaborators to support the vulnerable from the world’s most aged nation—creating jobs and futures for people with disabilities worldwide and tackling universal social challenges.
This award honors the 10+ years of tearful, sweat-driven efforts by Kyushu University researchers, disability employment facilities, parents, medical/caregiving professionals, Yokohama City and other governments, production/distribution members, dentists, dental hygienists, the dental community, and all stakeholders—validating our global expansion potential.
Launched in 2013 to address Japan’s aging crisis, the ORALPEACE Project hit a turning point in 2020 amid the pandemic—seven years after gaining traction. The pandemic highlighted oral hygiene’s importance. In 2022, it was adopted as STI supporting manned space development. Now in 2025, post-pandemic, new global trends emerge:
- Safety needs due to U.S./EU chemical regulations (e.g., 2025 U.S. fluoride restrictions).
- Low environmental impact demands (e.g., 2024 PFAS regulations).
- Global aging (Japan’s caregiving costs to 25 trillion yen by 2040; 1.5 billion+ global 65+ by 2050).
- Declining birthrates in developed nations (Japan losing ~100,000 children annually in the 2020s).
- Increasing large-scale disasters (earthquakes, tsunamis, fires).
- Manned space development (Artemis by 2030).
- STEM education (support for uniquely gifted children).
The world now demands ORALPEACE’s STI and SDGs-aligned social contribution story. The potential contribution of Japan’s unique national STI and social enterprise to global humanity in 10, 20, 30, or 100 years is immeasurable.
This award marks the dawn of a new stage and the starting line for a full-scale international project.
With further support, we aim to expand recognition and operations domestically and internationally, create more jobs for people with disabilities, pursue additional global awards, deepen cross-sector social impact, and sincerely scale high-quality, authentic social enterprise from Japan to the world—with greater speed and impact.
Thank you sincerely. We humbly ask for your continued support of the ORALPEACE Project.
TRIFE Inc. – ORALPEACE Project
【ORALPEACE Project Timeline】
- Dec 2012: Invention press conference for lactic acid bacteria antibacterial peptide “Neonisin” (Kyushu University Press Club)
- Jun 2013: Project launch press conference: “Innovative oral care products creating jobs for people with disabilities” (Kioi Forum)
- Jul 2013: Launch of ORALPEACE gel and spray
- Feb 2014: Grand Prize & Audience Award at Yokohama Business Grand Prix 2014
- Jul 2014: Only oral care product certified as METI “Acorn Mark” CO2-zero eco-product
- Feb 2015: Excellence Award at Kawasaki Entrepreneur Audition; others
- Feb 2015: Grand Prize at JAPAN Venture Awards 2015
- Mar 2015: Social Products Award 2015 – Consumer Jury Prize
- Apr 2015: “Neonisin” patent acquired; European organic certification
- Apr 2016: Donated/distributed ORALPEACE to Kumamoto earthquake victims
- Jun 2016: Launched “ORALPEACE for Pets”
- Sep 2016: Selected as one of “10 People Changing Japan’s Future” by Japan Foundation
- Mar 2017: Only oral care product certified under Kawasaki City “Kawasaki Standard”
- Jul 2017: Press conference for new “Neonisin-e” formulation covering oral candida (Yokohama Port Opening Memorial Hall)
- Oct 2017: First Good Design Award 2017 for oral care; “Neonisin-e” patent
- Sep 2018: “LOVE IS ORGANIC” (by ADK) shortlisted at Spikes Asia 2019 Film
- Mar 2019: First Japan Society for Bioscience Technology Award for oral care
- May 2019: Launched world’s first outdoor-dedicated toothpaste “ORALPEACE Outdoor Adventure”
- Feb 2020: Provided ORALPEACE free to 3,600 on Diamond Princess via Yokohama City
- Sep 2020: Featured on NHK World “Direct Talk” broadcast globally
- Dec 2020: Selected as ISS candidate by JAXA
- Jan 2021: Pivoted to space personal care venture
- Mar 2021: Expanded to 15 countries including Thailand, Europe, U.S., Asia
- Nov 2021: Officially selected for ISS by JAXA
- Feb 2022: Announced “Space Cosmetics FACEPEACE”
- Jun 2022: Upgraded to “Space Toothpaste ORALPEACE”
- Oct 2023: Sponsored U.S. community surf contest
- Jul 2024: Featured at Japan Society for Home Care Medicine
- Nov 2024: Began 12-episode series “Oral Peace Story” in Quintessence Publishing
- Jun 2025: Launched “ORALPEACE Baby & Kids Toothgel” post-U.S. fluoride ruling
- Oct 2025: Won JST “STI for SDGs Award” Encouragement Prize